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SWISS-2DPAGE

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SWISS-2DPAGE 
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Searching in 'SWISS-2DPAGE' for entry matching: APOC2_HUMAN




SWISS-2DPAGE:  APOC2_HUMAN


APOC2_HUMAN


General information about the entry
View entry in simple text format
Entry nameAPOC2_HUMAN
Primary accession numberP02655
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein C-II; Short=Apo-CII; Short=ApoC-II; AltName: Full=Apolipoprotein C2; Flags: Precursor;.
Gene nameName=APOC2
Synonyms=APC2
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=81006902; PubMed=7410381; [NCBI, Expasy, EBI, Israel, Japan]
Zannis V.I., Breslow J.L., Katz A.J.
''''''Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture'';'';''
J. Biol. Chem. 255(1):8612-8617(1980)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.51; Mw=9976
pI=4.58; Mw=9248

PATHOLOGICAL LEVEL:
INCREASED DURING TYPE III AND V HYPERLIPAEMIA [1].

POSITIONAL VARIANTS:
SAN FRANCISCO AND AFRICAN VARIANTS [1].

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
DOSAC-COBS 2D-PAGEP02655; P02655.
DOSAC-COBS-2DPAGEP02655; APOC2_HUMAN.
UniProtKB/Swiss-ProtP02655; APOC2_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameAPOC2_HUMAN
Primary accession numberP02655
Secondary accession number(s) C0JYY4 Q9BS39 Q9UDE3 Q9UNK3
Sequence was last modified on July 21, 1986 (version 1)
Annotations were last modified on October 19, 2011 (version 144)
Name and origin of the protein
DescriptionRecName: Full=Apolipoprotein C-II; Short=Apo-CII; Short=ApoC-II; AltName: Full=Apolipoprotein C2; Flags: Precursor;
Gene nameName=APOC2
Synonyms=APC2
Encoded onName=APOC2; Synonyms=APC2
Keywords3D-structure; Chylomicron; Complete proteome; Direct protein sequencing; Disease mutation; Hyperlipidemia; Lipid degradation; Lipid transport; Polymorphism; Reference proteome; Secreted; Signal; Transport; VLDL.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX05151; CAA28798.1; -; Genomic_DNA
EMBLX00568; CAA25234.1; -; mRNA
EMBLJ02698; AAA98743.1; -; Genomic_DNA
EMBLAY422955; AAQ91814.1; -; Genomic_DNA
EMBLBT006708; AAP35354.1; -; mRNA
EMBLFJ525875; ACN81313.1; -; Genomic_DNA
EMBLCH471126; EAW57311.1; -; Genomic_DNA
EMBLBC005348; AAH05348.3; -; mRNA
EMBLM29844; AAA51743.1; -; mRNA
EMBLM10612; AAB59380.1; -; Genomic_DNA
EMBLAF113884; AAD28193.1; -; mRNA
IPIIPI00021856; -; .
PIRA24238; LPHUC2; .
RefSeqNP_000474.2; NM_000483.4; .
UniGeneHs.75615; -; .
PDB1BY6; NMR; -; A=66-101
PDB1I5J; NMR; -; A=23-101
PDB1O8T; NMR; -; A=23-101
PDB1SOH; NMR; -; A=23-101
PDBsum1BY6; -; .
PDBsum1I5J; -; .
PDBsum1O8T; -; .
PDBsum1SOH; -; .
ProteinModelPortalP02655; -; .
SMRP02655; 23-101; .
IntActP02655; 1; .
STRINGP02655; -; .
SWISS-2DPAGEP02655; -; .
DOSAC-COBS-2DPAGEP02655; -; .
PeptideAtlasP02655; -; .
PRIDEP02655; -; .
EnsemblENST00000252490; ENSP00000252490; ENSG00000234906; .
EnsemblENST00000419266; ENSP00000406381; ENSG00000234906; .
GeneID344; -; .
KEGGhsa:344; -; .
UCSCuc002pah.1; human; .
CTD344; -; .
GeneCardsGC19P041879; -; .
HGNCHGNC:609; APOC2; .
MIM207750; phenotype; .
MIM608083; gene; .
neXtProtNX_P02655; -; .
Orphanet411; Hyperlipoproteinemia type 1; .
PharmGKBPA52; -; .
eggNOGprNOG20551; -; .
HOGENOMHBG281766; -; .
HOVERGENHBG050548; -; .
InParanoidP02655; -; .
OMAGIFTDQV; -; .
OrthoDBEOG4SXNF3; -; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
NextBio1419; -; .
PMAP-CutDBP02655; -; .
ArrayExpressP02655; -; .
BgeeP02655; -; .
CleanExHS_APC2; -; .
CleanExHS_APOC2; -; .
GenevestigatorP02655; -; .
GermOnlineENSG00000130207; Homo sapiens; .
GOGO:0042627; C:chylomicron; IDA:BHF-UCL; .
GOGO:0034363; C:intermediate-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034362; C:low-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL; .
GOGO:0055102; F:lipase inhibitor activity; IDA:BHF-UCL; .
GOGO:0008289; F:lipid binding; IDA:BHF-UCL; .
GOGO:0060230; F:lipoprotein lipase activator activity; IDA:BHF-UCL; .
GOGO:0016004; F:phospholipase activator activity; IDA:BHF-UCL; .
GOGO:0043274; F:phospholipase binding; IPI:BHF-UCL; .
GOGO:0042803; F:protein homodimerization activity; IMP:BHF-UCL; .
GOGO:0033344; P:cholesterol efflux; IDA:BHF-UCL; .
GOGO:0042632; P:cholesterol homeostasis; IC:BHF-UCL; .
GOGO:0034382; P:chylomicron remnant clearance; IDA:BHF-UCL; .
GOGO:0034371; P:chylomicron remodeling; IC:BHF-UCL; .
GOGO:0034384; P:high-density lipoprotein particle clearance; IMP:BHF-UCL; .
GOGO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW; .
GOGO:0042157; P:lipoprotein metabolic process; TAS:Reactome; .
GOGO:0032375; P:negative regulation of cholesterol transport; IMP:BHF-UCL; .
GOGO:0045833; P:negative regulation of lipid metabolic process; IDA:BHF-UCL; .
GOGO:0048261; P:negative regulation of receptor-mediated endocytosis; IDA:BHF-UCL; .
GOGO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IDA:BHF-UCL; .
GOGO:0033700; P:phospholipid efflux; IDA:BHF-UCL; .
GOGO:0045723; P:positive regulation of fatty acid biosynthetic process; IDA:BHF-UCL; .
GOGO:0051006; P:positive regulation of lipoprotein lipase activity; IDA:BHF-UCL; .
GOGO:0010518; P:positive regulation of phospholipase activity; IDA:BHF-UCL; .
GOGO:0060697; P:positive regulation of phospholipid catabolic process; IDA:BHF-UCL; .
GOGO:0010898; P:positive regulation of triglyceride catabolic process; IDA:BHF-UCL; .
GOGO:0010902; P:positive regulation of very-low-density lipoprotein particle remodeling; IC:BHF-UCL; .
GOGO:0043691; P:reverse cholesterol transport; IC:BHF-UCL; .
GOGO:0070328; P:triglyceride homeostasis; IMP:BHF-UCL; .
GOGO:0034372; P:very-low-density lipoprotein particle remodeling; TAS:BHF-UCL; .
InterProIPR008019; Apo-CII; .
InterProIPR023121; ApoC-II_domain; .
Gene3DG3DSA:1.10.1440.10; ApoC-II_domain; 1; .
PANTHERPTHR16566; Apo-CII; 1; .
PfamPF05355; Apo-CII; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server