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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: AL4A1_HUMAN



General information about the entry
View entry in simple text format
Entry nameAL4A1_HUMAN
Primary accession numberP30038
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 16)
Name and origin of the protein
DescriptionRecName: Full=Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Short=P5C dehydrogenase; EC=; AltName: Full=Aldehyde dehydrogenase family 4 member A1; Flags: Precursor;.
Gene nameName=ALDH4A1
Synonyms=ALDH4, P5CDH
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
Tissue: Liver
  map experimental info
  protein estimated location

pI=6.90; Mw=57325
pI=6.82; Mw=57009

MAPPING (identification):

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
UniProtKB/Swiss-ProtP30038; AL4A1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAL4A1_HUMAN
Primary accession numberP30038
Secondary accession number(s) A8K1Q7 Q16882 Q53HU4 Q5JNV6 Q8IZ38 Q96IF0 Q9UDI6
Sequence was last modified on February 1, 2005 (version 3)
Annotations were last modified on October 19, 2011 (version 126)
Name and origin of the protein
DescriptionRecName: Full=Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Short=P5C dehydrogenase; EC=; AltName: Full=Aldehyde dehydrogenase family 4 member A1; Flags: Precursor;
Gene nameName=ALDH4A1
Synonyms=ALDH4, P5CDH
Encoded onName=ALDH4A1; Synonyms=ALDH4, P5CDH
KeywordsAcetylation; Complete proteome; Direct protein sequencing; Disease mutation; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Proline metabolism; Reference proteome; Transit peptide.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU24267; AAC50501.1; -; mRNA
EMBLU24266; AAC50500.1; -; mRNA
EMBLAK289972; BAF82661.1; -; mRNA
EMBLAK222486; BAD96206.1; -; mRNA
EMBLAL080251; CAI23417.1; -; Genomic_DNA
EMBLAL954340; CAI23417.1; JOINED; Genomic_DNA
EMBLAL954340; CAI39493.1; -; Genomic_DNA
EMBLAL080251; CAI39493.1; JOINED; Genomic_DNA
EMBLCH471134; EAW94858.1; -; Genomic_DNA
EMBLBC007581; AAH07581.1; -; mRNA
EMBLBC023600; AAH23600.1; -; mRNA
IPIIPI00217871; -; .
RefSeqNP_001154976.1; NM_001161504.1; .
RefSeqNP_003739.2; NM_003748.3; .
RefSeqNP_733844.1; NM_170726.2; .
UniGeneHs.77448; -; .
ProteinModelPortalP30038; -; .
SMRP30038; 29-551; .
STRINGP30038; -; .
PhosphoSiteP30038; -; .
SWISS-2DPAGEP30038; -; .
OGPP30038; -; .
PRIDEP30038; -; .
EnsemblENST00000290597; ENSP00000290597; ENSG00000159423; .
EnsemblENST00000375341; ENSP00000364490; ENSG00000159423; .
GeneID8659; -; .
KEGGhsa:8659; -; .
UCSCuc001bbb.1; human; .
CTD8659; -; .
GeneCardsGC01M017442; -; .
H-InvDBHIX0022349; -; .
HPACAB004645; -; .
HPAHPA006401; -; .
MIM239510; phenotype; .
MIM606811; gene; .
neXtProtNX_P30038; -; .
Orphanet79101; Hyperprolinemia type II; .
eggNOGprNOG05273; -; .
GeneTreeENSGT00560000077335; -; .
HOVERGENHBG050484; -; .
InParanoidP30038; -; .
OrthoDBEOG4ZCT3Q; -; .
PhylomeDBP30038; -; .
BioCycMetaCyc:MONOMER-11403; -; .
ReactomeREACT_13; Metabolism of amino acids and derivatives; .
DrugBankDB00157; NADH; .
NextBio32473; -; .
ArrayExpressP30038; -; .
BgeeP30038; -; .
CleanExHS_ALDH4A1; -; .
GenevestigatorP30038; -; .
GermOnlineENSG00000159423; Homo sapiens; .
GOGO:0005759; C:mitochondrial matrix; TAS:Reactome; .
GOGO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; EXP:Reactome; .
GOGO:0004029; F:aldehyde dehydrogenase (NAD) activity; TAS:ProtInc; .
GOGO:0009055; F:electron carrier activity; TAS:UniProtKB; .
GOGO:0006561; P:proline biosynthetic process; IEA:InterPro; .
GOGO:0006562; P:proline catabolic process; TAS:Reactome; .
InterProIPR016161; Ald_DH/histidinol_DH; .
InterProIPR016163; Ald_DH_C; .
InterProIPR016160; Ald_DH_CS; .
InterProIPR016162; Ald_DH_N; .
InterProIPR015590; Aldehyde_DH_dom; .
InterProIPR005931; Delta1-pyrroline-5-COlate_DH-1; .
Gene3DG3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1; .
Gene3DG3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1; .
PfamPF00171; Aldedh; 1; .
SUPFAMSSF53720; Aldehyde_DH/Histidinol_DH; 1; .
TIGRFAMsTIGR01236; D1pyr5carbox1; 1; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server