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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: P11586 SWISS-2DPAGE:  P11586 P11586 General information about the entry View entry in simple text format Entry name C1TC_HUMAN Primary accession number P11586 integrated into SWISS-2DPAGE on  January 15, 1999 (release 9) 2D Annotations were last modified on October 1, 2001 (version 1) General Annotations were last modified on  May 19, 2011 (version 9) Name and origin of the protein Description RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic; Short=C1-THF synthase; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9; Includes: RecName: Full=Formyltetrahydrofolate synthetase; EC=6.3.4.3;. Gene name Name=MTHFD1 Synonyms=MTHFC, MTHFD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE 2D PAGE maps for identified proteins How to interpret a protein DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human) Tissue: Colon adenocarcinoma   map experimental info   protein estimated location   DLD1_HUMAN MAP LOCATIONS: SPOT 2D-001D1X: pI=6.79; Mw=125156   [identification data] MAPPING (identification): Peptide mass fingerprinting [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references REPRODUCTION-2DPAGE IPI00218342; IPI00218342. UniProtKB/Swiss-Prot P11586; C1TC_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name C1TC_HUMAN Primary accession number P11586 Secondary accession number(s) B2R5Y2 Q86VC9 Q9BVP5 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  October 19, 2011 (version 140) Name and origin of the protein Description RecName: Full=C-1-tetrahydrofolate synthase, cytoplasmic; Short=C1-THF synthase; Includes: RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5; Includes: RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9; Includes: RecName: Full=Formyltetrahydrofolate synthetase; EC=6.3.4.3; Gene name Name=MTHFD1 Synonyms=MTHFC, MTHFD Encoded on Name=MTHFD1; Synonyms=MTHFC, MTHFD Keywords 3D-structure; Acetylation; Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Histidine biosynthesis; Hydrolase; Ligase; Methionine biosynthesis; Multifunctional enzyme; NADP; Nucleotide-binding; One-carbon metabolism; Oxidoreductase; Phosphoprotein; Polymorphism; Purine biosynthesis; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J04031; AAA59574.1; -; mRNA EMBL AK312361; BAG35279.1; -; mRNA EMBL CH471061; EAW80857.1; -; Genomic_DNA EMBL BC001014; AAH01014.2; -; mRNA EMBL BC009806; AAH09806.1; -; mRNA EMBL BC050420; AAH50420.1; -; mRNA IPI IPI00218342; -; . PIR A31903; A31903; . RefSeq NP_005947.3; NM_005956.3; . UniGene Hs.652308; -; . PDB 1A4I; X-ray; 1.50 A; A/B=1-301 PDB 1DIA; X-ray; 2.20 A; A/B=1-306 PDB 1DIB; X-ray; 2.70 A; A/B=1-306 PDB 1DIG; X-ray; 2.20 A; A/B=1-306 PDBsum 1A4I; -; . PDBsum 1DIA; -; . PDBsum 1DIB; -; . PDBsum 1DIG; -; . ProteinModelPortal P11586; -; . SMR P11586; 2-296; 319-933; . IntAct P11586; 6; . MINT MINT-5000922; -; . STRING P11586; -; . PhosphoSite P11586; -; . SWISS-2DPAGE P11586; -; . REPRODUCTION-2DPAGE IPI00218342; -; . PRIDE P11586; -; . Ensembl ENST00000216605; ENSP00000216605; ENSG00000100714; . GeneID 4522; -; . KEGG hsa:4522; -; . UCSC uc001xhb.1; human; . CTD 4522; -; . GeneCards GC14P045027; -; . H-InvDB HIX0011731; -; . HGNC HGNC:7432; MTHFD1; . HPA HPA000704; -; . HPA HPA001290; -; . HPA HPA015006; -; . MIM 114500; phenotype; . MIM 172460; gene+phenotype; . MIM 601634; phenotype; . neXtProt NX_P11586; -; . Orphanet 3388; Neural tube defect; . PharmGKB PA31236; -; . eggNOG prNOG05153; -; . GeneTree ENSGT00600000084426; -; . HOVERGEN HBG004916; -; . InParanoid P11586; -; . OrthoDB EOG4GB75D; -; . PhylomeDB P11586; -; . BioCyc MetaCyc:MONOMER-11654; -; . BRENDA 6.3.4.3; 2681; . Reactome REACT_11193; Metabolism of vitamins and cofactors; . DrugBank DB00157; NADH; . DrugBank DB00116; Tetrahydrofolic acid; . NextBio 17468; -; . ArrayExpress P11586; -; . Bgee P11586; -; . CleanEx HS_MTHFD1; -; . Genevestigator P11586; -; . GermOnline ENSG00000100714; Homo sapiens; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0005739; C:mitochondrion; TAS:ProtInc; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:Reactome; . GO GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:Reactome; . GO GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC; . GO GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity; TAS:Reactome; . GO GO:0046655; P:folic acid metabolic process; TAS:Reactome; . GO GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro; . GO GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW; . GO GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW; . GO GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW; . GO GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW; . InterPro IPR000559; Formate_THF_ligase; . InterPro IPR020628; Formate_THF_ligase_CS; . InterPro IPR016040; NAD(P)-bd_dom; . InterPro IPR000672; THF_DH/CycHdrlase; . InterPro IPR020630; THF_DH/CycHdrlase_cat_dom; . InterPro IPR020867; THF_DH/CycHdrlase_CS; . InterPro IPR020631; THF_DH/CycHdrlase_NAD-bd_dom; . Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1; . Pfam PF01268; FTHFS; 1; . Pfam PF00763; THF_DHG_CYH; 1; . Pfam PF02882; THF_DHG_CYH_C; 1; . PRINTS PR00085; THFDHDRGNASE; . PROSITE PS00721; FTHFS_1; 1; . PROSITE PS00722; FTHFS_2; 1; . PROSITE PS00766; THF_DHG_CYH_1; 1; . PROSITE PS00767; THF_DHG_CYH_2; 1; . SWISS-2DPAGE (search AC)