World-2DPAGE Home


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04040




SWISS-2DPAGE:  P04040


P04040


General information about the entry
View entry in simple text format
Entry nameCATA_HUMAN
Primary accession numberP04040
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 3)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Catalase; EC=1.11.1.6;.
Gene nameName=CAT
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=79188222; PubMed=109131; [NCBI, ExPASy, EBI, Israel, Japan]
Edwards J., Anderson N.G., Nance S.L., Anderson N.L.
''''''Red cell proteins. I. Two-dimensional mapping of human erythrocyte lysate proteins'';'';''
Blood 53(1):1121-1132(1979)
[3]   MAPPING ON GEL
MEDLINE=93120196; PubMed=1477117; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Walzer C., Hochstrasser D.F., Bjellqvist B., Turler H., Balant L.P.
''''''Red blood cell protein map: a comparison between carrier-ampholyte pH gradient and immobilized pH gradient, and identification of four red blood cell enzymes'';'';''
Appl. Theor. Electrophor. 3(1):77-82(1992)
[4]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[5]   MAPPING ON GEL
MEDLINE=96007935; PubMed=7498158; [NCBI, ExPASy, EBI, Israel, Japan]
Gravel P., Sanchez J.-C., Walzer C., Golaz O., Hochstrasser D.F., Balant L.P., Hughes G.J., Garcia-Sevilla J., Guimon J.
''''''Human blood platelet protein map established by two-dimensional polyacrylamide gel electrophoresis'';'';''
Electrophoresis 16(1):1152-1159(1995)
[6]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[7]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
Comments
  • SUBUNIT: HOMOTETRAMER
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=6.51; Mw=57870
pI=6.75; Mw=57870
pI=7.07; Mw=57752

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [7].



ELC_HUMAN {Erythroleukemia Cell}
Homo sapiens (Human)
Tissue: Erythroleukemia
ELC_HUMAN
  map experimental info
  protein estimated location
 
ELC_HUMAN

MAP LOCATIONS:
pI=7.00; Mw=63293
pI=6.90; Mw=63293
pI=6.94; Mw=63184

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.96; Mw=58000
pI=6.92; Mw=58087
pI=7.00; Mw=58000
pI=6.88; Mw=58000

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=6.76; Mw=55800
pI=6.84; Mw=55544

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [6].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.70; Mw=58128
pI=6.98; Mw=57643
pI=6.82; Mw=57962

PATHOLOGICAL LEVEL:
DECREASED IN ACATALASIA.

MAPPING (identification):
MATCHING WITH A RED BLOOD CELL GEL [1].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=7.59; Mw=57241
pI=7.12; Mw=57374
pI=7.36; Mw=57241

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4].



PLATELET_HUMAN {Platelet}
Homo sapiens (Human)
Tissue: Platelet
PLATELET_HUMAN
  map experimental info
  protein estimated location
 
PLATELET_HUMAN

MAP LOCATIONS:
pI=7.52; Mw=54093
pI=7.73; Mw=54093
pI=7.30; Mw=53941

MAPPING (identification):
MATCHING WITH RBC AND LIVER MASTERS [5].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=6.71; Mw=58699
pI=6.78; Mw=58465
pI=6.85; Mw=58232
pI=6.92; Mw=58000
pI=7.00; Mw=58000

PATHOLOGICAL LEVEL:
DECREASED IN ACATALASIA.

MAPPING (identification):
IMMUNOBLOTTING [2] AND COMIGRATION [3].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
OGP-WWWP04040.
REPRODUCTION-2DPAGEIPI00465436; IPI00465436.
REPRODUCTION-2DPAGEP04040; P04040.
Siena-2DPAGEP04040; CATA_HUMAN.
UniProtKB/Swiss-ProtP04040; CATA_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCATA_HUMAN
Primary accession numberP04040
Secondary accession number(s) A8K6C0 B2RCZ9 D3DR07 Q2M1U4 Q4VXX5 Q9BWT9 Q9UC85
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 141)
Name and origin of the protein
DescriptionRecName: Full=Catalase; EC=1.11.1.6;
Gene nameName=CAT
Encoded onName=CAT
Keywords3D-structure; Complete proteome; Direct protein sequencing; Heme; Hydrogen peroxide; Iron; Metal-binding; Mitogen; NADP; Oxidoreductase; Peroxidase; Peroxisome; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX04085; CAA27721.1; -; Genomic_DNA
EMBLX04086; CAA27721.1; JOINED; Genomic_DNA
EMBLX04087; CAA27721.1; JOINED; Genomic_DNA
EMBLX04088; CAA27721.1; JOINED; Genomic_DNA
EMBLX04089; CAA27721.1; JOINED; Genomic_DNA
EMBLX04090; CAA27721.1; JOINED; Genomic_DNA
EMBLX04091; CAA27721.1; JOINED; Genomic_DNA
EMBLX04092; CAA27721.1; JOINED; Genomic_DNA
EMBLX04093; CAA27721.1; JOINED; Genomic_DNA
EMBLX04094; CAA27721.1; JOINED; Genomic_DNA
EMBLX04095; CAA27721.1; JOINED; Genomic_DNA
EMBLX04096; CAA27721.1; JOINED; Genomic_DNA
EMBLX04076; CAA27717.1; -; mRNA
EMBLAY028632; AAK29181.1; -; mRNA
EMBLAK291585; BAF84274.1; -; mRNA
EMBLAK315350; BAG37746.1; -; mRNA
EMBLAY545477; AAS37679.1; -; Genomic_DNA
EMBLAL035079; CAB45236.1; -; Genomic_DNA
EMBLCH471064; EAW68170.1; -; Genomic_DNA
EMBLCH471064; EAW68171.1; -; Genomic_DNA
EMBLBC110398; AAI10399.1; -; mRNA
EMBLBC112217; AAI12218.1; -; mRNA
EMBLBC112219; AAI12220.1; -; mRNA
EMBLL13609; AAA16651.1; -; Genomic_DNA
EMBLK02400; AAB59522.1; -; Genomic_DNA
IPIIPI00465436; -; .
PIRA23646; CSHU; .
RefSeqNP_001743.1; NM_001752.3; .
UniGeneHs.502302; -; .
PDB1DGB; X-ray; 2.20 A; A/B/C/D=4-501
PDB1DGF; X-ray; 1.50 A; A/B/C/D=5-501
PDB1DGG; X-ray; 1.80 A; A/B/C/D=5-501
PDB1DGH; X-ray; 2.00 A; A/B/C/D=4-501
PDB1F4J; X-ray; 2.40 A; A/B/C/D=1-527
PDB1QQW; X-ray; 2.75 A; A/B/C/D=1-527
PDBsum1DGB; -; .
PDBsum1DGF; -; .
PDBsum1DGG; -; .
PDBsum1DGH; -; .
PDBsum1F4J; -; .
PDBsum1QQW; -; .
ProteinModelPortalP04040; -; .
SMRP04040; 5-501; .
IntActP04040; 8; .
MINTMINT-1210583; -; .
STRINGP04040; -; .
PeroxiBase5282; HsKat01; .
PhosphoSiteP04040; -; .
SWISS-2DPAGEP04040; -; .
Aarhus/Ghent-2DPAGE1524; IEF; .
Aarhus/Ghent-2DPAGE1525; IEF; .
Aarhus/Ghent-2DPAGE1526; IEF; .
OGPP04040; -; .
REPRODUCTION-2DPAGEIPI00465436; -; .
REPRODUCTION-2DPAGEP04040; -; .
PeptideAtlasP04040; -; .
PRIDEP04040; -; .
EnsemblENST00000241052; ENSP00000241052; ENSG00000121691; .
GeneID847; -; .
KEGGhsa:847; -; .
NMPDRfig|9606.3.peg.5453; -; .
UCSCuc001mvm.1; human; .
CTD847; -; .
GeneCardsGC11P034157; -; .
H-InvDBHIX0009550; -; .
HGNCHGNC:1516; CAT; .
HPACAB001515; -; .
MIM115500; gene; .
MIM614097; phenotype; .
neXtProtNX_P04040; -; .
Orphanet926; Acatalasemia; .
PharmGKBPA26099; -; .
eggNOGprNOG05863; -; .
HOVERGENHBG003986; -; .
InParanoidP04040; -; .
OMAPVNCPFR; -; .
OrthoDBEOG45TCMV; -; .
PhylomeDBP04040; -; .
BioCycMetaCyc:MONOMER66-341; -; .
Pathway_Interaction_DBfoxopathway; FoxO family signaling; .
ReactomeREACT_1698; Metabolism of nucleotides; .
DrugBankDB01213; Fomepizole; .
NextBio3550; -; .
ArrayExpressP04040; -; .
BgeeP04040; -; .
CleanExHS_CAT; -; .
GenevestigatorP04040; -; .
GermOnlineENSG00000121691; Homo sapiens; .
GOGO:0005782; C:peroxisomal matrix; TAS:Reactome; .
GOGO:0005778; C:peroxisomal membrane; ISS:UniProtKB; .
GOGO:0004096; F:catalase activity; IDA:UniProtKB; .
GOGO:0020037; F:heme binding; IDA:UniProtKB; .
GOGO:0050661; F:NADP binding; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; IDA:UniProtKB; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IDA:UniProtKB; .
GOGO:0043066; P:negative regulation of apoptosis; IMP:UniProtKB; .
GOGO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW; .
GOGO:0051262; P:protein tetramerization; IDA:UniProtKB; .
GOGO:0006144; P:purine base metabolic process; TAS:Reactome; .
GOGO:0006195; P:purine nucleotide catabolic process; TAS:Reactome; .
GOGO:0009650; P:UV protection; IMP:UniProtKB; .
InterProIPR018028; Catalase; .
InterProIPR010582; Catalase-rel_immune_responsive; .
InterProIPR024708; Catalase_AS; .
InterProIPR024711; Catalase_clade1/3; .
InterProIPR020835; Catalase_dom; .
InterProIPR002226; Catalase_haem_BS; .
InterProIPR011614; Catalase_N; .
Gene3DG3DSA:2.40.180.10; Catalase_N; 1; .
PANTHERPTHR11465; Catalase; 1; .
PfamPF00199; Catalase; 1; .
PfamPF06628; Catalase-rel; 1; .
PIRSFPIRSF038928; Catalase_clade1-3; 1; .
PRINTSPR00067; CATALASE; .
SUPFAMSSF56634; Catalase_N; 1; .
PROSITEPS00437; CATALASE_1; 1; .
PROSITEPS00438; CATALASE_2; 1; .
PROSITEPS51402; CATALASE_3; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server