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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: CATD_HUMAN




SWISS-2DPAGE:  CATD_HUMAN


CATD_HUMAN


General information about the entry
View entry in simple text format
Entry nameCATD_HUMAN
Primary accession numberP07339
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 4)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin D; EC=3.4.23.5; Contains: RecName: Full=Cathepsin D light chain; Contains: RecName: Full=Cathepsin D heavy chain; Flags: Precursor;.
Gene nameName=CTSD
Synonyms=CPSD
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147969; PubMed=8313870; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
''''''Human liver protein map: update 1993'';'';''
Electrophoresis 14(1):1216-1222(1993)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[4]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[5]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: HEAVY CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=5.56; Mw=28114
pI=5.40; Mw=27363

MAPPING (identification):
MICROSEQUENCING [3].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.50; Mw=27320

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [4].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.51; Mw=27819

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.50; Mw=27826
pI=5.28; Mw=27952

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.67; Mw=33781
pI=5.67; Mw=33200

MAPPING (identification):
GEL MATCHING WITH THE LYMPHOMA MASTER GEL [5].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=5.63; Mw=33973

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=5.50; Mw=29497

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP07339; P07339.
DOSAC-COBS-2DPAGEP07339; CATD_HUMAN.
REPRODUCTION-2DPAGEIPI00011229; IPI00011229.
Siena-2DPAGEP07339; CATD_HUMAN.
UCD-2DPAGEP07339; CATD_HUMAN.
UniProtKB/Swiss-ProtP07339; CATD_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCATD_HUMAN
Primary accession numberP07339
Secondary accession number(s) Q6IB57
Sequence was last modified on April 1, 1988 (version 1)
Annotations were last modified on September 21, 2011 (version 143)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin D; EC=3.4.23.5; Contains: RecName: Full=Cathepsin D light chain; Contains: RecName: Full=Cathepsin D heavy chain; Flags: Precursor;
Gene nameName=CTSD
Synonyms=CPSD
Encoded onName=CTSD; Synonyms=CPSD
Keywords3D-structure; Alzheimer disease; Aspartyl protease; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Neurodegeneration; Neuronal ceroid lipofuscinosis; Polymorphism; Protease; Reference proteome; Signal; Zymogen.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM11233; AAB59529.1; -; mRNA
EMBLX05344; CAA28955.1; -; mRNA
EMBLM63138; AAA51922.1; -; Genomic_DNA
EMBLM63134; AAA51922.1; JOINED; Genomic_DNA
EMBLM63135; AAA51922.1; JOINED; Genomic_DNA
EMBLM63136; AAA51922.1; JOINED; Genomic_DNA
EMBLM63137; AAA51922.1; JOINED; Genomic_DNA
EMBLCR456947; CAG33228.1; -; mRNA
EMBLBT006910; AAP35556.1; -; mRNA
EMBLBT020155; AAV38957.1; -; mRNA
EMBLBC016320; AAH16320.1; -; mRNA
EMBLL12980; AAA16314.1; -; Genomic_DNA
EMBLS74689; AAD14156.1; -; Genomic_DNA
EMBLS52557; AAD13868.1; -; Genomic_DNA
IPIIPI00011229; -; .
PIRA25771; KHHUD; .
RefSeqNP_001900.1; NM_001909.4; .
UniGeneHs.654447; -; .
PDB1LYA; X-ray; 2.50 A; A/C=65-161
B/D=170-410PDB; 1LYB; X-ray; 2.50 A
A/C=65-161B/D=170-410; PDB; 1LYW; X-ray
2.50 AA/C/E/G=65-161; B/D/F/H=170-410; PDBsum; 1LYA
PDBsum1LYB; -; .
PDBsum1LYW; -; .
ProteinModelPortalP07339; -; .
SMRP07339; 21-410; .
IntActP07339; 8; .
MINTMINT-3005628; -; .
STRINGP07339; -; .
MEROPSA01.009; -; .
PhosphoSiteP07339; -; .
SWISS-2DPAGEP07339; -; .
DOSAC-COBS-2DPAGEP07339; -; .
REPRODUCTION-2DPAGEIPI00011229; -; .
Siena-2DPAGEP07339; -; .
UCD-2DPAGEP07339; -; .
PeptideAtlasP07339; -; .
PRIDEP07339; -; .
EnsemblENST00000236671; ENSP00000236671; ENSG00000117984; .
EnsemblENST00000407742; ENSP00000384947; ENSG00000117984; .
GeneID1509; -; .
KEGGhsa:1509; -; .
UCSCuc001luc.1; human; .
CTD1509; -; .
GeneCardsGC11M001564; -; .
H-InvDBHIX0009358; -; .
H-InvDBHIX0009359; -; .
HGNCHGNC:2529; CTSD; .
HPACAB000109; -; .
HPAHPA003001; -; .
MIM116840; gene; .
MIM610127; phenotype; .
neXtProtNX_P07339; -; .
Orphanet228337; CLN10 disease; .
PharmGKBPA27029; -; .
eggNOGprNOG10308; -; .
GeneTreeENSGT00600000084042; -; .
HOGENOMHBG590923; -; .
HOVERGENHBG000482; -; .
InParanoidP07339; -; .
OMASGFMGID; -; .
OrthoDBEOG40GCR5; -; .
PhylomeDBP07339; -; .
BioCycMetaCyc:MONOMER-14813; -; .
Pathway_Interaction_DBceramidepathway; Ceramide signaling pathway; .
DrugBankDB00047; Insulin Glargine recombinant; .
DrugBankDB00046; Insulin Lyspro recombinant; .
DrugBankDB00030; Insulin recombinant; .
DrugBankDB00071; Insulin; porcine; .
NextBio6247; -; .
PMAP-CutDBP07339; -; .
ArrayExpressP07339; -; .
BgeeP07339; -; .
CleanExHS_CTSD; -; .
GenevestigatorP07339; -; .
GermOnlineENSG00000117984; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005764; C:lysosome; NAS:UniProtKB; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0004190; F:aspartic-type endopeptidase activity; TAS:ProtInc; .
GOGO:0008219; P:cell death; IEA:UniProtKB-KW; .
GOGO:0006508; P:proteolysis; IEA:InterPro; .
InterProIPR001461; Peptidase_A1; .
InterProIPR021109; Peptidase_aspartic; .
InterProIPR001969; Peptidase_aspartic_AS; .
InterProIPR009007; Peptidase_aspartic_catalytic; .
InterProIPR012848; Propep_A1; .
Gene3DG3DSA:2.40.70.10; Pept_Aspartc_cat; 2; .
PANTHERPTHR13683; Peptidase_A1; 1; .
PfamPF07966; A1_Propeptide; 1; .
PfamPF00026; Asp; 1; .
PRINTSPR00792; PEPSIN; .
SUPFAMSSF50630; Pept_Aspartic; 1; .
PROSITEPS00141; ASP_PROTEASE; 2; .



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SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server