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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P16219




SWISS-2DPAGE:  P16219


P16219


General information about the entry
View entry in simple text format
Entry nameACADS_HUMAN
Primary accession numberP16219
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 3)
General Annotations were last modified on November 9, 2011 (version 12)
Name and origin of the protein
DescriptionRecName: Full=Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SCAD; EC=1.3.8.1; AltName: Full=Butyryl-CoA dehydrogenase; Flags: Precursor;.
Gene nameName=ACADS
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=97295305; PubMed=9150947; [NCBI, ExPASy, EBI, Israel, Japan]
Sarto C., Marocchi A., Sanchez J.-C., Giannone D., Frutiger S., Golaz O., Wilkins M.R., Doro G., Cappellano F., Hughes G.J., Hochstrasser D.F., Mocarelli P.
''''''Renal cell carcinoma and normal kidney protein expression'';'';''
Electrophoresis 18(1):599-604(1997)
[4]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
Comments
  • SUBUNIT: HOMOTETRAMER
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=6.32; Mw=37524

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [4].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.50; Mw=38000

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



KIDNEY_HUMAN {Kidney}
Homo sapiens (Human)
Tissue: Kidney
KIDNEY_HUMAN
  map experimental info
  protein estimated location
 
KIDNEY_HUMAN

MAP LOCATIONS:
pI=6.41; Mw=37376

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [3].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.38; Mw=38095

PATHOLOGICAL LEVEL:
DECREASED DURING ACUTE ACIDOSIS AND LIPID-STORAGE MYOPATHY.

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP16219; P16219.
DOSAC-COBS-2DPAGEP16219; ACADS_HUMAN.
UCD-2DPAGEP16219; ACADS_HUMAN.
UniProtKB/Swiss-ProtP16219; ACADS_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameACADS_HUMAN
Primary accession numberP16219
Secondary accession number(s) P78331
Sequence was last modified on April 1, 1990 (version 1)
Annotations were last modified on October 19, 2011 (version 140)
Name and origin of the protein
DescriptionRecName: Full=Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short=SCAD; EC=1.3.8.1; AltName: Full=Butyryl-CoA dehydrogenase; Flags: Precursor;
Gene nameName=ACADS
Encoded onName=ACADS
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM26393; AAA60307.1; -; mRNA
EMBLZ80345; CAB02492.1; -; Genomic_DNA
EMBLZ80347; CAB02492.1; JOINED; Genomic_DNA
EMBLU83992; AAD00552.1; -; Genomic_DNA
EMBLU83991; AAD00552.1; JOINED; Genomic_DNA
EMBLBC025963; AAH25963.1; -; mRNA
IPIIPI00027701; -; .
PIRA30605; A30605; .
RefSeqNP_000008.1; NM_000017.2; .
UniGeneHs.507076; -; .
PDB2VIG; X-ray; 1.90 A; A/B/C/D/E/F/G/H=30-412
PDBsum2VIG; -; .
ProteinModelPortalP16219; -; .
SMRP16219; 34-412; .
STRINGP16219; -; .
PhosphoSiteP16219; -; .
SWISS-2DPAGEP16219; -; .
DOSAC-COBS-2DPAGEP16219; -; .
UCD-2DPAGEP16219; -; .
PeptideAtlasP16219; -; .
PRIDEP16219; -; .
EnsemblENST00000242592; ENSP00000242592; ENSG00000122971; .
GeneID35; -; .
KEGGhsa:35; -; .
NMPDRfig|9606.3.peg.8377; -; .
UCSCuc001tza.2; human; .
CTD35; -; .
GeneCardsGC12P118172; -; .
H-InvDBHIX0011071; -; .
HGNCHGNC:90; ACADS; .
HPACAB019284; -; .
HPAHPA004799; -; .
HPAHPA022271; -; .
MIM201470; phenotype; .
MIM606885; gene; .
neXtProtNX_P16219; -; .
Orphanet26792; Deficiency of short chain acyl-CoA dehydrogenase; .
PharmGKBPA24426; -; .
eggNOGprNOG10082; -; .
GeneTreeENSGT00590000082821; -; .
HOGENOMHBG699365; -; .
HOVERGENHBG000224; -; .
InParanoidP16219; -; .
OMADYLAYSI; -; .
OrthoDBEOG4ZPDVH; -; .
PhylomeDBP16219; -; .
ReactomeREACT_22258; Metabolism of lipids and lipoproteins; .
DrugBankDB00157; NADH; .
NextBio135; -; .
ArrayExpressP16219; -; .
BgeeP16219; -; .
CleanExHS_ACADS; -; .
GenevestigatorP16219; -; .
GermOnlineENSG00000122971; Homo sapiens; .
GOGO:0005759; C:mitochondrial matrix; TAS:Reactome; .
InterProIPR006089; Acyl-CoA_DH_CS; .
InterProIPR006092; Acyl-CoA_DH_N; .
InterProIPR006090; Acyl-CoA_Oxase/DH_1; .
InterProIPR006091; Acyl-CoA_Oxase/DH_cen-dom; .
InterProIPR009075; AcylCo_DH/oxidase_C; .
InterProIPR013786; AcylCoA_DH/ox_N; .
InterProIPR009100; AcylCoA_DH/oxidase; .
Gene3DG3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1; .
Gene3DG3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1; .
Gene3DG3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1; .
PfamPF00441; Acyl-CoA_dh_1; 1; .
PfamPF02770; Acyl-CoA_dh_M; 1; .
PfamPF02771; Acyl-CoA_dh_N; 1; .
SUPFAMSSF56645; AcylCoA_dehyd_NM; 1; .
SUPFAMSSF47203; AcylCoADH_C_like; 1; .
PROSITEPS00072; ACYL_COA_DH_1; 1; .
PROSITEPS00073; ACYL_COA_DH_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server