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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: FETUA_HUMAN SWISS-2DPAGE:  FETUA_HUMAN FETUA_HUMAN General information about the entry View entry in simple text format Entry name FETUA_HUMAN Primary accession number P02765 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 15) Name and origin of the protein Description RecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Alpha-2-Z-globulin; AltName: Full=Ba-alpha-2-glycoprotein; AltName: Full=Fetuin-A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain B; Flags: Precursor;. Gene name Name=AHSG Synonyms=FETUA ORFNames=PRO2743 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=78094420; PubMed=271964; [NCBI, Expasy, EBI, Israel, Japan] Anderson N.L., Anderson N.G. ''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';'' Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977) [2]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) Comments SUBUNIT: A AND B CHAIN 2D PAGE maps for identified proteins How to interpret a protein CSF_HUMAN {Cerebrospinal Fluid} Homo sapiens (Human) Tissue: Cerebrospinal fluid   map experimental info   protein estimated location   CSF_HUMAN MAP LOCATIONS: SPOT 2D-000BTG: pI=4.43; Mw=60957 SPOT 2D-000BU5: pI=4.47; Mw=59576 SPOT 2D-000BU7: pI=4.42; Mw=59576 SPOT 2D-000BUA: pI=4.51; Mw=58672 SPOT 2D-000BUU: pI=4.55; Mw=58077 SPOT 2D-000BV6: pI=4.46; Mw=57930 SPOT 2D-000BVY: pI=4.50; Mw=57051 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [2]. HEPG2SP_HUMAN {HepG2 Secreted Proteins} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2SP_HUMAN MAP LOCATIONS: SPOT 2D-0008W0: pI=4.16; Mw=58201 SPOT 2D-0008WF: pI=4.21; Mw=57256 SPOT 2D-0008WM: pI=4.26; Mw=56882 SPOT 2D-0008WY: pI=4.33; Mw=55775 SPOT 2D-0008XO: pI=4.39; Mw=55050 SPOT 2D-0008Y2: pI=4.43; Mw=54690 SPOT 2D-0008YA: pI=4.28; Mw=53979 SPOT 2D-0008YC: pI=4.48; Mw=52583 SPOT 2D-0008YR: pI=4.33; Mw=53102 SPOT 2D-0008YX: pI=4.43; Mw=52240 SPOT 2D-0008Z0: pI=4.39; Mw=52411 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [2]. PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-0004QJ: pI=4.56; Mw=57706 SPOT 2D-0004R8: pI=4.58; Mw=56773 SPOT 2D-0004RK: pI=4.56; Mw=56466 SPOT 2D-0004RS: pI=4.61; Mw=56313 SPOT 2D-0004S9: pI=4.58; Mw=55553 SPOT 2D-0004SB: pI=4.61; Mw=55403 SPOT 2D-0004SY: pI=4.64; Mw=54804 SPOT 2D-0004T4: pI=4.68; Mw=54359 SPOT 2D-0004TI: pI=4.60; Mw=54212 SPOT 2D-0004TM: pI=4.64; Mw=54065 SPOT 2D-0004TY: pI=4.68; Mw=53336 SPOT 2D-0004U3: pI=4.71; Mw=53191 SPOT 2D-0004UA: pI=4.64; Mw=52903 SPOT 2D-0004V2: pI=4.71; Mw=52474 SPOT 2D-0004VB: pI=4.67; Mw=52474 NORMAL LEVEL: 400-850 MG/L. PATHOLOGICAL LEVEL: DECREASED DURING TUMORS AND INFLAMMATORY PROCESSES. MAPPING (identification): IMMUNOBLOTTING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P02765; P02765. DOSAC-COBS-2DPAGE P02765; FETUA_HUMAN. Siena-2DPAGE P02765; FETUA_HUMAN. UniProtKB/Swiss-Prot P02765; FETUA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name FETUA_HUMAN Primary accession number P02765 Secondary accession number(s) A8K9N6 B2R7G1 O14961 O14962 Q9P152 Sequence was last modified on  April 1, 1988 (version 1) Annotations were last modified on  October 19, 2011 (version 139) Name and origin of the protein Description RecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Alpha-2-Z-globulin; AltName: Full=Ba-alpha-2-glycoprotein; AltName: Full=Fetuin-A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain A; Contains: RecName: Full=Alpha-2-HS-glycoprotein chain B; Flags: Precursor; Gene name Name=AHSG Synonyms=FETUA ORFNames=PRO2743 Encoded on Name=AHSG; Synonyms=FETUA; ORFNames=PRO2743 Keywords Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Mineral balance; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M16961; AAA51683.1; -; mRNA EMBL D67013; BAA22652.1; -; Genomic_DNA EMBL AB038689; BAA92189.1; -; Genomic_DNA EMBL AK292751; BAF85440.1; -; mRNA EMBL AK312969; BAG35808.1; -; mRNA EMBL AC068631; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471052; EAW78189.1; -; Genomic_DNA EMBL BC048198; AAH48198.1; -; mRNA EMBL BC052590; AAH52590.1; -; mRNA EMBL D67012; BAA22651.1; -; mRNA EMBL AF119895; AAF69649.1; -; mRNA IPI IPI00953689; -; . PIR A29081; WOHU; . RefSeq NP_001613.2; NM_001622.2; . UniGene Hs.324746; -; . ProteinModelPortal P02765; -; . IntAct P02765; 8; . MINT MINT-5004009; -; . STRING P02765; -; . MEROPS I25.020; -; . MEROPS I25.021; -; . GlycoSuiteDB P02765; -; . PhosphoSite P02765; -; . SWISS-2DPAGE P02765; -; . DOSAC-COBS-2DPAGE P02765; -; . Siena-2DPAGE P02765; -; . PRIDE P02765; -; . Ensembl ENST00000411641; ENSP00000393887; ENSG00000145192; . GeneID 197; -; . KEGG hsa:197; -; . CTD 197; -; . GeneCards GC03P183739; -; . H-InvDB HIX0024338; -; . HGNC HGNC:349; AHSG; . HPA CAB026209; -; . HPA HPA001524; -; . HPA HPA001525; -; . MIM 138680; gene; . neXtProt NX_P02765; -; . PharmGKB PA24642; -; . eggNOG prNOG18563; -; . GeneTree ENSGT00530000063413; -; . HOVERGEN HBG051607; -; . InParanoid P02765; -; . OrthoDB EOG4QC164; -; . Pathway_Interaction_DB bmppathway; BMP receptor signaling; . NextBio 790; -; . PMAP-CutDB P02765; -; . ArrayExpress P02765; -; . Bgee P02765; -; . CleanEx HS_AHSG; -; . Genevestigator P02765; -; . GermOnline ENSG00000145192; Homo sapiens; . GO GO:0005615; C:extracellular space; NAS:UniProtKB; . GO GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro; . GO GO:0006953; P:acute-phase response; IDA:UniProtKB; . GO GO:0030502; P:negative regulation of bone mineralization; ISS:UniProtKB; . GO GO:0046627; P:negative regulation of insulin receptor signaling pathway; NAS:UniProtKB; . GO GO:0006907; P:pinocytosis; NAS:UniProtKB; . GO GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB; . GO GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB; . GO GO:0001501; P:skeletal system development; NAS:UniProtKB; . InterPro IPR000010; Prot_inh_cystat; . InterPro IPR001363; Prot_inh_fetuin_CS; . Pfam PF00031; Cystatin; 1; . SMART SM00043; CY; 2; . PROSITE PS51529; CYSTATIN_FETUIN_A; 2; . PROSITE PS01254; FETUIN_1; 1; . PROSITE PS01255; FETUIN_2; 1; . SWISS-2DPAGE (search AC)