World-2DPAGE Home


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P02753




SWISS-2DPAGE:  P02753


P02753


General information about the entry
View entry in simple text format
Entry nameRET4_HUMAN
Primary accession numberP02753
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Retinol-binding protein 4; AltName: Full=Plasma retinol-binding protein; Short=PRBP; Short=RBP; Contains: RecName: Full=Plasma retinol-binding protein(1-182); Contains: RecName: Full=Plasma retinol-binding protein(1-181); Contains: RecName: Full=Plasma retinol-binding protein(1-179); Contains: RecName: Full=Plasma retinol-binding protein(1-176); Flags: Precursor;.
Gene nameName=RBP4
ORFNames=PRO2222
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
[3]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=5.06; Mw=19621
pI=5.24; Mw=19621
pI=5.24; Mw=19254
pI=5.07; Mw=19208

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [3].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=5.27; Mw=18000

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [3].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.24; Mw=21071

PATHOLOGICAL LEVEL:
DECREASED DURING DERMATOSIS.

MAPPING (identification):
MATCHING WITH A PLASMA GEL [1].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.06; Mw=20089
pI=5.23; Mw=20201
pI=5.24; Mw=19759

NORMAL LEVEL:
30-60 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING MALNUTRITION, LIVER DISEASE AND VITAMIN A DEFICIENCY; INCREASED DURING RENAL FAILURE.

MAPPING (identification):
MICROSEQUENCING [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP02753; RETBP_HUMAN.
UniProtKB/Swiss-ProtP02753; RET4_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameRET4_HUMAN
Primary accession numberP02753
Secondary accession number(s) D3DR38 O43478 O43479 Q5VY24 Q8WWA3 Q9P178
Sequence was last modified on March 29, 2005 (version 3)
Annotations were last modified on October 19, 2011 (version 146)
Name and origin of the protein
DescriptionRecName: Full=Retinol-binding protein 4; AltName: Full=Plasma retinol-binding protein; Short=PRBP; Short=RBP; Contains: RecName: Full=Plasma retinol-binding protein(1-182); Contains: RecName: Full=Plasma retinol-binding protein(1-181); Contains: RecName: Full=Plasma retinol-binding protein(1-179); Contains: RecName: Full=Plasma retinol-binding protein(1-176); Flags: Precursor;
Gene nameName=RBP4
ORFNames=PRO2222
Encoded onName=RBP4; ORFNames=PRO2222
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Reference proteome; Retinol-binding; Secreted; Sensory transduction; Signal; Transport; Vision; Vitamin A.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX00129; CAA24959.1; -; mRNA
EMBLAL356214; CAH72328.1; -; Genomic_DNA
EMBLCH471066; EAW50065.1; -; Genomic_DNA
EMBLCH471066; EAW50066.1; -; Genomic_DNA
EMBLCH471066; EAW50067.1; -; Genomic_DNA
EMBLBC020633; AAH20633.1; -; mRNA
EMBLX02775; CAA26553.1; -; Genomic_DNA
EMBLX02824; CAB46489.1; -; Genomic_DNA
EMBLAF119868; AAF69622.1; ALT_INIT; mRNA
EMBLAF025334; AAC02945.1; -; Genomic_DNA
EMBLAF025335; AAC02946.1; -; Genomic_DNA
IPIIPI00022420; -; .
PIRA93494; VAHU; .
RefSeqNP_006735.2; NM_006744.3; .
UniGeneHs.50223; -; .
PDB1BRP; X-ray; 2.50 A; A=19-198
PDB1BRQ; X-ray; 2.50 A; A=19-198
PDB1JYD; X-ray; 1.70 A; A=19-198
PDB1JYJ; X-ray; 2.00 A; A=19-198
PDB1QAB; X-ray; 3.20 A; E/F=24-201
PDB1RBP; X-ray; 2.00 A; A=19-200
PDB1RLB; X-ray; 3.10 A; E/F=19-190
PDB2WQ9; X-ray; 1.65 A; A=19-192
PDB2WQA; X-ray; 2.85 A; E/F=19-194
PDB2WR6; X-ray; 1.80 A; A=19-192
PDB3BSZ; X-ray; 3.38 A; E/F=19-194
PDB3FMZ; X-ray; 2.90 A; A/B=19-201
PDBsum1BRP; -; .
PDBsum1BRQ; -; .
PDBsum1JYD; -; .
PDBsum1JYJ; -; .
PDBsum1QAB; -; .
PDBsum1RBP; -; .
PDBsum1RLB; -; .
PDBsum2WQ9; -; .
PDBsum2WQA; -; .
PDBsum2WR6; -; .
PDBsum3BSZ; -; .
PDBsum3FMZ; -; .
ProteinModelPortalP02753; -; .
SMRP02753; 19-192; .
IntActP02753; 1; .
STRINGP02753; -; .
SWISS-2DPAGEP02753; -; .
Siena-2DPAGEP02753; -; .
PRIDEP02753; -; .
EnsemblENST00000371464; ENSP00000360519; ENSG00000138207; .
EnsemblENST00000371467; ENSP00000360522; ENSG00000138207; .
GeneID5950; -; .
KEGGhsa:5950; -; .
UCSCuc001kit.1; human; .
CTD5950; -; .
GeneCardsGC10M088979; -; .
H-InvDBHIX0009047; -; .
HGNCHGNC:9922; RBP4; .
HPACAB004555; -; .
HPAHPA001641; -; .
MIM180250; gene+phenotype; .
neXtProtNX_P02753; -; .
PharmGKBPA34289; -; .
GeneTreeENSGT00510000047107; -; .
HOGENOMHBG715497; -; .
HOVERGENHBG004493; -; .
InParanoidP02753; -; .
OMAMEWVWAL; -; .
OrthoDBEOG4T4CWM; -; .
PhylomeDBP02753; -; .
DrugBankDB00162; Vitamin A; .
NextBio23182; -; .
ArrayExpressP02753; -; .
BgeeP02753; -; .
CleanExHS_RBP4; -; .
GenevestigatorP02753; -; .
GermOnlineENSG00000138207; Homo sapiens; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0016918; F:retinal binding; IEA:UniProtKB-KW; .
GOGO:0019841; F:retinol binding; IDA:BHF-UCL; .
GOGO:0034632; F:retinol transporter activity; IC:BHF-UCL; .
GOGO:0048738; P:cardiac muscle tissue development; ISS:BHF-UCL; .
GOGO:0048562; P:embryonic organ morphogenesis; ISS:BHF-UCL; .
GOGO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:BHF-UCL; .
GOGO:0048706; P:embryonic skeletal system development; ISS:BHF-UCL; .
GOGO:0048807; P:female genitalia morphogenesis; ISS:BHF-UCL; .
GOGO:0006094; P:gluconeogenesis; IMP:BHF-UCL; .
GOGO:0042593; P:glucose homeostasis; IDA:BHF-UCL; .
GOGO:0060347; P:heart trabecula formation; ISS:BHF-UCL; .
GOGO:0030324; P:lung development; ISS:BHF-UCL; .
GOGO:0030277; P:maintenance of gastrointestinal epithelium; IDA:BHF-UCL; .
GOGO:0060044; P:negative regulation of cardiac muscle cell proliferation; ISS:BHF-UCL; .
GOGO:0051024; P:positive regulation of immunoglobulin secretion; ISS:BHF-UCL; .
GOGO:0032024; P:positive regulation of insulin secretion; IMP:BHF-UCL; .
GOGO:0032526; P:response to retinoic acid; IDA:BHF-UCL; .
GOGO:0042572; P:retinol metabolic process; IMP:BHF-UCL; .
GOGO:0060157; P:urinary bladder development; ISS:BHF-UCL; .
GOGO:0060065; P:uterus development; ISS:BHF-UCL; .
GOGO:0060068; P:vagina development; ISS:BHF-UCL; .
InterProIPR012674; Calycin; .
InterProIPR011038; Calycin-like; .
InterProIPR002345; Lipocalin; .
InterProIPR022271; Lipocalin_ApoD; .
InterProIPR022272; Lipocalin_CS; .
InterProIPR000566; Lipocln_cytosolic_FA-bd_dom; .
InterProIPR002449; Retinol-bd; .
Gene3DG3DSA:2.40.128.20; Calycin; 1; .
PANTHERPTHR11873; Retinol_bd; 1; .
PfamPF00061; Lipocalin; 1; .
PIRSFPIRSF036893; Lipocalin_ApoD; 1; .
PRINTSPR00179; LIPOCALIN; .
PRINTSPR01174; RETINOLBNDNG; .
SUPFAMSSF50814; Calycin; 1; .
PROSITEPS00213; LIPOCALIN; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server