World-2DPAGE Home


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P10599




SWISS-2DPAGE:  P10599


P10599


General information about the entry
View entry in simple text format
Entry nameTHIO_HUMAN
Primary accession numberP10599
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 5)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin; Short=Trx; AltName: Full=ATL-derived factor; Short=ADF; AltName: Full=Surface-associated sulphydryl protein; Short=SASP;.
Gene nameName=TXN
Synonyms=TRDX, TRX, TRX1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[4]   MAPPING ON GEL
MEDLINE=96007935; PubMed=7498158; [NCBI, ExPASy, EBI, Israel, Japan]
Gravel P., Sanchez J.-C., Walzer C., Golaz O., Hochstrasser D.F., Balant L.P., Hughes G.J., Garcia-Sevilla J., Guimon J.
''''''Human blood platelet protein map established by two-dimensional polyacrylamide gel electrophoresis'';'';''
Electrophoresis 16(1):1152-1159(1995)
[5]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[6]   MAPPING ON GEL
Tonella L., Hoogland C., Appel R.D., Sanchez J.-C., Hochstrasser D.F.
Submitted (JUL-1997) to SWISS-2DPAGE
[7]   MAPPING ON GEL
MEDLINE=96314065; PubMed=8740185; [NCBI, ExPASy, EBI, Israel, Japan]
Lutomski D., Caron M., Cornillot J.D., Bourin P., Dupuy C., Pontet M., Bladier D., Joubert-Caron R.
''''''Identification of different galectins by immunoblotting after two- dimensional polyacrylamide get electrophoresis with immobilized pH gradients'';'';''
Electrophoresis 17(1):600-606(1996)
[8]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[9]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[10]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=4.84; Mw=11121

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [8].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=4.92; Mw=10391

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [9].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=4.92; Mw=10936

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



HL60_HUMAN {Promyelocytic leukemia cells}
Homo sapiens (Human)
Tissue: Promyelocytic leukemia
HL60_HUMAN
  map experimental info
  protein estimated location
 
HL60_HUMAN

MAP LOCATIONS:
pI=4.89; Mw=10727

MAPPING (identification):
MATCHING WITH THE KIDNEY MASTER GEL [6][7].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=4.88; Mw=11271  [identification data]

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL AND AMINO ACID COMPOSITION ANALYSIS [5].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=4.89; Mw=11907

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=4.74; Mw=16099  [identification data]

MAPPING (identification):
ESI tandem mass spectrometry [10].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=4.88; Mw=11056

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



PLATELET_HUMAN {Platelet}
Homo sapiens (Human)
Tissue: Platelet
PLATELET_HUMAN
  map experimental info
  protein estimated location
 
PLATELET_HUMAN

MAP LOCATIONS:
pI=4.90; Mw=11900

MAPPING (identification):
MATCHING WITH RBC AND LIVER MASTERS [4].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=4.89; Mw=12000

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [3].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=4.93; Mw=10599

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP10599; P10599.
DOSAC-COBS-2DPAGEP10599; THIO_HUMAN.
PHCI-2DPAGEP10599; THIO_HUMAN.
REPRODUCTION-2DPAGEIPI00216298; IPI00216298.
Siena-2DPAGEP10599; THIO_HUMAN.
UniProtKB/Swiss-ProtP10599; THIO_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTHIO_HUMAN
Primary accession numberP10599
Secondary accession number(s) Q53X69 Q96KI3 Q9UDG5
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 147)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin; Short=Trx; AltName: Full=ATL-derived factor; Short=ADF; AltName: Full=Surface-associated sulphydryl protein; Short=SASP;
Gene nameName=TXN
Synonyms=TRDX, TRX, TRX1
Encoded onName=TXN; Synonyms=TRDX, TRX, TRX1
Keywords3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Electron transport; Nucleus; Phosphoprotein; Redox-active center; Reference proteome; S-nitrosylation; Secreted; Transcription; Transcription regulation; Transport; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLJ04026; AAA74596.1; -; mRNA
EMBLX77584; CAA54687.1; -; mRNA
EMBLX54539; CAA38410.1; -; Genomic_DNA
EMBLX54540; CAA38410.1; JOINED; Genomic_DNA
EMBLX54541; CAA38410.1; JOINED; Genomic_DNA
EMBLAF276919; AAF86466.1; -; mRNA
EMBLAY004872; AAF87085.1; -; mRNA
EMBLAF313911; AAG34699.1; -; mRNA
EMBLAK289508; BAF82197.1; -; mRNA
EMBLCR407665; CAG28593.1; -; mRNA
EMBLAF548001; AAN33187.1; -; Genomic_DNA
EMBLAL158158; CAI14066.1; -; Genomic_DNA
EMBLCH471105; EAW59059.1; -; Genomic_DNA
EMBLBC003377; AAH03377.1; -; mRNA
EMBLBC054866; AAH54866.1; -; mRNA
IPIIPI00216298; -; .
PIRJH0568; JH0568; .
RefSeqNP_003320.2; NM_003329.2; .
UniGeneHs.435136; -; .
PDB1AIU; X-ray; 2.00 A; A=1-105
PDB1AUC; X-ray; 2.10 A; A=1-105
PDB1CQG; NMR; -; A=1-105
PDB1CQH; NMR; -; A=1-105
PDB1ERT; X-ray; 1.70 A; A=1-105
PDB1ERU; X-ray; 2.10 A; A=1-105
PDB1ERV; X-ray; 1.65 A; A=1-105
PDB1ERW; X-ray; 1.80 A; A=1-105
PDB1M7T; NMR; -; A=1-65
PDB1MDI; NMR; -; A=2-104
PDB1MDJ; NMR; -; A=2-104
PDB1MDK; NMR; -; A=2-104
PDB1TRS; NMR; -; A=1-105
PDB1TRU; NMR; -; A=1-105
PDB1TRV; NMR; -; A=1-105
PDB1TRW; NMR; -; A=1-105
PDB1W1C; Model; -; C=1-105
PDB1W1E; Model; -; C=1-105
PDB2HSH; X-ray; 1.35 A; A=1-105
PDB2HXK; X-ray; 1.65 A; A/B/C=1-105
PDB2IFQ; X-ray; 1.20 A; A/B/C=1-105
PDB2IIY; X-ray; 1.70 A; A=1-105
PDB3E3E; X-ray; 2.01 A; A/B=1-105
PDB3KD0; X-ray; 1.70 A; A=1-105
PDB3M9J; X-ray; 1.10 A; A/B=1-105
PDB3M9K; X-ray; 1.50 A; A/B=1-105
PDB3QFA; X-ray; 2.20 A; C/D=2-105
PDB3QFB; X-ray; 2.60 A; C/D=2-105
PDB3TRX; NMR; -; A=1-105
PDB4TRX; NMR; -; A=1-105
PDBsum1AIU; -; .
PDBsum1AUC; -; .
PDBsum1CQG; -; .
PDBsum1CQH; -; .
PDBsum1ERT; -; .
PDBsum1ERU; -; .
PDBsum1ERV; -; .
PDBsum1ERW; -; .
PDBsum1M7T; -; .
PDBsum1MDI; -; .
PDBsum1MDJ; -; .
PDBsum1MDK; -; .
PDBsum1TRS; -; .
PDBsum1TRU; -; .
PDBsum1TRV; -; .
PDBsum1TRW; -; .
PDBsum1W1C; -; .
PDBsum1W1E; -; .
PDBsum2HSH; -; .
PDBsum2HXK; -; .
PDBsum2IFQ; -; .
PDBsum2IIY; -; .
PDBsum3E3E; -; .
PDBsum3KD0; -; .
PDBsum3M9J; -; .
PDBsum3M9K; -; .
PDBsum3QFA; -; .
PDBsum3QFB; -; .
PDBsum3TRX; -; .
PDBsum4TRX; -; .
ProteinModelPortalP10599; -; .
SMRP10599; 1-105; .
DIPDIP-6129N; -; .
IntActP10599; 11; .
MINTMINT-1522967; -; .
STRINGP10599; -; .
Allergome3543; Hom s Trx; .
PhosphoSiteP10599; -; .
SWISS-2DPAGEP10599; -; .
Aarhus/Ghent-2DPAGE8006; IEF; .
Cornea-2DPAGEP10599; -; .
DOSAC-COBS-2DPAGEP10599; -; .
PHCI-2DPAGEP10599; -; .
REPRODUCTION-2DPAGEIPI00216298; -; .
Siena-2DPAGEP10599; -; .
PeptideAtlasP10599; -; .
PRIDEP10599; -; .
EnsemblENST00000374517; ENSP00000363641; ENSG00000136810; .
GeneID7295; -; .
KEGGhsa:7295; -; .
UCSCuc004bep.1; human; .
CTD7295; -; .
GeneCardsGC09M082608; -; .
H-InvDBHIX0008275; -; .
HGNCHGNC:12435; TXN; .
HPACAB008678; -; .
MIM187700; gene; .
neXtProtNX_P10599; -; .
PharmGKBPA37091; -; .
GeneTreeENSGT00530000063008; -; .
HOGENOMHBG493509; -; .
HOVERGENHBG009243; -; .
InParanoidP10599; -; .
OMAEKYGNVV; -; .
OrthoDBEOG47PX7J; -; .
PhylomeDBP10599; -; .
Pathway_Interaction_DBp38_mkk3_6pathway; p38 MAPK signaling pathway; .
Pathway_Interaction_DBptp1bpathway; Signaling events mediated by PTP1B; .
Pathway_Interaction_DBtnfpathway; TNF receptor signaling pathway; .
ReactomeREACT_1698; Metabolism of nucleotides; .
ReactomeREACT_6900; Immune System; .
NextBio28523; -; .
ArrayExpressP10599; -; .
BgeeP10599; -; .
CleanExHS_TXN; -; .
GenevestigatorP10599; -; .
GermOnlineENSG00000136810; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005576; C:extracellular region; IEA:UniProtKB-SubCell; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0009055; F:electron carrier activity; IEA:InterPro; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro; .
GOGO:0002218; P:activation of innate immune response; TAS:Reactome; .
GOGO:0008283; P:cell proliferation; TAS:ProtInc; .
GOGO:0007267; P:cell-cell signaling; TAS:ProtInc; .
GOGO:0006928; P:cellular component movement; TAS:ProtInc; .
GOGO:0022900; P:electron transport chain; IEA:UniProtKB-KW; .
GOGO:0006662; P:glycerol ether metabolic process; IEA:InterPro; .
GOGO:0045087; P:innate immune response; TAS:Reactome; .
GOGO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; .
GOGO:0043388; P:positive regulation of DNA binding; IDA:UniProtKB; .
GOGO:0033158; P:regulation of protein import into nucleus; translocation; IDA:UniProtKB
GOGO:0006355; P:regulation of transcription; DNA-dependent; IEA:UniProtKB-KW
GOGO:0009314; P:response to radiation; IDA:UniProtKB; .
GOGO:0007165; P:signal transduction; TAS:ProtInc; .
GOGO:0006351; P:transcription; DNA-dependent; IEA:UniProtKB-KW
GOGO:0006810; P:transport; IEA:UniProtKB-KW; .
InterProIPR005746; Thioredoxin; .
InterProIPR012336; Thioredoxin-like_fold; .
InterProIPR017937; Thioredoxin_CS; .
InterProIPR013766; Thioredoxin_domain; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PANTHERPTHR10438; Trx; 1; .
PfamPF00085; Thioredoxin; 1; .
PIRSFPIRSF000077; Thioredoxin; 1; .
PRINTSPR00421; THIOREDOXIN; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS00194; THIOREDOXIN_1; 1; .
PROSITEPS51352; THIOREDOXIN_2; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server