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Searching in 'SWISS-2DPAGE' for entry matching: M3K1_HUMAN




SWISS-2DPAGE:  M3K1_HUMAN


M3K1_HUMAN


General information about the entry
View entry in simple text format
Entry nameM3K1_HUMAN
Primary accession numberQ13233
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 1, 2000 (version 2)
General Annotations were last modified on May 19, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase kinase kinase 1; EC=2.7.11.25; AltName: Full=MAPK/ERK kinase kinase 1; Short=MEK kinase 1; Short=MEKK 1;.
Gene nameName=MAP3K1
Synonyms=MAPKKK1, MEKK, MEKK1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295311; PubMed=9150953; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F.
''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';''
Electrophoresis 18(1):638-641(1997)
[2]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=6.81; Mw=46815
pI=6.90; Mw=46815
pI=6.60; Mw=46694
pI=6.35; Mw=46694

MAPPING (identification):
IMMUNOBLOTTING [2].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.50; Mw=45349
pI=6.79; Mw=45349
pI=6.90; Mw=45096
pI=6.93; Mw=44844

MAPPING (identification):
IMMUNOBLOTTING [1].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.77; Mw=43848
pI=6.60; Mw=43848
pI=7.07; Mw=43727
pI=6.41; Mw=43486

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtQ13233; M3K1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameM3K1_HUMAN
Primary accession numberQ13233
Sequence was last modified on December 16, 2008 (version 4)
Annotations were last modified on October 19, 2011 (version 117)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase kinase kinase 1; EC=2.7.11.25; AltName: Full=MAPK/ERK kinase kinase 1; Short=MEK kinase 1; Short=MEKK 1;
Gene nameName=MAP3K1
Synonyms=MAPKKK1, MEKK, MEKK1
Encoded onName=MAP3K1; Synonyms=MAPKKK1, MEKK, MEKK1
KeywordsAcetylation; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAC008937; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAF042838; AAC97073.1; -; mRNA
EMBLU29671; AAB05828.1; -; Genomic_DNA
IPIIPI00855985; -; .
PIRG01887; G01887; .
RefSeqNP_005912.1; NM_005921.1; .
UniGeneHs.653654; -; .
ProteinModelPortalQ13233; -; .
SMRQ13233; 429-497; 1243-1509; .
DIPDIP-27520N; -; .
IntActQ13233; 15; .
MINTMINT-143285; -; .
STRINGQ13233; -; .
PhosphoSiteQ13233; -; .
SWISS-2DPAGEQ13233; -; .
PRIDEQ13233; -; .
EnsemblENST00000399503; ENSP00000382423; ENSG00000095015; .
GeneID4214; -; .
KEGGhsa:4214; -; .
CTD4214; -; .
GeneCardsGC05P053082; -; .
H-InvDBHIX0024789; -; .
HGNCHGNC:6848; MAP3K1; .
HPACAB004500; -; .
MIM600982; gene; .
MIM613762; phenotype; .
neXtProtNX_Q13233; -; .
Orphanet242; 46; XY complete gonadal dysgenesis; .
PharmGKBPA30592; -; .
eggNOGprNOG09698; -; .
GeneTreeENSGT00600000084224; -; .
HOGENOMHBG282047; -; .
HOVERGENHBG006302; -; .
InParanoidQ13233; -; .
OMAQGFVPCK; -; .
OrthoDBEOG4F1X27; -; .
Pathway_Interaction_DBbcr_5pathway; BCR signaling pathway; .
Pathway_Interaction_DBcaspase_pathway; Caspase cascade in apoptosis; .
Pathway_Interaction_DBceramidepathway; Ceramide signaling pathway; .
Pathway_Interaction_DBfaspathway; FAS signaling pathway (CD95); .
Pathway_Interaction_DBfcer1pathway; Fc-epsilon receptor I signaling in mast cells; .
Pathway_Interaction_DBifngpathway; IFN-gamma pathway; .
Pathway_Interaction_DBtcrjnkpathway; JNK signaling in the CD4+ TCR pathway; .
Pathway_Interaction_DBavb3_opn_pathway; Osteopontin-mediated events; .
Pathway_Interaction_DBp38_mkk3_6pathway; p38 MAPK signaling pathway; .
Pathway_Interaction_DBsmad2_3pathway; Regulation of cytoplasmic and nuclear SMAD2/3 signaling; .
Pathway_Interaction_DBnfat_3pathway; Role of Calcineurin-dependent NFAT signaling in lymphocytes; .
Pathway_Interaction_DBtnfpathway; TNF receptor signaling pathway; .
Pathway_Interaction_DBtrail_pathway; TRAIL signaling pathway; .
ReactomeREACT_6900; Immune System; .
NextBio16613; -; .
ArrayExpressQ13233; -; .
BgeeQ13233; -; .
CleanExHS_MAP3K1; -; .
GenevestigatorQ13233; -; .
GermOnlineENSG00000095015; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005524; F:ATP binding; NAS:UniProtKB; .
GOGO:0008270; F:zinc ion binding; IEA:InterPro; .
GOGO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB; .
GOGO:0045087; P:innate immune response; TAS:Reactome; .
GOGO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome; .
GOGO:0008063; P:Toll signaling pathway; TAS:Reactome; .
GOGO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome; .
GOGO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome; .
GOGO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR000719; Prot_kinase_cat_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR017442; Se/Thr_kinase-like_dom; .
InterProIPR008271; Ser/Thr_kinase_AS; .
InterProIPR002290; Ser/Thr_kinase_dom; .
InterProIPR001841; Znf_RING; .
InterProIPR013083; Znf_RING/FYVE/PHD; .
InterProIPR007527; Znf_SWIM; .
Gene3DG3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 1; .
PfamPF00069; Pkinase; 1; .
SMARTSM00184; RING; 1; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; Kinase_like; 1; .
PROSITEPS00107; PROTEIN_KINASE_ATP; 1; .
PROSITEPS50011; PROTEIN_KINASE_DOM; 1; .
PROSITEPS00108; PROTEIN_KINASE_ST; 1; .
PROSITEPS00518; ZF_RING_1; FALSE_NEG; .
PROSITEPS50089; ZF_RING_2; 1; .
PROSITEPS50966; ZF_SWIM; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server