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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P05156




SWISS-2DPAGE:  P05156


P05156


General information about the entry
View entry in simple text format
Entry nameCFAI_HUMAN
Primary accession numberP05156
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 1, 2000 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Complement factor I; EC=3.4.21.45; AltName: Full=C3B/C4B inactivator; Contains: RecName: Full=Complement factor I heavy chain; Contains: RecName: Full=Complement factor I light chain; Flags: Precursor;.
Gene nameName=CFI
Synonyms=IF
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=93092937; PubMed=1459097; [NCBI, ExPASy, EBI, Israel, Japan]
Hughes G.J., Frutiger S., Paquet N., Ravier F., Pasquali C., Sanchez J.-C., James R.W., Tissot J.-D., Bjellqvist B., Hochstrasser D.F.
''''''Plasma protein map: an update by microsequencing'';'';''
Electrophoresis 13(1):707-714(1992)
Comments
  • SUBUNIT: LIGHT AND HEAVY CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=5.03; Mw=37900

NORMAL LEVEL:
35 MG/L [1].

PATHOLOGICAL LEVEL:
HEREDITARY DEFICIENCY [1].

MAPPING (identification):
MICROSEQUENCING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP05156; CFAI_HUMAN.
UniProtKB/Swiss-ProtP05156; CFAI_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameCFAI_HUMAN
Primary accession numberP05156
Secondary accession number(s) O60442
Sequence was last modified on January 11, 2011 (version 2)
Annotations were last modified on October 19, 2011 (version 135)
Name and origin of the protein
DescriptionRecName: Full=Complement factor I; EC=3.4.21.45; AltName: Full=C3B/C4B inactivator; Contains: RecName: Full=Complement factor I heavy chain; Contains: RecName: Full=Complement factor I light chain; Flags: Precursor;
Gene nameName=CFI
Synonyms=IF
Encoded onName=CFI; Synonyms=IF
Keywords3D-structure; Cleavage on pair of basic residues; Complement pathway; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemolytic uremic syndrome; Hydrolase; Immunity; Innate immunity; Polymorphism; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLY00318; CAA68416.1; ALT_INIT; mRNA
EMBLJ02770; AAA52455.1; -; mRNA
EMBLAC126283; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLAF005095; AAC08733.2; -; Genomic_DNA
IPIIPI00291867; -; .
PIRA29154; A29154; .
RefSeqNP_000195.2; NM_000204.3; .
UniGeneHs.312485; -; .
PDB2XRC; X-ray; 2.69 A; A/B/C/D=19-583
PDBsum2XRC; -; .
ProteinModelPortalP05156; -; .
SMRP05156; 48-575; .
STRINGP05156; -; .
MEROPSS01.199; -; .
SWISS-2DPAGEP05156; -; .
PeptideAtlasP05156; -; .
PRIDEP05156; -; .
EnsemblENST00000394634; ENSP00000378130; ENSG00000205403; .
GeneID3426; -; .
KEGGhsa:3426; -; .
UCSCuc003hzr.2; human; .
CTD3426; -; .
GeneCardsGC04M106394; -; .
H-InvDBHIX0004438; -; .
HGNCHGNC:5394; CFI; .
HPACAB016777; -; .
HPAHPA001143; -; .
HPAHPA024061; -; .
MIM217030; gene; .
MIM610984; phenotype; .
MIM612923; phenotype; .
neXtProtNX_P05156; -; .
Orphanet93580; Atypical hemolytic uremic syndrome with I factor anomaly; .
Orphanet93559; C3 deposition glomerulonephritis without proliferation; .
Orphanet244275; De novo thrombotic microangiopathy after kidney transplantation; .
Orphanet244242; HELLP syndrome; .
Orphanet200418; Immunodeficiency with factor I anomaly; .
eggNOGprNOG05272; -; .
HOVERGENHBG005311; -; .
BRENDA3.4.21.45; 2681; .
NextBio13512; -; .
ArrayExpressP05156; -; .
BgeeP05156; -; .
CleanExHS_CFI; -; .
GenevestigatorP05156; -; .
GermOnlineENSG00000205403; Homo sapiens; .
GOGO:0005615; C:extracellular space; IEA:UniProtKB-SubCell; .
GOGO:0016020; C:membrane; IEA:InterPro; .
GOGO:0005044; F:scavenger receptor activity; IEA:InterPro; .
GOGO:0004252; F:serine-type endopeptidase activity; TAS:ProtInc; .
GOGO:0006958; P:complement activation; classical pathway; IEA:UniProtKB-KW
GOGO:0045087; P:innate immune response; IEA:UniProtKB-KW; .
GOGO:0006508; P:proteolysis; IEA:InterPro; .
InterProIPR003884; FacI_MAC; .
InterProIPR023415; LDLR_class-A_CS; .
InterProIPR002172; LDrepeatLR_classA_rpt; .
InterProIPR009003; Pept_cys/ser_Trypsin-like; .
InterProIPR018114; Peptidase_S1/S6_AS; .
InterProIPR001254; Peptidase_S1_S6; .
InterProIPR001314; Peptidase_S1A; .
InterProIPR001190; Srcr_rcpt; .
InterProIPR017448; Srcr_rcpt-rel; .
Gene3DG3DSA:4.10.400.10; LDL_rcpt_classA_cys-rich; 2; .
PfamPF00057; Ldl_recept_a; 2; .
PfamPF00530; SRCR; 1; .
PfamPF00089; Trypsin; 1; .
PRINTSPR00722; CHYMOTRYPSIN; .
SMARTSM00057; FIMAC; 1; .
SMARTSM00192; LDLa; 2; .
SMARTSM00202; SR; 1; .
SMARTSM00020; Tryp_SPc; 1; .
SUPFAMSSF57424; LDL_rcpt_classA_cys-rich; 2; .
SUPFAMSSF50494; Pept_Ser_Cys; 1; .
SUPFAMSSF56487; Srcr_receptor; 1; .
PROSITEPS51465; KAZAL_2; 1; .
PROSITEPS01209; LDLRA_1; 1; .
PROSITEPS50068; LDLRA_2; 2; .
PROSITEPS00420; SRCR_1; FALSE_NEG; .
PROSITEPS50287; SRCR_2; 1; .
PROSITEPS50240; TRYPSIN_DOM; 1; .
PROSITEPS00134; TRYPSIN_HIS; 1; .
PROSITEPS00135; TRYPSIN_SER; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server