General information about the entry |
View entry in simple text format |
Entry name | CD44_HUMAN |
Primary accession number | P16070 |
integrated into SWISS-2DPAGE on | September 1, 1997 (release 6) |
2D Annotations were last modified on | December 1, 2000 (version 2) |
General Annotations were last modified on | May 19, 2011 (version 10) |
Name and origin of the protein |
Description | RecName: Full=CD44 antigen; AltName: Full=CDw44; AltName: Full=Epican; AltName: Full=Extracellular matrix receptor III; Short=ECMR-III; AltName: Full=GP90 lymphocyte homing/adhesion receptor; AltName: Full=HUTCH-I; AltName: Full=Heparan sulfate proteoglycan; AltName: Full=Hermes antigen; AltName: Full=Hyaluronate receptor; AltName: Full=Phagocytic glycoprotein 1; Short=PGP-1; AltName: Full=Phagocytic glycoprotein I; Short=PGP-I; AltName: CD_antigen=CD44; Flags: Precursor;. |
Gene name | Name=CD44 Synonyms=LHR, MDU2, MDU3, MIC4
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Annotated species | Homo sapiens (Human) [TaxID: 9606] |
Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
References |
[1] |
MAPPING ON GEL MEDLINE=98163346; PubMed=9504818; [NCBI, Expasy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F. ''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';'' Electrophoresis 18(1):2842-2848(1997)
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[2] |
PROTEIN EXPRESSION MEDLINE=96024065; PubMed=7553660; [NCBI, Expasy, EBI, Israel, Japan]
Gunthert U., Stauder R., Mayer B., Terpe H.J., Finke L., Friedrichs K. ''''''Are CD44 variant isoforms involved in human tumour progression?'';'';'' Cancer Surv. 24(1):19-42(1995)
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[3] |
MAPPING ON GEL Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F. Submitted (JAN-1999) to SWISS-2DPAGE
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2D PAGE maps for identified proteins
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How to interpret a protein
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CEC_HUMAN {Colorectal epithelia cells} Homo sapiens (Human)
Tissue: Colon epithelium
map experimental info protein estimated location
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CEC_HUMAN
MAP LOCATIONS:
EXPRESSION: HAS BEEN OBSERVED AS A VERY EARLY EVENT IN THE PROGRESSION OF COLON CARCINOMA [2].
MAPPING (identification): IMMUNODETECTION [1].
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DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)} Homo sapiens (Human)
Tissue: Colon adenocarcinoma
map experimental info protein estimated location
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DLD1_HUMAN
MAP LOCATIONS:
MAPPING (identification): IMMUNOBLOTTING [3].
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Copyright |
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
Cross-references |
UniProtKB/Swiss-Prot | P16070; CD44_HUMAN. |
2D PAGE maps for identified proteins
|
- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
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External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 2011_10 |
Entry name | CD44_HUMAN |
Primary accession number | P16070 |
Secondary accession number(s) | A5YRN9 D3DR12 D3DR13 P22511 Q04858 Q13419 Q13957 Q13958 Q13959 Q13960 Q13961 Q13967 Q13968 Q13980 Q15861 Q16064 Q16065 Q16066 Q16208 Q16522 Q86T72 Q86Z27 Q8N694 Q92493 Q96J24 Q9H5A5 Q9UC28 Q9UC29 Q9UC30 Q9UCB0 Q9UJ36 |
Sequence was last modified on | October 5, 2010 (version 3) |
Annotations were last modified on | September 21, 2011 (version 152) |
Name and origin of the protein |
Description | RecName: Full=CD44 antigen; AltName: Full=CDw44; AltName: Full=Epican; AltName: Full=Extracellular matrix receptor III; Short=ECMR-III; AltName: Full=GP90 lymphocyte homing/adhesion receptor; AltName: Full=HUTCH-I; AltName: Full=Heparan sulfate proteoglycan; AltName: Full=Hermes antigen; AltName: Full=Hyaluronate receptor; AltName: Full=Phagocytic glycoprotein 1; Short=PGP-1; AltName: Full=Phagocytic glycoprotein I; Short=PGP-I; AltName: CD_antigen=CD44; Flags: Precursor; |
Gene name | Name=CD44 Synonyms=LHR, MDU2, MDU3, MIC4 |
Encoded on | Name=CD44; Synonyms=LHR, MDU2, MDU3, MIC4 |
Keywords | 3D-structure; Alternative splicing; Blood group antigen; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Proteoglycan; Pyrrolidone carboxylic acid; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Copyright |
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | M24915; AAA35674.1; -; mRNA |
EMBL | M59040; AAA51950.1; -; mRNA |
EMBL | X55150; CAA38951.1; -; mRNA |
EMBL | X56794; CAA40133.1; -; mRNA |
EMBL | X66733; CAA47271.1; -; mRNA |
EMBL | L05423; AAB13622.1; -; Genomic_DNA |
EMBL | L05407; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05409; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13622.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13622.1; JOINED; Genomic_DNA |
EMBL | L05423; AAB13623.1; -; Genomic_DNA |
EMBL | L05407; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05411; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05412; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05414; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05415; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05416; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05417; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05418; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05419; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13623.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13623.1; JOINED; Genomic_DNA |
EMBL | L05424; AAB13624.1; -; Genomic_DNA |
EMBL | L05407; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13624.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13624.1; JOINED; Genomic_DNA |
EMBL | L05424; AAB13625.1; -; Genomic_DNA |
EMBL | L05407; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05411; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05412; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05414; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05416; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05417; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05418; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05419; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13625.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13625.1; JOINED; Genomic_DNA |
EMBL | L05424; AAB13626.1; -; Genomic_DNA |
EMBL | L05407; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05411; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05412; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05414; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05416; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05417; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05418; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05419; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13626.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13626.1; JOINED; Genomic_DNA |
EMBL | L05424; AAB13627.1; -; Genomic_DNA |
EMBL | L05407; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05417; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05418; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13627.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13627.1; JOINED; Genomic_DNA |
EMBL | L05424; AAB13628.1; -; Genomic_DNA |
EMBL | L05407; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05408; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05410; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05411; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05412; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05414; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05415; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05416; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05417; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05418; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05419; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05420; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05421; AAB13628.1; JOINED; Genomic_DNA |
EMBL | L05422; AAB13628.1; JOINED; Genomic_DNA |
EMBL | M69215; AAB13628.1; JOINED; Genomic_DNA |
EMBL | AJ251595; CAB61878.1; -; mRNA |
EMBL | S66400; AAB27917.1; -; mRNA |
EMBL | S66400; AAB27918.2; -; mRNA |
EMBL | S66400; AAB27919.1; -; mRNA |
EMBL | U40373; AAA82949.1; -; mRNA |
EMBL | AY101192; AAM50040.1; -; mRNA |
EMBL | AY101193; AAM50041.1; -; mRNA |
EMBL | EF581837; ABQ59315.1; -; mRNA |
EMBL | AL832642; CAD89965.1; -; mRNA |
EMBL | AL133330; CAC10347.1; -; Genomic_DNA |
EMBL | AL136989; -; NOT_ANNOTATED_CDS; Genomic_DNA |
EMBL | AL356215; -; NOT_ANNOTATED_CDS; Genomic_DNA |
EMBL | CH471064; EAW68147.1; -; Genomic_DNA |
EMBL | CH471064; EAW68148.1; -; Genomic_DNA |
EMBL | CH471064; EAW68149.1; -; Genomic_DNA |
EMBL | CH471064; EAW68151.1; -; Genomic_DNA |
EMBL | BC004372; AAH04372.1; -; mRNA |
EMBL | BC067348; AAH67348.1; -; mRNA |
EMBL | M25078; AAA36138.1; -; mRNA |
EMBL | X55938; CAA39404.1; -; mRNA |
EMBL | S72928; AAB30429.1; -; Genomic_DNA |
EMBL | X62739; CAA44602.1; -; mRNA |
IPI | IPI00220678; -; . |
IPI | IPI00297160; -; . |
IPI | IPI00305064; -; . |
IPI | IPI00418465; -; . |
IPI | IPI00419219; -; . |
IPI | IPI00827555; -; . |
IPI | IPI00827650; -; . |
IPI | IPI00827795; -; . |
IPI | IPI00827893; -; . |
IPI | IPI00827937; -; . |
IPI | IPI00827982; -; . |
IPI | IPI00828056; -; . |
IPI | IPI00828064; -; . |
IPI | IPI00828108; -; . |
IPI | IPI00828192; -; . |
IPI | IPI00956122; -; . |
IPI | IPI00984539; -; . |
PIR | A47195; A47195; . |
PIR | I37369; I37369; . |
PIR | I77371; I77371; . |
PIR | I77372; I77372; . |
PIR | JH0417; JH0417; . |
PIR | JH0518; JH0518; . |
PIR | S13530; S13530; . |
PIR | S24222; S24222; . |
RefSeq | NP_000601.3; NM_000610.3; . |
RefSeq | NP_001001389.1; NM_001001389.1; . |
RefSeq | NP_001001390.1; NM_001001390.1; . |
RefSeq | NP_001001391.1; NM_001001391.1; . |
RefSeq | NP_001001392.1; NM_001001392.1; . |
RefSeq | NP_001189484.1; NM_001202555.1; . |
RefSeq | NP_001189485.1; NM_001202556.1; . |
RefSeq | NP_001189486.1; NM_001202557.1; . |
UniGene | Hs.502328; -; . |
PDB | 1POZ; NMR; -; A=20-178 |
PDB | 1UUH; X-ray; 2.20 A; A/B=20-178 |
PDB | 2I83; NMR; -; A=20-178 |
PDBsum | 1POZ; -; . |
PDBsum | 1UUH; -; . |
PDBsum | 2I83; -; . |
ProteinModelPortal | P16070; -; . |
SMR | P16070; 20-178; . |
DIP | DIP-1121N; -; . |
IntAct | P16070; 10; . |
STRING | P16070; -; . |
PhosphoSite | P16070; -; . |
SWISS-2DPAGE | P16070; -; . |
PRIDE | P16070; -; . |
Ensembl | ENST00000278385; ENSP00000278385; ENSG00000026508; . |
GeneID | 960; -; . |
KEGG | hsa:960; -; . |
UCSC | uc001mwc.2; human; . |
CTD | 960; -; . |
GeneCards | GC11P034858; -; . |
HGNC | HGNC:1681; CD44; . |
HPA | CAB000112; -; . |
HPA | CAB000316; -; . |
HPA | HPA005785; -; . |
MIM | 107269; gene; . |
MIM | 172290; gene; . |
MIM | 609027; phenotype; . |
neXtProt | NX_P16070; -; . |
eggNOG | prNOG17304; -; . |
HOVERGEN | HBG003850; -; . |
InParanoid | P16070; -; . |
OMA | EDCTSVT; -; . |
Pathway_Interaction_DB | avb3_opn_pathway; Osteopontin-mediated events; . |
Pathway_Interaction_DB | a4b1_paxindep_pathway; Paxillin-independent events mediated by a4b1 and a4b7; . |
Reactome | REACT_6900; Immune System; . |
DrugBank | DB00070; Hyaluronidase; . |
NextBio | 4000; -; . |
ArrayExpress | P16070; -; . |
Bgee | P16070; -; . |
Genevestigator | P16070; -; . |
GermOnline | ENSG00000026508; Homo sapiens; . |
GO | GO:0009986; C:cell surface; IDA:BHF-UCL; . |
GO | GO:0005794; C:Golgi apparatus; IDA:HPA; . |
GO | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB; . |
GO | GO:0005518; F:collagen binding; NAS:UniProtKB; . |
GO | GO:0005540; F:hyaluronic acid binding; NAS:UniProtKB; . |
GO | GO:0004872; F:receptor activity; IEA:UniProtKB-KW; . |
GO | GO:0016337; P:cell-cell adhesion; NAS:UniProtKB; . |
GO | GO:0007160; P:cell-matrix adhesion; NAS:UniProtKB; . |
GO | GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome; . |
GO | GO:0043066; P:negative regulation of apoptosis; IDA:BHF-UCL; . |
GO | GO:0043518; P:negative regulation of DNA damage response; signal transduction by p53 class mediator; IDA:BHF-UCL |
GO | GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; . |
GO | GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL; . |
GO | GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL; . |
InterPro | IPR016186; C-type_lectin-like; . |
InterPro | IPR016187; C-type_lectin_fold; . |
InterPro | IPR001231; CD44_antigen; . |
InterPro | IPR000538; Link; . |
Gene3D | G3DSA:3.10.100.10; C-type_lectin-like; 1; . |
Pfam | PF00193; Xlink; 1; . |
PRINTS | PR00658; CD44; . |
PRINTS | PR01265; LINKMODULE; . |
SMART | SM00445; LINK; 1; . |
SUPFAM | SSF56436; C-type_lectin_fold; 1; . |
PROSITE | PS01241; LINK_1; 1; . |
PROSITE | PS50963; LINK_2; 1; . |