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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P30041




SWISS-2DPAGE:  P30041


P30041


General information about the entry
View entry in simple text format
Entry namePRDX6_HUMAN
Primary accession numberP30041
Secondary accession number(s) P32077
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 3)
General Annotations were last modified on November 9, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=24 kDa protein; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Liver 2D page spot 40; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Red blood cells page spot 12;.
Gene nameName=PRDX6
Synonyms=AOP2, KIAA0106
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
Tonella L., Hoogland C., Appel R.D., Sanchez J.-C., Hochstrasser D.F.
Submitted (JUL-1997) to SWISS-2DPAGE
[4]   MAPPING ON GEL
MEDLINE=96314065; PubMed=8740185; [NCBI, ExPASy, EBI, Israel, Japan]
Lutomski D., Caron M., Cornillot J.D., Bourin P., Dupuy C., Pontet M., Bladier D., Joubert-Caron R.
''''''Identification of different galectins by immunoblotting after two- dimensional polyacrylamide get electrophoresis with immobilized pH gradients'';'';''
Electrophoresis 17(1):600-606(1996)
[5]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[6]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, ExPASy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[7]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=6.17; Mw=25202

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [5].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.28; Mw=25861

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



HL60_HUMAN {Promyelocytic leukemia cells}
Homo sapiens (Human)
Tissue: Promyelocytic leukemia
HL60_HUMAN
  map experimental info
  protein estimated location
 
HL60_HUMAN

MAP LOCATIONS:
pI=6.35; Mw=23368

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [3][4].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.27; Mw=25710

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=6.73; Mw=25482  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [7].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=6.26; Mw=25930

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=6.45; Mw=25743

MAPPING (identification):
MICROSEQUENCING [6].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=6.27; Mw=25748

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP30041; P30041.
DOSAC-COBS-2DPAGEP30041; PRDX6_HUMAN.
OGP-WWWP30041.
REPRODUCTION-2DPAGEIPI00220301; IPI00220301.
REPRODUCTION-2DPAGEP30041; P30041.
Siena-2DPAGEP30041; PRDX6_HUMAN.
UniProtKB/Swiss-ProtP30041; PRDX6_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePRDX6_HUMAN
Primary accession numberP30041
Secondary accession number(s) A8JZY7 P32077 Q5TAH4 Q5ZEZ8
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 130)
Name and origin of the protein
DescriptionRecName: Full=Peroxiredoxin-6; EC=1.11.1.15; AltName: Full=1-Cys peroxiredoxin; Short=1-Cys PRX; AltName: Full=24 kDa protein; AltName: Full=Acidic calcium-independent phospholipase A2; Short=aiPLA2; EC=3.1.1.-; AltName: Full=Antioxidant protein 2; AltName: Full=Liver 2D page spot 40; AltName: Full=Non-selenium glutathione peroxidase; Short=NSGPx; EC=1.11.1.9; AltName: Full=Red blood cells page spot 12;
Gene nameName=PRDX6
Synonyms=AOP2, KIAA0106
Encoded onName=PRDX6; Synonyms=AOP2, KIAA0106
Keywords3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD14662; BAA03496.1; -; mRNA
EMBLDQ230990; ABB02185.1; -; Genomic_DNA
EMBLAL139142; CAI20936.1; -; Genomic_DNA
EMBLAK289352; BAF82041.1; -; mRNA
EMBLCH471067; EAW90944.1; -; Genomic_DNA
EMBLBC035857; AAH35857.1; -; mRNA
EMBLBC053550; AAH53550.1; -; mRNA
EMBLAJ844621; CAH59743.1; -; mRNA
IPIIPI00220301; -; .
RefSeqNP_004896.1; NM_004905.2; .
UniGeneHs.120; -; .
PDB1PRX; X-ray; 2.00 A; A/B=1-224
PDBsum1PRX; -; .
ProteinModelPortalP30041; -; .
SMRP30041; 5-224; .
IntActP30041; 8; .
STRINGP30041; -; .
PeroxiBase4426; Hs1CysPrx01; .
PhosphoSiteP30041; -; .
SWISS-2DPAGEP30041; -; .
Cornea-2DPAGEP30041; -; .
DOSAC-COBS-2DPAGEP30041; -; .
OGPP30041; -; .
REPRODUCTION-2DPAGEIPI00220301; -; .
REPRODUCTION-2DPAGEP30041; -; .
Siena-2DPAGEP30041; -; .
PeptideAtlasP30041; -; .
PRIDEP30041; -; .
EnsemblENST00000340385; ENSP00000342026; ENSG00000117592; .
GeneID9588; -; .
KEGGhsa:9588; -; .
UCSCuc001giy.1; human; .
CTD9588; -; .
GeneCardsGC01P144671; -; .
H-InvDBHIX0001339; -; .
H-InvDBHIX0028696; -; .
HGNCHGNC:16753; PRDX6; .
HPACAB008663; -; .
HPAHPA006983; -; .
MIM602316; gene; .
neXtProtNX_P30041; -; .
PharmGKBPA134992760; -; .
eggNOGprNOG12211; -; .
GeneTreeENSGT00550000074794; -; .
HOGENOMHBG493509; -; .
HOVERGENHBG105234; -; .
InParanoidP30041; -; .
OMANYPILAD; -; .
OrthoDBEOG4M399H; -; .
PhylomeDBP30041; -; .
BRENDA1.11.1.15; 2681; .
NextBio35979; -; .
ArrayExpressP30041; -; .
BgeeP30041; -; .
CleanExHS_PRDX6; -; .
GenevestigatorP30041; -; .
GermOnlineENSG00000117592; Homo sapiens; .
GOGO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell; .
GOGO:0005829; C:cytosol; NAS:UniProtKB; .
GOGO:0005764; C:lysosome; IEA:UniProtKB-SubCell; .
GOGO:0051920; F:peroxiredoxin activity; IEA:EC; .
GOGO:0004623; F:phospholipase A2 activity; IDA:UniProtKB; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0009395; P:phospholipid catabolic process; IDA:UniProtKB; .
InterProIPR000866; AhpC/TSA; .
InterProIPR024706; Peroxiredoxin_AhpC-typ; .
InterProIPR019479; Peroxiredoxin_C; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PfamPF10417; 1-cysPrx_C; 1; .
PfamPF00578; AhpC-TSA; 1; .
PIRSFPIRSF000239; AHPC; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS51352; THIOREDOXIN_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server