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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P01019 SWISS-2DPAGE:  P01019 P01019 General information about the entry View entry in simple text format Entry name ANGT_HUMAN Primary accession number P01019 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 15) Name and origin of the protein Description RecName: Full=Angiotensinogen; AltName: Full=Serpin A8; Contains: RecName: Full=Angiotensin-1; AltName: Full=Angiotensin I; Short=Ang I; Contains: RecName: Full=Angiotensin-2; AltName: Full=Angiotensin II; Short=Ang II; Contains: RecName: Full=Angiotensin-3; AltName: Full=Angiotensin III; Short=Ang III; AltName: Full=Des-Asp[1]-angiotensin II; Flags: Precursor;. Gene name Name=AGT Synonyms=SERPINA8 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan] Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F. ''''''Plasma protein map: an update by microsequencing'';'';'' Electrophoresis 13(1):707-714(1992) Comments SUBUNIT: SINGLE CHAIN 2D PAGE maps for identified proteins How to interpret a protein PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-0004Q0: pI=5.07; Mw=58973 NORMAL LEVEL: 30-60 MG/L [1]. PATHOLOGICAL LEVEL: INCREASED DURING HYPERTENSION [1]. MAPPING (identification): MICROSEQUENCING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references UniProtKB/Swiss-Prot P01019; ANGT_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name ANGT_HUMAN Primary accession number P01019 Secondary accession number(s) Q16358 Q16359 Q96F91 Sequence was last modified on  July 21, 1986 (version 1) Annotations were last modified on  October 19, 2011 (version 146) Name and origin of the protein Description RecName: Full=Angiotensinogen; AltName: Full=Serpin A8; Contains: RecName: Full=Angiotensin-1; AltName: Full=Angiotensin I; Short=Ang I; Contains: RecName: Full=Angiotensin-2; AltName: Full=Angiotensin II; Short=Ang II; Contains: RecName: Full=Angiotensin-3; AltName: Full=Angiotensin III; Short=Ang III; AltName: Full=Des-Asp[1]-angiotensin II; Flags: Precursor; Gene name Name=AGT Synonyms=SERPINA8 Encoded on Name=AGT; Synonyms=SERPINA8 Keywords 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Polymorphism; Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL K02215; AAA51731.1; -; mRNA EMBL M24689; AAA51679.1; -; Genomic_DNA EMBL M24686; AAA51679.1; JOINED; Genomic_DNA EMBL M24687; AAA51679.1; JOINED; Genomic_DNA EMBL M24688; AAA51679.1; JOINED; Genomic_DNA EMBL X15324; CAA33385.1; -; Genomic_DNA EMBL X15325; CAA33385.1; JOINED; Genomic_DNA EMBL X15326; CAA33385.1; JOINED; Genomic_DNA EMBL X15327; CAA33385.1; JOINED; Genomic_DNA EMBL BC011519; AAH11519.1; -; mRNA EMBL M69110; AAA52282.1; -; mRNA EMBL S78529; AAD14287.1; -; Genomic_DNA EMBL S78530; AAD14288.1; -; Genomic_DNA IPI IPI00032220; -; . PIR A35203; ANHU; . RefSeq NP_000020.1; NM_000029.3; . UniGene Hs.19383; -; . PDB 1N9U; NMR; -; A=34-43 PDB 1N9V; NMR; -; A=34-41 PDB 2JP8; NMR; -; P=34-40 PDB 2WXW; X-ray; 3.30 A; A=34-485 PDB 2X0B; X-ray; 4.33 A; B/D/F/H=34-485 PDBsum 1N9U; -; . PDBsum 1N9V; -; . PDBsum 2JP8; -; . PDBsum 2WXW; -; . PDBsum 2X0B; -; . ProteinModelPortal P01019; -; . SMR P01019; 34-482; . DIP DIP-309N; -; . IntAct P01019; 3; . MINT MINT-1472115; -; . STRING P01019; -; . MEROPS I04.953; -; . PhosphoSite P01019; -; . SWISS-2DPAGE P01019; -; . PeptideAtlas P01019; -; . PRIDE P01019; -; . Ensembl ENST00000366667; ENSP00000355627; ENSG00000135744; . GeneID 183; -; . KEGG hsa:183; -; . UCSC uc001hty.2; human; . CTD 183; -; . GeneCards GC01M201323; -; . H-InvDB HIX0001686; -; . HGNC HGNC:333; AGT; . HPA HPA001557; -; . MIM 106150; gene; . MIM 145500; phenotype; . MIM 267430; phenotype; . neXtProt NX_P01019; -; . Orphanet 243761; Essential hypertension; . Orphanet 97369; Renal tubular dysgenesis of genetic origin; . eggNOG prNOG11287; -; . HOVERGEN HBG004233; -; . InParanoid P01019; -; . OMA TYVHFQG; -; . OrthoDB EOG44TP89; -; . PhylomeDB P01019; -; . Pathway_Interaction_DB prlsignalingeventspathway; Signaling events mediated by PRL; . Reactome REACT_14797; Signaling by GPCR; . Reactome REACT_22258; Metabolism of lipids and lipoproteins; . DrugBank DB01258; Aliskiren; . DrugBank DB01076; Atorvastatin; . DrugBank DB01340; Cilazapril; . DrugBank DB01029; Irbesartan; . DrugBank DB00722; Lisinopril; . DrugBank DB01092; Ouabain; . DrugBank DB00641; Simvastatin; . NextBio 748; -; . PMAP-CutDB P01019; -; . ArrayExpress P01019; -; . Bgee P01019; -; . CleanEx HS_AGT; -; . Genevestigator P01019; -; . GermOnline ENSG00000135744; Homo sapiens; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0005625; C:soluble fraction; TAS:ProtInc; . GO GO:0010698; F:acetyltransferase activator activity; IDA:BHF-UCL; . GO GO:0008083; F:growth factor activity; TAS:BHF-UCL; . GO GO:0005179; F:hormone activity; ISS:BHF-UCL; . GO GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome; . GO GO:0031702; F:type 1 angiotensin receptor binding; IPI:BHF-UCL; . GO GO:0031703; F:type 2 angiotensin receptor binding; IPI:BHF-UCL; . GO GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; NAS:BHF-UCL; . GO GO:0001974; P:blood vessel remodeling; TAS:BHF-UCL; . GO GO:0007267; P:cell-cell signaling; TAS:ProtInc; . GO GO:0044255; P:cellular lipid metabolic process; TAS:Reactome; . GO GO:0007199; P:G-protein signaling; coupled to cGMP nucleotide second messenger; TAS:BHF-UCL GO GO:0001822; P:kidney development; IMP:BHF-UCL; . GO GO:0034374; P:low-density lipoprotein particle remodeling; NAS:BHF-UCL; . GO GO:0051387; P:negative regulation of nerve growth factor receptor signaling pathway; IDA:BHF-UCL; . GO GO:0007263; P:nitric oxide mediated signal transduction; TAS:BHF-UCL; . GO GO:0010535; P:positive regulation of activation of JAK2 kinase activity; IMP:UniProtKB; . GO GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IDA:UniProtKB; . GO GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:BHF-UCL; . GO GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL; . GO GO:0001819; P:positive regulation of cytokine production; TAS:BHF-UCL; . GO GO:0010595; P:positive regulation of endothelial cell migration; IDA:BHF-UCL; . GO GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL; . GO GO:0048146; P:positive regulation of fibroblast proliferation; ISS:BHF-UCL; . GO GO:0050729; P:positive regulation of inflammatory response; TAS:BHF-UCL; . GO GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IC:BHF-UCL; . GO GO:0033864; P:positive regulation of NAD(P)H oxidase activity; TAS:BHF-UCL; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:BHF-UCL; . GO GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:BHF-UCL; . GO GO:0061098; P:positive regulation of protein tyrosine kinase activity; IMP:UniProtKB; . GO GO:0045893; P:positive regulation of transcription; DNA-dependent; IDA:UniProtKB GO GO:0030162; P:regulation of proteolysis; IBA:RefGenome; . GO GO:0002019; P:regulation of renal output by angiotensin; NAS:BHF-UCL; . GO GO:0019229; P:regulation of vasoconstriction; NAS:BHF-UCL; . GO GO:0002018; P:renin-angiotensin regulation of aldosterone production; NAS:BHF-UCL; . GO GO:0014873; P:response to muscle activity involved in regulation of muscle adaptation; ISS:BHF-UCL; . InterPro IPR000227; Angiotensngn; . InterPro IPR000215; Protease_inhib_I4_serpin; . InterPro IPR023795; Protease_inhib_I4_serpin_CS; . InterPro IPR023796; Sepin_dom; . PANTHER PTHR11461; Prot_inh_serpin; 1; . Pfam PF00079; Serpin; 1; . PRINTS PR00654; ANGIOTENSNGN; . SMART SM00093; SERPIN; 1; . SUPFAM SSF56574; Prot_inh_serpin; 1; . PROSITE PS00284; SERPIN; 1; . SWISS-2DPAGE (search AC)