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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: MYC_HUMAN




SWISS-2DPAGE:  MYC_HUMAN


MYC_HUMAN


General information about the entry
View entry in simple text format
Entry nameMYC_HUMAN
Primary accession numberP01106
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Myc proto-oncogene protein; AltName: Full=Class E basic helix-loop-helix protein 39; Short=bHLHe39; AltName: Full=Proto-oncogene c-Myc; AltName: Full=Transcription factor p64;.
Gene nameName=MYC
Synonyms=BHLHE39
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295311; PubMed=9150953; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F.
''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';''
Electrophoresis 18(1):638-641(1997)
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.12; Mw=44719

MAPPING (identification):
IMMUNOBLOTTING [1].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.15; Mw=44335

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtP01106; MYC_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameMYC_HUMAN
Primary accession numberP01106
Secondary accession number(s) A8WFE7 P01107 Q14026
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 161)
Name and origin of the protein
DescriptionRecName: Full=Myc proto-oncogene protein; AltName: Full=Class E basic helix-loop-helix protein 39; Short=bHLHe39; AltName: Full=Proto-oncogene c-Myc; AltName: Full=Transcription factor p64;
Gene nameName=MYC
Synonyms=BHLHE39
Encoded onName=MYC; Synonyms=BHLHE39
Keywords3D-structure; Acetylation; Activator; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Glycoprotein; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL00058; AAA59882.1; -; Genomic_DNA
EMBLL00057; AAA59882.1; JOINED; Genomic_DNA
EMBLK00535; AAA59880.1; -; Genomic_DNA
EMBLK00534; AAA59880.1; JOINED; Genomic_DNA
EMBLK00535; ABW69847.1; -; Genomic_DNA
EMBLK00534; ABW69847.1; JOINED; Genomic_DNA
EMBLX00196; CAA25015.2; -; Genomic_DNA
EMBLX00198; CAA25015.2; JOINED; Genomic_DNA
EMBLX00364; CAA25106.1; -; Genomic_DNA
EMBLV00568; CAA23831.1; -; mRNA
EMBLK01906; AAA59881.1; -; Genomic_DNA
EMBLK01905; AAA59881.1; JOINED; Genomic_DNA
EMBLK02276; AAA36340.1; -; mRNA
EMBLX00676; CAA25288.1; -; Genomic_DNA
EMBLD10493; BAA01374.2; -; Genomic_DNA
EMBLD10493; BAA01375.1; -; Genomic_DNA
EMBLBT019768; AAV38573.1; -; mRNA
EMBLAY214166; AAO21131.1; -; Genomic_DNA
EMBLAK312883; BAG35731.1; -; mRNA
EMBLAC103819; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471060; EAW92098.1; -; Genomic_DNA
EMBLBC000141; AAH00141.2; -; mRNA
EMBLBC000917; AAH00917.2; -; mRNA
EMBLBC058901; AAH58901.2; -; mRNA
EMBLM13929; AAA88092.1; -; mRNA
IPIIPI00033016; -; .
IPIIPI00935431; -; .
PIRA01349; TVHUM; .
PIRA01350; TVHUT; .
RefSeqNP_002458.2; NM_002467.4; .
UniGeneHs.202453; -; .
PDB1A93; NMR; -; A=406-434
PDB1EE4; X-ray; 2.10 A; C/D/E/F=320-328
PDB1MV0; NMR; -; A=55-68
PDB1NKP; X-ray; 1.80 A; A/D=353-434
PDB2A93; NMR; -; A=406-434
PDBsum1A93; -; .
PDBsum1EE4; -; .
PDBsum1MV0; -; .
PDBsum1NKP; -; .
PDBsum2A93; -; .
ProteinModelPortalP01106; -; .
SMRP01106; 353-434; .
DisProtDP00260; -; .
DIPDIP-28143N; -; .
IntActP01106; 642; .
MINTMINT-257327; -; .
STRINGP01106; -; .
GlycoSuiteDBP01106; -; .
PhosphoSiteP01106; -; .
SWISS-2DPAGEP01106; -; .
PRIDEP01106; -; .
EnsemblENST00000377970; ENSP00000367207; ENSG00000136997; .
GeneID4609; -; .
KEGGhsa:4609; -; .
CTD4609; -; .
GeneCardsGC08P124069; -; .
H-InvDBHIX0007784; -; .
HGNCHGNC:7553; MYC; .
HPACAB000084; -; .
HPACAB010307; -; .
MIM113970; phenotype; .
MIM190080; gene; .
neXtProtNX_P01106; -; .
Orphanet543; Burkitt lymphoma; .
PharmGKBPA31353; -; .
eggNOGprNOG11147; -; .
HOGENOMHBG445611; -; .
HOVERGENHBG000472; -; .
InParanoidP01106; -; .
PhylomeDBP01106; -; .
Pathway_Interaction_DBwnt_canonical_pathway; Canonical Wnt signaling pathway; .
Pathway_Interaction_DBceramidepathway; Ceramide signaling pathway; .
Pathway_Interaction_DBfoxm1pathway; FOXM1 transcription factor network; .
Pathway_Interaction_DBil2_pi3kpathway; IL2 signaling events mediated by PI3K; .
Pathway_Interaction_DBil2_stat5pathway; IL2 signaling events mediated by STAT5; .
Pathway_Interaction_DBil2_1pathway; IL2-mediated signaling events; .
Pathway_Interaction_DBil6_7pathway; IL6-mediated signaling events; .
Pathway_Interaction_DBpdgfrbpathway; PDGFR-beta signaling pathway; .
Pathway_Interaction_DBps1pathway; Presenilin action in Notch and Wnt signaling; .
Pathway_Interaction_DBsmad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; .
Pathway_Interaction_DBtelomerasepathway; Regulation of Telomerase; .
NextBio17740; -; .
ArrayExpressP01106; -; .
BgeeP01106; -; .
CleanExHS_MYC; -; .
GenevestigatorP01106; -; .
GermOnlineENSG00000136997; Homo sapiens; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; IDA:UniProtKB; .
GOGO:0070888; F:E-box binding; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc; .
GOGO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB; .
GOGO:0007050; P:cell cycle arrest; TAS:ProtInc; .
GOGO:0008283; P:cell proliferation; TAS:ProtInc; .
GOGO:0006879; P:cellular iron ion homeostasis; TAS:ProtInc; .
GOGO:0090096; P:positive regulation of metanephric cap mesenchymal cell proliferation; ISS:UniProtKB; .
GOGO:0045893; P:positive regulation of transcription; DNA-dependent; IDA:UniProtKB
GOGO:0032204; P:regulation of telomere maintenance; IMP:BHF-UCL; .
GOGO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc; .
GOGO:0042493; P:response to drug; IEP:UniProtKB; .
InterProIPR011598; HLH_DNA-bd; .
InterProIPR003327; Myc-LZ; .
InterProIPR002418; Tscrpt_reg_Myc; .
InterProIPR012682; Tscrpt_reg_Myc_N; .
Gene3DG3DSA:4.10.280.10; HLH_DNA_bd; 1; .
PfamPF00010; HLH; 1; .
PfamPF02344; Myc-LZ; 1; .
PfamPF01056; Myc_N; 1; .
PIRSFPIRSF001705; Myc_protein; 1; .
PRINTSPR00044; LEUZIPPRMYC; .
SMARTSM00353; HLH; 1; .
SUPFAMSSF47459; HLH_basic; 1; .
PROSITEPS50888; HLH; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server