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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: GSTP1_HUMAN SWISS-2DPAGE:  GSTP1_HUMAN GSTP1_HUMAN General information about the entry View entry in simple text format Entry name GSTP1_HUMAN Primary accession number P09211 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on March 31, 2004 (version 5) General Annotations were last modified on  May 19, 2011 (version 12) Name and origin of the protein Description RecName: Full=Glutathione S-transferase P; EC=2.5.1.18; AltName: Full=GST class-pi; AltName: Full=GSTP1-1;. Gene name Name=GSTP1 Synonyms=FAEES3, GST3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=94147969; PubMed=8313870; [NCBI, Expasy, EBI, Israel, Japan] Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F. ''''''Human liver protein map: update 1993'';'';'' Electrophoresis 14(1):1216-1222(1993) [2]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) [3]   MAPPING ON GEL MEDLINE=94147970; PubMed=8313871; [NCBI, Expasy, EBI, Israel, Japan] Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F. ''''''Plasma and red blood cell protein maps: update 1993'';'';'' Electrophoresis 14(1):1223-1231(1993) [4]   MAPPING ON GEL MEDLINE=97295305; PubMed=9150947; [NCBI, Expasy, EBI, Israel, Japan] Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P. ''''''Renal cell carcinoma and normal kidney protein expression'';'';'' Electrophoresis 18(1):599-604(1997) [5]   MAPPING ON GEL MEDLINE=98163346; PubMed=9504818; [NCBI, Expasy, EBI, Israel, Japan] Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F. ''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';'' Electrophoresis 18(1):2842-2848(1997) [6]   MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE [7]   MAPPING ON GEL Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D. ''''''New insights into HIV lymphocyte infection'';'';'' (IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004) Comments SUBUNIT: HOMODIMER 2D PAGE maps for identified proteins How to interpret a protein CEC_HUMAN {Colorectal epithelia cells} Homo sapiens (Human) Tissue: Colon epithelium   map experimental info   protein estimated location   CEC_HUMAN MAP LOCATIONS: SPOT 2D-000UP8: pI=5.46; Mw=22917 MAPPING (identification): MATCHING WITH THE LIVER MASTER GEL [5]. DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human) Tissue: Colon adenocarcinoma   map experimental info   protein estimated location   DLD1_HUMAN MAP LOCATIONS: SPOT 2D-001EUM: pI=5.42; Mw=22876   [identification data] MAPPING (identification): Peptide mass fingerprinting [6]. HEPG2_HUMAN {HepG2} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2_HUMAN MAP LOCATIONS: SPOT 2D-0003Q9: pI=5.43; Mw=23319 MAPPING (identification): MICROSEQUENCING AND MATCHING WITH THE LIVER MASTER GEL [2]. KIDNEY_HUMAN {Kidney} Homo sapiens (Human) Tissue: Kidney   map experimental info   protein estimated location   KIDNEY_HUMAN MAP LOCATIONS: SPOT 2D-000NSN: pI=5.38; Mw=23171 MAPPING (identification): MATCHING WITH THE LIVER MASTER GEL [4]. LIVER_HUMAN {Liver} Homo sapiens (Human) Tissue: Liver   map experimental info   protein estimated location   LIVER_HUMAN MAP LOCATIONS: SPOT 2D-0001EW: pI=5.39; Mw=23224 SPOT 2D-0001EY: pI=5.42; Mw=23224 MAPPING (identification): MICROSEQUENCING [1]. LYMPHOCYTE_HUMAN {Lymphocytes} Homo sapiens (Human) Tissue: Lymphocyte   map experimental info   protein estimated location   LYMPHOCYTE_HUMAN MAP LOCATIONS: SPOT 2D-001YDX: pI=5.43; Mw=23712   [identification data] MAPPING (identification): Peptide mass fingerprinting [7]. LYMPHOMA_HUMAN {Lymphoma} Homo sapiens (Human) Tissue: Lymphoma   map experimental info   protein estimated location   LYMPHOMA_HUMAN MAP LOCATIONS: SPOT 2D-00085X: pI=5.45; Mw=22946 MAPPING (identification): MATCHING WITH THE LIVER MASTER GEL [2]. RBC_HUMAN {Red blood cells} Homo sapiens (Human) Tissue: Erythrocyte   map experimental info   protein estimated location   RBC_HUMAN MAP LOCATIONS: SPOT 2D-0006K6: pI=5.44; Mw=23647 SPOT 2D-0006KZ: pI=5.45; Mw=22515 MAPPING (identification): MICROSEQUENCING [3]. U937_HUMAN {Macrophage Like Cell Line} Homo sapiens (Human) Tissue: Histiocytic lymphoma   map experimental info   protein estimated location   U937_HUMAN MAP LOCATIONS: SPOT 2D-000D4X: pI=5.44; Mw=23328 MAPPING (identification): MATCHING WITH THE LIVER MASTER GEL [2]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references DOSAC-COBS 2D-PAGE P09211; P09211. DOSAC-COBS-2DPAGE P09211; GSTP1_HUMAN. HSC-2DPAGE P09211; HUMAN. OGP-WWW P09211. PHCI-2DPAGE P09211; GTP_HUMAN. REPRODUCTION-2DPAGE IPI00219757; IPI00219757. Siena-2DPAGE P09211; GSTP1_HUMAN. UCD-2DPAGE P09211; GSTP1_HUMAN. UniProtKB/Swiss-Prot P09211; GSTP1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name GSTP1_HUMAN Primary accession number P09211 Secondary accession number(s) O00460 Q15690 Q5TZY3 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  October 19, 2011 (version 146) Name and origin of the protein Description RecName: Full=Glutathione S-transferase P; EC=2.5.1.18; AltName: Full=GST class-pi; AltName: Full=GSTP1-1; Gene name Name=GSTP1 Synonyms=FAEES3, GST3 Encoded on Name=GSTP1; Synonyms=FAEES3, GST3 Keywords 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Transferase. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X06547; CAA29794.1; -; mRNA EMBL M24485; AAA56823.1; -; Genomic_DNA EMBL X08058; CAA30847.1; -; Genomic_DNA EMBL X08094; CAA30894.1; -; Genomic_DNA EMBL X08095; CAA30894.1; JOINED; Genomic_DNA EMBL X08096; CAA30894.1; JOINED; Genomic_DNA EMBL X15480; CAA33508.1; -; mRNA EMBL U12472; AAA64919.1; -; Genomic_DNA EMBL U30897; AAC51280.1; -; mRNA EMBL U62589; AAC51237.1; -; mRNA EMBL U21689; AAC13869.1; -; Genomic_DNA EMBL BT019949; AAV38752.1; -; mRNA EMBL BT019950; AAV38753.1; -; mRNA EMBL CR450361; CAG29357.1; -; mRNA EMBL AY324387; AAP72967.1; -; Genomic_DNA EMBL BC010915; AAH10915.1; -; mRNA IPI IPI00219757; -; . PIR A41177; A41177; . PIR JS0153; A37378; . RefSeq NP_000843.1; NM_000852.3; . UniGene Hs.523836; -; . PDB 10GS; X-ray; 2.20 A; A/B=2-210 PDB 11GS; X-ray; 2.30 A; A/B=2-209 PDB 12GS; X-ray; 2.10 A; A/B=1-210 PDB 13GS; X-ray; 1.90 A; A/B=1-210 PDB 14GS; X-ray; 2.80 A; A/B=2-209 PDB 16GS; X-ray; 1.90 A; A/B=2-209 PDB 17GS; X-ray; 1.90 A; A/B=1-210 PDB 18GS; X-ray; 1.90 A; A/B=2-209 PDB 19GS; X-ray; 1.90 A; A/B=2-209 PDB 1AQV; X-ray; 1.94 A; A/B=2-210 PDB 1AQW; X-ray; 1.80 A; A/B/C/D=2-210 PDB 1AQX; X-ray; 2.00 A; A/B/C/D=2-210 PDB 1EOG; X-ray; 2.10 A; A/B=3-210 PDB 1EOH; X-ray; 2.50 A; A/B/C/D/E/F/G/H=2-210 PDB 1GSS; X-ray; 2.80 A; A/B=2-210 PDB 1KBN; X-ray; 2.00 A; A/B=2-209 PDB 1LBK; X-ray; 1.86 A; A/B=2-202 PDB 1MD3; X-ray; 2.03 A; A/B=2-209 PDB 1MD4; X-ray; 2.10 A; A/B=2-209 PDB 1PGT; X-ray; 1.80 A; A/B=1-210 PDB 1PX6; X-ray; 2.10 A; A/B=2-209 PDB 1PX7; X-ray; 2.03 A; A/B=2-209 PDB 1ZGN; X-ray; 2.10 A; A/B=2-209 PDB 20GS; X-ray; 2.45 A; A/B=2-209 PDB 22GS; X-ray; 1.90 A; A/B=1-210 PDB 2A2R; X-ray; 1.40 A; A/B=2-209 PDB 2A2S; X-ray; 1.70 A; A/B=2-209 PDB 2GSS; X-ray; 1.90 A; A/B=2-210 PDB 2J9H; X-ray; 2.40 A; A/B=2-210 PDB 2PGT; X-ray; 1.90 A; A/B=1-210 PDB 3CSH; X-ray; 1.55 A; A/B=2-210 PDB 3CSI; X-ray; 1.90 A; A/B/C/D=2-210 PDB 3CSJ; X-ray; 1.90 A; A/B=2-210 PDB 3DD3; X-ray; 2.25 A; A/B=1-210 PDB 3DGQ; X-ray; 1.60 A; A/B=1-210 PDB 3GSS; X-ray; 1.90 A; A/B=2-210 PDB 3GUS; X-ray; 1.53 A; A/B=2-210 PDB 3HJM; X-ray; 2.10 A; A/B/C/D=2-210 PDB 3HJO; X-ray; 1.95 A; A/B=2-210 PDB 3HKR; X-ray; 1.80 A; A/B=2-210 PDB 3IE3; X-ray; 1.80 A; A/B=2-210 PDB 3KM6; X-ray; 2.10 A; A/B=2-210 PDB 3KMN; X-ray; 1.80 A; A/B=2-210 PDB 3KMO; X-ray; 2.60 A; A/B=2-210 PDB 3N9J; X-ray; 1.85 A; A/B=1-210 PDB 3PGT; X-ray; 2.14 A; A/B=1-210 PDB 4GSS; X-ray; 2.50 A; A/B=2-209 PDB 4PGT; X-ray; 2.10 A; A/B=1-210 PDB 5GSS; X-ray; 1.95 A; A/B=2-210 PDB 6GSS; X-ray; 1.90 A; A/B=2-210 PDB 7GSS; X-ray; 2.20 A; A/B=2-210 PDB 8GSS; X-ray; 1.90 A; A/B/C=2-210 PDB 9GSS; X-ray; 1.97 A; A/B=2-210 PDBsum 10GS; -; . PDBsum 11GS; -; . PDBsum 12GS; -; . PDBsum 13GS; -; . PDBsum 14GS; -; . PDBsum 16GS; -; . PDBsum 17GS; -; . PDBsum 18GS; -; . PDBsum 19GS; -; . PDBsum 1AQV; -; . PDBsum 1AQW; -; . PDBsum 1AQX; -; . PDBsum 1EOG; -; . PDBsum 1EOH; -; . PDBsum 1GSS; -; . PDBsum 1KBN; -; . PDBsum 1LBK; -; . PDBsum 1MD3; -; . PDBsum 1MD4; -; . PDBsum 1PGT; -; . PDBsum 1PX6; -; . PDBsum 1PX7; -; . PDBsum 1ZGN; -; . PDBsum 20GS; -; . PDBsum 22GS; -; . PDBsum 2A2R; -; . PDBsum 2A2S; -; . PDBsum 2GSS; -; . PDBsum 2J9H; -; . PDBsum 2PGT; -; . PDBsum 3CSH; -; . PDBsum 3CSI; -; . PDBsum 3CSJ; -; . PDBsum 3DD3; -; . PDBsum 3DGQ; -; . PDBsum 3GSS; -; . PDBsum 3GUS; -; . PDBsum 3HJM; -; . PDBsum 3HJO; -; . PDBsum 3HKR; -; . PDBsum 3IE3; -; . PDBsum 3KM6; -; . PDBsum 3KMN; -; . PDBsum 3KMO; -; . PDBsum 3N9J; -; . PDBsum 3PGT; -; . PDBsum 4GSS; -; . PDBsum 4PGT; -; . PDBsum 5GSS; -; . PDBsum 6GSS; -; . PDBsum 7GSS; -; . PDBsum 8GSS; -; . PDBsum 9GSS; -; . ProteinModelPortal P09211; -; . SMR P09211; 1-210; . IntAct P09211; 18; . MINT MINT-4998983; -; . STRING P09211; -; . PhosphoSite P09211; -; . SWISS-2DPAGE P09211; -; . Aarhus/Ghent-2DPAGE 5101; IEF; . Cornea-2DPAGE P09211; -; . DOSAC-COBS-2DPAGE P09211; -; . OGP P09211; -; . PHCI-2DPAGE P09211; -; . REPRODUCTION-2DPAGE IPI00219757; -; . Siena-2DPAGE P09211; -; . UCD-2DPAGE P09211; -; . PRIDE P09211; -; . Ensembl ENST00000398606; ENSP00000381607; ENSG00000084207; . GeneID 2950; -; . KEGG hsa:2950; -; . NMPDR fig|9606.3.peg.6143; -; . UCSC uc001omf.1; human; . CTD 2950; -; . GeneCards GC11P063681; -; . H-InvDB HIX0009866; -; . HGNC HGNC:4638; GSTP1; . HPA CAB019298; -; . HPA HPA019779; -; . HPA HPA019869; -; . MIM 134660; gene; . neXtProt NX_P09211; -; . PharmGKB PA29028; -; . eggNOG prNOG17586; -; . GeneTree ENSGT00550000074559; -; . HOGENOM HBG563238; -; . HOVERGEN HBG108324; -; . InParanoid P09211; -; . OMA NQISFAD; -; . OrthoDB EOG48SGTZ; -; . PhylomeDB P09211; -; . Reactome REACT_13433; Biological oxidations; . DrugBank DB00903; Ethacrynic acid; . DrugBank DB00143; Glutathione; . NextBio 11692; -; . PMAP-CutDB P09211; -; . ArrayExpress P09211; -; . Bgee P09211; -; . CleanEx HS_GSTP1; -; . Genevestigator P09211; -; . GermOnline ENSG00000084207; Homo sapiens; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043234; C:protein complex; IDA:BHF-UCL; . GO GO:0035731; F:dinitrosyl-iron complex binding; IDA:BHF-UCL; . GO GO:0004364; F:glutathione transferase activity; IDA:UniProtKB; . GO GO:0008432; F:JUN kinase binding; ISS:BHF-UCL; . GO GO:0019207; F:kinase regulator activity; ISS:BHF-UCL; . GO GO:0070026; F:nitric oxide binding; NAS:BHF-UCL; . GO GO:0035730; F:S-nitrosoglutathione binding; IDA:BHF-UCL; . GO GO:0006916; P:anti-apoptosis; TAS:UniProtKB; . GO GO:0071222; P:cellular response to lipopolysaccharide; ISS:BHF-UCL; . GO GO:0035726; P:common myeloid progenitor cell proliferation; ISS:BHF-UCL; . GO GO:0006749; P:glutathione metabolic process; IDA:UniProtKB; . GO GO:0002674; P:negative regulation of acute inflammatory response; NAS:BHF-UCL; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; . GO GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL; . GO GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:BHF-UCL; . GO GO:0032691; P:negative regulation of interleukin-1 beta production; IDA:BHF-UCL; . GO GO:0043508; P:negative regulation of JUN kinase activity; IDA:BHF-UCL; . GO GO:0070664; P:negative regulation of leukocyte proliferation; ISS:BHF-UCL; . GO GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; IDA:BHF-UCL; . GO GO:0060547; P:negative regulation of necrotic cell death; ISS:BHF-UCL; . GO GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL; . GO GO:0032873; P:negative regulation of stress-activated MAPK cascade; ISS:BHF-UCL; . GO GO:0032720; P:negative regulation of tumor necrosis factor production; IDA:BHF-UCL; . GO GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IC:BHF-UCL; . GO GO:0035732; P:nitric oxide storage; NAS:BHF-UCL; . GO GO:0032930; P:positive regulation of superoxide anion generation; ISS:BHF-UCL; . GO GO:0000302; P:response to reactive oxygen species; ISS:BHF-UCL; . GO GO:0006805; P:xenobiotic metabolic process; IDA:UniProtKB; . InterPro IPR010987; Glutathione-S-Trfase_C-like; . InterPro IPR004045; Glutathione_S-Trfase_N; . InterPro IPR017933; Glutathione_S_Trfase/Cl_chnl_C; . InterPro IPR004046; GST_C; . InterPro IPR003082; GST_pi; . InterPro IPR012336; Thioredoxin-like_fold; . Gene3D G3DSA:1.20.1050.10; GST_C_like; 1; . Gene3D G3DSA:3.40.30.10; Thioredoxin_fold; 1; . Pfam PF00043; GST_C; 1; . Pfam PF02798; GST_N; 1; . PRINTS PR01268; GSTRNSFRASEP; . SUPFAM SSF47616; GST_C_like; 1; . SUPFAM SSF52833; Thiordxn-like_fd; 1; . PROSITE PS50405; GST_CTER; 1; . PROSITE PS50404; GST_NTER; 1; . SWISS-2DPAGE (search AC)