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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P04792




SWISS-2DPAGE:  P04792


P04792


General information about the entry
View entry in simple text format
Entry nameHSPB1_HUMAN
Primary accession numberP04792
integrated into SWISS-2DPAGE on April 1, 2000 (release 12)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 8)
Name and origin of the protein
DescriptionRecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27;.
Gene nameName=HSPB1
Synonyms=HSP27, HSP28
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
NUCLEI_LIVER_HUMAN
  map experimental info
  protein estimated location
 
NUCLEI_LIVER_HUMAN

MAP LOCATIONS:
pI=5.62; Mw=24205  [identification data]
pI=6.18; Mw=23865  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP04792; P04792.
DOSAC-COBS-2DPAGEP04792; HSPB1_HUMAN.
HSC-2DPAGEP04792; HUMAN.
OGP-WWWP04792.
REPRODUCTION-2DPAGEP04792; P04792.
REPRODUCTION-2DPAGEIPI00025512; IPI00025512.
Siena-2DPAGEP04792; HSPB1_HUMAN.
UCD-2DPAGEP04792; HSPB1_HUMAN.
UniProtKB/Swiss-ProtP04792; HSPB1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameHSPB1_HUMAN
Primary accession numberP04792
Secondary accession number(s) B2R4N8 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36
Sequence was last modified on September 26, 2001 (version 2)
Annotations were last modified on October 19, 2011 (version 147)
Name and origin of the protein
DescriptionRecName: Full=Heat shock protein beta-1; Short=HspB1; AltName: Full=28 kDa heat shock protein; AltName: Full=Estrogen-regulated 24 kDa protein; AltName: Full=Heat shock 27 kDa protein; Short=HSP 27; AltName: Full=Stress-responsive protein 27; Short=SRP27;
Gene nameName=HSPB1
Synonyms=HSP27, HSP28
Encoded onName=HSPB1; Synonyms=HSP27, HSP28
Keywords3D-structure; Acetylation; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Neurodegeneration; Neuropathy; Nucleus; Phosphoprotein; Reference proteome; Stress response.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL39370; AAA62175.1; ALT_FRAME; Genomic_DNA
EMBLX54079; CAA38016.1; -; mRNA
EMBLZ23090; CAA80636.1; -; mRNA
EMBLAB020027; BAB17232.1; -; mRNA
EMBLU90906; AAB51056.1; -; mRNA
EMBLCR407614; CAG28542.1; -; mRNA
EMBLCR536489; CAG38728.1; -; mRNA
EMBLBT019888; AAV38691.1; -; mRNA
EMBLAK311894; BAG34835.1; -; mRNA
EMBLDQ379985; ABC88475.1; -; Genomic_DNA
EMBLAC006388; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471220; EAW71803.1; -; Genomic_DNA
EMBLBC000510; AAH00510.1; -; mRNA
EMBLBC012292; AAH12292.1; -; mRNA
EMBLBC012768; AAH12768.1; -; mRNA
EMBLBC014920; AAH14920.1; -; mRNA
EMBLBC073768; AAH73768.1; -; mRNA
EMBLX16477; CAA34498.1; ALT_FRAME; mRNA
EMBLS74571; AAB20722.1; ALT_FRAME; mRNA
IPIIPI00025512; -; .
PIRS12102; HHHU27; .
RefSeqNP_001531.1; NM_001540.3; .
UniGeneHs.520973; -; .
PDB3Q9P; X-ray; 2.00 A; A=90-171
PDB3Q9Q; X-ray; 2.20 A; A/B=90-171
PDBsum3Q9P; -; .
PDBsum3Q9Q; -; .
ProteinModelPortalP04792; -; .
SMRP04792; 97-165; .
DIPDIP-412N; -; .
IntActP04792; 31; .
MINTMINT-1368692; -; .
STRINGP04792; -; .
PhosphoSiteP04792; -; .
SWISS-2DPAGEP04792; -; .
Aarhus/Ghent-2DPAGE4110; IEF; .
Aarhus/Ghent-2DPAGE5102; IEF; .
Aarhus/Ghent-2DPAGE6104; IEF; .
Cornea-2DPAGEP04792; -; .
DOSAC-COBS-2DPAGEP04792; -; .
OGPP04792; -; .
REPRODUCTION-2DPAGEIPI00025512; -; .
REPRODUCTION-2DPAGEP04792; -; .
UCD-2DPAGEP04792; -; .
PeptideAtlasP04792; -; .
PRIDEP04792; -; .
EnsemblENST00000248553; ENSP00000248553; ENSG00000106211; .
GeneID3315; -; .
KEGGhsa:3315; -; .
UCSCuc003uew.1; human; .
CTD3315; -; .
GeneCardsGC07P071018; -; .
H-InvDBHIX0006788; -; .
HGNCHGNC:5246; HSPB1; .
HPACAB002061; -; .
HPACAB004439; -; .
HPAHPA000497; -; .
MIM602195; gene; .
MIM606595; phenotype; .
MIM608634; phenotype; .
neXtProtNX_P04792; -; .
Orphanet99940; Autosomal dominant Charcot-Marie-Tooth disease type 2F; .
Orphanet139525; Distal hereditary motor neuropathy type 2; .
PharmGKBPA29511; -; .
eggNOGprNOG08210; -; .
GeneTreeENSGT00550000074302; -; .
HOVERGENHBG054766; -; .
InParanoidP04792; -; .
OMAVTFEARA; -; .
OrthoDBEOG4DR9DF; -; .
PhylomeDBP04792; -; .
Pathway_Interaction_DBp38_mk2pathway; p38 signaling mediated by MAPKAP kinases; .
Pathway_Interaction_DBvegfr1_2_pathway; Signaling events mediated by VEGFR1 and VEGFR2; .
Pathway_Interaction_DBp38alphabetadownstreampathway; Signaling mediated by p38-alpha and p38-beta; .
ReactomeREACT_21257; Metabolism of RNA; .
NextBio13148; -; .
ArrayExpressP04792; -; .
BgeeP04792; -; .
CleanExHS_HSPB1; -; .
GenevestigatorP04792; -; .
GOGO:0009986; C:cell surface; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0000502; C:proteasome complex; ISS:BHF-UCL; .
GOGO:0005819; C:spindle; IEA:UniProtKB-SubCell; .
GOGO:0072568; F:protein kinase C delta binding; ISS:BHF-UCL; .
GOGO:0008426; F:protein kinase C inhibitor activity; ISS:BHF-UCL; .
GOGO:0043130; F:ubiquitin binding; ISS:BHF-UCL; .
GOGO:0001525; P:angiogenesis; IMP:BHF-UCL; .
GOGO:0006916; P:anti-apoptosis; TAS:UniProtKB; .
GOGO:0043534; P:blood vessel endothelial cell migration; IMP:BHF-UCL; .
GOGO:0008219; P:cell death; IEA:UniProtKB-KW; .
GOGO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IMP:BHF-UCL; .
GOGO:0035767; P:endothelial cell chemotaxis; IMP:BHF-UCL; .
GOGO:0016071; P:mRNA metabolic process; TAS:Reactome; .
GOGO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL; .
GOGO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; ISS:BHF-UCL; .
GOGO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; ISS:BHF-UCL; .
GOGO:0006446; P:regulation of translational initiation; TAS:ProtInc; .
GOGO:0006986; P:response to unfolded protein; NAS:UniProtKB; .
GOGO:0009615; P:response to virus; IEP:UniProtKB; .
InterProIPR001436; Alpha-crystallin/HSP; .
InterProIPR002068; Hsp20; .
InterProIPR008978; HSP20-like_chaperone; .
PfamPF00011; HSP20; 1; .
PIRSFPIRSF036514; Sm_HSP_B1; 1; .
PRINTSPR00299; ACRYSTALLIN; .
SUPFAMSSF49764; HSP20_chap; 1; .
PROSITEPS01031; HSP20; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server