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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: PON1_HUMAN SWISS-2DPAGE:  PON1_HUMAN PON1_HUMAN General information about the entry View entry in simple text format Entry name PON1_HUMAN Primary accession number P27169 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on March 31, 2004 (version 1) General Annotations were last modified on  May 19, 2011 (version 13) Name and origin of the protein Description RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; EC=3.1.1.2; EC=3.1.1.81; EC=3.1.8.1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=K-45; AltName: Full=Serum aryldialkylphosphatase 1;. Gene name Name=PON1 Synonyms=PON Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=93170324; PubMed=8382160; [NCBI, Expasy, EBI, Israel, Japan] Blatter M.-C., James R.W., Messmer S., Barja F., Pometta D. ''''''Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase'';'';'' Eur. J. Biochem. 211(1):871-879(1993) Comments SUBUNIT: SINGLE CHAIN 2D PAGE maps for identified proteins How to interpret a protein PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-0004Z6: pI=4.84; Mw=45937 SPOT 2D-00050H: pI=4.93; Mw=43391 MAPPING (identification): IMMUNOBLOTTING [1]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references Siena-2DPAGE P27169; PON1_HUMAN. UniProtKB/Swiss-Prot P27169; PON1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name PON1_HUMAN Primary accession number P27169 Secondary accession number(s) B2RA40 Q16052 Q6B0J6 Q9UCB1 Sequence was last modified on  October 5, 2010 (version 3) Annotations were last modified on  September 21, 2011 (version 134) Name and origin of the protein Description RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; EC=3.1.1.2; EC=3.1.1.81; EC=3.1.8.1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=K-45; AltName: Full=Serum aryldialkylphosphatase 1; Gene name Name=PON1 Synonyms=PON Encoded on Name=PON1; Synonyms=PON Keywords 3D-structure; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; HDL; Hydrolase; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M63012; AAB59538.1; -; mRNA EMBL M63013; AAA60142.1; -; mRNA EMBL M63014; AAA60143.1; -; mRNA EMBL S56555; AAB25717.1; -; Genomic_DNA EMBL S56546; AAB25717.1; JOINED; Genomic_DNA EMBL S56548; AAB25717.1; JOINED; Genomic_DNA EMBL S64696; AAB27899.1; -; mRNA EMBL S64615; AAB27714.2; -; mRNA EMBL U55885; AAB41835.1; -; Genomic_DNA EMBL U55877; AAB41835.1; JOINED; Genomic_DNA EMBL U55878; AAB41835.1; JOINED; Genomic_DNA EMBL U55879; AAB41835.1; JOINED; Genomic_DNA EMBL U55880; AAB41835.1; JOINED; Genomic_DNA EMBL U55881; AAB41835.1; JOINED; Genomic_DNA EMBL U55882; AAB41835.1; JOINED; Genomic_DNA EMBL U55883; AAB41835.1; JOINED; Genomic_DNA EMBL D84371; BAA12327.1; -; mRNA EMBL U53784; AAA97957.1; -; mRNA EMBL Z70723; CAA94728.1; -; mRNA EMBL AK314027; BAG36737.1; -; mRNA EMBL AF539592; AAM97935.1; -; Genomic_DNA EMBL AC004022; AAC35293.1; -; Genomic_DNA EMBL CH236949; EAL24133.1; -; Genomic_DNA EMBL CH471091; EAW76771.1; -; Genomic_DNA EMBL BC074719; AAH74719.1; -; mRNA IPI IPI00218732; -; . PIR A45451; A45451; . RefSeq NP_000437.3; NM_000446.5; . UniGene Hs.370995; -; . PDB 1V04; X-ray; 2.20 A; A=1-353 PDB 1XHR; Model; -; A=40-355 PDBsum 1V04; -; . PDBsum 1XHR; -; . ProteinModelPortal P27169; -; . SMR P27169; 16-355; . STRING P27169; -; . PhosphoSite P27169; -; . SWISS-2DPAGE P27169; -; . PeptideAtlas P27169; -; . PRIDE P27169; -; . Ensembl ENST00000222381; ENSP00000222381; ENSG00000005421; . GeneID 5444; -; . KEGG hsa:5444; -; . CTD 5444; -; . GeneCards GC07M089534; -; . H-InvDB HIX0033662; -; . HGNC HGNC:9204; PON1; . HPA HPA001610; -; . MIM 168820; gene+phenotype; . MIM 612633; phenotype; . neXtProt NX_P27169; -; . Orphanet 803; Amyotrophic lateral sclerosis; . PharmGKB PA33529; -; . eggNOG prNOG17627; -; . HOGENOM HBG613410; -; . HOVERGEN HBG003604; -; . InParanoid P27169; -; . OMA FFYDSEN; -; . OrthoDB EOG4XD3RN; -; . BRENDA 3.1.1.2; 2681; . DrugBank DB01076; Atorvastatin; . DrugBank DB01327; Cefazolin; . NextBio 21069; -; . ArrayExpress P27169; -; . Bgee P27169; -; . CleanEx HS_PON1; -; . Genevestigator P27169; -; . GermOnline ENSG00000005421; Homo sapiens; . GO GO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL; . GO GO:0004063; F:aryldialkylphosphatase activity; IDA:UniProtKB; . GO GO:0004064; F:arylesterase activity; IDA:UniProtKB; . GO GO:0005509; F:calcium ion binding; IDA:UniProtKB; . GO GO:0005543; F:phospholipid binding; IDA:BHF-UCL; . GO GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL; . GO GO:0019439; P:aromatic compound catabolic process; IDA:BHF-UCL; . GO GO:0046395; P:carboxylic acid catabolic process; IDA:BHF-UCL; . GO GO:0046434; P:organophosphate catabolic process; IDA:BHF-UCL; . GO GO:0046470; P:phosphatidylcholine metabolic process; IDA:BHF-UCL; . GO GO:0051099; P:positive regulation of binding; IDA:BHF-UCL; . GO GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL; . GO GO:0032411; P:positive regulation of transporter activity; IDA:BHF-UCL; . GO GO:0009605; P:response to external stimulus; NAS:UniProtKB; . InterPro IPR011042; 6-blade_b-propeller_TolB-like; . InterPro IPR002640; Arylesterase; . InterPro IPR008363; Paraoxonase1; . Gene3D G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1; . Pfam PF01731; Arylesterase; 1; . PRINTS PR01785; PARAOXONASE; . PRINTS PR01786; PARAOXONASE1; . SWISS-2DPAGE (search AC)