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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P18206 SWISS-2DPAGE:  P18206 P18206 General information about the entry View entry in simple text format Entry name VINC_HUMAN Primary accession number P18206 integrated into SWISS-2DPAGE on  January 15, 1999 (release 9) 2D Annotations were last modified on March 31, 2004 (version 1) General Annotations were last modified on  May 19, 2011 (version 9) Name and origin of the protein Description RecName: Full=Vinculin; AltName: Full=Metavinculin;. Gene name Name=VCL Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE 2D PAGE maps for identified proteins How to interpret a protein DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human) Tissue: Colon adenocarcinoma   map experimental info   protein estimated location   DLD1_HUMAN MAP LOCATIONS: SPOT 2D-001CZK: pI=5.89; Mw=129569   [identification data] MAPPING (identification): Peptide mass fingerprinting [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P18206; P18206. DOSAC-COBS-2DPAGE P18206; VINC_HUMAN. HSC-2DPAGE P18206; HUMAN. OGP-WWW P18206. REPRODUCTION-2DPAGE IPI00291175; IPI00291175. Siena-2DPAGE P18206; VINC_HUMAN. UCD-2DPAGE P18206; VINC_HUMAN. UniProtKB/Swiss-Prot P18206; VINC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name VINC_HUMAN Primary accession number P18206 Secondary accession number(s) Q16450 Q5SWX2 Q7Z3B8 Q8IXU7 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  October 19, 2011 (version 138) Name and origin of the protein Description RecName: Full=Vinculin; AltName: Full=Metavinculin; Gene name Name=VCL Encoded on Name=VCL Keywords 3D-structure; Acetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Lipoprotein; Membrane; Myristate; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M33308; AAA61283.1; -; mRNA EMBL BX537994; CAD97952.1; -; mRNA EMBL AL596247; CAI13972.1; -; Genomic_DNA EMBL AL731576; CAI13972.1; JOINED; Genomic_DNA EMBL AL731576; CAI39673.1; -; Genomic_DNA EMBL AL596247; CAI39673.1; JOINED; Genomic_DNA EMBL BC039174; AAH39174.1; -; mRNA EMBL L04933; AAA61271.1; -; Genomic_DNA EMBL S87180; AAB21656.1; -; Genomic_DNA EMBL S87175; AAB21656.1; JOINED; Genomic_DNA EMBL S87178; AAB21656.1; JOINED; Genomic_DNA EMBL S87223; AAB21657.1; -; Genomic_DNA EMBL S87218; AAB21657.1; JOINED; Genomic_DNA IPI IPI00291175; -; . IPI IPI00307162; -; . IPI IPI00384973; -; . PIR A35955; A35955; . RefSeq NP_003364.1; NM_003373.3; . RefSeq NP_054706.1; NM_014000.2; . UniGene Hs.643896; -; . PDB 1RKC; X-ray; 2.70 A; A=1-258 PDB 1RKE; X-ray; 2.35 A; A=1-258 B=882-1134 PDB; 1SYQ; X-ray; 2.42 A A=1-258 PDB; 1TR2; X-ray; 2.90 A A/B=1-1134 PDB; 1YDI; X-ray; 1.80 A A=1-258 PDB; 2GWW; X-ray; 2.72 A A=1-257 PDB; 2HSQ; X-ray; 3.97 A A=2-257 PDB; 2IBF; X-ray; 3.20 A A=1-258 PDB; 3H2U; X-ray; 2.75 A A/C=879-1134 PDB; 3H2V; X-ray; 2.90 A A/B/C/D=879-1134 PDB; 3MYI; X-ray; 2.20 A A=959-1130 PDB; 3RF3; X-ray; 1.61 A A/B=1-258 PDB; 3S90; X-ray; 1.97 A A/B=1-252 PDBsum; 1RKC; -; . PDBsum 1RKE; -; . PDBsum 1SYQ; -; . PDBsum 1TR2; -; . PDBsum 1YDI; -; . PDBsum 2GWW; -; . PDBsum 2HSQ; -; . PDBsum 2IBF; -; . PDBsum 3H2U; -; . PDBsum 3H2V; -; . PDBsum 3MYI; -; . PDBsum 3RF3; -; . PDBsum 3S90; -; . ProteinModelPortal P18206; -; . SMR P18206; 1-258; 961-1129; . DIP DIP-35570N; -; . IntAct P18206; 7; . MINT MINT-92846; -; . STRING P18206; -; . PhosphoSite P18206; -; . SWISS-2DPAGE P18206; -; . Aarhus/Ghent-2DPAGE 3708; IEF; . DOSAC-COBS-2DPAGE P18206; -; . OGP P18206; -; . REPRODUCTION-2DPAGE IPI00291175; -; . UCD-2DPAGE P18206; -; . PRIDE P18206; -; . Ensembl ENST00000211998; ENSP00000211998; ENSG00000035403; . GeneID 7414; -; . KEGG hsa:7414; -; . UCSC uc001jwd.1; human; . UCSC uc001jwe.1; human; . CTD 7414; -; . GeneCards GC10P069753; -; . HGNC HGNC:12665; VCL; . HPA CAB002453; -; . HPA HPA002131; -; . MIM 193065; gene; . MIM 611407; phenotype; . MIM 613255; phenotype; . neXtProt NX_P18206; -; . Orphanet 154; Familial isolated dilated cardiomyopathy; . Orphanet 155; Familial isolated hypertrophic cardiomyopathy; . eggNOG prNOG17973; -; . HOGENOM HBG358349; -; . HOVERGEN HBG079758; -; . InParanoid P18206; -; . OMA ELTHQVH; -; . OrthoDB EOG4P5K8C; -; . PhylomeDB P18206; -; . Pathway_Interaction_DB avb3_integrin_pathway; Integrins in angiogenesis; . Pathway_Interaction_DB vegfr1_2_pathway; Signaling events mediated by VEGFR1 and VEGFR2; . Reactome REACT_17044; Muscle contraction; . Reactome REACT_604; Hemostasis; . NextBio 29028; -; . ArrayExpress P18206; -; . Bgee P18206; -; . CleanEx HS_VCL; -; . Genevestigator P18206; -; . GermOnline ENSG00000035403; Homo sapiens; . GO GO:0043034; C:costamere; ISS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005925; C:focal adhesion; ISS:UniProtKB; . GO GO:0003779; F:actin binding; IEA:UniProtKB-KW; . GO GO:0045294; F:alpha-catenin binding; IPI:UniProtKB; . GO GO:0008013; F:beta-catenin binding; ISS:BHF-UCL; . GO GO:0002166; F:beta-dystroglycan binding; IPI:UniProtKB; . GO GO:0045296; F:cadherin binding; ISS:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IEA:InterPro; . GO GO:0034333; P:adherens junction assembly; IMP:BHF-UCL; . GO GO:0043297; P:apical junction assembly; IMP:UniProtKB; . GO GO:0007160; P:cell-matrix adhesion; TAS:BHF-UCL; . GO GO:0006928; P:cellular component movement; TAS:UniProtKB; . GO GO:0090136; P:epithelial cell-cell adhesion; IMP:BHF-UCL; . GO GO:0030032; P:lamellipodium assembly; ISS:UniProtKB; . GO GO:0002009; P:morphogenesis of an epithelium; IMP:BHF-UCL; . GO GO:0006936; P:muscle contraction; TAS:Reactome; . GO GO:0030336; P:negative regulation of cell migration; TAS:UniProtKB; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0034394; P:protein localization at cell surface; IMP:BHF-UCL; . InterPro IPR017997; Vinculin; . InterPro IPR006077; Vinculin/catenin; . InterPro IPR000633; Vinculin_CS; . Pfam PF01044; Vinculin; 3; . PRINTS PR00806; VINCULIN; . SUPFAM SSF47220; Vinculin/catenin; 8; . PROSITE PS00663; VINCULIN_1; 1; . PROSITE PS00664; VINCULIN_2; 3; . SWISS-2DPAGE (search AC)