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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: O75347 SWISS-2DPAGE:  O75347 O75347 General information about the entry View entry in simple text format Entry name TBCA_HUMAN Primary accession number O75347 integrated into SWISS-2DPAGE on  March 31, 2004 (release 17) 2D Annotations were last modified on March 31, 2004 (version 1) General Annotations were last modified on  May 19, 2011 (version 5) Name and origin of the protein Description RecName: Full=Tubulin-specific chaperone A; AltName: Full=TCP1-chaperonin cofactor A; AltName: Full=Tubulin-folding cofactor A; Short=CFA;. Gene name Name=TBCA Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D. ''''''New insights into HIV lymphocyte infection'';'';'' (IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004) Comments SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state 2D PAGE maps for identified proteins How to interpret a protein LYMPHOCYTE_HUMAN {Lymphocytes} Homo sapiens (Human) Tissue: Lymphocyte   map experimental info   protein estimated location   LYMPHOCYTE_HUMAN MAP LOCATIONS: SPOT 2D-001YFY: pI=5.16; Mw=16734   [identification data] MAPPING (identification): MALDI tandem mass spectrometry [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references OGP-WWW O75347. UniProtKB/Swiss-Prot O75347; TBCA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name TBCA_HUMAN Primary accession number O75347 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  September 21, 2011 (version 100) Name and origin of the protein Description RecName: Full=Tubulin-specific chaperone A; AltName: Full=TCP1-chaperonin cofactor A; AltName: Full=Tubulin-folding cofactor A; Short=CFA; Gene name Name=TBCA Encoded on Name=TBCA Keywords 3D-structure; Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF038952; AAC39866.1; -; mRNA EMBL BT007354; AAP36018.1; -; mRNA EMBL BC018210; AAH18210.1; -; mRNA IPI IPI00217236; -; . RefSeq NP_004598.1; NM_004607.2; . UniGene Hs.291212; -; . PDB 1H7C; X-ray; 1.80 A; A=1-108 PDBsum 1H7C; -; . ProteinModelPortal O75347; -; . SMR O75347; 4-106; . IntAct O75347; 3; . STRING O75347; -; . PhosphoSite O75347; -; . SWISS-2DPAGE O75347; -; . OGP O75347; -; . PeptideAtlas O75347; -; . PRIDE O75347; -; . Ensembl ENST00000380377; ENSP00000369736; ENSG00000171530; . GeneID 6902; -; . KEGG hsa:6902; -; . UCSC uc003kfh.1; human; . CTD 6902; -; . GeneCards GC05M072194; -; . H-InvDB HIX0004973; -; . HGNC HGNC:11579; TBCA; . HPA HPA036487; -; . MIM 610058; gene; . neXtProt NX_O75347; -; . PharmGKB PA36343; -; . eggNOG prNOG21342; -; . HOVERGEN HBG004499; -; . InParanoid O75347; -; . OMA MMYEKEA; -; . OrthoDB EOG4W6NXN; -; . PhylomeDB O75347; -; . Reactome REACT_17015; Metabolism of proteins; . NextBio 26989; -; . ArrayExpress O75347; -; . Bgee O75347; -; . CleanEx HS_TBCA; -; . Genevestigator O75347; -; . GermOnline ENSG00000171530; Homo sapiens; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005874; C:microtubule; IEA:UniProtKB-KW; . GO GO:0051087; F:chaperone binding; TAS:ProtInc; . GO GO:0051082; F:unfolded protein binding; IEA:InterPro; . GO GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome; . GO GO:0007023; P:post-chaperonin tubulin folding pathway; TAS:ProtInc; . GO GO:0007021; P:tubulin complex assembly; IEA:InterPro; . InterPro IPR004226; CofA_tubulin-bd; . PANTHER PTHR21500; CofA_tubulin_bd; 1; . Pfam PF02970; TBCA; 1; . ProDom PD010430; CofA_tubulin_bd; 1; . SUPFAM SSF46988; Tub_bind_cof_A; 1; . SWISS-2DPAGE (search AC)