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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P30048




SWISS-2DPAGE:  P30048


P30048


General information about the entry
View entry in simple text format
Entry namePRDX3_HUMAN
Primary accession numberP30048
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 4)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin-dependent peroxide reductase, mitochondrial; EC=1.11.1.15; AltName: Full=Antioxidant protein 1; Short=AOP-1; AltName: Full=HBC189; AltName: Full=Peroxiredoxin III; Short=Prx-III; AltName: Full=Peroxiredoxin-3; AltName: Full=Protein MER5 homolog; Flags: Precursor;.
Gene nameName=PRDX3
Synonyms=AOP1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, Expasy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=94147970; PubMed=8313871; [NCBI, Expasy, EBI, Israel, Japan]
Golaz O., Hughes G.J., Frutiger S., Paquet N., Bairoch A., Pasquali C., Sanchez J.-C., Tissot J.-D., Appel R.D., Walzer C., Balant L.P., Hochstrasser D.F.
''''''Plasma and red blood cell protein maps: update 1993'';'';''
Electrophoresis 14(1):1223-1231(1993)
[4]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, Expasy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
[5]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[6]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=6.07; Mw=22917

MAPPING (identification):
MICROSEQUENCING [4].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.95; Mw=23034

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [5].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=6.02; Mw=24216

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.02; Mw=23541

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=6.44; Mw=23198  [identification data]

MAPPING (identification):
MALDI tandem mass spectrometry [6].



RBC_HUMAN {Red blood cells}
Homo sapiens (Human)
Tissue: Erythrocyte
RBC_HUMAN
  map experimental info
  protein estimated location
 
RBC_HUMAN

MAP LOCATIONS:
pI=5.41; Mw=21321

MAPPING (identification):
INTERNAL SEQUENCE [3].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=6.02; Mw=23591

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
OGP-WWWP30048.
Siena-2DPAGEP30048; PRDX3_HUMAN.
UCD-2DPAGEP30048; PRDX3_HUMAN.
UniProtKB/Swiss-ProtP30048; PRDX3_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePRDX3_HUMAN
Primary accession numberP30048
Secondary accession number(s) B2R7Z0 D3DRC9 P35690 Q0D2H1 Q13776 Q5T5V2 Q96HK4
Sequence was last modified on November 1, 1997 (version 3)
Annotations were last modified on October 19, 2011 (version 144)
Name and origin of the protein
DescriptionRecName: Full=Thioredoxin-dependent peroxide reductase, mitochondrial; EC=1.11.1.15; AltName: Full=Antioxidant protein 1; Short=AOP-1; AltName: Full=HBC189; AltName: Full=Peroxiredoxin III; Short=Prx-III; AltName: Full=Peroxiredoxin-3; AltName: Full=Protein MER5 homolog; Flags: Precursor;
Gene nameName=PRDX3
Synonyms=AOP1
Encoded onName=PRDX3; Synonyms=AOP1
KeywordsAcetylation; Antioxidant; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Oxidoreductase; Peroxidase; Polymorphism; Redox-active center; Reference proteome; Transit peptide.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLD49396; BAA08389.1; -; mRNA
EMBLAK313169; BAG35987.1; -; mRNA
EMBLCR450344; CAG29340.1; -; mRNA
EMBLBT020007; AAV38810.1; -; mRNA
EMBLDQ298752; ABB84468.1; -; Genomic_DNA
EMBLAL355861; CAI15802.1; -; Genomic_DNA
EMBLCH471066; EAW49399.1; -; Genomic_DNA
EMBLBC002685; AAH02685.1; -; mRNA
EMBLBC007062; AAH07062.1; -; mRNA
EMBLBC008435; AAH08435.1; -; mRNA
EMBLBC009601; AAH09601.1; -; mRNA
EMBLBC021691; AAH21691.1; -; mRNA
EMBLBC022373; AAH22373.1; -; mRNA
EMBLBC059169; AAH59169.1; -; mRNA
EMBLBC111397; AAI11398.1; -; mRNA
IPIIPI00024919; -; .
RefSeqNP_006784.1; NM_006793.2; .
RefSeqNP_054817.2; NM_014098.2; .
UniGeneHs.523302; -; .
ProteinModelPortalP30048; -; .
SMRP30048; 63-223; .
IntActP30048; 25; .
STRINGP30048; -; .
PeroxiBase4492; Hs2CysPrx03; .
PhosphoSiteP30048; -; .
SWISS-2DPAGEP30048; -; .
OGPP30048; -; .
Siena-2DPAGEP30048; -; .
UCD-2DPAGEP30048; -; .
PeptideAtlasP30048; -; .
PRIDEP30048; -; .
EnsemblENST00000298510; ENSP00000298510; ENSG00000165672; .
GeneID10935; -; .
KEGGhsa:10935; -; .
NMPDRfig|9606.3.peg.4727; -; .
UCSCuc001lec.1; human; .
CTD10935; -; .
GeneCardsGC10M114556; -; .
H-InvDBHIX0009251; -; .
HGNCHGNC:9354; PRDX3; .
HPACAB008656; -; .
MIM604769; gene; .
neXtProtNX_P30048; -; .
PharmGKBPA33724; -; .
eggNOGprNOG14139; -; .
HOVERGENHBG000286; -; .
InParanoidP30048; -; .
OMAANPDEVC; -; .
OrthoDBEOG4S7JQS; -; .
PhylomeDBP30048; -; .
NextBio41537; -; .
ArrayExpressP30048; -; .
BgeeP30048; -; .
CleanExHS_PRDX3; -; .
GenevestigatorP30048; -; .
GermOnlineENSG00000165672; Homo sapiens; .
GOGO:0005769; C:early endosome; IDA:UniProtKB; .
GOGO:0005739; C:mitochondrion; IDA:UniProtKB; .
GOGO:0008785; F:alkyl hydroperoxide reductase activity; NAS:UniProtKB; .
GOGO:0043027; F:caspase inhibitor activity; IMP:UniProtKB; .
GOGO:0004601; F:peroxidase activity; IEA:UniProtKB-KW; .
GOGO:0051920; F:peroxiredoxin activity; IEA:EC; .
GOGO:0008022; F:protein C-terminus binding; IPI:UniProtKB; .
GOGO:0019901; F:protein kinase binding; IPI:UniProtKB; .
GOGO:0042744; P:hydrogen peroxide catabolic process; IMP:UniProtKB; .
GOGO:0007005; P:mitochondrion organization; IMP:UniProtKB; .
GOGO:0030099; P:myeloid cell differentiation; ISS:UniProtKB; .
GOGO:0033673; P:negative regulation of kinase activity; IDA:UniProtKB; .
GOGO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB; .
GOGO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB; .
GOGO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB; .
GOGO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB; .
InterProIPR000866; AhpC/TSA; .
InterProIPR024706; Peroxiredoxin_AhpC-typ; .
InterProIPR019479; Peroxiredoxin_C; .
InterProIPR012336; Thioredoxin-like_fold; .
Gene3DG3DSA:3.40.30.10; Thioredoxin_fold; 1; .
PfamPF10417; 1-cysPrx_C; 1; .
PfamPF00578; AhpC-TSA; 1; .
PIRSFPIRSF000239; AHPC; 1; .
SUPFAMSSF52833; Thiordxn-like_fd; 1; .
PROSITEPS51352; THIOREDOXIN_2; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server