| General information about the entry |
| View entry in simple text format |
| Entry name | CO4B_HUMAN |
| Primary accession number | P0C0L5 |
| Secondary accession number(s) | P01028 |
| integrated into SWISS-2DPAGE on | August 1, 1993 (release 0) |
| 2D Annotations were last modified on | December 1, 2000 (version 1) |
| General Annotations were last modified on | May 19, 2011 (version 13) |
| Name and origin of the protein |
| Description | RecName: Full=Complement C4-B; AltName: Full=Basic complement C4; AltName: Full=C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; Contains: RecName: Full=Complement C4 beta chain; Contains: RecName: Full=Complement C4-B alpha chain; Contains: RecName: Full=C4a anaphylatoxin; Contains: RecName: Full=C4b-B; Contains: RecName: Full=C4d-B; Contains: RecName: Full=Complement C4 gamma chain; Flags: Precursor;. |
| Gene name | Name=C4B
Synonyms=CO4, CPAMD3
|
| Annotated species | Homo sapiens (Human) [TaxID: 9606] |
| Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
| References |
| [1] |
MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
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| [2] |
MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
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| Comments |
- SUBUNIT: ALPHA, BETA AND GAMMA CHAIN
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| 2D PAGE maps for identified proteins
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How to interpret a protein
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CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
map experimental info
protein estimated location
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CSF_HUMAN
MAP LOCATIONS:
MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].
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HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
map experimental info
protein estimated location
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HEPG2SP_HUMAN
MAP LOCATIONS:
MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].
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PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
map experimental info
protein estimated location
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PLASMA_HUMAN
MAP LOCATIONS:
NORMAL LEVEL:
200-500 MG/L.
PATHOLOGICAL LEVEL:
DECREASED DURING LUPUS ERYTHEMATOSUS AND HEREDITARY ANGIOEDEMA.
POSITIONAL VARIANTS:
MORE THAN 10 VARIANTS.
MAPPING (identification):
MICROSEQUENCING [1].
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| Copyright |
| This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
| Cross-references |
| DOSAC-COBS-2DPAGE | P0C0L5; CO4B_HUMAN. |
| UniProtKB/Swiss-Prot | P0C0L5; CO4B_HUMAN. |
| 2D PAGE maps for identified proteins
|
- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
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