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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P30085




SWISS-2DPAGE:  P30085


P30085


General information about the entry
View entry in simple text format
Entry nameKCY_HUMAN
Primary accession numberP30085
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMarch 31, 2004 (version 2)
General Annotations were last modified on May 19, 2011 (version 16)
Name and origin of the protein
DescriptionRecName: Full=UMP-CMP kinase; EC=2.7.4.14; AltName: Full=Cytidine monophosphate kinase; AltName: Full=Cytidylate kinase; AltName: Full=Deoxycytidylate kinase; AltName: Full=Uridine monophosphate kinase; AltName: Full=Uridine monophosphate/cytidine monophosphate kinase; Short=UMP/CMP kinase; Short=UMP/CMPK;.
Gene nameName=CMPK1
Synonyms=CMK, CMPK, UCK, UMK, UMPK
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=98163346; PubMed=9504818; [NCBI, ExPASy, EBI, Israel, Japan]
Reymond M.A., Sanchez J.-C., Hughes G.J., Riese J., Tortola S., Peinado M.A., Kirchner T., Hohenberger W., Hochstrasser D.F., Kockerling F.
''''''Standardized characterization of gene expression in human colorectal epithelium by two-dimensional electrophoresis'';'';''
Electrophoresis 18(1):2842-2848(1997)
2D PAGE maps for identified proteins
How to interpret a protein

CEC_HUMAN {Colorectal epithelia cells}
Homo sapiens (Human)
Tissue: Colon epithelium
CEC_HUMAN
  map experimental info
  protein estimated location
 
CEC_HUMAN

MAP LOCATIONS:
pI=5.42; Mw=21422

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL AND MICROSEQUENCING [3].



ELC_HUMAN {Erythroleukemia Cell}
Homo sapiens (Human)
Tissue: Erythroleukemia
ELC_HUMAN
  map experimental info
  protein estimated location
 
ELC_HUMAN

MAP LOCATIONS:
pI=5.42; Mw=21616

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.41; Mw=21859

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.37; Mw=21816

MAPPING (identification):
MICROSEQUENCING [1].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=5.43; Mw=21387

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=5.41; Mw=21450

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
OGP-WWWP30085.
Siena-2DPAGEP30085; KCY_HUMAN.
UniProtKB/Swiss-ProtP30085; KCY_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameKCY_HUMAN
Primary accession numberP30085
Secondary accession number(s) Q53GB7 Q5SVZ0 Q96C07 Q9UBQ8 Q9UIA2
Sequence was last modified on December 1, 2000 (version 3)
Annotations were last modified on October 19, 2011 (version 123)
Name and origin of the protein
DescriptionRecName: Full=UMP-CMP kinase; EC=2.7.4.14; AltName: Full=Cytidine monophosphate kinase; AltName: Full=Cytidylate kinase; AltName: Full=Deoxycytidylate kinase; AltName: Full=Uridine monophosphate kinase; AltName: Full=Uridine monophosphate/cytidine monophosphate kinase; Short=UMP/CMP kinase; Short=UMP/CMPK;
Gene nameName=CMPK1
Synonyms=CMK, CMPK, UCK, UMK, UMPK
Encoded onName=CMPK1; Synonyms=CMK, CMPK, UCK, UMK, UMPK
Keywords3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Pyrimidine biosynthesis; Reference proteome; Transferase.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLAF070416; AAF17709.1; ALT_INIT; mRNA
EMBLAF259961; AAG22609.1; -; mRNA
EMBLAF110643; AAD48583.1; -; mRNA
EMBLAF087865; AAP97174.1; -; mRNA
EMBLAF112216; AAF17204.1; -; mRNA
EMBLAK223014; BAD96734.1; ALT_INIT; mRNA
EMBLAL513322; CAI13471.1; ALT_SEQ; Genomic_DNA
EMBLAL607122; CAI13471.1; JOINED; Genomic_DNA
EMBLAL607122; CAI14972.1; ALT_SEQ; Genomic_DNA
EMBLAL513322; CAI14972.1; JOINED; Genomic_DNA
EMBLBC014961; AAH14961.1; ALT_INIT; mRNA
IPIIPI00219953; -; .
PIRB45482; B45482; .
RefSeqNP_001129612.1; NM_001136140.1; .
RefSeqNP_057392.1; NM_016308.2; .
UniGeneHs.727554; -; .
PDB1TEV; X-ray; 2.10 A; A=1-196
PDBsum1TEV; -; .
ProteinModelPortalP30085; -; .
SMRP30085; 3-196; .
MINTMINT-5000978; -; .
STRINGP30085; -; .
PhosphoSiteP30085; -; .
SWISS-2DPAGEP30085; -; .
OGPP30085; -; .
Siena-2DPAGEP30085; -; .
PRIDEP30085; -; .
EnsemblENST00000371873; ENSP00000360939; ENSG00000162368; .
GeneID51727; -; .
KEGGhsa:51727; -; .
UCSCuc001cri.1; human; .
CTD51727; -; .
HGNCHGNC:18170; CMPK1; .
MIM191710; gene; .
neXtProtNX_P30085; -; .
eggNOGprNOG09408; -; .
GeneTreeENSGT00390000016215; -; .
HOVERGENHBG108060; -; .
InParanoidP30085; -; .
BioCycMetaCyc:HS08663-MONOMER; -; .
BRENDA2.7.4.14; 2681; .
ReactomeREACT_1698; Metabolism of nucleotides; .
DrugBankDB00441; Gemcitabine; .
NextBio55784; -; .
ArrayExpressP30085; -; .
BgeeP30085; -; .
CleanExHS_CMPK1; -; .
GenevestigatorP30085; -; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005634; C:nucleus; TAS:ProtInc; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004127; F:cytidylate kinase activity; IEA:EC; .
GOGO:0016776; F:phosphotransferase activity; phosphate group as acceptor; IEA:InterPro
GOGO:0004849; F:uridine kinase activity; TAS:ProtInc; .
GOGO:0015949; P:nucleobase-containing small molecule interconversion; TAS:Reactome; .
InterProIPR000850; Adenylate_kin; .
InterProIPR006266; UMP_CMP_kinase; .
PANTHERPTHR23359; Adenylate_kin; 1; .
PfamPF00406; ADK; 1; .
PRINTSPR00094; ADENYLTKNASE; .
TIGRFAMsTIGR01359; UMP_CMP_kin_fam; 1; .
PROSITEPS00113; ADENYLATE_KINASE; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server