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SWISS-2DPAGE

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SWISS-2DPAGE 
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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P68363




SWISS-2DPAGE:  P68363


P68363


General information about the entry
View entry in simple text format
Entry nameTBA1B_HUMAN
Primary accession numberP68363
Secondary accession number(s) P05209
integrated into SWISS-2DPAGE on May 15, 2003 (release 16)
2D Annotations were last modified onMarch 31, 2004 (version 2)
General Annotations were last modified on May 19, 2011 (version 6)
Name and origin of the protein
DescriptionRecName: Full=Tubulin alpha-1B chain; AltName: Full=Alpha-tubulin ubiquitous; AltName: Full=Tubulin K-alpha-1; AltName: Full=Tubulin alpha-ubiquitous chain;.
Gene nameName=TUBA1B
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
PubMed=12429849; [NCBI, Expasy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
[2]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
Comments
  • SUBUNIT: DIMER OF ALPHA AND BETA CHAINS
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=56716  [identification data]
Mw=55139  [identification data]

MAPPING (identification):
Tandem mass spectrometry [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=5.06; Mw=43286  [identification data]

EXPRESSION:
expressed predominantly in CD8 and CD4 lymphocytes [2].

MAPPING (identification):
MALDI tandem mass spectrometry [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss).
Cross-references
HSC-2DPAGEP04687; HUMAN.
OGP-WWWP05209.
UCD-2DPAGEP68363; TBA1B_HUMAN.
UniProtKB/Swiss-ProtP68363; TBA1B_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTBA1B_HUMAN
Primary accession numberP68363
Secondary accession number(s) P04687 P05209 Q27I68
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 83)
Name and origin of the protein
DescriptionRecName: Full=Tubulin alpha-1B chain; AltName: Full=Alpha-tubulin ubiquitous; AltName: Full=Tubulin K-alpha-1; AltName: Full=Tubulin alpha-ubiquitous chain;
Gene nameName=TUBA1B
Encoded onName=TUBA1B
Keywords3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTP-binding; Isopeptide bond; Methylation; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLK00558; AAA91576.1; -; mRNA
EMBLAF081484; AAC31959.1; -; mRNA
EMBLDQ400107; ABD60581.1; -; mRNA
EMBLBC000696; AAH00696.1; -; mRNA
EMBLBC001128; AAH01128.1; -; mRNA
EMBLBC006379; AAH06379.1; -; mRNA
EMBLBC006481; AAH06481.1; -; mRNA
EMBLBC008659; AAH08659.1; -; mRNA
EMBLBC009314; AAH09314.1; -; mRNA
EMBLBC009509; AAH09509.1; -; mRNA
EMBLBC009512; AAH09512.1; -; mRNA
EMBLBC009513; AAH09513.1; -; mRNA
EMBLBC010494; AAH10494.1; -; mRNA
EMBLBC011572; AAH11572.1; -; mRNA
EMBLBC015883; AAH15883.1; -; mRNA
EMBLBC017004; AAH17004.1; -; mRNA
EMBLBC030820; AAH30820.1; -; mRNA
EMBLBC071904; AAH71904.1; -; mRNA
IPIIPI00930688; -; .
PIRI77403; I77403; .
RefSeqNP_006073.2; NM_006082.2; .
UniGeneHs.524390; -; .
PDB2E4H; NMR; -; B=416-451
PDBsum2E4H; -; .
ProteinModelPortalP68363; -; .
SMRP68363; 1-440; .
DisProtDP00115; -; .
IntActP68363; 6; .
MINTMINT-4998849; -; .
STRINGP68363; -; .
PhosphoSiteP68363; -; .
SWISS-2DPAGEP68363; -; .
OGPP68363; -; .
PRIDEP68363; -; .
EnsemblENST00000336023; ENSP00000336799; ENSG00000123416; .
GeneID10376; -; .
KEGGhsa:10376; -; .
UCSCuc001rtk.1; human; .
CTD10376; -; .
GeneCardsGC12M046552; -; .
HGNCHGNC:18809; TUBA1B; .
HPACAB011513; -; .
MIM602530; gene; .
neXtProtNX_P68363; -; .
PharmGKBPA162407332; -; .
eggNOGmaNOG21857; -; .
GeneTreeENSGT00600000084100; -; .
HOGENOMHBG750007; -; .
HOVERGENHBG000089; -; .
InParanoidP68363; -; .
OMAVGIDSTT; -; .
OrthoDBEOG44J2HZ; -; .
PhylomeDBP68363; -; .
Pathway_Interaction_DBhdac_classii_pathway; Signaling events mediated by HDAC Class II; .
Pathway_Interaction_DBhdac_classiii_pathway; Signaling events mediated by HDAC Class III; .
ReactomeREACT_11123; Membrane Trafficking; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_17015; Metabolism of proteins; .
ReactomeREACT_18266; Axon guidance; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_604; Hemostasis; .
NextBio39315; -; .
ArrayExpressP68363; -; .
BgeeP68363; -; .
CleanExHS_TUBA1B; -; .
GenevestigatorP68363; -; .
GermOnlineENSG00000123416; Homo sapiens; .
GOGO:0005525; F:GTP binding; IEA:UniProtKB-KW; .
GOGO:0003924; F:GTPase activity; IEA:InterPro; .
GOGO:0005515; F:protein binding; IPI:UniProtKB; .
GOGO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome; .
GOGO:0051301; P:cell division; TAS:BHF-UCL; .
GOGO:0030705; P:cytoskeleton-dependent intracellular transport; TAS:BHF-UCL; .
GOGO:0007018; P:microtubule-based movement; IEA:InterPro; .
GOGO:0051258; P:protein polymerization; IEA:InterPro; .
InterProIPR002452; Alpha_tubulin; .
InterProIPR008280; Tub_FtsZ_C; .
InterProIPR000217; Tubulin; .
InterProIPR018316; Tubulin/FtsZ_2-layer-sand-dom; .
InterProIPR023123; Tubulin_C; .
InterProIPR017975; Tubulin_CS; .
InterProIPR003008; Tubulin_FtsZ_GTPase; .
Gene3DG3DSA:3.30.1330.20; Tubulin/FtsZ_2-layer-sand-dom; 1; .
Gene3DG3DSA:1.10.287.600; Tubulin_C; 1; .
Gene3DG3DSA:3.40.50.1440; Tubulin_FtsZ; 1; .
PANTHERPTHR11588; Tubulin; 1; .
PfamPF00091; Tubulin; 1; .
PfamPF03953; Tubulin_C; 1; .
PRINTSPR01162; ALPHATUBULIN; .
PRINTSPR01161; TUBULIN; .
SMARTSM00864; Tubulin; 1; .
SMARTSM00865; Tubulin_C; 1; .
SUPFAMSSF55307; Tub_FtsZ_C; 1; .
SUPFAMSSF52490; Tubulin_FtsZ; 1; .
PROSITEPS00227; TUBULIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server