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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: PGDH_HUMAN




SWISS-2DPAGE:  PGDH_HUMAN


PGDH_HUMAN


General information about the entry
View entry in simple text format
Entry namePGDH_HUMAN
Primary accession numberP15428
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 30, 2004 (version 2)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=15-hydroxyprostaglandin dehydrogenase [NAD+]; Short=15-PGDH; EC=1.1.1.141; AltName: Full=Prostaglandin dehydrogenase 1;.
Gene nameName=HPGD
Synonyms=PGDH1
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147969; PubMed=8313870; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
''''''Human liver protein map: update 1993'';'';''
Electrophoresis 14(1):1216-1222(1993)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
Comments
  • SUBUNIT: HOMODIMER
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.59; Mw=25086

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [3].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.60; Mw=25475

MAPPING (identification):
MICROSEQUENCING AND MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.62; Mw=25479

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP15428; PGDH_HUMAN.
UniProtKB/Swiss-ProtP15428; PGDH_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry namePGDH_HUMAN
Primary accession numberP15428
Secondary accession number(s) D3DP43 Q06F08
Sequence was last modified on April 1, 1990 (version 1)
Annotations were last modified on October 19, 2011 (version 120)
Name and origin of the protein
DescriptionRecName: Full=15-hydroxyprostaglandin dehydrogenase [NAD+]; Short=15-PGDH; EC=1.1.1.141; AltName: Full=Prostaglandin dehydrogenase 1;
Gene nameName=HPGD
Synonyms=PGDH1
Encoded onName=HPGD; Synonyms=PGDH1
Keywords3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Fatty acid metabolism; Lipid metabolism; NAD; Oxidoreductase; Polymorphism; Prostaglandin metabolism; Reference proteome; Tumor suppressor.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLL76465; AAA89175.1; -; mRNA
EMBLJ05594; AAA89174.1; -; mRNA
EMBLAK314624; BAG37190.1; -; mRNA
EMBLDQ903072; ABI75347.1; -; Genomic_DNA
EMBLCH471056; EAX04734.1; -; Genomic_DNA
EMBLCH471056; EAX04736.1; -; Genomic_DNA
EMBLBC018986; AAH18986.1; -; mRNA
IPIIPI00305286; -; .
PIRA35802; A35802; .
RefSeqNP_000851.2; NM_000860.4; .
RefSeqNP_001139288.1; NM_001145816.1; .
UniGeneHs.596913; -; .
PDB2GDZ; X-ray; 1.65 A; A=3-256
PDBsum2GDZ; -; .
ProteinModelPortalP15428; -; .
SMRP15428; 3-258; .
STRINGP15428; -; .
SWISS-2DPAGEP15428; -; .
Siena-2DPAGEP15428; -; .
PRIDEP15428; -; .
EnsemblENST00000296522; ENSP00000296522; ENSG00000164120; .
GeneID3248; -; .
KEGGhsa:3248; -; .
UCSCuc003itu.1; human; .
CTD3248; -; .
GeneCardsGC04M171160; -; .
H-InvDBHIX0004645; -; .
HGNCHGNC:5154; HPGD; .
HPAHPA004919; -; .
HPAHPA005679; -; .
MIM119900; phenotype; .
MIM259100; phenotype; .
MIM601688; gene; .
neXtProtNX_P15428; -; .
Orphanet1525; Cranio-osteoarthropathy; .
Orphanet217059; Isolated congenital digital clubbing; .
Orphanet2796; Pachydermoperiostosis; .
HOGENOMHBG750976; -; .
HOVERGENHBG107379; -; .
InParanoidP15428; -; .
OMADPSMIAN; -; .
OrthoDBEOG4R23VH; -; .
PhylomeDBP15428; -; .
DrugBankDB00157; NADH; .
NextBio12913; -; .
ArrayExpressP15428; -; .
BgeeP15428; -; .
CleanExHS_HPGD; -; .
GenevestigatorP15428; -; .
GermOnlineENSG00000164120; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:HPA; .
GOGO:0016404; F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity; IDA:UniProtKB; .
GOGO:0070403; F:NAD+ binding; IDA:UniProtKB; .
GOGO:0004957; F:prostaglandin E receptor activity; IDA:UniProtKB; .
GOGO:0042803; F:protein homodimerization activity; TAS:UniProtKB; .
GOGO:0097070; P:ductus arteriosus closure; ISS:UniProtKB; .
GOGO:0007565; P:female pregnancy; IDA:UniProtKB; .
GOGO:0019372; P:lipoxygenase pathway; TAS:UniProtKB; .
GOGO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB; .
GOGO:0007567; P:parturition; IDA:UniProtKB; .
GOGO:0006693; P:prostaglandin metabolic process; IDA:UniProtKB; .
GOGO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB; .
InterProIPR002198; DH_sc/Rdtase_SDR; .
InterProIPR002347; Glc/ribitol_DH; .
InterProIPR016040; NAD(P)-bd_dom; .
InterProIPR020904; Sc_DH/Rdtase_CS; .
Gene3DG3DSA:3.40.50.720; NAD(P)-bd; 1; .
PfamPF00106; adh_short; 1; .
PRINTSPR00081; GDHRDH; .
PRINTSPR00080; SDRFAMILY; .
PROSITEPS00061; ADH_SHORT; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server