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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P07858




SWISS-2DPAGE:  P07858


P07858


General information about the entry
View entry in simple text format
Entry nameCATB_HUMAN
Primary accession numberP07858
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin B; EC=3.4.22.1; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;.
Gene nameName=CTSB
Synonyms=CPSB
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: DIMER OF AN HEAVY CHAIN AND A LIGHT CHAIN CROSS-LINKED BY A DISULFIDE BOND
2D PAGE maps for identified proteins
How to interpret a protein

LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.15; Mw=23809

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=5.25; Mw=23006

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP07858; CATB_HUMAN.
UCD-2DPAGEP07858; CATB_HUMAN.
UniProtKB/Swiss-ProtP07858; CATB_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCATB_HUMAN
Primary accession numberP07858
Secondary accession number(s) B3KQR5 B3KRR5 Q503A6 Q96D87
Sequence was last modified on June 21, 2005 (version 3)
Annotations were last modified on September 21, 2011 (version 144)
Name and origin of the protein
DescriptionRecName: Full=Cathepsin B; EC=3.4.22.1; AltName: Full=APP secretase; Short=APPS; AltName: Full=Cathepsin B1; Contains: RecName: Full=Cathepsin B light chain; Contains: RecName: Full=Cathepsin B heavy chain; Flags: Precursor;
Gene nameName=CTSB
Synonyms=CPSB
Encoded onName=CTSB; Synonyms=CPSB
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Polymorphism; Protease; Reference proteome; Signal; Thiol protease; Zymogen.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM14221; AAA52129.1; -; mRNA
EMBLL16510; AAC37547.1; -; mRNA
EMBLAK092070; BAG52477.1; -; mRNA
EMBLAK075393; BAG52127.1; -; mRNA
EMBLCH471157; EAW65630.1; -; Genomic_DNA
EMBLBC010240; AAH10240.1; -; mRNA
EMBLBC095408; AAH95408.1; -; mRNA
EMBLM13230; AAA52125.1; -; mRNA
IPIIPI00295741; -; .
PIRA26498; KHHUB; .
RefSeqNP_001899.1; NM_001908.3; .
RefSeqNP_680090.1; NM_147780.2; .
RefSeqNP_680091.1; NM_147781.2; .
RefSeqNP_680092.1; NM_147782.2; .
RefSeqNP_680093.1; NM_147783.2; .
UniGeneHs.520898; -; .
PDB1CSB; X-ray; 2.00 A; A/D=80-126
B/E=129-333PDB; 1GMY; X-ray; 1.90 A
A/B/C=79-339PDB; 1HUC; X-ray; 2.10 A
A/C=80-126B/D=129-333; PDB; 1PBH; X-ray
3.20 AA=18-333; PDB; 2IPP; X-ray
2.15 AA=80-126; B=129-333; PDB; 2PBH
X-ray3.30 A; A=18-333; PDB; 3AI8
X-ray2.11 A; A/B=78-333; PDB; 3CBJ
X-ray1.80 A; A=74-339; PDB; 3CBK
X-ray2.67 A; A=74-339; PDB; 3K9M
X-ray2.61 A; A/B=80-333; PDB; 3PBH
X-ray2.50 A; A=18-333; PDBsum; 1CSB
PDBsum1GMY; -; .
PDBsum1HUC; -; .
PDBsum1PBH; -; .
PDBsum2IPP; -; .
PDBsum2PBH; -; .
PDBsum3AI8; -; .
PDBsum3CBJ; -; .
PDBsum3CBK; -; .
PDBsum3K9M; -; .
PDBsum3PBH; -; .
ProteinModelPortalP07858; -; .
SMRP07858; 18-333; .
IntActP07858; 12; .
MINTMINT-1397666; -; .
STRINGP07858; -; .
MEROPSC01.060; -; .
PhosphoSiteP07858; -; .
SWISS-2DPAGEP07858; -; .
UCD-2DPAGEP07858; -; .
PeptideAtlasP07858; -; .
PRIDEP07858; -; .
EnsemblENST00000345125; ENSP00000342070; ENSG00000164733; .
EnsemblENST00000353047; ENSP00000345672; ENSG00000164733; .
EnsemblENST00000434271; ENSP00000415889; ENSG00000164733; .
EnsemblENST00000453527; ENSP00000409917; ENSG00000164733; .
GeneID1508; -; .
KEGGhsa:1508; -; .
UCSCuc003wum.1; human; .
CTD1508; -; .
GeneCardsGC08M010630; -; .
H-InvDBHIX0007320; -; .
HGNCHGNC:2527; CTSB; .
HPACAB000457; -; .
HPAHPA018156; -; .
MIM116810; gene; .
neXtProtNX_P07858; -; .
PharmGKBPA27027; -; .
eggNOGprNOG04690; -; .
HOGENOMHBG385498; -; .
HOVERGENHBG003480; -; .
InParanoidP07858; -; .
OMATIPPCEH; -; .
OrthoDBEOG4K6G4C; -; .
PhylomeDBP07858; -; .
BRENDA3.4.22.1; 2681; .
NextBio6235; -; .
PMAP-CutDBP07858; -; .
ArrayExpressP07858; -; .
BgeeP07858; -; .
CleanExHS_CTSB; -; .
GenevestigatorP07858; -; .
GermOnlineENSG00000164733; Homo sapiens; .
GOGO:0005764; C:lysosome; IEA:UniProtKB-SubCell; .
GOGO:0042470; C:melanosome; IEA:UniProtKB-SubCell; .
GOGO:0004197; F:cysteine-type endopeptidase activity; IDA:BHF-UCL; .
GOGO:0006508; P:proteolysis; IDA:BHF-UCL; .
GOGO:0042981; P:regulation of apoptosis; TAS:UniProtKB; .
GOGO:0050790; P:regulation of catalytic activity; IEA:InterPro; .
InterProIPR000169; Pept_cys_AS; .
InterProIPR013128; Peptidase_C1A; .
InterProIPR000668; Peptidase_C1A_C; .
InterProIPR015643; Peptidase_C1A_cathepsin-B; .
InterProIPR012599; Propeptide_C1A; .
PANTHERPTHR12411:SF16; CathepsinB_like; 1; .
PANTHERPTHR12411; Peptidase_C1A; 1; .
PfamPF00112; Peptidase_C1; 1; .
PfamPF08127; Propeptide_C1; 1; .
PRINTSPR00705; PAPAIN; .
SMARTSM00645; Pept_C1; 1; .
PROSITEPS00640; THIOL_PROTEASE_ASN; 1; .
PROSITEPS00139; THIOL_PROTEASE_CYS; 1; .
PROSITEPS00639; THIOL_PROTEASE_HIS; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server