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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: CERU_HUMAN SWISS-2DPAGE:  CERU_HUMAN CERU_HUMAN General information about the entry View entry in simple text format Entry name CERU_HUMAN Primary accession number P00450 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on December 1, 2000 (version 1) General Annotations were last modified on  May 19, 2011 (version 12) Name and origin of the protein Description RecName: Full=Ceruloplasmin; EC=1.16.3.1; AltName: Full=Ferroxidase; Flags: Precursor;. Gene name Name=CP Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan] Anderson N.L., Anderson N.G. ''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';'' Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977) [2]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) Comments SUBUNIT: MONOMER 2D PAGE maps for identified proteins How to interpret a protein CSF_HUMAN {Cerebrospinal Fluid} Homo sapiens (Human) Tissue: Cerebrospinal fluid   map experimental info   protein estimated location   CSF_HUMAN MAP LOCATIONS: SPOT 2D-000BE3: pI=5.15; Mw=152053 SPOT 2D-000BE5: pI=5.17; Mw=151291 SPOT 2D-000BE6: pI=5.20; Mw=150533 SPOT 2D-000BE7: pI=5.22; Mw=150533 SPOT 2D-000BE8: pI=5.26; Mw=149779 SPOT 2D-000BEE: pI=5.28; Mw=149779 SPOT 2D-000BEI: pI=4.83; Mw=146064 SPOT 2D-000BEJ: pI=5.32; Mw=146800 SPOT 2D-000BEV: pI=4.91; Mw=145333 SPOT 2D-000BF1: pI=4.95; Mw=143880 SPOT 2D-000BF9: pI=5.03; Mw=143159 SPOT 2D-000BFG: pI=5.08; Mw=141728 SPOT 2D-000BFK: pI=5.10; Mw=141728 SPOT 2D-000BFO: pI=5.14; Mw=139609 SPOT 2D-000BFQ: pI=5.17; Mw=138213 SPOT 2D-000BFS: pI=5.21; Mw=137521 SPOT 2D-000BFT: pI=5.25; Mw=137521 SPOT 2D-000BFU: pI=5.29; Mw=137521 SPOT 2D-000BGB: pI=5.12; Mw=132770 SPOT 2D-000BGC: pI=5.29; Mw=132770 SPOT 2D-000BGF: pI=5.14; Mw=132121 SPOT 2D-000BGI: pI=5.17; Mw=131475 SPOT 2D-000BGK: pI=5.21; Mw=130832 SPOT 2D-000BGL: pI=5.25; Mw=130193 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [2]. HEPG2SP_HUMAN {HepG2 Secreted Proteins} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2SP_HUMAN MAP LOCATIONS: SPOT 2D-0008JV: pI=4.70; Mw=135572 SPOT 2D-0008JZ: pI=4.75; Mw=133299 SPOT 2D-0008K7: pI=4.81; Mw=131064 SPOT 2D-0008K9: pI=4.88; Mw=129595 SPOT 2D-0008KB: pI=4.96; Mw=128867 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [2]. PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-00045W: pI=5.14; Mw=161288 SPOT 2D-000460: pI=5.17; Mw=161288 SPOT 2D-000461: pI=5.19; Mw=160170 SPOT 2D-000462: pI=5.22; Mw=159059 SPOT 2D-000463: pI=5.24; Mw=157957 SPOT 2D-00046C: pI=5.27; Mw=157957 SPOT 2D-00046D: pI=5.30; Mw=156862 SPOT 2D-00046Q: pI=5.33; Mw=155774 SPOT 2D-00046V: pI=5.36; Mw=153622 SPOT 2D-000481: pI=4.96; Mw=136487 SPOT 2D-00048A: pI=5.00; Mw=133668 SPOT 2D-00048I: pI=5.05; Mw=131821 SPOT 2D-00048J: pI=5.10; Mw=133668 SPOT 2D-00048Q: pI=5.14; Mw=131821 SPOT 2D-00048X: pI=5.17; Mw=130908 SPOT 2D-00048Y: pI=5.20; Mw=130000 SPOT 2D-000494: pI=4.96; Mw=129081 SPOT 2D-000495: pI=5.24; Mw=129081 SPOT 2D-00049D: pI=4.98; Mw=128169 SPOT 2D-00049E: pI=5.09; Mw=126365 SPOT 2D-00049J: pI=5.00; Mw=127264 SPOT 2D-00049L: pI=5.03; Mw=126365 SPOT 2D-00049M: pI=5.06; Mw=125472 SPOT 2D-00049N: pI=5.12; Mw=125472 SPOT 2D-00049O: pI=5.16; Mw=124585 SPOT 2D-00049P: pI=5.20; Mw=123705 SPOT 2D-00049S: pI=5.24; Mw=123705 NORMAL LEVEL: 150-600 MG/L. PATHOLOGICAL LEVEL: DECREASED DURING WILSONS DISEASE; INCREASED DURING INFLAMMATORY DISEASES, RETICULOENDOTHELIAL DISEASE, BILE DUCT OBSTRUCTION AND OESTROGEN ADMINISTRATION. POSITIONAL VARIANTS: CPA, CPB, CPC, CPNH, CPBPT AND CPTH VARIANTS. MAPPING (identification): IMMUNOBLOTTING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P00450; P00450. DOSAC-COBS-2DPAGE P00450; CERU_HUMAN. Siena-2DPAGE P00450; CERU_HUMAN. UniProtKB/Swiss-Prot P00450; CERU_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name CERU_HUMAN Primary accession number P00450 Secondary accession number(s) Q14063 Q2PP18 Q9UKS4 Sequence was last modified on  August 13, 1987 (version 1) Annotations were last modified on  October 19, 2011 (version 144) Name and origin of the protein Description RecName: Full=Ceruloplasmin; EC=1.16.3.1; AltName: Full=Ferroxidase; Flags: Precursor; Gene name Name=CP Encoded on Name=CP Keywords 3D-structure; Complete proteome; Copper; Copper transport; Direct protein sequencing; Disulfide bond; Glycoprotein; Ion transport; Metal-binding; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M13699; AAA51976.1; -; mRNA EMBL DQ314867; ABC40726.1; -; Genomic_DNA EMBL D45045; BAA08085.1; -; Genomic_DNA EMBL D00025; BAA00019.1; -; mRNA EMBL X04135; CAA27752.1; -; mRNA EMBL X04136; CAA27753.1; -; mRNA EMBL X04137; CAA27754.1; -; mRNA EMBL X04138; CAA27755.1; -; mRNA EMBL AF132978; AAF02483.1; -; Genomic_DNA EMBL M13536; AAA51975.1; -; mRNA EMBL J05506; -; NOT_ANNOTATED_CDS; Genomic_DNA IPI IPI00017601; -; . PIR A25443; KUHU; . RefSeq NP_000087.1; NM_000096.3; . UniGene Hs.558314; -; . PDB 1KCW; X-ray; 3.00 A; A=20-1065 PDB 2J5W; X-ray; 2.80 A; A=1-1065 PDBsum 1KCW; -; . PDBsum 2J5W; -; . ProteinModelPortal P00450; -; . IntAct P00450; 4; . STRING P00450; -; . GlycoSuiteDB P00450; -; . PhosphoSite P00450; -; . SWISS-2DPAGE P00450; -; . DOSAC-COBS-2DPAGE P00450; -; . Siena-2DPAGE P00450; -; . PeptideAtlas P00450; -; . PRIDE P00450; -; . Ensembl ENST00000264613; ENSP00000264613; ENSG00000047457; . GeneID 1356; -; . KEGG hsa:1356; -; . UCSC uc003ewy.2; human; . CTD 1356; -; . GeneCards GC03M146261; -; . H-InvDB HIX0003762; -; . HGNC HGNC:2295; CP; . HPA CAB008591; -; . HPA HPA001834; -; . MIM 117700; gene; . MIM 604290; phenotype; . neXtProt NX_P00450; -; . Orphanet 48818; Aceruloplasminemia; . eggNOG prNOG19766; -; . HOGENOM HBG357170; -; . HOVERGEN HBG003674; -; . InParanoid P00450; -; . BioCyc MetaCyc:HS00590-MONOMER; -; . Pathway_Interaction_DB hif1_tfpathway; HIF-1-alpha transcription factor network; . Reactome REACT_15518; Transmembrane transport of small molecules; . DrugBank DB00055; Drotrecogin alfa; . NextBio 5493; -; . PMAP-CutDB P00450; -; . ArrayExpress P00450; -; . Bgee P00450; -; . CleanEx HS_CP; -; . Genevestigator P00450; -; . GermOnline ENSG00000047457; Homo sapiens; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0051087; F:chaperone binding; IPI:BHF-UCL; . GO GO:0005507; F:copper ion binding; IEA:InterPro; . GO GO:0004322; F:ferroxidase activity; TAS:ProtInc; . GO GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome; . GO GO:0006825; P:copper ion transport; IEA:UniProtKB-KW; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . InterPro IPR001117; Cu-oxidase; . InterPro IPR011706; Cu-oxidase_2; . InterPro IPR011707; Cu-oxidase_3; . InterPro IPR002355; Cu_oxidase_Cu_BS; . InterPro IPR008972; Cupredoxin; . Gene3D G3DSA:2.60.40.420; Cupredoxin; 6; . Pfam PF00394; Cu-oxidase; 1; . Pfam PF07731; Cu-oxidase_2; 1; . Pfam PF07732; Cu-oxidase_3; 2; . SUPFAM SSF49503; Cupredoxin; 6; . PROSITE PS00079; MULTICOPPER_OXIDASE1; 3; . PROSITE PS00080; MULTICOPPER_OXIDASE2; 1; . SWISS-2DPAGE (search AC)