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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04637




SWISS-2DPAGE:  P04637


P04637


General information about the entry
View entry in simple text format
Entry nameP53_HUMAN
Primary accession numberP04637
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53;.
Gene nameName=TP53
Synonyms=P53
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295311; PubMed=9150953; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F.
''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';''
Electrophoresis 18(1):638-641(1997)
[2]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=6.65; Mw=51091
pI=6.54; Mw=51091
pI=6.23; Mw=51091
pI=6.78; Mw=50698
pI=6.90; Mw=50309

MAPPING (identification):
IMMUNOBLOTTING [2].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.31; Mw=53782
pI=6.34; Mw=53483
pI=6.61; Mw=53333
pI=6.73; Mw=53184
pI=6.84; Mw=53036
pI=6.49; Mw=51143
pI=6.72; Mw=51143
pI=6.35; Mw=50715
pI=6.86; Mw=50715
pI=6.92; Mw=50433

MAPPING (identification):
IMMUNOBLOTTING [1].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.49; Mw=57009
pI=6.57; Mw=57009
pI=6.18; Mw=56538
pI=6.34; Mw=56382
pI=6.24; Mw=56382
pI=6.68; Mw=52619
pI=6.80; Mw=52619
pI=6.43; Mw=51327
pI=6.55; Mw=51469
pI=6.31; Mw=51327

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UniProtKB/Swiss-ProtP04637; P53_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameP53_HUMAN
Primary accession numberP04637
Secondary accession number(s) Q15086 Q15087 Q15088 Q16535 Q16807 Q16808 Q16809 Q16810 Q16811 Q16848 Q2XN98 Q3LRW1 Q3LRW2 Q3LRW3 Q3LRW4 Q3LRW5 Q86UG1 Q8J016 Q99659 Q9BTM4 Q9HAQ8 Q9NP68 Q9NPJ2 Q9NZD0 Q9UBI2 Q9UQ61
Sequence was last modified on November 24, 2009 (version 4)
Annotations were last modified on October 19, 2011 (version 190)
Name and origin of the protein
DescriptionRecName: Full=Cellular tumor antigen p53; AltName: Full=Antigen NY-CO-13; AltName: Full=Phosphoprotein p53; AltName: Full=Tumor suppressor p53;
Gene nameName=TP53
Synonyms=P53
Encoded onName=TP53; Synonyms=P53
Keywords3D-structure; Acetylation; Activator; Alternative promoter usage; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Disease mutation; DNA-binding; Endoplasmic reticulum; Glycoprotein; Host-virus interaction; Isopeptide bond; Li-Fraumeni syndrome; Metal-binding; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation; Zinc.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX02469; CAA26306.1; -; mRNA
EMBLM13121; AAA59987.1; -; Genomic_DNA
EMBLM13112; AAA59987.1; JOINED; Genomic_DNA
EMBLM13113; AAA59987.1; JOINED; Genomic_DNA
EMBLM13114; AAA59987.1; JOINED; Genomic_DNA
EMBLM13115; AAA59987.1; JOINED; Genomic_DNA
EMBLM13116; AAA59987.1; JOINED; Genomic_DNA
EMBLM13117; AAA59987.1; JOINED; Genomic_DNA
EMBLM13118; AAA59987.1; JOINED; Genomic_DNA
EMBLM13119; AAA59987.1; JOINED; Genomic_DNA
EMBLM13120; AAA59987.1; JOINED; Genomic_DNA
EMBLK03199; AAA59989.1; -; mRNA
EMBLM14694; AAA61211.1; -; mRNA
EMBLM14695; AAA61212.1; -; mRNA
EMBLM22898; AAA59988.1; -; Genomic_DNA
EMBLM22882; AAA59988.1; JOINED; Genomic_DNA
EMBLM22883; AAA59988.1; JOINED; Genomic_DNA
EMBLM22884; AAA59988.1; JOINED; Genomic_DNA
EMBLM22887; AAA59988.1; JOINED; Genomic_DNA
EMBLM22888; AAA59988.1; JOINED; Genomic_DNA
EMBLM22894; AAA59988.1; JOINED; Genomic_DNA
EMBLM22895; AAA59988.1; JOINED; Genomic_DNA
EMBLM22896; AAA59988.1; JOINED; Genomic_DNA
EMBLM22897; AAA59988.1; JOINED; Genomic_DNA
EMBLX01405; CAA25652.1; -; mRNA
EMBLX60011; CAA42626.1; -; mRNA
EMBLX60012; CAA42627.1; ALT_TERM; mRNA
EMBLX60013; CAA42628.1; -; mRNA
EMBLX60014; CAA42629.1; -; mRNA
EMBLX60015; CAA42630.1; -; mRNA
EMBLX60016; CAA42631.1; -; mRNA
EMBLX60017; CAA42632.1; -; mRNA
EMBLX60018; CAA42633.1; -; mRNA
EMBLX60019; CAA42634.1; -; mRNA
EMBLX60020; CAA42635.1; -; mRNA
EMBLAF307851; AAG28785.1; -; mRNA
EMBLDQ186648; ABA29753.1; -; mRNA
EMBLDQ186649; ABA29754.1; -; mRNA
EMBLDQ186650; ABA29755.1; -; mRNA
EMBLDQ186651; ABA29756.1; -; mRNA
EMBLDQ186652; ABA29757.1; -; mRNA
EMBLDQ191317; ABB80262.1; -; mRNA
EMBLDQ286964; ABB80266.1; -; mRNA
EMBLX54156; CAA38095.1; -; Genomic_DNA
EMBLU94788; AAC12971.1; -; Genomic_DNA
EMBLAY838896; AAV80424.1; -; Genomic_DNA
EMBLAF135121; AAD28535.1; -; Genomic_DNA
EMBLAF135120; AAD28535.1; JOINED; Genomic_DNA
EMBLAF136271; AAD28628.1; -; Genomic_DNA
EMBLAF136270; AAD28628.1; JOINED; Genomic_DNA
EMBLAB082923; BAC16799.1; -; mRNA
EMBLAK312568; BAG35463.1; -; mRNA
EMBLAC007421; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAC087388; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471108; EAW90143.1; -; Genomic_DNA
EMBLCH471108; EAW90144.1; -; Genomic_DNA
EMBLBC003596; AAH03596.1; -; mRNA
EMBLAY429684; AAR10356.1; -; mRNA
EMBLAY390341; AAQ90158.1; -; Genomic_DNA
EMBLAY359814; AAR13239.1; -; Genomic_DNA
EMBLU63714; AAB39322.1; -; Genomic_DNA
EMBLAF209136; AAF36362.1; -; Genomic_DNA
EMBLAF209128; AAF36354.1; -; Genomic_DNA
EMBLAF209129; AAF36355.1; -; Genomic_DNA
EMBLAF209130; AAF36356.1; -; Genomic_DNA
EMBLAF209131; AAF36357.1; -; Genomic_DNA
EMBLAF209132; AAF36358.1; -; Genomic_DNA
EMBLAF209133; AAF36359.1; -; Genomic_DNA
EMBLAF209134; AAF36360.1; -; Genomic_DNA
EMBLAF209135; AAF36361.1; -; Genomic_DNA
EMBLAF209148; AAF36374.1; -; Genomic_DNA
EMBLAF209149; AAF36375.1; -; Genomic_DNA
EMBLAF209150; AAF36376.1; -; Genomic_DNA
EMBLAF209151; AAF36377.1; -; Genomic_DNA
EMBLAF209152; AAF36378.1; -; Genomic_DNA
EMBLAF209153; AAF36379.1; -; Genomic_DNA
EMBLAF209154; AAF36380.1; -; Genomic_DNA
EMBLAF209155; AAF36381.1; -; Genomic_DNA
EMBLAF209156; AAF36382.1; -; Genomic_DNA
EMBLAF210309; AAF63442.1; -; Genomic_DNA
EMBLAF210308; AAF63442.1; JOINED; Genomic_DNA
EMBLAF210310; AAF63443.1; -; Genomic_DNA
EMBLAF240684; AAK76358.1; -; Genomic_DNA
EMBLAF240685; AAK76359.1; -; Genomic_DNA
EMBLAY270155; AAP30003.1; -; Genomic_DNA
IPIIPI00025087; -; .
IPIIPI00375319; -; .
IPIIPI00796188; -; .
IPIIPI00894418; -; .
IPIIPI00895905; -; .
IPIIPI00973801; -; .
IPIIPI01008713; -; .
IPIIPI01009016; -; .
IPIIPI01009039; -; .
PIRA25224; DNHU53; .
RefSeqNP_000537.3; NM_000546.4; .
RefSeqNP_001119584.1; NM_001126112.1; .
RefSeqNP_001119585.1; NM_001126113.1; .
RefSeqNP_001119586.1; NM_001126114.1; .
RefSeqNP_001119587.1; NM_001126115.1; .
RefSeqNP_001119588.1; NM_001126116.1; .
RefSeqNP_001119589.1; NM_001126117.1; .
UniGeneHs.654481; -; .
PDB1A1U; NMR; -; A/C=324-358
PDB1AIE; X-ray; 1.50 A; A=326-356
PDB1C26; X-ray; 1.70 A; A=325-356
PDB1DT7; NMR; -; X/Y=367-388
PDB1GZH; X-ray; 2.60 A; A/C=95-292
PDB1H26; X-ray; 2.24 A; E=376-386
PDB1HS5; NMR; -; A/B=324-357
PDB1JSP; NMR; -; A=367-386
PDB1KZY; X-ray; 2.50 A; A/B=95-289
PDB1MA3; X-ray; 2.00 A; B=372-389
PDB1OLG; NMR; -; A/B/C/D=319-360
PDB1OLH; NMR; -; A/B/C/D=319-360
PDB1PES; NMR; -; A/B/C/D=325-355
PDB1PET; NMR; -; A/B/C/D=325-355
PDB1SAE; NMR; -; A/B/C/D=319-360
PDB1SAF; NMR; -; A/B/C/D=319-360
PDB1SAH; NMR; -; A/B/C/D=319-360
PDB1SAJ; NMR; -; A/B/C/D=319-360
PDB1SAK; NMR; -; A/B/C/D=319-360
PDB1SAL; NMR; -; A/B/C/D=319-360
PDB1TSR; X-ray; 2.20 A; A/B/C=94-312
PDB1TUP; X-ray; 2.20 A; A/B/C=94-312
PDB1UOL; X-ray; 1.90 A; A/B=94-312
PDB1XQH; X-ray; 1.75 A; B/F=369-377
PDB1YC5; X-ray; 1.40 A; B=372-389
PDB1YCQ; X-ray; 2.30 A; B=13-29
PDB1YCR; X-ray; 2.60 A; B=15-29
PDB1YCS; X-ray; 2.20 A; A=94-292
PDB2AC0; X-ray; 1.80 A; A/B/C/D=94-293
PDB2ADY; X-ray; 2.50 A; A/B=94-293
PDB2AHI; X-ray; 1.85 A; A/B/C/D=94-293
PDB2ATA; X-ray; 2.20 A; A/B/C/D=94-293
PDB2B3G; X-ray; 1.60 A; B=33-60
PDB2BIM; X-ray; 1.98 A; A/B=94-312
PDB2BIN; X-ray; 1.90 A; A=94-312
PDB2BIO; X-ray; 1.90 A; A=94-312
PDB2BIP; X-ray; 1.80 A; A=94-312
PDB2BIQ; X-ray; 1.80 A; A=94-312
PDB2F1X; X-ray; 2.30 A; A/B=359-368
PDB2FEJ; NMR; -; A=94-297
PDB2FOJ; X-ray; 1.60 A; B=363-367
PDB2FOO; X-ray; 2.20 A; B=358-363
PDB2GS0; NMR; -; B=20-73
PDB2H1L; X-ray; 3.16 A; M/N/O/P/Q/R/S/T/U/V/W/X=92-292
PDB2H2D; X-ray; 1.70 A; B=372-389
PDB2H2F; X-ray; 2.20 A; B=372-389
PDB2H4F; X-ray; 2.00 A; D=372-389
PDB2H4H; X-ray; 1.99 A; B=372-389
PDB2H4J; X-ray; 2.10 A; D=372-389
PDB2H59; X-ray; 1.90 A; D/E=372-389
PDB2J0Z; NMR; -; A/B/C/D=326-356
PDB2J10; NMR; -; A/B/C/D=326-356
PDB2J11; NMR; -; A/B/C/D=332-356
PDB2J1W; X-ray; 1.80 A; A/B=94-312
PDB2J1X; X-ray; 1.65 A; A/B=94-312
PDB2J1Y; X-ray; 1.69 A; A/B/C/D=94-293
PDB2J1Z; X-ray; 1.80 A; A/B=94-312
PDB2J20; X-ray; 1.80 A; A/B=94-312
PDB2J21; X-ray; 1.60 A; A/B=94-312
PDB2K8F; NMR; -; B=1-39
PDB2L14; NMR; -; B=13-61
PDB2OCJ; X-ray; 2.05 A; A/B/C/D=94-312
PDB2PCX; X-ray; 1.54 A; A=94-292
PDB2QVQ; X-ray; 2.00 A; A=94-289
PDB2QXA; X-ray; 1.50 A; A/B/C/D=95-289
PDB2QXB; X-ray; 2.50 A; A/B/C/D=95-289
PDB2QXC; X-ray; 1.85 A; A/B/C/D=95-289
PDB2VUK; X-ray; 1.50 A; A/B=94-312
PDB2WGX; X-ray; 1.75 A; A/B=94-310
PDB2X0U; X-ray; 1.60 A; A/B=94-312
PDB2X0V; X-ray; 1.80 A; A/B=94-312
PDB2X0W; X-ray; 2.10 A; A/B=94-312
PDB2XWR; X-ray; 1.68 A; A/B=89-293
PDB2YBG; X-ray; 1.90 A; A/B/C/D=94-293
PDB2Z5S; X-ray; 2.30 A; P/Q/R=15-29
PDB2Z5T; X-ray; 2.30 A; P/Q/R=15-29
PDB3D05; X-ray; 1.70 A; A=94-293
PDB3D06; X-ray; 1.20 A; A=94-293
PDB3D07; X-ray; 2.20 A; A/B=94-293
PDB3D08; X-ray; 1.40 A; A=94-293
PDB3D09; X-ray; 1.90 A; A=94-293
PDB3D0A; X-ray; 1.80 A; A/B/C/D=94-293
PDB3DAB; X-ray; 1.90 A; B/D/F/H=15-29
PDB3DAC; X-ray; 1.80 A; B/P=17-37
PDB3IGK; X-ray; 1.70 A; A=94-293
PDB3IGL; X-ray; 1.80 A; A=94-293
PDB3KMD; X-ray; 2.15 A; A/B/C/D=92-291
PDB3KZ8; X-ray; 1.91 A; A/B=94-293
PDB3LW1; X-ray; 1.28 A; P=385-393
PDB3PDH; X-ray; 1.80 A; D=372-389
PDB3Q01; X-ray; 2.10 A; A/B=94-356
PDB3Q05; X-ray; 2.40 A; A/B/C/D=94-355
PDB3Q06; X-ray; 3.20 A; A/B/C/D=96-354
PDB3SAK; NMR; -; A/B/C/D=319-360
PDB3TG5; X-ray; 2.30 A; B=365-375
PDBsum1A1U; -; .
PDBsum1AIE; -; .
PDBsum1C26; -; .
PDBsum1DT7; -; .
PDBsum1GZH; -; .
PDBsum1H26; -; .
PDBsum1HS5; -; .
PDBsum1JSP; -; .
PDBsum1KZY; -; .
PDBsum1MA3; -; .
PDBsum1OLG; -; .
PDBsum1OLH; -; .
PDBsum1PES; -; .
PDBsum1PET; -; .
PDBsum1SAE; -; .
PDBsum1SAF; -; .
PDBsum1SAH; -; .
PDBsum1SAJ; -; .
PDBsum1SAK; -; .
PDBsum1SAL; -; .
PDBsum1TSR; -; .
PDBsum1TUP; -; .
PDBsum1UOL; -; .
PDBsum1XQH; -; .
PDBsum1YC5; -; .
PDBsum1YCQ; -; .
PDBsum1YCR; -; .
PDBsum1YCS; -; .
PDBsum2AC0; -; .
PDBsum2ADY; -; .
PDBsum2AHI; -; .
PDBsum2ATA; -; .
PDBsum2B3G; -; .
PDBsum2BIM; -; .
PDBsum2BIN; -; .
PDBsum2BIO; -; .
PDBsum2BIP; -; .
PDBsum2BIQ; -; .
PDBsum2F1X; -; .
PDBsum2FEJ; -; .
PDBsum2FOJ; -; .
PDBsum2FOO; -; .
PDBsum2GS0; -; .
PDBsum2H1L; -; .
PDBsum2H2D; -; .
PDBsum2H2F; -; .
PDBsum2H4F; -; .
PDBsum2H4H; -; .
PDBsum2H4J; -; .
PDBsum2H59; -; .
PDBsum2J0Z; -; .
PDBsum2J10; -; .
PDBsum2J11; -; .
PDBsum2J1W; -; .
PDBsum2J1X; -; .
PDBsum2J1Y; -; .
PDBsum2J1Z; -; .
PDBsum2J20; -; .
PDBsum2J21; -; .
PDBsum2K8F; -; .
PDBsum2L14; -; .
PDBsum2OCJ; -; .
PDBsum2PCX; -; .
PDBsum2QVQ; -; .
PDBsum2QXA; -; .
PDBsum2QXB; -; .
PDBsum2QXC; -; .
PDBsum2VUK; -; .
PDBsum2WGX; -; .
PDBsum2X0U; -; .
PDBsum2X0V; -; .
PDBsum2X0W; -; .
PDBsum2XWR; -; .
PDBsum2YBG; -; .
PDBsum2Z5S; -; .
PDBsum2Z5T; -; .
PDBsum3D05; -; .
PDBsum3D06; -; .
PDBsum3D07; -; .
PDBsum3D08; -; .
PDBsum3D09; -; .
PDBsum3D0A; -; .
PDBsum3DAB; -; .
PDBsum3DAC; -; .
PDBsum3IGK; -; .
PDBsum3IGL; -; .
PDBsum3KMD; -; .
PDBsum3KZ8; -; .
PDBsum3LW1; -; .
PDBsum3PDH; -; .
PDBsum3Q01; -; .
PDBsum3Q05; -; .
PDBsum3Q06; -; .
PDBsum3SAK; -; .
PDBsum3TG5; -; .
ProteinModelPortalP04637; -; .
SMRP04637; 13-61; 91-360; .
DisProtDP00086; -; .
DIPDIP-368N; -; .
IntActP04637; 159; .
MINTMINT-91013; -; .
STRINGP04637; -; .
PhosphoSiteP04637; -; .
SWISS-2DPAGEP04637; -; .
PRIDEP04637; -; .
EnsemblENST00000269305; ENSP00000269305; ENSG00000141510; .
EnsemblENST00000359597; ENSP00000352610; ENSG00000141510; .
EnsemblENST00000396473; ENSP00000379735; ENSG00000141510; .
EnsemblENST00000419024; ENSP00000402130; ENSG00000141510; .
EnsemblENST00000420246; ENSP00000391127; ENSG00000141510; .
EnsemblENST00000445888; ENSP00000391478; ENSG00000141510; .
EnsemblENST00000455263; ENSP00000398846; ENSG00000141510; .
GeneID7157; -; .
KEGGhsa:7157; -; .
UCSCuc002gij.2; human; .
CTD7157; -; .
GeneCardsGC17M007465; -; .
HGNCHGNC:11998; TP53; .
HPACAB002973; -; .
HPACAB039238; -; .
HPACAB039239; -; .
MIM133239; phenotype; .
MIM151623; phenotype; .
MIM191170; gene+phenotype; .
MIM202300; phenotype; .
MIM211980; phenotype; .
MIM260500; phenotype; .
MIM275355; phenotype; .
neXtProtNX_P04637; -; .
Orphanet67038; Chronic B-cell lymphocytic leukemia; .
Orphanet1333; Familial pancreatic carcinoma; .
Orphanet360; Glioblastoma; .
Orphanet524; Li-Fraumeni syndrome; .
Orphanet2807; Papilloma of choroid plexus; .
PharmGKBPA36679; -; .
HOVERGENHBG005201; -; .
InParanoidP04637; -; .
OMAIHYNFMC; -; .
OrthoDBEOG45757H; -; .
Pathway_Interaction_DBaurora_a_pathway; Aurora A signaling; .
Pathway_Interaction_DBbard1pathway; BARD1 signaling events; .
Pathway_Interaction_DBpi3kciaktpathway; Class I PI3K signaling events mediated by Akt; .
Pathway_Interaction_DBhif1apathway; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha; .
Pathway_Interaction_DBp75ntrpathway; p75(NTR)-mediated signaling; .
Pathway_Interaction_DBhdac_classiii_pathway; Signaling events mediated by HDAC Class III; .
Pathway_Interaction_DBp38alphabetadownstreampathway; Signaling mediated by p38-alpha and p38-beta; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_604; Hemostasis; .
PMAP-CutDBP04637; -; .
ArrayExpressP04637; -; .
BgeeP04637; -; .
GenevestigatorP04637; -; .
GermOnlineENSG00000141510; Homo sapiens; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; IBA:RefGenome; .
GOGO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell; .
GOGO:0005626; C:insoluble fraction; IDA:UniProtKB; .
GOGO:0005739; C:mitochondrion; IDA:UniProtKB; .
GOGO:0000790; C:nuclear chromatin; IDA:BHF-UCL; .
GOGO:0016363; C:nuclear matrix; IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0016605; C:PML body; IDA:BHF-UCL; .
GOGO:0043234; C:protein complex; IDA:BHF-UCL; .
GOGO:0005657; C:replication fork; IBA:RefGenome; .
GOGO:0005524; F:ATP binding; IDA:UniProtKB; .
GOGO:0051087; F:chaperone binding; IPI:UniProtKB; .
GOGO:0003682; F:chromatin binding; IDA:MGI; .
GOGO:0005507; F:copper ion binding; IDA:UniProtKB; .
GOGO:0003684; F:damaged DNA binding; IBA:RefGenome; .
GOGO:0000739; F:DNA strand annealing activity; IDA:UniProtKB; .
GOGO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB; .
GOGO:0002039; F:p53 binding; IBA:RefGenome; .
GOGO:0002020; F:protease binding; IPI:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:IntAct; .
GOGO:0046982; F:protein heterodimerization activity; IPI:UniProtKB; .
GOGO:0019901; F:protein kinase binding; IPI:UniProtKB; .
GOGO:0047485; F:protein N-terminus binding; IPI:UniProtKB; .
GOGO:0051721; F:protein phosphatase 2A binding; IPI:UniProtKB; .
GOGO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL; .
GOGO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; .
GOGO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL; .
GOGO:0016564; ?:transcription repressor activity; IBA:RefGenome; .
GOGO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; .
GOGO:0008270; F:zinc ion binding; TAS:UniProtKB; .
GOGO:0008635; P:activation of caspase activity by cytochrome c; IDA:UniProtKB; .
GOGO:0006284; P:base-excision repair; TAS:UniProtKB; .
GOGO:0007596; P:blood coagulation; TAS:Reactome; .
GOGO:0007050; P:cell cycle arrest; IDA:BHF-UCL; .
GOGO:0030154; P:cell differentiation; TAS:UniProtKB; .
GOGO:0008283; P:cell proliferation; TAS:UniProtKB; .
GOGO:0034613; P:cellular protein localization; IDA:UniProtKB; .
GOGO:0035690; P:cellular response to drug; IEP:UniProtKB; .
GOGO:0042149; P:cellular response to glucose starvation; IDA:MGI; .
GOGO:0071456; P:cellular response to hypoxia; IEP:UniProtKB; .
GOGO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; .
GOGO:0034644; P:cellular response to UV; IBA:RefGenome; .
GOGO:0008340; P:determination of adult lifespan; ISS:BHF-UCL; .
GOGO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome
GOGO:0042771; P:DNA damage response; signal transduction by p53 class mediator resulting in induction of apoptosis; IDA:UniProtKB
GOGO:0006978; P:DNA damage response; signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IMP:BHF-UCL
GOGO:0006983; P:ER overload response; IDA:MGI; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0043066; P:negative regulation of apoptosis; IDA:UniProtKB; .
GOGO:0030308; P:negative regulation of cell growth; IMP:UniProtKB; .
GOGO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL; .
GOGO:0051097; P:negative regulation of helicase activity; TAS:UniProtKB; .
GOGO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL; .
GOGO:0006289; P:nucleotide-excision repair; IMP:UniProtKB; .
GOGO:0090403; P:oxidative stress-induced premature senescence; IMP:BHF-UCL; .
GOGO:0031065; P:positive regulation of histone deacetylation; IBA:RefGenome; .
GOGO:0043525; P:positive regulation of neuron apoptosis; IBA:RefGenome; .
GOGO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:BHF-UCL; .
GOGO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; .
GOGO:0070245; P:positive regulation of thymocyte apoptosis; ISS:BHF-UCL; .
GOGO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL; .
GOGO:0008104; P:protein localization; IDA:UniProtKB; .
GOGO:0051262; P:protein tetramerization; TAS:UniProtKB; .
GOGO:0007265; P:Ras protein signal transduction; IEP:BHF-UCL; .
GOGO:0046902; P:regulation of mitochondrial membrane permeability; TAS:UniProtKB; .
GOGO:0090399; P:replicative senescence; IMP:BHF-UCL; .
GOGO:0046677; P:response to antibiotic; IEP:UniProtKB; .
GOGO:0010332; P:response to gamma radiation; IMP:BHF-UCL; .
GOGO:0010165; P:response to X-ray; IBA:RefGenome; .
InterProIPR008967; p53-like_TF_DNA-bd; .
InterProIPR012346; p53/RUNT-type_TF_DNA-bd; .
InterProIPR011615; p53_DNA-bd; .
InterProIPR010991; p53_tetrameristn; .
InterProIPR013872; p53_transactivation_domain; .
InterProIPR002117; p53_tumour_suppressor; .
Gene3DG3DSA:2.60.40.720; p53_RUNT_DNA_bd; 1; .
Gene3DG3DSA:4.10.170.10; p53_tetrameristn; 1; .
PANTHERPTHR11447; Trp53; 1; .
PfamPF00870; P53; 1; .
PfamPF08563; P53_TAD; 1; .
PfamPF07710; P53_tetramer; 1; .
PRINTSPR00386; P53SUPPRESSR; .
SUPFAMSSF49417; P53_like_DNA_bnd; 1; .
SUPFAMSSF47719; p53_tetrameristn; 1; .
PROSITEPS00348; P53; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server