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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: TBB2C_HUMAN




SWISS-2DPAGE:  TBB2C_HUMAN


TBB2C_HUMAN


General information about the entry
View entry in simple text format
Entry nameTBB2C_HUMAN
Primary accession numberP68371
Secondary accession number(s) P05217
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 3)
General Annotations were last modified on May 19, 2011 (version 13)
Name and origin of the protein
DescriptionRecName: Full=Tubulin beta-2C chain; AltName: Full=Tubulin beta-2 chain;.
Gene nameName=TUBB2C
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=94147969; PubMed=8313870; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Pasquali C., Sanchez J.-C., Tissot J.-D., Bairoch A., Appel R.D., Hochstrasser D.F.
''''''Human liver protein map: update 1993'';'';''
Electrophoresis 14(1):1216-1222(1993)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[4]   MAPPING ON GEL
PubMed=12429849; [NCBI, ExPASy, EBI, Israel, Japan]
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
''''''Functional proteomic analysis of human nucleolus'';'';''
Mol. Biol. Cell. 13(1):4100-4109(2002)
Comments
  • SUBUNIT: DIMER OF ALPHA AND BETA CHAINS
2D PAGE maps for identified proteins
How to interpret a protein

NUCLEOLI_HELA_1D_HUMAN {SDS-PAGE of nucleolar proteins from Human HeLa cells}
Homo sapiens (Human)
Tissue: Cervix carcinoma
NUCLEOLI_HELA_1D_HUMAN
  map experimental info
  protein estimated location
 
NUCLEOLI_HELA_1D_HUMAN

MAP LOCATIONS:
Mw=55139

MAPPING (identification):
Peptide mass fingerprinting [4].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.28; Mw=30447

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [3].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.32; Mw=30800

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=5.32; Mw=30944

MAPPING (identification):
MICROSEQUENCING (MREIVH[IL]QAG) [1].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=5.33; Mw=31689

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
OGP-WWWP05217.
REPRODUCTION-2DPAGEIPI00007752; IPI00007752.
Siena-2DPAGEP05217; TBB2_HUMAN.
UCD-2DPAGEP05217; TBB2C_HUMAN.
UniProtKB/Swiss-ProtP68371; TBB2C_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTBB2C_HUMAN
Primary accession numberP68371
Secondary accession number(s) A2BFA2 P05217
Sequence was last modified on August 13, 1987 (version 1)
Annotations were last modified on October 19, 2011 (version 80)
Name and origin of the protein
DescriptionRecName: Full=Tubulin beta-2C chain; AltName: Full=Tubulin beta-2 chain;
Gene nameName=TUBB2C
Encoded onName=TUBB2C
KeywordsAcetylation; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding; Phosphoprotein; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX02344; CAA26203.1; -; Genomic_DNA
EMBLBX255925; CAM24148.1; -; Genomic_DNA
EMBLBC001911; AAH01911.1; -; mRNA
EMBLBC002783; AAH02783.1; -; mRNA
EMBLBC002885; AAH02885.1; -; mRNA
EMBLBC004188; AAH04188.1; -; mRNA
EMBLBC007889; AAH07889.1; -; mRNA
EMBLBC012835; AAH12835.1; -; mRNA
EMBLBC019359; AAH19359.1; -; mRNA
EMBLBC019829; AAH19829.1; -; mRNA
EMBLBC039175; AAH39175.1; -; mRNA
EMBLBC071889; AAH71889.1; -; mRNA
IPIIPI00007752; -; .
PIRI38370; I38370; .
RefSeqNP_006079.1; NM_006088.5; .
UniGeneHs.433615; -; .
ProteinModelPortalP68371; -; .
SMRP68371; 2-427; .
IntActP68371; 15; .
MINTMINT-1390314; -; .
STRINGP68371; -; .
PhosphoSiteP68371; -; .
SWISS-2DPAGEP68371; -; .
OGPP05217; -; .
REPRODUCTION-2DPAGEIPI00007752; -; .
Siena-2DPAGEP68371; -; .
PeptideAtlasP68371; -; .
PRIDEP68371; -; .
EnsemblENSRNOT00000013863; ENSRNOP00000013863; ENSRNOG00000010170; .
EnsemblENST00000340384; ENSP00000341289; ENSG00000188229; .
GeneID10383; -; .
KEGGhsa:10383; -; .
UCSCuc004cmh.1; human; .
CTD10383; -; .
GeneCardsGC09P109595; -; .
H-InvDBHIX0022973; -; .
HGNCHGNC:20771; TUBB2C; .
HPACAB010880; -; .
MIM602660; gene; .
neXtProtNX_P68371; -; .
PharmGKBPA142670672; -; .
eggNOGprNOG15957; -; .
HOGENOMHBG750007; -; .
HOVERGENHBG000089; -; .
InParanoidP68371; -; .
OMAEVINDEH; -; .
OrthoDBEOG4DFPNJ; -; .
PhylomeDBP68371; -; .
ReactomeREACT_11123; Membrane Trafficking; .
ReactomeREACT_152; Cell Cycle; Mitotic; .
ReactomeREACT_17015; Metabolism of proteins; .
ReactomeREACT_18266; Axon guidance; .
ReactomeREACT_383; DNA Replication; .
ReactomeREACT_604; Hemostasis; .
NextBio39335; -; .
ArrayExpressP68371; -; .
BgeeP68371; -; .
CleanExHS_TUBB2C; -; .
GenevestigatorP68371; -; .
GermOnlineENSG00000188229; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005874; C:microtubule; IEA:UniProtKB-KW; .
GOGO:0005525; F:GTP binding; IEA:UniProtKB-KW; .
GOGO:0003924; F:GTPase activity; IEA:InterPro; .
GOGO:0042288; F:MHC class I protein binding; TAS:UniProtKB; .
GOGO:0005198; F:structural molecule activity; IEA:InterPro; .
GOGO:0051082; F:unfolded protein binding; NAS:UniProtKB; .
GOGO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome; .
GOGO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome; .
GOGO:0007018; P:microtubule-based movement; IEA:InterPro; .
GOGO:0042267; P:natural killer cell mediated cytotoxicity; NAS:UniProtKB; .
GOGO:0051258; P:protein polymerization; IEA:InterPro; .
InterProIPR013838; Beta-tubulin_BS; .
InterProIPR002453; Beta_tubulin; .
InterProIPR008280; Tub_FtsZ_C; .
InterProIPR000217; Tubulin; .
InterProIPR018316; Tubulin/FtsZ_2-layer-sand-dom; .
InterProIPR023123; Tubulin_C; .
InterProIPR017975; Tubulin_CS; .
InterProIPR003008; Tubulin_FtsZ_GTPase; .
Gene3DG3DSA:3.30.1330.20; Tubulin/FtsZ_2-layer-sand-dom; 1; .
Gene3DG3DSA:1.10.287.600; Tubulin_C; 1; .
Gene3DG3DSA:3.40.50.1440; Tubulin_FtsZ; 1; .
PANTHERPTHR11588; Tubulin; 1; .
PfamPF00091; Tubulin; 1; .
PfamPF03953; Tubulin_C; 1; .
PRINTSPR01163; BETATUBULIN; .
PRINTSPR01161; TUBULIN; .
SMARTSM00864; Tubulin; 1; .
SMARTSM00865; Tubulin_C; 1; .
SUPFAMSSF55307; Tub_FtsZ_C; 1; .
SUPFAMSSF52490; Tubulin_FtsZ; 1; .
PROSITEPS00227; TUBULIN; 1; .
PROSITEPS00228; TUBULIN_B_AUTOREG; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server