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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P09382




SWISS-2DPAGE:  P09382


P09382


General information about the entry
View entry in simple text format
Entry nameLEG1_HUMAN
Primary accession numberP09382
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onMarch 31, 2004 (version 3)
General Annotations were last modified on May 19, 2011 (version 10)
Name and origin of the protein
DescriptionRecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa laminin-binding protein; Short=HLBP14; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=HBL; AltName: Full=HPL; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=Putative MAPK-activating protein PM12; AltName: Full=S-Lac lectin 1;.
Gene nameName=LGALS1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[2]   MAPPING ON GEL
Tonella L., Hoogland C., Appel R.D., Sanchez J.-C., Hochstrasser D.F.
Submitted (JUL-1997) to SWISS-2DPAGE
[3]   MAPPING ON GEL
MEDLINE=96314065; PubMed=8740185; [NCBI, ExPASy, EBI, Israel, Japan]
Lutomski D., Caron M., Cornillot J.D., Bourin P., Dupuy C., Pontet M., Bladier D., Joubert-Caron R.
''''''Identification of different galectins by immunoblotting after two- dimensional polyacrylamide get electrophoresis with immobilized pH gradients'';'';''
Electrophoresis 17(1):600-606(1996)
[4]   PROTEIN EXPRESSION
MEDLINE=89093123; PubMed=2910856; [NCBI, ExPASy, EBI, Israel, Japan]
Couraud P.O., Casentini-Borocz D., Bringman T.S., Griffith J., McGrogan M., Nedwin G.E.
''''''Molecular cloning, characterization, and expression of a human 14-kDa lectin'';'';''
J. Biol. Chem. 264(1):1310-1316(1989)
[5]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[6]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=4.93; Mw=12076

MAPPING (identification):
MATCHING WITH THE KIDNEY MASTER GEL [5].



HL60_HUMAN {Promyelocytic leukemia cells}
Homo sapiens (Human)
Tissue: Promyelocytic leukemia
HL60_HUMAN
  map experimental info
  protein estimated location
 
HL60_HUMAN

MAP LOCATIONS:
pI=5.01; Mw=11094

EXPRESSION:
IS UNAFFECTED BY N-GLYCANASE TREATMENT AND IS NOT GLYCOSYLATED [4].

MAPPING (identification):
COMIGRATION [2][3].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=5.04; Mw=11822

MAPPING (identification):
MATCHING WITH THE HL60 MASTER GEL [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=4.94; Mw=16289  [identification data]

MAPPING (identification):
MALDI tandem mass spectrometry [6].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP09382; P09382.
DOSAC-COBS-2DPAGEP09382; LEG1_HUMAN.
PHCI-2DPAGEP09382; LEG1_HUMAN.
REPRODUCTION-2DPAGEP09382; P09382.
REPRODUCTION-2DPAGEIPI00219219; IPI00219219.
Siena-2DPAGEP09382; LEG1_HUMAN.
UCD-2DPAGEP09382; LEG1_HUMAN.
UniProtKB/Swiss-ProtP09382; LEG1_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameLEG1_HUMAN
Primary accession numberP09382
Secondary accession number(s) B2R5E8 Q9UDK5
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on October 19, 2011 (version 148)
Name and origin of the protein
DescriptionRecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa laminin-binding protein; Short=HLBP14; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=HBL; AltName: Full=HPL; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=Putative MAPK-activating protein PM12; AltName: Full=S-Lac lectin 1;
Gene nameName=LGALS1
Encoded onName=LGALS1
Keywords3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Extracellular matrix; Lectin; Phosphoprotein; Reference proteome; Secreted.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX14829; CAA32938.1; -; mRNA
EMBLJ04456; AAA36170.1; -; mRNA
EMBLX15256; CAA33328.1; -; mRNA
EMBLEU363770; ACA58297.1; -; mRNA
EMBLM57678; AAB00777.1; -; Genomic_DNA
EMBLAB097036; BAC77389.1; -; mRNA
EMBLCR456511; CAG30397.1; -; mRNA
EMBLAK312161; BAG35095.1; -; mRNA
EMBLBT006775; AAP35421.1; -; mRNA
EMBLZ83844; CAB42897.1; -; Genomic_DNA
EMBLCH471095; EAW60178.1; -; Genomic_DNA
EMBLBC001693; AAH01693.1; -; mRNA
EMBLBC020675; AAH20675.1; -; mRNA
IPIIPI00219219; -; .
PIRA37134; LNHUGB; .
RefSeqNP_002296.1; NM_002305.3; .
UniGeneHs.445351; -; .
PDB1GZW; X-ray; 1.70 A; A/B=2-134
PDB1W6M; X-ray; 2.30 A; A/B=4-135
PDB1W6N; X-ray; 1.65 A; A/B=4-134
PDB1W6O; X-ray; 1.90 A; A/B=4-134
PDB1W6P; X-ray; 1.80 A; A/B=4-134
PDB1W6Q; X-ray; 2.10 A; A/B=2-134
PDB2KM2; NMR; -; A/B=2-135
PDB2ZKN; X-ray; 1.86 A; A/B=4-135
PDB3OY8; X-ray; 2.19 A; A/B=2-135
PDB3OYW; X-ray; 2.50 A; A/B=2-135
PDBsum1GZW; -; .
PDBsum1W6M; -; .
PDBsum1W6N; -; .
PDBsum1W6O; -; .
PDBsum1W6P; -; .
PDBsum1W6Q; -; .
PDBsum2KM2; -; .
PDBsum2ZKN; -; .
PDBsum3OY8; -; .
PDBsum3OYW; -; .
ProteinModelPortalP09382; -; .
SMRP09382; 2-135; .
DIPDIP-46153N; -; .
IntActP09382; 3; .
MINTMINT-3306493; -; .
STRINGP09382; -; .
PhosphoSiteP09382; -; .
SWISS-2DPAGEP09382; -; .
Cornea-2DPAGEP09382; -; .
DOSAC-COBS-2DPAGEP09382; -; .
PHCI-2DPAGEP09382; -; .
REPRODUCTION-2DPAGEIPI00219219; -; .
REPRODUCTION-2DPAGEP09382; -; .
UCD-2DPAGEP09382; -; .
PeptideAtlasP09382; -; .
PRIDEP09382; -; .
EnsemblENST00000215909; ENSP00000215909; ENSG00000100097; .
GeneID3956; -; .
KEGGhsa:3956; -; .
UCSCuc003atn.1; human; .
CTD3956; -; .
GeneCardsGC22P021039; -; .
H-InvDBHIX0203173; -; .
HGNCHGNC:6561; LGALS1; .
HPACAB002157; -; .
HPAHPA000646; -; .
MIM150570; gene; .
neXtProtNX_P09382; -; .
PharmGKBPA30337; -; .
eggNOGprNOG20242; -; .
HOGENOMHBG717055; -; .
HOVERGENHBG006255; -; .
InParanoidP09382; -; .
OMAGGAWGAE; -; .
OrthoDBEOG4GXFP7; -; .
PhylomeDBP09382; -; .
BindingDBP09382; -; .
NextBio15523; -; .
PMAP-CutDBP09382; -; .
ArrayExpressP09382; -; .
BgeeP09382; -; .
CleanExHS_LGALS1; -; .
GenevestigatorP09382; -; .
GermOnlineENSG00000100097; Homo sapiens; .
GOGO:0005737; C:cytoplasm; TAS:UniProtKB; .
GOGO:0005615; C:extracellular space; IDA:BHF-UCL; .
GOGO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell; .
GOGO:0016936; F:galactoside binding; IEA:InterPro; .
GOGO:0004871; F:signal transducer activity; IMP:UniProtKB; .
GOGO:0006915; P:apoptosis; TAS:ProtInc; .
GOGO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB; .
GOGO:0042981; P:regulation of apoptosis; TAS:UniProtKB; .
InterProIPR008985; ConA-like_lec_gl; .
InterProIPR013320; ConA-like_subgrp; .
InterProIPR015535; Galectin_1; .
InterProIPR001079; Galectin_CRD; .
Gene3DG3DSA:2.60.120.200; ConA_like_subgrp; 1; .
PANTHERPTHR11346:SF30; Galectin_1; 1; .
PfamPF00337; Gal-bind_lectin; 1; .
SMARTSM00908; Gal-bind_lectin; 1; .
SMARTSM00276; GLECT; 1; .
SUPFAMSSF49899; ConA_like_lec_gl; 1; .
PROSITEPS51304; GALECTIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server