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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: EXOS7_HUMAN




SWISS-2DPAGE:  EXOS7_HUMAN


EXOS7_HUMAN


General information about the entry
View entry in simple text format
Entry nameEXOS7_HUMAN
Primary accession numberQ15024
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex component RRP42; AltName: Full=Exosome component 7; AltName: Full=Ribosomal RNA-processing protein 42; AltName: Full=p8;.
Gene nameName=EXOSC7
Synonyms=KIAA0116, RRP42
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
Comments
  • SUBUNIT: COMPONENT OF THE EXOSOME MULTIENZYME RIBONUCLEASE COMPLEX COMPOSED OF AT LEAST 11 PROTEINS: RRP4, RRP40, RRP41/SKI6, RRP42, RRP43, RRP44/DIS3, PM/SCL-75, RRP46, CSL4 AND PM/SCL-100 (ONLY IN THE NUCLEAR COMPLEX). ALSO ASSOCIATED WITH THE GTPASE RAN (BY SIMILARITY)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=37156  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtQ15024; EXOS7_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameEXOS7_HUMAN
Primary accession numberQ15024
Secondary accession number(s) Q96E72
Sequence was last modified on February 8, 2011 (version 3)
Annotations were last modified on October 19, 2011 (version 112)
Name and origin of the protein
DescriptionRecName: Full=Exosome complex component RRP42; AltName: Full=Exosome component 7; AltName: Full=Ribosomal RNA-processing protein 42; AltName: Full=p8;
Gene nameName=EXOSC7
Synonyms=KIAA0116, RRP42
Encoded onName=EXOSC7; Synonyms=KIAA0116, RRP42
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Exosome; Nucleus; Polymorphism; Reference proteome; RNA-binding; rRNA processing.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAC104165; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLBC012831; AAH12831.1; -; mRNA
EMBLD29958; BAA06226.1; -; mRNA
IPIIPI00014198; -; .
RefSeqNP_055819.2; NM_015004.3; .
UniGeneHs.719958; -; .
PDB2NN6; X-ray; 3.35 A; E=1-291
PDBsum2NN6; -; .
ProteinModelPortalQ15024; -; .
SMRQ15024; 5-285; .
IntActQ15024; 17; .
MINTMINT-1457458; -; .
STRINGQ15024; -; .
PhosphoSiteQ15024; -; .
SWISS-2DPAGEQ15024; -; .
PeptideAtlasQ15024; -; .
PRIDEQ15024; -; .
EnsemblENST00000265564; ENSP00000265564; ENSG00000075914; .
GeneID23016; -; .
KEGGhsa:23016; -; .
CTD23016; -; .
GeneCardsGC03P044992; -; .
H-InvDBHIX0003236; -; .
HGNCHGNC:28112; EXOSC7; .
HPAHPA036182; -; .
MIM606488; gene; .
neXtProtNX_Q15024; -; .
eggNOGprNOG07468; -; .
GeneTreeENSGT00530000063093; -; .
HOGENOMHBG737187; -; .
HOVERGENHBG051521; -; .
InParanoidQ15024; -; .
OMAGRSCEDY; -; .
OrthoDBEOG47SSF7; -; .
PhylomeDBQ15024; -; .
ReactomeREACT_21257; Metabolism of RNA; .
ArrayExpressQ15024; -; .
BgeeQ15024; -; .
GenevestigatorQ15024; -; .
GermOnlineENSG00000075914; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0000178; C:exosome (RNase complex); IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IEA:UniProtKB-SubCell; .
GOGO:0000175; F:3'-5'-exoribonuclease activity; TAS:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0003723; F:RNA binding; TAS:UniProtKB; .
GOGO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; TAS:Reactome; .
GOGO:0006364; P:rRNA processing; TAS:UniProtKB; .
InterProIPR001247; ExoRNase_PH_dom1; .
InterProIPR015847; ExoRNase_PH_dom2; .
InterProIPR020568; Ribosomal_S5_D2-typ_fold; .
PfamPF01138; RNase_PH; 1; .
PfamPF03725; RNase_PH_C; 1; .
SUPFAMSSF54211; Ribosomal_S5_D2-typ_fold; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server