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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: GSTP1_HUMAN




SWISS-2DPAGE:  GSTP1_HUMAN


GSTP1_HUMAN


General information about the entry
View entry in simple text format
Entry nameGSTP1_HUMAN
Primary accession numberP09211
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 5)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Glutathione S-transferase P; EC=2.5.1.18; AltName: Full=GST class-pi; AltName: Full=GSTP1-1;.
Gene nameName=GSTP1
Synonyms=FAEES3, GST3
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147969; PubMed=8313870; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
''''''Human liver protein map: update 1993'';'';''
Electrophoresis 14(1):1216-1222(1993)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[4]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[5]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[6]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[7]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: HOMODIMER
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=5.46; Mw=22917

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [5].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.42; Mw=22876  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [6].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.43; Mw=23319

MAPPING (identification):
MICROSEQUENCING AND MATCHING WITH THE LIVER MASTER GEL [2].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=5.38; Mw=23171

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.39; Mw=23224
pI=5.42; Mw=23224

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.43; Mw=23712  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [7].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=5.45; Mw=22946

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=5.44; Mw=23647
pI=5.45; Mw=22515

MAPPING (identification):
MICROSEQUENCING [3].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=5.44; Mw=23328

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP09211; P09211.
DOSAC-COBS-2DPAGEP09211; GSTP1_HUMAN.
HSC-2DPAGEP09211; HUMAN.
OGP-WWWP09211.
PHCI-2DPAGEP09211; GTP_HUMAN.
REPRODUCTION-2DPAGEIPI00219757; IPI00219757.
Siena-2DPAGEP09211; GSTP1_HUMAN.
UCD-2DPAGEP09211; GSTP1_HUMAN.
UniProtKB/Swiss-ProtP09211; GSTP1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameGSTP1_HUMAN
Primary accession numberP09211
Secondary accession number(s) O00460 Q15690 Q5TZY3
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=Glutathione S-transferase P; EC=2.5.1.18; AltName: Full=GST class-pi; AltName: Full=GSTP1-1;
Gene nameName=GSTP1
Synonyms=FAEES3, GST3
Encoded onName=GSTP1; Synonyms=FAEES3, GST3
Keywords3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Transferase.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX06547; CAA29794.1; -; mRNA
EMBLM24485; AAA56823.1; -; Genomic_DNA
EMBLX08058; CAA30847.1; -; Genomic_DNA
EMBLX08094; CAA30894.1; -; Genomic_DNA
EMBLX08095; CAA30894.1; JOINED; Genomic_DNA
EMBLX08096; CAA30894.1; JOINED; Genomic_DNA
EMBLX15480; CAA33508.1; -; mRNA
EMBLU12472; AAA64919.1; -; Genomic_DNA
EMBLU30897; AAC51280.1; -; mRNA
EMBLU62589; AAC51237.1; -; mRNA
EMBLU21689; AAC13869.1; -; Genomic_DNA
EMBLBT019949; AAV38752.1; -; mRNA
EMBLBT019950; AAV38753.1; -; mRNA
EMBLCR450361; CAG29357.1; -; mRNA
EMBLAY324387; AAP72967.1; -; Genomic_DNA
EMBLBC010915; AAH10915.1; -; mRNA
IPIIPI00219757; -; .
PIRA41177; A41177; .
PIRJS0153; A37378; .
RefSeqNP_000843.1; NM_000852.3; .
UniGeneHs.523836; -; .
PDB10GS; X-ray; 2.20 A; A/B=2-210
PDB11GS; X-ray; 2.30 A; A/B=2-209
PDB12GS; X-ray; 2.10 A; A/B=1-210
PDB13GS; X-ray; 1.90 A; A/B=1-210
PDB14GS; X-ray; 2.80 A; A/B=2-209
PDB16GS; X-ray; 1.90 A; A/B=2-209
PDB17GS; X-ray; 1.90 A; A/B=1-210
PDB18GS; X-ray; 1.90 A; A/B=2-209
PDB19GS; X-ray; 1.90 A; A/B=2-209
PDB1AQV; X-ray; 1.94 A; A/B=2-210
PDB1AQW; X-ray; 1.80 A; A/B/C/D=2-210
PDB1AQX; X-ray; 2.00 A; A/B/C/D=2-210
PDB1EOG; X-ray; 2.10 A; A/B=3-210
PDB1EOH; X-ray; 2.50 A; A/B/C/D/E/F/G/H=2-210
PDB1GSS; X-ray; 2.80 A; A/B=2-210
PDB1KBN; X-ray; 2.00 A; A/B=2-209
PDB1LBK; X-ray; 1.86 A; A/B=2-202
PDB1MD3; X-ray; 2.03 A; A/B=2-209
PDB1MD4; X-ray; 2.10 A; A/B=2-209
PDB1PGT; X-ray; 1.80 A; A/B=1-210
PDB1PX6; X-ray; 2.10 A; A/B=2-209
PDB1PX7; X-ray; 2.03 A; A/B=2-209
PDB1ZGN; X-ray; 2.10 A; A/B=2-209
PDB20GS; X-ray; 2.45 A; A/B=2-209
PDB22GS; X-ray; 1.90 A; A/B=1-210
PDB2A2R; X-ray; 1.40 A; A/B=2-209
PDB2A2S; X-ray; 1.70 A; A/B=2-209
PDB2GSS; X-ray; 1.90 A; A/B=2-210
PDB2J9H; X-ray; 2.40 A; A/B=2-210
PDB2PGT; X-ray; 1.90 A; A/B=1-210
PDB3CSH; X-ray; 1.55 A; A/B=2-210
PDB3CSI; X-ray; 1.90 A; A/B/C/D=2-210
PDB3CSJ; X-ray; 1.90 A; A/B=2-210
PDB3DD3; X-ray; 2.25 A; A/B=1-210
PDB3DGQ; X-ray; 1.60 A; A/B=1-210
PDB3GSS; X-ray; 1.90 A; A/B=2-210
PDB3GUS; X-ray; 1.53 A; A/B=2-210
PDB3HJM; X-ray; 2.10 A; A/B/C/D=2-210
PDB3HJO; X-ray; 1.95 A; A/B=2-210
PDB3HKR; X-ray; 1.80 A; A/B=2-210
PDB3IE3; X-ray; 1.80 A; A/B=2-210
PDB3KM6; X-ray; 2.10 A; A/B=2-210
PDB3KMN; X-ray; 1.80 A; A/B=2-210
PDB3KMO; X-ray; 2.60 A; A/B=2-210
PDB3N9J; X-ray; 1.85 A; A/B=1-210
PDB3PGT; X-ray; 2.14 A; A/B=1-210
PDB4GSS; X-ray; 2.50 A; A/B=2-209
PDB4PGT; X-ray; 2.10 A; A/B=1-210
PDB5GSS; X-ray; 1.95 A; A/B=2-210
PDB6GSS; X-ray; 1.90 A; A/B=2-210
PDB7GSS; X-ray; 2.20 A; A/B=2-210
PDB8GSS; X-ray; 1.90 A; A/B/C=2-210
PDB9GSS; X-ray; 1.97 A; A/B=2-210
PDBsum10GS; -; .
PDBsum11GS; -; .
PDBsum12GS; -; .
PDBsum13GS; -; .
PDBsum14GS; -; .
PDBsum16GS; -; .
PDBsum17GS; -; .
PDBsum18GS; -; .
PDBsum19GS; -; .
PDBsum1AQV; -; .
PDBsum1AQW; -; .
PDBsum1AQX; -; .
PDBsum1EOG; -; .
PDBsum1EOH; -; .
PDBsum1GSS; -; .
PDBsum1KBN; -; .
PDBsum1LBK; -; .
PDBsum1MD3; -; .
PDBsum1MD4; -; .
PDBsum1PGT; -; .
PDBsum1PX6; -; .
PDBsum1PX7; -; .
PDBsum1ZGN; -; .
PDBsum20GS; -; .
PDBsum22GS; -; .
PDBsum2A2R; -; .
PDBsum2A2S; -; .
PDBsum2GSS; -; .
PDBsum2J9H; -; .
PDBsum2PGT; -; .
PDBsum3CSH; -; .
PDBsum3CSI; -; .
PDBsum3CSJ; -; .
PDBsum3DD3; -; .
PDBsum3DGQ; -; .
PDBsum3GSS; -; .
PDBsum3GUS; -; .
PDBsum3HJM; -; .
PDBsum3HJO; -; .
PDBsum3HKR; -; .
PDBsum3IE3; -; .
PDBsum3KM6; -; .
PDBsum3KMN; -; .
PDBsum3KMO; -; .
PDBsum3N9J; -; .
PDBsum3PGT; -; .
PDBsum4GSS; -; .
PDBsum4PGT; -; .
PDBsum5GSS; -; .
PDBsum6GSS; -; .
PDBsum7GSS; -; .
PDBsum8GSS; -; .
PDBsum9GSS; -; .
ProteinModelPortalP09211; -; .
SMRP09211; 1-210; .
IntActP09211; 18; .
MINTMINT-4998983; -; .
STRINGP09211; -; .
PhosphoSiteP09211; -; .
SWISS-2DPAGEP09211; -; .
Aarhus/Ghent-2DPAGE5101; IEF; .
Cornea-2DPAGEP09211; -; .
DOSAC-COBS-2DPAGEP09211; -; .
OGPP09211; -; .
PHCI-2DPAGEP09211; -; .
REPRODUCTION-2DPAGEIPI00219757; -; .
Siena-2DPAGEP09211; -; .
UCD-2DPAGEP09211; -; .
PRIDEP09211; -; .
EnsemblENST00000398606; ENSP00000381607; ENSG00000084207; .
GeneID2950; -; .
KEGGhsa:2950; -; .
NMPDRfig|9606.3.peg.6143; -; .
UCSCuc001omf.1; human; .
CTD2950; -; .
GeneCardsGC11P063681; -; .
H-InvDBHIX0009866; -; .
HGNCHGNC:4638; GSTP1; .
HPACAB019298; -; .
HPAHPA019779; -; .
HPAHPA019869; -; .
MIM134660; gene; .
neXtProtNX_P09211; -; .
PharmGKBPA29028; -; .
eggNOGprNOG17586; -; .
GeneTreeENSGT00550000074559; -; .
HOGENOMHBG563238; -; .
HOVERGENHBG108324; -; .
InParanoidP09211; -; .
OMANQISFAD; -; .
OrthoDBEOG48SGTZ; -; .
PhylomeDBP09211; -; .
ReactomeREACT_13433; Biological oxidations; .
DrugBankDB00903; Ethacrynic acid; .
DrugBankDB00143; Glutathione; .
NextBio11692; -; .
PMAP-CutDBP09211; -; .
ArrayExpressP09211; -; .
BgeeP09211; -; .
CleanExHS_GSTP1; -; .
GenevestigatorP09211; -; .
GermOnlineENSG00000084207; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0043234; C:protein complex; IDA:BHF-UCL; .
GOGO:0035731; F:dinitrosyl-iron complex binding; IDA:BHF-UCL; .
GOGO:0004364; F:glutathione transferase activity; IDA:UniProtKB; .
GOGO:0008432; F:JUN kinase binding; ISS:BHF-UCL; .
GOGO:0019207; F:kinase regulator activity; ISS:BHF-UCL; .
GOGO:0070026; F:nitric oxide binding; NAS:BHF-UCL; .
GOGO:0035730; F:S-nitrosoglutathione binding; IDA:BHF-UCL; .
GOGO:0006916; P:anti-apoptosis; TAS:UniProtKB; .
GOGO:0071222; P:cellular response to lipopolysaccharide; ISS:BHF-UCL; .
GOGO:0035726; P:common myeloid progenitor cell proliferation; ISS:BHF-UCL; .
GOGO:0006749; P:glutathione metabolic process; IDA:UniProtKB; .
GOGO:0002674; P:negative regulation of acute inflammatory response; NAS:BHF-UCL; .
GOGO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; .
GOGO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL; .
GOGO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:BHF-UCL; .
GOGO:0032691; P:negative regulation of interleukin-1 beta production; IDA:BHF-UCL; .
GOGO:0043508; P:negative regulation of JUN kinase activity; IDA:BHF-UCL; .
GOGO:0070664; P:negative regulation of leukocyte proliferation; ISS:BHF-UCL; .
GOGO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IDA:BHF-UCL; .
GOGO:0060547; P:negative regulation of necrotic cell death; ISS:BHF-UCL; .
GOGO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL; .
GOGO:0032873; P:negative regulation of stress-activated MAPK cascade; ISS:BHF-UCL; .
GOGO:0032720; P:negative regulation of tumor necrosis factor production; IDA:BHF-UCL; .
GOGO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IC:BHF-UCL; .
GOGO:0035732; P:nitric oxide storage; NAS:BHF-UCL; .
GOGO:0032930; P:positive regulation of superoxide anion generation; ISS:BHF-UCL; .
GOGO:0000302; P:response to reactive oxygen species; ISS:BHF-UCL; .
GOGO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB; .
InterProIPR010987; Glutathione-S-Trfase_C-like; .
InterProIPR004045; Glutathione_S-Trfase_N; .
InterProIPR017933; Glutathione_S_Trfase/Cl_chnl_C; .
InterProIPR004046; GST_C; .
InterProIPR003082; GST_pi; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:1.20.1050.10; GST_C_like; 1; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PfamPF00043; GST_C; 1; .
PfamPF02798; GST_N; 1; .
PRINTSPR01268; GSTRNSFRASEP; .
SUPFAMSSF47616; GST_C_like; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS50405; GST_CTER; 1; .
PROSITEPS50404; GST_NTER; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server