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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: Q06323




SWISS-2DPAGE:  Q06323


Q06323


General information about the entry
View entry in simple text format
Entry namePSME1_HUMAN
Primary accession numberQ06323
integrated into SWISS-2DPAGE on March 31, 2004 (release 17)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 5)
Name and origin of the protein
DescriptionRecName: Full=Proteasome activator complex subunit 1; AltName: Full=11S regulator complex subunit alpha; Short=REG-alpha; AltName: Full=Activator of multicatalytic protease subunit 1; AltName: Full=Interferon gamma up-regulated I-5111 protein; Short=IGUP I-5111; AltName: Full=Proteasome activator 28 subunit alpha; Short=PA28a; Short=PA28alpha;.
Gene nameName=PSME1
Synonyms=IFI5111
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: HETERODIMER OF PSME1 AND PSME2, WHICH FORMS A HEXADIMERIC RING. PSME1 CAN FORM HOMOHEPTAMERS
2D PAGE maps for identified proteins
How to interpret a protein

LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.64; Mw=27372  [identification data]

MAPPING (identification):
MALDI tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEQ06323; Q06323.
DOSAC-COBS-2DPAGEQ06323; PSME1_HUMAN.
OGP-WWWQ06323.
PHCI-2DPAGEQ06323.
Siena-2DPAGEQ06323; PSME1_HUMAN.
UniProtKB/Swiss-ProtQ06323; PSME1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePSME1_HUMAN
Primary accession numberQ06323
Secondary accession number(s) Q9UEF4
Sequence was last modified on November 1, 1995 (version 1)
Annotations were last modified on October 19, 2011 (version 112)
Name and origin of the protein
DescriptionRecName: Full=Proteasome activator complex subunit 1; AltName: Full=11S regulator complex subunit alpha; Short=REG-alpha; AltName: Full=Activator of multicatalytic protease subunit 1; AltName: Full=Interferon gamma up-regulated I-5111 protein; Short=IGUP I-5111; AltName: Full=Proteasome activator 28 subunit alpha; Short=PA28a; Short=PA28alpha;
Gene nameName=PSME1
Synonyms=IFI5111
Encoded onName=PSME1; Synonyms=IFI5111
Keywords3D-structure; Complete proteome; Direct protein sequencing; Polymorphism; Proteasome; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL07633; AAA16521.1; -; mRNA
EMBLU10360; AAA53230.1; -; Genomic_DNA
EMBLAF078829; AAF02217.1; -; Genomic_DNA
EMBLBT019337; AAV38144.1; -; mRNA
EMBLBC000352; AAH00352.1; -; mRNA
EMBLBC007503; AAH07503.1; -; mRNA
EMBLAB007137; BAA28836.1; -; Genomic_DNA
IPIIPI00479722; -; .
PIRA54859; A54859; .
RefSeqNP_006254.1; NM_006263.2; .
RefSeqNP_788955.1; NM_176783.1; .
UniGeneHs.75348; -; .
PDB1AVO; X-ray; 2.80 A; A/C/E/G/I/K/M=4-63
B/D/F/H/J/L/N=104-242PDBsum; 1AVO; -; .
ProteinModelPortalQ06323; -; .
SMRQ06323; 4-63; 104-242; .
IntActQ06323; 12; .
STRINGQ06323; -; .
SWISS-2DPAGEQ06323; -; .
Aarhus/Ghent-2DPAGE5111; IEF; .
DOSAC-COBS-2DPAGEQ06323; -; .
OGPQ06323; -; .
PHCI-2DPAGEQ06323; -; .
PRIDEQ06323; -; .
EnsemblENST00000206451; ENSP00000206451; ENSG00000092010; .
GeneID5720; -; .
KEGGhsa:5720; -; .
UCSCuc001wmg.1; human; .
CTD5720; -; .
GeneCardsGC14P004720; -; .
H-InvDBHIX0202077; -; .
HGNCHGNC:9568; PSME1; .
HPAHPA006632; -; .
MIM600654; gene; .
neXtProtNX_Q06323; -; .
eggNOGprNOG17779; -; .
HOVERGENHBG053745; -; .
OrthoDBEOG42V8H5; -; .
ReactomeREACT_11045; Signaling by Wnt; .
ReactomeREACT_13; Metabolism of amino acids and derivatives; .
ReactomeREACT_13505; Proteasome mediated degradation of PAK-2p34; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_21257; Metabolism of RNA; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_578; Apoptosis; .
ReactomeREACT_6185; HIV Infection; .
ReactomeREACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; .
ReactomeREACT_6900; Immune System; .
NextBio22232; -; .
ArrayExpressQ06323; -; .
BgeeQ06323; -; .
CleanExHS_PSME1; -; .
GenevestigatorQ06323; -; .
GermOnlineENSG00000092010; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0008537; C:proteasome activator complex; IEA:InterPro; .
GOGO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; .
GOGO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome; .
GOGO:0006915; P:apoptosis; TAS:Reactome; .
GOGO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome
GOGO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0016071; P:mRNA metabolic process; TAS:Reactome; .
GOGO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; .
GOGO:0000209; P:protein polyubiquitination; TAS:Reactome; .
GOGO:0042981; P:regulation of apoptosis; TAS:Reactome; .
GOGO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; .
GOGO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0016032; P:viral reproduction; TAS:Reactome; .
InterProIPR003185; Proteasome_activ_REG_asu; .
InterProIPR009077; Proteasome_activ_REG_asu/bsu; .
InterProIPR003186; Proteasome_activ_REG_bsu; .
Gene3DG3DSA:1.20.5.120; PA28_alpha-like; 1; .
Gene3DG3DSA:1.20.120.180; PA28_beta; 1; .
PANTHERPTHR10660; Proteasome_activ_REG_asu/bsu; 1; .
PfamPF02251; PA28_alpha; 1; .
PfamPF02252; PA28_beta; 1; .
SUPFAMSSF47216; Prot_act_regA; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server