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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: CX6A1_HUMAN




SWISS-2DPAGE:  CX6A1_HUMAN


CX6A1_HUMAN


General information about the entry
View entry in simple text format
Entry nameCX6A1_HUMAN
Primary accession numberP12074
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Cytochrome c oxidase subunit 6A1, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIa-liver; AltName: Full=Cytochrome c oxidase subunit VIA-liver; Short=COX VIa-L; Flags: Precursor;.
Gene nameName=COX6A1
Synonyms=COX6AL
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
Comments
  • SUBUNIT: ONE OF THE NUCLEAR-CODED POLYPEPTIDE CHAINS OF CYTOCHROME C OXIDASE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=6.62; Mw=10801

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [3].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.75; Mw=11189

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.73; Mw=12035

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtP12074; CX6A1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCX6A1_HUMAN
Primary accession numberP12074
Secondary accession number(s) B2R500 O43714 Q32Q37
Sequence was last modified on July 15, 1999 (version 4)
Annotations were last modified on September 21, 2011 (version 115)
Name and origin of the protein
DescriptionRecName: Full=Cytochrome c oxidase subunit 6A1, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIa-liver; AltName: Full=Cytochrome c oxidase subunit VIA-liver; Short=COX VIa-L; Flags: Precursor;
Gene nameName=COX6A1
Synonyms=COX6AL
Encoded onName=COX6A1; Synonyms=COX6AL
KeywordsComplete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAK312009; BAG34947.1; -; mRNA
EMBLAL021546; CAA16494.1; -; Genomic_DNA
EMBLBC007723; AAH07723.1; -; mRNA
EMBLBC070186; AAH70186.1; -; mRNA
EMBLBC107861; AAI07862.1; -; mRNA
EMBLX15341; CAA33392.1; ALT_FRAME; mRNA
IPIIPI00021793; -; .
RefSeqNP_004364.2; NM_004373.2; .
UniGeneHs.369624; -; .
ProteinModelPortalP12074; -; .
SMRP12074; 25-107; .
IntActP12074; 1; .
STRINGP12074; -; .
SWISS-2DPAGEP12074; -; .
PRIDEP12074; -; .
EnsemblENST00000229379; ENSP00000229379; ENSG00000111775; .
GeneID1337; -; .
KEGGhsa:1337; -; .
UCSCuc001tyf.1; human; .
CTD1337; -; .
GeneCardsGC12P117884; -; .
H-InvDBHIX0011062; -; .
HGNCHGNC:2277; COX6A1; .
MIM602072; gene; .
neXtProtNX_P12074; -; .
PharmGKBPA26794; -; .
eggNOGprNOG20674; -; .
HOGENOMHBG715320; -; .
HOVERGENHBG060482; -; .
InParanoidP12074; -; .
OMANAYLKHQ; -; .
OrthoDBEOG4N04GG; -; .
PhylomeDBP12074; -; .
ReactomeREACT_6305; Respiratory electron transport; ATP synthesis by chemiosmotic coupling; and heat production by uncoupling proteins
NextBio5431; -; .
BgeeP12074; -; .
CleanExHS_COX6A1; -; .
GenevestigatorP12074; -; .
GermOnlineENSG00000111775; Homo sapiens; .
GOGO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro; .
GOGO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro; .
GOGO:0022904; P:respiratory electron transport chain; TAS:Reactome; .
InterProIPR001349; Cyt_c_oxidase_su6a; .
InterProIPR018507; Cyt_c_oxidase_su6a_CS; .
Gene3DG3DSA:4.10.95.10; COX6A; 1; .
PANTHERPTHR11504; COX6A; 1; .
PfamPF02046; COX6A; 1; .
PIRSFPIRSF000277; COX6A1; 1; .
ProDomPD006036; Cyt_c_oxidase_su6a; 1; .
SUPFAMSSF81411; COX6A; 1; .
PROSITEPS01329; COX6A; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server