resource logo

SWISS-2DPAGE

Attention: World-2DPAGE is no longer maintained.


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02652




SWISS-2DPAGE:  P02652


P02652


General information about the entry
View entry in simple text format
Entry nameAPOA2_HUMAN
Primary accession numberP02652
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onOctober 1, 2001 (version 1)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-II; Short=Apo-AII; Short=ApoA-II; AltName: Full=Apolipoprotein A2; Contains: RecName: Full=Apolipoprotein A-II(1-76); Flags: Precursor;.
Gene nameName=APOA2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
Comments
  • SUBUNIT: HOMODIMER
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.74; Mw=12520
pI=4.71; Mw=7250

NORMAL LEVEL:
260-660 MG/L [1].

PATHOLOGICAL LEVEL:
DECREASED DURING TANGIER DISEASE AND ARTERIOSCLEROSIS [1]; INCREASED DURING LIVER DISEASE [1].

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
Siena-2DPAGEP02652; APOA2_HUMAN.
UniProtKB/Swiss-ProtP02652; APOA2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAPOA2_HUMAN
Primary accession numberP02652
Secondary accession number(s) B2R524
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein A-II; Short=Apo-AII; Short=ApoA-II; AltName: Full=Apolipoprotein A2; Contains: RecName: Full=Apolipoprotein A-II(1-76); Flags: Precursor;
Gene nameName=APOA2
Encoded onName=APOA2
Keywords3D-structure; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; HDL; Host-virus interaction; Lipid transport; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX04898; CAA28583.1; -; Genomic_DNA
EMBLX00955; CAA25467.1; -; mRNA
EMBLX02905; CAA26665.1; -; Genomic_DNA
EMBLX02619; CAA26474.1; -; Genomic_DNA
EMBLM29882; AAA51701.1; -; mRNA
EMBLAY100524; AAM49807.1; -; Genomic_DNA
EMBLAK312034; BAG34971.1; -; mRNA
EMBLBT006786; AAP35432.1; -; mRNA
EMBLAL590714; CAH72151.1; -; Genomic_DNA
EMBLBC005282; AAH05282.1; -; mRNA
IPIIPI00021854; -; .
PIRA93586; LPHUA2; .
RefSeqNP_001634.1; NM_001643.1; .
UniGeneHs.237658; -; .
PDB1L6L; X-ray; 2.30 A; 1/2/3/4/5/6/7/8/A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/Q/S/T/U/V/W/X/Y/Z=24-100
PDB2OU1; X-ray; 2.00 A; A/B/C/D/E/F/G/H/I/J/K/L=24-100
PDBsum1L6L; -; .
PDBsum2OU1; -; .
ProteinModelPortalP02652; -; .
SMRP02652; 25-100; .
IntActP02652; 2; .
STRINGP02652; -; .
PhosphoSiteP02652; -; .
SWISS-2DPAGEP02652; -; .
Siena-2DPAGEP02652; -; .
PeptideAtlasP02652; -; .
PRIDEP02652; -; .
EnsemblENST00000367990; ENSP00000356969; ENSG00000158874; .
GeneID336; -; .
KEGGhsa:336; -; .
UCSCuc001fzc.1; human; .
CTD336; -; .
GeneCardsGC01M132549; -; .
H-InvDBHIX0001240; -; .
HGNCHGNC:601; APOA2; .
HPACAB025885; -; .
MIM107670; gene; .
neXtProtNX_P02652; -; .
Orphanet238269; Familial renal amyloidosis due to Apolipoprotein AII variant; .
PharmGKBPA24886; -; .
eggNOGprNOG20443; -; .
GeneTreeENSGT00390000003306; -; .
HOGENOMHBG125866; -; .
HOVERGENHBG050544; -; .
InParanoidP02652; -; .
OMAKAYFEKT; -; .
OrthoDBEOG42NJ1Z; -; .
PhylomeDBP02652; -; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
NextBio1391; -; .
PMAP-CutDBP02652; -; .
ArrayExpressP02652; -; .
BgeeP02652; -; .
CleanExHS_APOA2; -; .
GenevestigatorP02652; -; .
GermOnlineENSG00000158874; Homo sapiens; .
GOGO:0042627; C:chylomicron; IDA:BHF-UCL; .
GOGO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome; .
GOGO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034190; F:apolipoprotein receptor binding; IPI:BHF-UCL; .
GOGO:0015485; F:cholesterol binding; IDA:BHF-UCL; .
GOGO:0070653; F:high-density lipoprotein particle receptor binding; IPI:BHF-UCL; .
GOGO:0055102; F:lipase inhibitor activity; IDA:BHF-UCL; .
GOGO:0031210; F:phosphatidylcholine binding; IDA:BHF-UCL; .
GOGO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL; .
GOGO:0046982; F:protein heterodimerization activity; IPI:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; .
GOGO:0033344; P:cholesterol efflux; IDA:BHF-UCL; .
GOGO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL; .
GOGO:0046340; P:diacylglycerol catabolic process; IDA:BHF-UCL; .
GOGO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL; .
GOGO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL; .
GOGO:0034375; P:high-density lipoprotein particle remodeling; IDA:BHF-UCL; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0042157; P:lipoprotein metabolic process; TAS:Reactome; .
GOGO:0034374; P:low-density lipoprotein particle remodeling; IDA:BHF-UCL; .
GOGO:0060621; P:negative regulation of cholesterol import; IDA:BHF-UCL; .
GOGO:0060695; P:negative regulation of cholesterol transporter activity; IDA:BHF-UCL; .
GOGO:0002740; P:negative regulation of cytokine secretion involved in immune response; IDA:BHF-UCL; .
GOGO:0060192; P:negative regulation of lipase activity; IDA:BHF-UCL; .
GOGO:0050995; P:negative regulation of lipid catabolic process; IDA:BHF-UCL; .
GOGO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IDA:BHF-UCL; .
GOGO:0006656; P:phosphatidylcholine biosynthetic process; IDA:BHF-UCL; .
GOGO:0009395; P:phospholipid catabolic process; IDA:BHF-UCL; .
GOGO:0033700; P:phospholipid efflux; IDA:BHF-UCL; .
GOGO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; .
GOGO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IDA:UniProtKB; .
GOGO:0050996; P:positive regulation of lipid catabolic process; IDA:BHF-UCL; .
GOGO:0006457; P:protein folding; IDA:BHF-UCL; .
GOGO:0031647; P:regulation of protein stability; IDA:BHF-UCL; .
GOGO:0009749; P:response to glucose stimulus; IDA:BHF-UCL; .
GOGO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL; .
GOGO:0006641; P:triglyceride metabolic process; TAS:BHF-UCL; .
GOGO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IDA:BHF-UCL; .
InterProIPR006801; ApoA-II; .
PANTHERPTHR11027; ApoA-II; 1; .
PfamPF04711; ApoA-II; 1; .
ProDomPD010397; ApoA-II; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server