World-2DPAGE Home


SWISS-2DPAGE 
Search by  [accession number] *
[description, ID or gene] 
[author names] 
[spot ID / serial number] 
[identification methods] 
[pI / Mw range] 
[combined fields] 

Maps  [experimental info] 
[protein list] 
[graphical interface]

     Select Remote Interfaces
[All Interfaces]
World-2DPAGE Portal
World-2DPAGE Repository

Exclude local DBs
has only effect if a remote
interface is selected
     

Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: TRFE_HUMAN




SWISS-2DPAGE:  TRFE_HUMAN


TRFE_HUMAN


General information about the entry
View entry in simple text format
Entry nameTRFE_HUMAN
Primary accession numberP02787
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onMay 15, 2003 (version 2)
General Annotations were last modified on May 19, 2011 (version 15)
Name and origin of the protein
DescriptionRecName: Full=Serotransferrin; Short=Transferrin; AltName: Full=Beta-1 metal-binding globulin; AltName: Full=Siderophilin; Flags: Precursor;.
Gene nameName=TF
ORFNames=PRO1400
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93162045; PubMed=1286669; [NCBI, ExPASy, EBI, Israel, Japan]
Hochstrasser D.F., Frutiger S., Paquet N., Bairoch A., Ravier F., Pasquali C., Sanchez J.-C., Tissot J.-D., Bjellqvist B., Vargas R., Appel R.D., Hughes G.J.
''''''Human liver protein map: a reference database established by microsequencing and gel comparison'';'';''
Electrophoresis 13(1):992-1001(1992)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
[3]   MAPPING ON GEL
MEDLINE=78094420; PubMed=271964; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.L., Anderson N.G.
''''''High resolution two-dimensional electrophoresis of human plasma proteins'';'';''
Proc. Natl. Acad. Sci. U.S.A. 74(1):5421-5425(1977)
[4]   MAPPING ON GEL
MEDLINE=96007935; PubMed=7498158; [NCBI, ExPASy, EBI, Israel, Japan]
Gravel P., Sanchez J.-C., Walzer C., Golaz O., Hochstrasser D.F., Balant L.P., Hughes G.J., Garcia-Sevilla J., Guimon J.
''''''Human blood platelet protein map established by two-dimensional polyacrylamide gel electrophoresis'';'';''
Electrophoresis 16(1):1152-1159(1995)
[5]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=6.09; Mw=87680
pI=6.16; Mw=86727
pI=6.21; Mw=86412
pI=6.28; Mw=85472
pI=6.34; Mw=84851
pI=6.17; Mw=82114
pI=6.22; Mw=81517
pI=6.25; Mw=81221
pI=6.29; Mw=80631
pI=6.35; Mw=79175
pI=6.40; Mw=78887
pI=6.48; Mw=78600
pI=6.56; Mw=78030
pI=6.68; Mw=76621
pI=6.80; Mw=76064

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=5.71; Mw=9362
pI=5.73; Mw=9254

MAPPING (identification):
MATCHING WITH THE HEPG2 MASTER GEL [5].



HEPG2_HUMAN {HepG2}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2_HUMAN
  map experimental info
  protein estimated location
 
HEPG2_HUMAN

MAP LOCATIONS:
pI=5.55; Mw=10689
pI=5.72; Mw=9588
pI=5.74; Mw=9588

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=5.97; Mw=84631
pI=5.94; Mw=84946
pI=6.00; Mw=83695
pI=6.12; Mw=82769
pI=6.25; Mw=81551
pI=6.37; Mw=80648
pI=6.49; Mw=80052
pI=6.70; Mw=79756
pI=6.60; Mw=79461

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



LIVER_HUMAN {Liver}
Homo sapiens (Human)
Tissue: Liver
LIVER_HUMAN
  map experimental info
  protein estimated location
 
LIVER_HUMAN

MAP LOCATIONS:
pI=6.23; Mw=74616
pI=6.29; Mw=74429
pI=6.37; Mw=74429
pI=6.15; Mw=74616
pI=6.47; Mw=74429
pI=6.56; Mw=74616
pI=5.53; Mw=11882
pI=5.76; Mw=9966

PATHOLOGICAL LEVEL:
INCREASED DURING PREGNANCY AND CHRONIC IRON DEFICIENCY.

POSITIONAL VARIANTS:
MORE THAN 20 VARIANTS.

MAPPING (identification):
MATCHING WITH A PLASMA GEL [1].



LYMPHOMA_HUMAN {Lymphoma}
Homo sapiens (Human)
Tissue: Lymphoma
LYMPHOMA_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOMA_HUMAN

MAP LOCATIONS:
pI=6.36; Mw=85658
pI=6.47; Mw=84882

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=6.14; Mw=87170
pI=6.17; Mw=86838
pI=6.20; Mw=86838
pI=6.24; Mw=86179
pI=6.27; Mw=85850
pI=6.33; Mw=84551
pI=6.40; Mw=80768
pI=6.21; Mw=82010
pI=6.24; Mw=81698
pI=6.27; Mw=80768
pI=6.33; Mw=80768
pI=6.31; Mw=79849
pI=6.45; Mw=79545
pI=6.55; Mw=79545
pI=6.63; Mw=80154
pI=6.50; Mw=79545
pI=6.39; Mw=75987
pI=6.34; Mw=76861
pI=6.64; Mw=76861
pI=6.45; Mw=75987
pI=6.50; Mw=75697
pI=6.55; Mw=76277

NORMAL LEVEL:
2000-4000 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING IMFLAMMATION, TUMORS, NEPHROSIS AND HAEMOCHROMATOSIS; INCREASED DURING PREGNANCY AND IRON DEFICIENCY.

POSITIONAL VARIANTS:
MORE THAN 20 VARIANTS.

MAPPING (identification):
IMMUNOBLOTTING [3].



PLATELET_HUMAN {Platelet}
Homo sapiens (Human)
Tissue: Platelet
PLATELET_HUMAN
  map experimental info
  protein estimated location
 
PLATELET_HUMAN

MAP LOCATIONS:
pI=6.32; Mw=73896
pI=6.45; Mw=73106
pI=6.39; Mw=73303
pI=6.59; Mw=72910

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [4].



U937_HUMAN {Macrophage Like Cell Line}
Homo sapiens (Human)
Tissue: Histiocytic lymphoma
U937_HUMAN
  map experimental info
  protein estimated location
 
U937_HUMAN

MAP LOCATIONS:
pI=6.86; Mw=99201
pI=6.93; Mw=99201

MAPPING (identification):
MATCHING WITH THE LIVER MASTER GEL [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP02787; P02787.
DOSAC-COBS-2DPAGEP02787; TRFE_HUMAN.
HSC-2DPAGEP02787; HUMAN.
REPRODUCTION-2DPAGEP02787; P02787.
REPRODUCTION-2DPAGEIPI00022463; IPI00022463.
Siena-2DPAGEP02787; TRFE_HUMAN.
UCD-2DPAGEP02787; TRFE_HUMAN.
UniProtKB/Swiss-ProtP02787; TRFE_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTRFE_HUMAN
Primary accession numberP02787
Secondary accession number(s) O43890 Q1HBA5 Q9NQB8 Q9UHV0
Sequence was last modified on November 30, 2010 (version 3)
Annotations were last modified on October 19, 2011 (version 157)
Name and origin of the protein
DescriptionRecName: Full=Serotransferrin; Short=Transferrin; AltName: Full=Beta-1 metal-binding globulin; AltName: Full=Siderophilin; Flags: Precursor;
Gene nameName=TF
ORFNames=PRO1400
Encoded onName=TF; ORFNames=PRO1400
Keywords3D-structure; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Ion transport; Iron; Iron transport; Metal-binding; Methylation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLM12530; AAA61140.1; -; mRNA
EMBLM17611; AAA61147.1; -; Genomic_DNA
EMBLM17610; AAA61147.1; JOINED; Genomic_DNA
EMBLM17614; AAA61148.1; -; Genomic_DNA
EMBLM17612; AAA61148.1; JOINED; Genomic_DNA
EMBLM17613; AAA61148.1; JOINED; Genomic_DNA
EMBLS95936; AAB22049.1; -; mRNA
EMBLAF288144; AAK77664.1; -; Genomic_DNA
EMBLAF294270; AAK77664.1; JOINED; Genomic_DNA
EMBLAF294271; AAK77664.1; JOINED; Genomic_DNA
EMBLAF288139; AAK77664.1; JOINED; Genomic_DNA
EMBLAF288140; AAK77664.1; JOINED; Genomic_DNA
EMBLAF288141; AAK77664.1; JOINED; Genomic_DNA
EMBLAF288142; AAK77664.1; JOINED; Genomic_DNA
EMBLAF288143; AAK77664.1; JOINED; Genomic_DNA
EMBLAY308797; AAP45055.1; -; Genomic_DNA
EMBLDQ525716; ABF47110.1; -; Genomic_DNA
EMBLAC080128; -; NOT_ANNOTATED_CDS; mRNA
EMBLAC083905; -; NOT_ANNOTATED_CDS; mRNA
EMBLCH471052; EAW79167.1; -; Genomic_DNA
EMBLBC059367; AAH59367.1; -; mRNA
EMBLM21569; AAA61143.2; -; Genomic_DNA
EMBLM15673; AAA61143.2; JOINED; Genomic_DNA
EMBLM21570; AAA61145.1; -; Genomic_DNA
EMBLX04600; CAA28265.1; -; Genomic_DNA
EMBLAJ252279; CAB96907.1; -; mRNA
EMBLM11372; AAA61141.1; -; Genomic_DNA
EMBLM11361; AAA61141.1; JOINED; Genomic_DNA
EMBLM11362; AAA61141.1; JOINED; Genomic_DNA
EMBLM11363; AAA61141.1; JOINED; Genomic_DNA
EMBLM11364; AAA61141.1; JOINED; Genomic_DNA
EMBLM11365; AAA61141.1; JOINED; Genomic_DNA
EMBLM11366; AAA61141.1; JOINED; Genomic_DNA
EMBLM11367; AAA61141.1; JOINED; Genomic_DNA
EMBLM11368; AAA61141.1; JOINED; Genomic_DNA
EMBLM11369; AAA61141.1; JOINED; Genomic_DNA
EMBLM11370; AAA61141.1; JOINED; Genomic_DNA
EMBLM11371; AAA61141.1; JOINED; Genomic_DNA
EMBLAF118063; AAF22007.1; ALT_INIT; mRNA
EMBLM12525; AAA61142.1; -; mRNA
EMBLU88581; AAB97880.1; -; mRNA
EMBLAF058327; AAC63506.1; -; Genomic_DNA
EMBLM26641; AAA61233.1; -; mRNA
IPIIPI00022463; -; .
PIRA20981; TFHUP; .
RefSeqNP_001054.1; NM_001063.3; .
UniGeneHs.518267; -; .
UniGeneHs.729019; -; .
PDB1A8E; X-ray; 1.60 A; A=22-350
PDB1A8F; X-ray; 1.80 A; A=22-350
PDB1B3E; X-ray; 2.50 A; A=23-352
PDB1BP5; X-ray; 2.20 A; A/B/C/D=20-356
PDB1BTJ; X-ray; 3.20 A; A/B=20-356
PDB1D3K; X-ray; 1.80 A; A=22-350
PDB1D4N; X-ray; 2.00 A; A=22-350
PDB1DTG; X-ray; 2.40 A; A=20-353
PDB1FQE; X-ray; 1.80 A; A=20-350
PDB1FQF; X-ray; 2.10 A; A=20-350
PDB1JQF; X-ray; 1.85 A; A=20-353
PDB1N7W; X-ray; 2.20 A; A=22-350
PDB1N7X; X-ray; 2.10 A; A=20-350
PDB1N84; X-ray; 2.05 A; A=20-350
PDB1OQG; X-ray; 1.90 A; A=20-354
PDB1OQH; X-ray; 2.40 A; A=20-354
PDB1RYO; X-ray; 1.20 A; A=20-346
PDB1SUV; EM; 7.50 A; C/D=22-350
PDB2HAU; X-ray; 2.70 A; A/B=23-698
PDB2HAV; X-ray; 2.70 A; A/B=23-698
PDB2O7U; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I=20-356
PDB2O84; X-ray; 2.60 A; X=20-356
PDB3FGS; X-ray; 1.80 A; A=20-356
PDB3S9L; X-ray; 3.22 A; C/D=20-698
PDB3S9M; X-ray; 3.32 A; C/D=20-698
PDB3S9N; X-ray; 3.25 A; C/D=20-698
PDBsum1A8E; -; .
PDBsum1A8F; -; .
PDBsum1B3E; -; .
PDBsum1BP5; -; .
PDBsum1BTJ; -; .
PDBsum1D3K; -; .
PDBsum1D4N; -; .
PDBsum1DTG; -; .
PDBsum1FQE; -; .
PDBsum1FQF; -; .
PDBsum1JQF; -; .
PDBsum1N7W; -; .
PDBsum1N7X; -; .
PDBsum1N84; -; .
PDBsum1OQG; -; .
PDBsum1OQH; -; .
PDBsum1RYO; -; .
PDBsum1SUV; -; .
PDBsum2HAU; -; .
PDBsum2HAV; -; .
PDBsum2O7U; -; .
PDBsum2O84; -; .
PDBsum3FGS; -; .
PDBsum3S9L; -; .
PDBsum3S9M; -; .
PDBsum3S9N; -; .
ProteinModelPortalP02787; -; .
SMRP02787; 22-698; .
DIPDIP-2738N; -; .
IntActP02787; 25; .
MINTMINT-1400694; -; .
STRINGP02787; -; .
MEROPSS60.972; -; .
MEROPSS60.975; -; .
GlycoSuiteDBP02787; -; .
PhosphoSiteP02787; -; .
SWISS-2DPAGEP02787; -; .
Cornea-2DPAGEP02787; -; .
DOSAC-COBS-2DPAGEP02787; -; .
REPRODUCTION-2DPAGEIPI00022463; -; .
REPRODUCTION-2DPAGEP02787; -; .
Siena-2DPAGEP02787; -; .
UCD-2DPAGEP02787; -; .
PRIDEP02787; -; .
EnsemblENST00000264998; ENSP00000264998; ENSG00000091513; .
EnsemblENST00000402696; ENSP00000385834; ENSG00000091513; .
GeneID7018; -; .
KEGGhsa:7018; -; .
UCSCuc003epv.1; human; .
CTD7018; -; .
GeneCardsGC03P130844; -; .
H-InvDBHIX0024281; -; .
HGNCHGNC:11740; TF; .
HPACAB009538; -; .
HPAHPA001527; -; .
HPAHPA005692; -; .
MIM190000; gene; .
MIM209300; phenotype; .
neXtProtNX_P02787; -; .
Orphanet1195; Atransferrinemia; .
HOGENOMHBG714005; -; .
HOVERGENHBG000055; -; .
InParanoidP02787; -; .
OMAAETTEDC; -; .
OrthoDBEOG4CRKZG; -; .
Pathway_Interaction_DBephbfwdpathway; EPHB forward signaling; .
Pathway_Interaction_DBhif1_tfpathway; HIF-1-alpha transcription factor network; .
ReactomeREACT_15518; Transmembrane transport of small molecules; .
ReactomeREACT_604; Hemostasis; .
DrugBankDB01370; Aluminium; .
DrugBankDB01402; Bismuth; .
DrugBankDB00893; Iron Dextran; .
NextBio27415; -; .
PMAP-CutDBP02787; -; .
ArrayExpressP02787; -; .
BgeeP02787; -; .
CleanExHS_TF; -; .
GenevestigatorP02787; -; .
GermOnlineENSG00000091513; Homo sapiens; .
GOGO:0016324; C:apical plasma membrane; IDA:UniProtKB; .
GOGO:0009925; C:basal plasma membrane; IDA:UniProtKB; .
GOGO:0005905; C:coated pit; IDA:UniProtKB; .
GOGO:0005769; C:early endosome; IDA:UniProtKB; .
GOGO:0030139; C:endocytic vesicle; IDA:MGI; .
GOGO:0010008; C:endosome membrane; TAS:Reactome; .
GOGO:0005576; C:extracellular region; NAS:UniProtKB; .
GOGO:0005770; C:late endosome; IDA:UniProtKB; .
GOGO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; .
GOGO:0055037; C:recycling endosome; IDA:UniProtKB; .
GOGO:0030141; C:stored secretory granule; TAS:Reactome; .
GOGO:0008199; F:ferric iron binding; IEA:InterPro; .
GOGO:0006879; P:cellular iron ion homeostasis; TAS:Reactome; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0033572; P:transferrin transport; TAS:Reactome; .
GOGO:0055085; P:transmembrane transport; TAS:Reactome; .
InterProIPR001156; Peptidase_S60; .
InterProIPR016357; Transferrin; .
InterProIPR018195; Transferrin_Fe_BS; .
PANTHERPTHR11485; Peptidase_S60; 1; .
PfamPF00405; Transferrin; 2; .
PIRSFPIRSF002549; Transferrin; 1; .
PRINTSPR00422; TRANSFERRIN; .
SMARTSM00094; TR_FER; 2; .
PROSITEPS00205; TRANSFERRIN_LIKE_1; 1; .
PROSITEPS00206; TRANSFERRIN_LIKE_2; 2; .
PROSITEPS00207; TRANSFERRIN_LIKE_3; 2; .
PROSITEPS51408; TRANSFERRIN_LIKE_4; 2; .



SWISS-2DPAGE image

SWISS-2DPAGE (search AC)


Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server