resource logo

SWISS-2DPAGE

Attention: World-2DPAGE is no longer maintained.


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P38936




SWISS-2DPAGE:  P38936


P38936


General information about the entry
View entry in simple text format
Entry nameCDN1A_HUMAN
Primary accession numberP38936
integrated into SWISS-2DPAGE on September 1, 1997 (release 6)
2D Annotations were last modified onMay 15, 2003 (version 1)
General Annotations were last modified on May 19, 2011 (version 14)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase inhibitor 1; AltName: Full=CDK-interacting protein 1; AltName: Full=Melanoma differentiation-associated protein 6; Short=MDA-6; AltName: Full=p21;.
Gene nameName=CDKN1A
Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=97295311; PubMed=9150953; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F.
''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';''
Electrophoresis 18(1):638-641(1997)
2D PAGE maps for identified proteins
How to interpret a protein

HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=7.92; Mw=19736
pI=7.02; Mw=19432

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
UniProtKB/Swiss-ProtP38936; CDN1A_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCDN1A_HUMAN
Primary accession numberP38936
Secondary accession number(s) Q14010 Q9BUT4
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on October 19, 2011 (version 135)
Name and origin of the protein
DescriptionRecName: Full=Cyclin-dependent kinase inhibitor 1; AltName: Full=CDK-interacting protein 1; AltName: Full=Melanoma differentiation-associated protein 6; Short=MDA-6; AltName: Full=p21;
Gene nameName=CDKN1A
Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Encoded onName=CDKN1A; Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Keywords3D-structure; Acetylation; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Protein kinase inhibitor; Reference proteome; Ubl conjugation; Zinc; Zinc-finger.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL25610; AAA16109.1; -; mRNA
EMBLS67388; AAB29246.1; -; mRNA
EMBLU09579; AAA85641.1; -; mRNA
EMBLU03106; AAC04313.1; -; mRNA
EMBLL26165; AAA19811.1; -; mRNA
EMBLL47232; AAB59559.1; ALT_INIT; mRNA
EMBLL47233; AAB59560.1; ALT_INIT; mRNA
EMBLAF497972; AAM11787.1; -; Genomic_DNA
EMBLZ85996; CAB06656.1; -; Genomic_DNA
EMBLBC000275; AAH00275.1; -; mRNA
EMBLBC000312; AAH00312.1; -; mRNA
EMBLBC001935; AAH01935.1; -; mRNA
EMBLBC013967; AAH13967.1; -; mRNA
IPIIPI00009384; -; .
PIRI54380; I54380; .
PIRI68674; I68674; .
RefSeqNP_000380.1; NM_000389.4; .
RefSeqNP_001207706.1; NM_001220777.1; .
RefSeqNP_001207707.1; NM_001220778.1; .
RefSeqNP_510867.1; NM_078467.2; .
UniGeneHs.370771; -; .
PDB1AXC; X-ray; 2.60 A; B/D/F=139-160
PDB2ZVV; X-ray; 2.00 A; X/Y=139-160
PDB2ZVW; X-ray; 2.50 A; I/J/K/L/M/N/O/P=139-160
PDBsum1AXC; -; .
PDBsum2ZVV; -; .
PDBsum2ZVW; -; .
ProteinModelPortalP38936; -; .
SMRP38936; 14-79; .
DisProtDP00016; -; .
DIPDIP-246N; -; .
DIPDIP-458N; -; .
IntActP38936; 34; .
MINTMINT-104203; -; .
STRINGP38936; -; .
PhosphoSiteP38936; -; .
SWISS-2DPAGEP38936; -; .
PRIDEP38936; -; .
EnsemblENST00000244741; ENSP00000244741; ENSG00000124762; .
EnsemblENST00000373711; ENSP00000362815; ENSG00000124762; .
EnsemblENST00000405375; ENSP00000384849; ENSG00000124762; .
EnsemblENST00000448526; ENSP00000409259; ENSG00000124762; .
GeneID1026; -; .
KEGGhsa:1026; -; .
UCSCuc003omm.2; human; .
CTD1026; -; .
GeneCardsGC06P036364; -; .
H-InvDBHIX0200868; -; .
HGNCHGNC:1784; CDKN1A; .
HPACAB000064; -; .
MIM116899; gene; .
neXtProtNX_P38936; -; .
PharmGKBPA104; -; .
eggNOGprNOG05825; -; .
HOVERGENHBG050868; -; .
InParanoidP38936; -; .
OrthoDBEOG437RG1; -; .
PhylomeDBP38936; -; .
Pathway_Interaction_DBangiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling; .
Pathway_Interaction_DBpi3kciaktpathway; Class I PI3K signaling events mediated by Akt; .
Pathway_Interaction_DBsmad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; .
Pathway_Interaction_DBhdac_classiii_pathway; Signaling events mediated by HDAC Class III; .
Pathway_Interaction_DBprlsignalingeventspathway; Signaling events mediated by PRL; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_1538; Cell Cycle Checkpoints; .
ReactomeREACT_383; DNA Replication; .
NextBio4309; -; .
ArrayExpressP38936; -; .
BgeeP38936; -; .
CleanExHS_CDKN1A; -; .
GenevestigatorP38936; -; .
GermOnlineENSG00000124762; Homo sapiens; .
GOGO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IDA:BHF-UCL; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0070557; C:PCNA-p21 complex; IDA:UniProtKB; .
GOGO:0019912; F:cyclin-dependent protein kinase activating kinase activity; IDA:UniProtKB; .
GOGO:0004693; F:cyclin-dependent protein kinase activity; EXP:Reactome; .
GOGO:0004861; F:cyclin-dependent protein kinase inhibitor activity; TAS:ProtInc; .
GOGO:0046872; F:metal ion binding; IEA:UniProtKB-KW; .
GOGO:0007050; P:cell cycle arrest; IDA:BHF-UCL; .
GOGO:0031668; P:cellular response to extracellular stimulus; IMP:BHF-UCL; .
GOGO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; .
GOGO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; IDA:BHF-UCL
GOGO:0000080; P:G1 phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0000082; P:G1/S transition of mitotic cell cycle; IDA:BHF-UCL; .
GOGO:0000086; P:G2/M transition of mitotic cell cycle; IMP:BHF-UCL; .
GOGO:0008629; P:induction of apoptosis by intracellular signals; TAS:ProtInc; .
GOGO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL; .
GOGO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL; .
GOGO:0048146; P:positive regulation of fibroblast proliferation; IMP:BHF-UCL; .
GOGO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; .
GOGO:0007265; P:Ras protein signal transduction; IEP:BHF-UCL; .
GOGO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; .
GOGO:0090400; P:stress-induced premature senescence; TAS:BHF-UCL; .
InterProIPR003175; CDI; .
PANTHERPTHR10265; CDI; 1; .
PfamPF02234; CDI; 1; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server