General information about the entry |
View entry in simple text format |
Entry name | CDN1A_HUMAN |
Primary accession number | P38936 |
integrated into SWISS-2DPAGE on | September 1, 1997 (release 6) |
2D Annotations were last modified on | May 15, 2003 (version 1) |
General Annotations were last modified on | May 19, 2011 (version 14) |
Name and origin of the protein |
Description | RecName: Full=Cyclin-dependent kinase inhibitor 1; AltName: Full=CDK-interacting protein 1; AltName: Full=Melanoma differentiation-associated protein 6; Short=MDA-6; AltName: Full=p21;. |
Gene name | Name=CDKN1A Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
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Annotated species | Homo sapiens (Human) [TaxID: 9606] |
Taxonomy | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
References |
[1] |
MAPPING ON GEL MEDLINE=97295311; PubMed=9150953; [NCBI, Expasy, EBI, Israel, Japan]
Sanchez J.-C., Wirth P., Jaccoud S., Appel R.D., Sarto C., Wilkins M.R., Hochstrasser D.F. ''''''Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots'';'';'' Electrophoresis 18(1):638-641(1997)
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2D PAGE maps for identified proteins
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How to interpret a protein
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HEPG2_HUMAN {HepG2} Homo sapiens (Human)
Tissue: Hepatoblastoma
map experimental info protein estimated location
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HEPG2_HUMAN
MAP LOCATIONS:
MAPPING (identification): IMMUNOBLOTTING [1].
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Copyright |
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). |
Cross-references |
UniProtKB/Swiss-Prot | P38936; CDN1A_HUMAN. |
2D PAGE maps for identified proteins
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- How to interpret a protein map
- You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
- Warning 1: the displayed region reflects
an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information.
It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
- Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
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External data extracted from UniProtKB/Swiss-Prot |
Extracted from UniProtKB/Swiss-Prot, release: 2011_10 |
Entry name | CDN1A_HUMAN |
Primary accession number | P38936 |
Secondary accession number(s) | Q14010 Q9BUT4 |
Sequence was last modified on | January 23, 2007 (version 3) |
Annotations were last modified on | October 19, 2011 (version 135) |
Name and origin of the protein |
Description | RecName: Full=Cyclin-dependent kinase inhibitor 1; AltName: Full=CDK-interacting protein 1; AltName: Full=Melanoma differentiation-associated protein 6; Short=MDA-6; AltName: Full=p21; |
Gene name | Name=CDKN1A Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1 |
Encoded on | Name=CDKN1A; Synonyms=CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1 |
Keywords | 3D-structure; Acetylation; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Protein kinase inhibitor; Reference proteome; Ubl conjugation; Zinc; Zinc-finger. |
Copyright |
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License |
Cross-references |
EMBL | L25610; AAA16109.1; -; mRNA |
EMBL | S67388; AAB29246.1; -; mRNA |
EMBL | U09579; AAA85641.1; -; mRNA |
EMBL | U03106; AAC04313.1; -; mRNA |
EMBL | L26165; AAA19811.1; -; mRNA |
EMBL | L47232; AAB59559.1; ALT_INIT; mRNA |
EMBL | L47233; AAB59560.1; ALT_INIT; mRNA |
EMBL | AF497972; AAM11787.1; -; Genomic_DNA |
EMBL | Z85996; CAB06656.1; -; Genomic_DNA |
EMBL | BC000275; AAH00275.1; -; mRNA |
EMBL | BC000312; AAH00312.1; -; mRNA |
EMBL | BC001935; AAH01935.1; -; mRNA |
EMBL | BC013967; AAH13967.1; -; mRNA |
IPI | IPI00009384; -; . |
PIR | I54380; I54380; . |
PIR | I68674; I68674; . |
RefSeq | NP_000380.1; NM_000389.4; . |
RefSeq | NP_001207706.1; NM_001220777.1; . |
RefSeq | NP_001207707.1; NM_001220778.1; . |
RefSeq | NP_510867.1; NM_078467.2; . |
UniGene | Hs.370771; -; . |
PDB | 1AXC; X-ray; 2.60 A; B/D/F=139-160 |
PDB | 2ZVV; X-ray; 2.00 A; X/Y=139-160 |
PDB | 2ZVW; X-ray; 2.50 A; I/J/K/L/M/N/O/P=139-160 |
PDBsum | 1AXC; -; . |
PDBsum | 2ZVV; -; . |
PDBsum | 2ZVW; -; . |
ProteinModelPortal | P38936; -; . |
SMR | P38936; 14-79; . |
DisProt | DP00016; -; . |
DIP | DIP-246N; -; . |
DIP | DIP-458N; -; . |
IntAct | P38936; 34; . |
MINT | MINT-104203; -; . |
STRING | P38936; -; . |
PhosphoSite | P38936; -; . |
SWISS-2DPAGE | P38936; -; . |
PRIDE | P38936; -; . |
Ensembl | ENST00000244741; ENSP00000244741; ENSG00000124762; . |
Ensembl | ENST00000373711; ENSP00000362815; ENSG00000124762; . |
Ensembl | ENST00000405375; ENSP00000384849; ENSG00000124762; . |
Ensembl | ENST00000448526; ENSP00000409259; ENSG00000124762; . |
GeneID | 1026; -; . |
KEGG | hsa:1026; -; . |
UCSC | uc003omm.2; human; . |
CTD | 1026; -; . |
GeneCards | GC06P036364; -; . |
H-InvDB | HIX0200868; -; . |
HGNC | HGNC:1784; CDKN1A; . |
HPA | CAB000064; -; . |
MIM | 116899; gene; . |
neXtProt | NX_P38936; -; . |
PharmGKB | PA104; -; . |
eggNOG | prNOG05825; -; . |
HOVERGEN | HBG050868; -; . |
InParanoid | P38936; -; . |
OrthoDB | EOG437RG1; -; . |
PhylomeDB | P38936; -; . |
Pathway_Interaction_DB | angiopoietinreceptor_pathway; Angiopoietin receptor Tie2-mediated signaling; . |
Pathway_Interaction_DB | pi3kciaktpathway; Class I PI3K signaling events mediated by Akt; . |
Pathway_Interaction_DB | smad2_3nuclearpathway; Regulation of nuclear SMAD2/3 signaling; . |
Pathway_Interaction_DB | hdac_classiii_pathway; Signaling events mediated by HDAC Class III; . |
Pathway_Interaction_DB | prlsignalingeventspathway; Signaling events mediated by PRL; . |
Reactome | REACT_152; Cell Cycle; Mitotic; . |
Reactome | REACT_1538; Cell Cycle Checkpoints; . |
Reactome | REACT_383; DNA Replication; . |
NextBio | 4309; -; . |
ArrayExpress | P38936; -; . |
Bgee | P38936; -; . |
CleanEx | HS_CDKN1A; -; . |
Genevestigator | P38936; -; . |
GermOnline | ENSG00000124762; Homo sapiens; . |
GO | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IDA:BHF-UCL; . |
GO | GO:0005829; C:cytosol; TAS:Reactome; . |
GO | GO:0005654; C:nucleoplasm; TAS:Reactome; . |
GO | GO:0070557; C:PCNA-p21 complex; IDA:UniProtKB; . |
GO | GO:0019912; F:cyclin-dependent protein kinase activating kinase activity; IDA:UniProtKB; . |
GO | GO:0004693; F:cyclin-dependent protein kinase activity; EXP:Reactome; . |
GO | GO:0004861; F:cyclin-dependent protein kinase inhibitor activity; TAS:ProtInc; . |
GO | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . |
GO | GO:0007050; P:cell cycle arrest; IDA:BHF-UCL; . |
GO | GO:0031668; P:cellular response to extracellular stimulus; IMP:BHF-UCL; . |
GO | GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL; . |
GO | GO:0006977; P:DNA damage response; signal transduction by p53 class mediator resulting in cell cycle arrest; IDA:BHF-UCL |
GO | GO:0000080; P:G1 phase of mitotic cell cycle; TAS:Reactome; . |
GO | GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:BHF-UCL; . |
GO | GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:BHF-UCL; . |
GO | GO:0008629; P:induction of apoptosis by intracellular signals; TAS:ProtInc; . |
GO | GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL; . |
GO | GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL; . |
GO | GO:0048146; P:positive regulation of fibroblast proliferation; IMP:BHF-UCL; . |
GO | GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL; . |
GO | GO:0007265; P:Ras protein signal transduction; IEP:BHF-UCL; . |
GO | GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome; . |
GO | GO:0090400; P:stress-induced premature senescence; TAS:BHF-UCL; . |
InterPro | IPR003175; CDI; . |
PANTHER | PTHR10265; CDI; 1; . |
Pfam | PF02234; CDI; 1; . |