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Sample Preparation and Post-separation Analysis Searching in 'SWISS-2DPAGE' for entry matching: RET4_HUMAN SWISS-2DPAGE:  RET4_HUMAN RET4_HUMAN General information about the entry View entry in simple text format Entry name RET4_HUMAN Primary accession number P02753 integrated into SWISS-2DPAGE on  August 1, 1993 (release 0) 2D Annotations were last modified on May 15, 2003 (version 1) General Annotations were last modified on  May 19, 2011 (version 14) Name and origin of the protein Description RecName: Full=Retinol-binding protein 4; AltName: Full=Plasma retinol-binding protein; Short=PRBP; Short=RBP; Contains: RecName: Full=Plasma retinol-binding protein(1-182); Contains: RecName: Full=Plasma retinol-binding protein(1-181); Contains: RecName: Full=Plasma retinol-binding protein(1-179); Contains: RecName: Full=Plasma retinol-binding protein(1-176); Flags: Precursor;. Gene name Name=RBP4 ORFNames=PRO2222 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   MAPPING ON GEL MEDLINE=93162045; PubMed=1286669; [NCBI, Expasy, EBI, Israel, Japan] Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J. ''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';'' Electrophoresis 13(1):992-1001(1992) [2]   MAPPING ON GEL MEDLINE=93092937; PubMed=1459097; [NCBI, Expasy, EBI, Israel, Japan] Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F. ''''''Plasma protein map: an update by microsequencing'';'';'' Electrophoresis 13(1):707-714(1992) [3]   MAPPING ON GEL MEDLINE=96007934; PubMed=7498157; [NCBI, Expasy, EBI, Israel, Japan] Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F. ''''''Inside SWISS-2DPAGE database'';'';'' Electrophoresis 16(1):1131-1151(1995) Comments SUBUNIT: SINGLE CHAIN 2D PAGE maps for identified proteins How to interpret a protein CSF_HUMAN {Cerebrospinal Fluid} Homo sapiens (Human) Tissue: Cerebrospinal fluid   map experimental info   protein estimated location   CSF_HUMAN MAP LOCATIONS: SPOT 2D-000CDE: pI=5.06; Mw=19621 SPOT 2D-000CDF: pI=5.24; Mw=19621 SPOT 2D-000CDK: pI=5.24; Mw=19254 SPOT 2D-000CDM: pI=5.07; Mw=19208 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [3]. HEPG2SP_HUMAN {HepG2 Secreted Proteins} Homo sapiens (Human) Tissue: Hepatoblastoma   map experimental info   protein estimated location   HEPG2SP_HUMAN MAP LOCATIONS: SPOT 2D-0009JT: pI=5.27; Mw=18000 MAPPING (identification): MATCHING WITH THE PLASMA MASTER GEL [3]. LIVER_HUMAN {Liver} Homo sapiens (Human) Tissue: Liver   map experimental info   protein estimated location   LIVER_HUMAN MAP LOCATIONS: SPOT 2D-0001GE: pI=5.24; Mw=21071 PATHOLOGICAL LEVEL: DECREASED DURING DERMATOSIS. MAPPING (identification): MATCHING WITH A PLASMA GEL [1]. PLASMA_HUMAN {Plasma} Homo sapiens (Human) Tissue: Plasma   map experimental info   protein estimated location   PLASMA_HUMAN MAP LOCATIONS: SPOT 2D-0005FO: pI=5.06; Mw=20089 SPOT 2D-0005FP: pI=5.23; Mw=20201 SPOT 2D-0005FS: pI=5.24; Mw=19759 NORMAL LEVEL: 30-60 MG/L. PATHOLOGICAL LEVEL: DECREASED DURING MALNUTRITION, LIVER DISEASE AND VITAMIN A DEFICIENCY; INCREASED DURING RENAL FAILURE. MAPPING (identification): MICROSEQUENCING [2]. Copyright This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from legal@sib.swiss). Cross-references Siena-2DPAGE P02753; RETBP_HUMAN. UniProtKB/Swiss-Prot P02753; RET4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_10 Entry name RET4_HUMAN Primary accession number P02753 Secondary accession number(s) D3DR38 O43478 O43479 Q5VY24 Q8WWA3 Q9P178 Sequence was last modified on  March 29, 2005 (version 3) Annotations were last modified on  October 19, 2011 (version 146) Name and origin of the protein Description RecName: Full=Retinol-binding protein 4; AltName: Full=Plasma retinol-binding protein; Short=PRBP; Short=RBP; Contains: RecName: Full=Plasma retinol-binding protein(1-182); Contains: RecName: Full=Plasma retinol-binding protein(1-181); Contains: RecName: Full=Plasma retinol-binding protein(1-179); Contains: RecName: Full=Plasma retinol-binding protein(1-176); Flags: Precursor; Gene name Name=RBP4 ORFNames=PRO2222 Encoded on Name=RBP4; ORFNames=PRO2222 Keywords 3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Reference proteome; Retinol-binding; Secreted; Sensory transduction; Signal; Transport; Vision; Vitamin A. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X00129; CAA24959.1; -; mRNA EMBL AL356214; CAH72328.1; -; Genomic_DNA EMBL CH471066; EAW50065.1; -; Genomic_DNA EMBL CH471066; EAW50066.1; -; Genomic_DNA EMBL CH471066; EAW50067.1; -; Genomic_DNA EMBL BC020633; AAH20633.1; -; mRNA EMBL X02775; CAA26553.1; -; Genomic_DNA EMBL X02824; CAB46489.1; -; Genomic_DNA EMBL AF119868; AAF69622.1; ALT_INIT; mRNA EMBL AF025334; AAC02945.1; -; Genomic_DNA EMBL AF025335; AAC02946.1; -; Genomic_DNA IPI IPI00022420; -; . PIR A93494; VAHU; . RefSeq NP_006735.2; NM_006744.3; . UniGene Hs.50223; -; . PDB 1BRP; X-ray; 2.50 A; A=19-198 PDB 1BRQ; X-ray; 2.50 A; A=19-198 PDB 1JYD; X-ray; 1.70 A; A=19-198 PDB 1JYJ; X-ray; 2.00 A; A=19-198 PDB 1QAB; X-ray; 3.20 A; E/F=24-201 PDB 1RBP; X-ray; 2.00 A; A=19-200 PDB 1RLB; X-ray; 3.10 A; E/F=19-190 PDB 2WQ9; X-ray; 1.65 A; A=19-192 PDB 2WQA; X-ray; 2.85 A; E/F=19-194 PDB 2WR6; X-ray; 1.80 A; A=19-192 PDB 3BSZ; X-ray; 3.38 A; E/F=19-194 PDB 3FMZ; X-ray; 2.90 A; A/B=19-201 PDBsum 1BRP; -; . PDBsum 1BRQ; -; . PDBsum 1JYD; -; . PDBsum 1JYJ; -; . PDBsum 1QAB; -; . PDBsum 1RBP; -; . PDBsum 1RLB; -; . PDBsum 2WQ9; -; . PDBsum 2WQA; -; . PDBsum 2WR6; -; . PDBsum 3BSZ; -; . PDBsum 3FMZ; -; . ProteinModelPortal P02753; -; . SMR P02753; 19-192; . IntAct P02753; 1; . STRING P02753; -; . SWISS-2DPAGE P02753; -; . Siena-2DPAGE P02753; -; . PRIDE P02753; -; . Ensembl ENST00000371464; ENSP00000360519; ENSG00000138207; . Ensembl ENST00000371467; ENSP00000360522; ENSG00000138207; . GeneID 5950; -; . KEGG hsa:5950; -; . UCSC uc001kit.1; human; . CTD 5950; -; . GeneCards GC10M088979; -; . H-InvDB HIX0009047; -; . HGNC HGNC:9922; RBP4; . HPA CAB004555; -; . HPA HPA001641; -; . MIM 180250; gene+phenotype; . neXtProt NX_P02753; -; . PharmGKB PA34289; -; . GeneTree ENSGT00510000047107; -; . HOGENOM HBG715497; -; . HOVERGEN HBG004493; -; . InParanoid P02753; -; . OMA MEWVWAL; -; . OrthoDB EOG4T4CWM; -; . PhylomeDB P02753; -; . DrugBank DB00162; Vitamin A; . NextBio 23182; -; . ArrayExpress P02753; -; . Bgee P02753; -; . CleanEx HS_RBP4; -; . Genevestigator P02753; -; . GermOnline ENSG00000138207; Homo sapiens; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0005515; F:protein binding; IPI:UniProtKB; . GO GO:0016918; F:retinal binding; IEA:UniProtKB-KW; . GO GO:0019841; F:retinol binding; IDA:BHF-UCL; . GO GO:0034632; F:retinol transporter activity; IC:BHF-UCL; . GO GO:0048738; P:cardiac muscle tissue development; ISS:BHF-UCL; . GO GO:0048562; P:embryonic organ morphogenesis; ISS:BHF-UCL; . GO GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:BHF-UCL; . GO GO:0048706; P:embryonic skeletal system development; ISS:BHF-UCL; . GO GO:0048807; P:female genitalia morphogenesis; ISS:BHF-UCL; . GO GO:0006094; P:gluconeogenesis; IMP:BHF-UCL; . GO GO:0042593; P:glucose homeostasis; IDA:BHF-UCL; . GO GO:0060347; P:heart trabecula formation; ISS:BHF-UCL; . GO GO:0030324; P:lung development; ISS:BHF-UCL; . GO GO:0030277; P:maintenance of gastrointestinal epithelium; IDA:BHF-UCL; . GO GO:0060044; P:negative regulation of cardiac muscle cell proliferation; ISS:BHF-UCL; . GO GO:0051024; P:positive regulation of immunoglobulin secretion; ISS:BHF-UCL; . GO GO:0032024; P:positive regulation of insulin secretion; IMP:BHF-UCL; . GO GO:0032526; P:response to retinoic acid; IDA:BHF-UCL; . GO GO:0042572; P:retinol metabolic process; IMP:BHF-UCL; . GO GO:0060157; P:urinary bladder development; ISS:BHF-UCL; . GO GO:0060065; P:uterus development; ISS:BHF-UCL; . GO GO:0060068; P:vagina development; ISS:BHF-UCL; . InterPro IPR012674; Calycin; . InterPro IPR011038; Calycin-like; . InterPro IPR002345; Lipocalin; . InterPro IPR022271; Lipocalin_ApoD; . InterPro IPR022272; Lipocalin_CS; . InterPro IPR000566; Lipocln_cytosolic_FA-bd_dom; . InterPro IPR002449; Retinol-bd; . Gene3D G3DSA:2.40.128.20; Calycin; 1; . PANTHER PTHR11873; Retinol_bd; 1; . Pfam PF00061; Lipocalin; 1; . PIRSF PIRSF036893; Lipocalin_ApoD; 1; . PRINTS PR00179; LIPOCALIN; . PRINTS PR01174; RETINOLBNDNG; . SUPFAM SSF50814; Calycin; 1; . PROSITE PS00213; LIPOCALIN; 1; . SWISS-2DPAGE (search AC)