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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P61978




SWISS-2DPAGE:  P61978


P61978


General information about the entry
View entry in simple text format
Entry nameHNRPK_HUMAN
Primary accession numberP61978
Secondary accession number(s) Q07244
integrated into SWISS-2DPAGE on November 9, 2001 (release 15)
2D Annotations were last modified onDecember 30, 2004 (version 2)
General Annotations were last modified on May 19, 2011 (version 7)
Name and origin of the protein
DescriptionRecName: Full=Heterogeneous nuclear ribonucleoprotein K; Short=hnRNP K; AltName: Full=Transformation up-regulated nuclear protein; Short=TUNP;.
Gene nameName=HNRNPK
Synonyms=HNRPK
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=63488  [identification data]
Mw=61882  [identification data]

MAPPING (identification):
BAND 1D-001V8C: PEPTIDE MASS FINGERPRINTING [1]; Tandem mass spectrometry [1].



NUCLEOLI_HELA_2D_HUMAN {2D-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_2D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_2D_HUMAN

MAP LOCATIONS:
pI=5.50; Mw=63566  [identification data]
pI=5.52; Mw=63805  [identification data]
pI=5.61; Mw=63805  [identification data]
pI=5.43; Mw=61915  [identification data]

MAPPING (identification):
SPOTS 1VI[9AI]: Peptide mass fingerprinting [1];
SPOT 2D-001VIB: Tandem mass spectrometry [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
UCD-2DPAGEP61978; HNRPK_HUMAN.
UniProtKB/Swiss-ProtP61978; HNRPK_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameHNRPK_HUMAN
Primary accession numberP61978
Secondary accession number(s) Q07244 Q15671 Q59F98 Q5T6W4 Q60577 Q922Y7 Q96J62
Sequence was last modified on June 7, 2004 (version 1)
Annotations were last modified on October 19, 2011 (version 110)
Name and origin of the protein
DescriptionRecName: Full=Heterogeneous nuclear ribonucleoprotein K; Short=hnRNP K; AltName: Full=Transformation up-regulated nuclear protein; Short=TUNP;
Gene nameName=HNRNPK
Synonyms=HNRPK
Encoded onName=HNRNPK; Synonyms=HNRPK
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Host-virus interaction; Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLS74678; AAB20770.1; -; mRNA
EMBLX72727; CAA51267.1; -; mRNA
EMBLAB209562; BAD92799.1; ALT_INIT; mRNA
EMBLAL354733; CAI16020.1; -; Genomic_DNA
EMBLCH471089; EAW62675.1; -; Genomic_DNA
EMBLBC000355; AAH00355.1; -; mRNA
EMBLBC014980; AAH14980.1; -; mRNA
IPIIPI00216049; -; .
IPIIPI00216746; -; .
IPIIPI00807545; -; .
PIRS43363; S43363; .
RefSeqNP_002131.2; NM_002140.3; .
RefSeqNP_112552.1; NM_031262.2; .
RefSeqNP_112553.1; NM_031263.2; .
UniGeneHs.522257; -; .
PDB1J5K; NMR; -; A=379-463
PDB1KHM; NMR; -; A=379-463
PDB1ZZI; X-ray; 1.80 A; A/B=385-463
PDB1ZZJ; X-ray; 2.30 A; A/B/C=385-463
PDB1ZZK; X-ray; 0.95 A; A=385-463
PDBsum1J5K; -; .
PDBsum1KHM; -; .
PDBsum1ZZI; -; .
PDBsum1ZZJ; -; .
PDBsum1ZZK; -; .
ProteinModelPortalP61978; -; .
SMRP61978; 40-215; 385-463; .
DIPDIP-31805N; -; .
IntActP61978; 38; .
MINTMINT-225422; -; .
STRINGP61978; -; .
PhosphoSiteP61978; -; .
SWISS-2DPAGEP61978; -; .
PRIDEP61978; -; .
EnsemblENST00000351839; ENSP00000317788; ENSG00000165119; .
EnsemblENST00000360384; ENSP00000353552; ENSG00000165119; .
EnsemblENST00000376264; ENSP00000365440; ENSG00000165119; .
GeneID3190; -; .
KEGGhsa:3190; -; .
UCSCuc004ang.2; human; .
UCSCuc004anh.2; human; .
CTD3190; -; .
GeneCardsGC09M056408; -; .
H-InvDBHIX0008131; -; .
H-InvDBHIX0200444; -; .
HGNCHGNC:5044; HNRNPK; .
HPACAB004435; -; .
HPACAB016225; -; .
HPAHPA007644; -; .
MIM600712; gene; .
neXtProtNX_P61978; -; .
PharmGKBPA162391350; -; .
eggNOGprNOG07231; -; .
GeneTreeENSGT00550000074311; -; .
HOVERGENHBG051916; -; .
OMAXGLQLPS; -; .
OrthoDBEOG49KFRD; -; .
ReactomeREACT_1675; mRNA Processing; .
ReactomeREACT_71; Gene Expression; .
NextBio12686; -; .
PMAP-CutDBP61978; -; .
ArrayExpressP61978; -; .
BgeeP61978; -; .
CleanExHS_HNRNPK; -; .
GenevestigatorP61978; -; .
GermOnlineENSG00000165119; Homo sapiens; .
GOGO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; .
GOGO:0005737; C:cytoplasm; TAS:ProtInc; .
GOGO:0030530; C:heterogeneous nuclear ribonucleoprotein complex; TAS:ProtInc; .
GOGO:0000790; C:nuclear chromatin; IDA:BHF-UCL; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0003723; F:RNA binding; TAS:ProtInc; .
GOGO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IMP:BHF-UCL; .
GOGO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IMP:BHF-UCL; .
GOGO:0003697; F:single-stranded DNA binding; TAS:BHF-UCL; .
GOGO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW; .
GOGO:0000398; P:nuclear mRNA splicing; via spliceosome; IC:UniProtKB
GOGO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; IMP:BHF-UCL; .
GOGO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:BHF-UCL; .
GOGO:0072369; P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; .
GOGO:0010988; P:regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL; .
GOGO:0007165; P:signal transduction; TAS:ProtInc; .
InterProIPR004087; KH; .
InterProIPR004088; KH_type_1; .
InterProIPR018111; KH_type_1_subgr; .
InterProIPR012987; ROK_N; .
PfamPF00013; KH_1; 3; .
PfamPF08067; ROKNT; 1; .
SMARTSM00322; KH; 3; .
PROSITEPS50084; KH_TYPE_1; 3; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server