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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02671




SWISS-2DPAGE:  P02671


P02671


General information about the entry
View entry in simple text format
Entry nameFIBA_HUMAN
Primary accession numberP02671
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on November 9, 2011 (version 17)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen alpha chain; Contains: RecName: Full=Fibrinopeptide A; Contains: RecName: Full=Fibrinogen alpha chain; Flags: Precursor;.
Gene nameName=FGA
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: ALPHA, BETA AND GAMMA CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=6.71; Mw=69531
pI=6.89; Mw=69017
pI=6.80; Mw=69531
pI=6.98; Mw=68001
pI=7.13; Mw=67249
pI=7.21; Mw=67000
pI=7.06; Mw=67000
pI=6.79; Mw=65912
pI=6.69; Mw=66345
pI=6.88; Mw=65054
pI=6.97; Mw=64842
pI=7.06; Mw=64418
pI=7.24; Mw=63998

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=7.65; Mw=66818
pI=6.74; Mw=67513
pI=6.95; Mw=67256
pI=7.03; Mw=67000
pI=6.85; Mw=67256
pI=7.18; Mw=66456
pI=6.66; Mw=66097
pI=7.39; Mw=66456
pI=6.75; Mw=65917
pI=6.85; Mw=65739
pI=6.94; Mw=65739
pI=7.03; Mw=65383
pI=7.66; Mw=64326
pI=6.65; Mw=63459
pI=7.39; Mw=63804
pI=6.78; Mw=63459
pI=6.89; Mw=63287
pI=7.00; Mw=63115
pI=7.18; Mw=63115

NORMAL LEVEL:
2000-4500 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING DISSAMINATED INTRAVASCULAR COAGULATION AND HYPERFIBRINOLYSIS; INCREASED DURING ACUTE INFLAMMATION.

POSITIONAL VARIANTS:
LILLE-1, ROUEN-1, MUNICH-1, DETROIT-1 AND AARHUS-1 VARIANTS.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWP02671.
Siena-2DPAGEP02671; FIBA_HUMAN.
UniProtKB/Swiss-ProtP02671; FIBA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameFIBA_HUMAN
Primary accession numberP02671
Secondary accession number(s) D3DP14 D3DP15 Q4QQH7 Q9BX62 Q9UCH2
Sequence was last modified on October 1, 1996 (version 2)
Annotations were last modified on September 21, 2011 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Fibrinogen alpha chain; Contains: RecName: Full=Fibrinopeptide A; Contains: RecName: Full=Fibrinogen alpha chain; Flags: Precursor;
Gene nameName=FGA
Encoded onName=FGA
Keywords3D-structure; Alternative splicing; Amyloid; Amyloidosis; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM64982; AAA17056.1; -; Genomic_DNA
EMBLM64982; AAA17055.1; -; Genomic_DNA
EMBLM58569; AAC97142.1; -; Transcribed_RNA
EMBLM58569; AAC97143.1; -; Transcribed_RNA
EMBLAF361104; AAK31372.1; -; Genomic_DNA
EMBLAF361104; AAK31373.1; -; Genomic_DNA
EMBLCH471056; EAX04925.1; -; Genomic_DNA
EMBLCH471056; EAX04926.1; -; Genomic_DNA
EMBLCH471056; EAX04927.1; -; Genomic_DNA
EMBLCH471056; EAX04928.1; -; Genomic_DNA
EMBLBC098280; AAH98280.1; -; mRNA
EMBLBC099706; AAH99706.1; -; mRNA
EMBLBC099720; AAH99720.1; -; mRNA
EMBLBC101935; AAI01936.1; -; mRNA
EMBLJ00128; AAA52427.1; -; mRNA
EMBLJ00127; AAA52426.1; -; mRNA
EMBLK02272; AAA52428.1; -; mRNA
EMBLM26878; AAA52444.1; -; mRNA
IPIIPI00021885; -; .
IPIIPI00029717; -; .
PIRA93956; FGHUA; .
PIRD44234; D44234; .
RefSeqNP_000499.1; NM_000508.3; .
RefSeqNP_068657.1; NM_021871.2; .
UniGeneHs.351593; -; .
PDB1BBR; X-ray; 2.30 A; F/G/I=26-35
PDB1FZA; X-ray; 2.90 A; A/D=130-216
PDB1FZB; X-ray; 2.90 A; A/D=130-216
PDB1FZC; X-ray; 2.30 A; A/D=130-216
PDB1FZD; X-ray; 2.10 A; A/B/C/D/E/F/G/H=666-866
PDB1FZE; X-ray; 3.00 A; A/D=130-216
PDB1FZF; X-ray; 2.70 A; A/D=130-216
PDB1FZG; X-ray; 2.50 A; A/D=130-216
PDB1LT9; X-ray; 2.80 A; A/D=145-210
PDB1LTJ; X-ray; 2.80 A; A/D=145-210
PDB1N86; X-ray; 3.20 A; A/D=130-216
PDB1N8E; X-ray; 4.50 A; A/D=130-218
PDB1RE3; X-ray; 2.45 A; A/D=145-210
PDB1RE4; X-ray; 2.70 A; A/D=145-210
PDB1RF0; X-ray; 2.81 A; A/D=145-210
PDB1RF1; X-ray; 2.53 A; A/D=145-210
PDB1YCP; X-ray; 2.50 A; F/N=20-42
PDB2A45; X-ray; 3.65 A; G/J=36-92
PDB2FFD; X-ray; 2.89 A; A/D=145-210
PDB2H43; X-ray; 2.70 A; A/D=130-216
PDB2HLO; X-ray; 2.60 A; A/D=130-216
PDB2HOD; X-ray; 2.90 A; A/D/G/J=130-216
PDB2HPC; X-ray; 2.90 A; A/D/G/J=130-216
PDB2OYH; X-ray; 2.40 A; A/D=145-210
PDB2OYI; X-ray; 2.70 A; A/D=145-210
PDB2Q9I; X-ray; 2.80 A; A/D=130-216
PDB2XNX; X-ray; 3.30 A; A/D/G/J=130-216
PDB2XNY; X-ray; 7.50 A; A/D=130-216
PDB2Z4E; X-ray; 2.70 A; A/D=130-216
PDB3AT0; X-ray; 2.50 A; B=332-347
PDB3BVH; X-ray; 2.60 A; A/D=148-209
PDB3E1I; X-ray; 2.30 A; A/D=130-216
PDB3GHG; X-ray; 2.90 A; A/D/G/J=20-581
PDB3H32; X-ray; 3.60 A; A/D=20-216
PDB3HUS; X-ray; 3.04 A; A/D=145-210
PDBsum1BBR; -; .
PDBsum1FZA; -; .
PDBsum1FZB; -; .
PDBsum1FZC; -; .
PDBsum1FZD; -; .
PDBsum1FZE; -; .
PDBsum1FZF; -; .
PDBsum1FZG; -; .
PDBsum1LT9; -; .
PDBsum1LTJ; -; .
PDBsum1N86; -; .
PDBsum1N8E; -; .
PDBsum1RE3; -; .
PDBsum1RE4; -; .
PDBsum1RF0; -; .
PDBsum1RF1; -; .
PDBsum1YCP; -; .
PDBsum2A45; -; .
PDBsum2FFD; -; .
PDBsum2H43; -; .
PDBsum2HLO; -; .
PDBsum2HOD; -; .
PDBsum2HPC; -; .
PDBsum2OYH; -; .
PDBsum2OYI; -; .
PDBsum2Q9I; -; .
PDBsum2XNX; -; .
PDBsum2XNY; -; .
PDBsum2Z4E; -; .
PDBsum3AT0; -; .
PDBsum3BVH; -; .
PDBsum3E1I; -; .
PDBsum3GHG; -; .
PDBsum3H32; -; .
PDBsum3HUS; -; .
ProteinModelPortalP02671; -; .
SMRP02671; 46-231; 411-601; 629-866
DIPDIP-29643N; -; .
IntActP02671; 10; .
MINTMINT-1033042; -; .
STRINGP02671; -; .
PhosphoSiteP02671; -; .
SWISS-2DPAGEP02671; -; .
OGPP02671; -; .
Siena-2DPAGEP02671; -; .
PeptideAtlasP02671; -; .
PRIDEP02671; -; .
EnsemblENST00000302053; ENSP00000306361; ENSG00000171560; .
GeneID2243; -; .
KEGGhsa:2243; -; .
NMPDRfig|9606.3.peg.24776; -; .
UCSCuc003iod.1; human; .
CTD2243; -; .
GeneCardsGC04M151244; -; .
HGNCHGNC:3661; FGA; .
HPACAB016776; -; .
MIM105200; phenotype; .
MIM134820; gene+phenotype; .
MIM202400; phenotype; .
neXtProtNX_P02671; -; .
Orphanet98880; Familial afibrinogenemia; .
Orphanet98881; Familial dysfibrinogenemia; .
Orphanet248408; Familial hypodysfibrinogenemia; .
Orphanet101041; Familial hypofibrinogenemia; .
Orphanet93562; Familial renal amyloidosis due to fibrinogen A alpha-chain variant; .
PharmGKBPA429; -; .
eggNOGprNOG19217; -; .
HOGENOMHBG716848; -; .
HOVERGENHBG005668; -; .
InParanoidP02671; -; .
OMAWGTFEEV; -; .
OrthoDBEOG4XPQFB; -; .
PhylomeDBP02671; -; .
ReactomeREACT_13552; Integrin cell surface interactions; .
ReactomeREACT_604; Hemostasis; .
ReactomeREACT_75925; Amyloids; .
DrugBankDB00009; Alteplase; .
DrugBankDB00029; Anistreplase; .
DrugBankDB00015; Reteplase; .
DrugBankDB00364; Sucralfate; .
DrugBankDB00031; Tenecteplase; .
NextBio9073; -; .
PMAP-CutDBP02671; -; .
ArrayExpressP02671; -; .
BgeeP02671; -; .
CleanExHS_FGA; -; .
GenevestigatorP02671; -; .
GermOnlineENSG00000171560; Homo sapiens; .
GOGO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; .
GOGO:0005577; C:fibrinogen complex; TAS:ProtInc; .
GOGO:0031093; C:platelet alpha granule lumen; TAS:Reactome; .
GOGO:0043499; F:eukaryotic cell surface binding; IDA:BHF-UCL; .
GOGO:0030674; F:protein binding; bridging; IEA:InterPro
GOGO:0005102; F:receptor binding; IEA:InterPro; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0051258; P:protein polymerization; IEA:InterPro; .
GOGO:0051592; P:response to calcium ion; IDA:BHF-UCL; .
GOGO:0007165; P:signal transduction; IEA:InterPro; .
InterProIPR002181; Fibrinogen_a/b/g_C; .
InterProIPR014716; Fibrinogen_a/b/g_C_1; .
InterProIPR014715; Fibrinogen_a/b/g_C_2; .
InterProIPR012290; Fibrinogen_a/b/g_coil_dom; .
InterProIPR021996; Fibrinogen_aC; .
InterProIPR020837; Fibrinogen_CS; .
Gene3DG3DSA:3.90.215.10; Fibrinogen_a/b/g_C_1; 1; .
Gene3DG3DSA:4.10.530.10; Fibrinogen_a/b/g_C_2; 1; .
Gene3DG3DSA:1.20.5.50; Fibrinogen_a/b/g_coil; 1; .
PfamPF08702; Fib_alpha; 1; .
PfamPF12160; Fibrinogen_aC; 1; .
PfamPF00147; Fibrinogen_C; 1; .
SMARTSM00186; FBG; 1; .
SUPFAMSSF56496; Fibrinogen_a/b/g_C; 1; .
PROSITEPS00514; FIBRINOGEN_C_1; 1; .
PROSITEPS51406; FIBRINOGEN_C_2; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server