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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02741




SWISS-2DPAGE:  P02741


P02741


General information about the entry
View entry in simple text format
Entry nameCRP_HUMAN
Primary accession numberP02741
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=C-reactive protein; Contains: RecName: Full=C-reactive protein(1-205); Flags: Precursor;.
Gene nameName=CRP
Synonyms=PTX1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Anderson N.L.
Personal communication (1993)
Comments
  • SUBUNIT: HOMOPENTAMER
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.12; Mw=23760

NORMAL LEVEL:
2-5 MG/L [1].

PATHOLOGICAL LEVEL:
INCREASED DURING ACUTE AND CHRONIC BACTERIAL INFECTIONS, CELL NECROSIS, CHRONIC RENAL FAILURE, HODGKINS DISEASE AND ACTIVE RHEUMATOID ARTHRITIS [1].

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP02741; P02741.
DOSAC-COBS-2DPAGEP02741; CRP_HUMAN.
Siena-2DPAGEP02741; CRP_HUMAN.
UniProtKB/Swiss-ProtP02741; CRP_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCRP_HUMAN
Primary accession numberP02741
Secondary accession number(s) A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75
Sequence was last modified on January 1, 1988 (version 1)
Annotations were last modified on October 19, 2011 (version 149)
Name and origin of the protein
DescriptionRecName: Full=C-reactive protein; Contains: RecName: Full=C-reactive protein(1-205); Flags: Precursor;
Gene nameName=CRP
Synonyms=PTX1
Encoded onName=CRP; Synonyms=PTX1
Keywords3D-structure; Acute phase; Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Metal-binding; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM11880; AAB59526.1; -; Genomic_DNA
EMBLM11725; AAA52075.1; -; Genomic_DNA
EMBLX56692; CAA40020.1; -; mRNA
EMBLX56214; CAA39671.1; -; mRNA
EMBLAF442818; AAL48218.2; -; Genomic_DNA
EMBLAK289443; BAF82132.1; -; mRNA
EMBLAF449713; AAL40835.1; -; Genomic_DNA
EMBLAL445528; CAH73654.1; -; Genomic_DNA
EMBLAL445528; CAH73656.1; -; Genomic_DNA
EMBLCH471121; EAW52778.1; -; Genomic_DNA
EMBLCH471121; EAW52779.1; -; Genomic_DNA
EMBLCH471121; EAW52780.1; -; Genomic_DNA
EMBLBC020766; AAH20766.1; -; mRNA
EMBLBC125135; AAI25136.1; -; mRNA
EMBLM35163; AAA52076.1; -; mRNA
EMBLK00518; AAA52074.1; -; mRNA
IPIIPI00022389; -; .
IPIIPI00218876; -; .
PIRA24515; CJHU; .
RefSeqNP_000558.2; NM_000567.2; .
UniGeneHs.709456; -; .
UniGeneHs.76452; -; .
PDB1B09; X-ray; 2.50 A; A/B/C/D/E=19-224
PDB1CRV; Model; -; A/B/C/D/E=19-224
PDB1GNH; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J=19-224
PDB1LJ7; X-ray; 3.15 A; A/B/C/D/E/F/G/H/I/J=19-224
PDB3L2Y; X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=19-224
PDBsum1B09; -; .
PDBsum1CRV; -; .
PDBsum1GNH; -; .
PDBsum1LJ7; -; .
PDBsum3L2Y; -; .
ProteinModelPortalP02741; -; .
SMRP02741; 19-224; .
IntActP02741; 3; .
MINTMINT-1206167; -; .
STRINGP02741; -; .
SWISS-2DPAGEP02741; -; .
DOSAC-COBS-2DPAGEP02741; -; .
PeptideAtlasP02741; -; .
PRIDEP02741; -; .
EnsemblENST00000255030; ENSP00000255030; ENSG00000132693; .
GeneID1401; -; .
KEGGhsa:1401; -; .
UCSCuc001ftw.1; human; .
UCSCuc001ftx.1; human; .
CTD1401; -; .
GeneCardsGC01M131038; -; .
H-InvDBHIX0028720; -; .
HGNCHGNC:2367; CRP; .
HPACAB005036; -; .
HPAHPA027367; -; .
HPAHPA027396; -; .
MIM123260; gene; .
neXtProtNX_P02741; -; .
PharmGKBPA120; -; .
eggNOGprNOG08533; -; .
GeneTreeENSGT00550000074240; -; .
HOGENOMHBG716040; -; .
HOVERGENHBG005405; -; .
InParanoidP02741; -; .
OMACTSWESA; -; .
OrthoDBEOG4R23VS; -; .
PhylomeDBP02741; -; .
Pathway_Interaction_DBil6_7pathway; IL6-mediated signaling events; .
DrugBankDB01076; Atorvastatin; .
DrugBankDB01393; Bezafibrate; .
NextBio5737; -; .
ArrayExpressP02741; -; .
BgeeP02741; -; .
CleanExHS_CRP; -; .
GenevestigatorP02741; -; .
GermOnlineENSG00000132693; Homo sapiens; .
GOGO:0033265; F:choline binding; TAS:BHF-UCL; .
GOGO:0051637; F:Gram-positive bacterial cell surface binding; TAS:BHF-UCL; .
GOGO:0030169; F:low-density lipoprotein particle binding; IDA:BHF-UCL; .
GOGO:0046872; F:metal ion binding; IEA:UniProtKB-KW; .
GOGO:0006953; P:acute-phase response; TAS:BHF-UCL; .
GOGO:0010888; P:negative regulation of lipid storage; IDA:BHF-UCL; .
GOGO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IDA:BHF-UCL; .
GOGO:0008228; P:opsonization; TAS:BHF-UCL; .
InterProIPR008985; ConA-like_lec_gl; .
InterProIPR013320; ConA-like_subgrp; .
InterProIPR001759; Pentaxin; .
Gene3DG3DSA:2.60.120.200; ConA_like_subgrp; 1; .
PfamPF00354; Pentaxin; 1; .
PRINTSPR00895; PENTAXIN; .
SMARTSM00159; PTX; 1; .
SUPFAMSSF49899; ConA_like_lec_gl; 1; .
PROSITEPS00289; PENTAXIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server