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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P06753




SWISS-2DPAGE:  P06753


P06753


General information about the entry
View entry in simple text format
Entry nameTPM3_HUMAN
Primary accession numberP06753
Secondary accession number(s) P12324
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onDecember 30, 2004 (version 3)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-3 chain; AltName: Full=Gamma-tropomyosin; AltName: Full=Tropomyosin-3; AltName: Full=Tropomyosin-5; Short=hTM5;.
Gene nameName=TPM3
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
[2]   MAPPING ON GEL
MEDLINE=20529951; PubMed=11079567; [NCBI, ExPASy, EBI, Israel, Japan]
Jung E., Hoogland C., Chiappe D., Sanchez J.-C., Hochstrasser D.F.
''''''The establishment of a human liver nuclei 2-DE reference map'';'';''
Electrophoresis 21(1):3483-3487(2000)
[3]   MAPPING ON GEL
Vuadens F., Crettaz D., Telenti A., Quadroni M., Duchosal M.A., Schneider P., Tissot J.-D.
''''''New insights into HIV lymphocyte infection'';'';''
(IN) Sanchez J.-C., Corthals G.L., Hochstrasser D.F. (eds.)Biomedical Application of Proteomics, pp.245-262, Wiley-VCH, Weinheim (2004)
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
DLD1_HUMAN
  map experimental info
  protein estimated location
 
DLD1_HUMAN

MAP LOCATIONS:
pI=4.69; Mw=28941  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].



LYMPHOCYTE_HUMAN {Lymphocytes}
Homo sapiens (Human)
Tissue: Lymphocyte
LYMPHOCYTE_HUMAN
  map experimental info
  protein estimated location
 
LYMPHOCYTE_HUMAN

MAP LOCATIONS:
pI=4.66; Mw=28835  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [3].



NUCLEI_LIVER_HUMAN {Soluble nuclear proteins and matrix from liver tissue}
Homo sapiens (Human)
Tissue: Liver
NUCLEI_LIVER_HUMAN
  map experimental info
  protein estimated location
 
NUCLEI_LIVER_HUMAN

MAP LOCATIONS:
pI=4.64; Mw=28076  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [2].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
DOSAC-COBS 2D-PAGEP06753; P06753.
DOSAC-COBS-2DPAGEP06753; TPM3_HUMAN.
OGP-WWWP12324.
PHCI-2DPAGEP12324.
UCD-2DPAGEP06753; TPM3_HUMAN.
UniProtKB/Swiss-ProtP06753; TPM3_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameTPM3_HUMAN
Primary accession numberP06753
Secondary accession number(s) D3DV71 P12324 Q2QD06 Q5VU71 Q969Q2 Q9NQH8
Sequence was last modified on January 1, 1988 (version 1)
Annotations were last modified on October 19, 2011 (version 142)
Name and origin of the protein
DescriptionRecName: Full=Tropomyosin alpha-3 chain; AltName: Full=Gamma-tropomyosin; AltName: Full=Tropomyosin-3; AltName: Full=Tropomyosin-5; Short=hTM5;
Gene nameName=TPM3
Encoded onName=TPM3
KeywordsAcetylation; Actin-binding; Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Muscle protein; Nemaline myopathy; Phosphoprotein; Proto-oncogene; Reference proteome.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX04201; CAA27798.1; ALT_INIT; mRNA
EMBLAY004867; AAF87083.1; -; mRNA
EMBLX04588; CAB37185.1; -; mRNA
EMBLAL590431; CAH71264.1; -; Genomic_DNA
EMBLAL590431; CAH71269.1; -; Genomic_DNA
EMBLCH471121; EAW53231.1; -; Genomic_DNA
EMBLCH471121; EAW53235.1; -; Genomic_DNA
EMBLBC000771; AAH00771.1; -; mRNA
EMBLBC008407; AAH08407.1; ALT_INIT; mRNA
EMBLBC008425; AAH08425.1; ALT_INIT; mRNA
EMBLBC015403; AAH15403.1; -; mRNA
EMBLBC072428; AAH72428.1; -; mRNA
EMBLDQ120714; ABC40673.1; -; Genomic_DNA
EMBLX03541; CAA27243.1; ALT_TERM; mRNA
IPIIPI00183968; -; .
IPIIPI00218319; -; .
IPIIPI00218320; -; .
PIRA25530; A25530; .
PIRS06210; A24199; .
RefSeqNP_001036816.1; NM_001043351.1; .
RefSeqNP_001036817.1; NM_001043352.1; .
RefSeqNP_689476.2; NM_152263.2; .
RefSeqNP_705935.1; NM_153649.3; .
UniGeneHs.535581; -; .
UniGeneHs.644306; -; .
UniGeneHs.654421; -; .
ProteinModelPortalP06753; -; .
SMRP06753; 8-284; .
IntActP06753; 3; .
MINTMINT-1142638; -; .
STRINGP06753; -; .
PhosphoSiteP06753; -; .
SWISS-2DPAGEP06753; -; .
Aarhus/Ghent-2DPAGE9121; IEF; .
Cornea-2DPAGEP06753; -; .
DOSAC-COBS-2DPAGEP06753; -; .
PHCI-2DPAGEP06753; -; .
PRIDEP06753; -; .
EnsemblENST00000271850; ENSP00000271850; ENSG00000143549; .
GeneID7170; -; .
KEGGhsa:7170; -; .
UCSCuc001fea.1; human; .
UCSCuc001feb.1; human; .
CTD7170; -; .
GeneCardsGC01M125491; -; .
HGNCHGNC:12012; TPM3; .
HPAHPA000261; -; .
HPAHPA009066; -; .
MIM164970; gene; .
MIM188550; phenotype; .
MIM191030; gene; .
MIM609284; phenotype; .
neXtProtNX_P06753; -; .
Orphanet2020; Congenital fiber-type disproportion myopathy; .
Orphanet171433; Intermediate nemaline myopathy; .
Orphanet171439; Mild nemaline myopathy; .
PharmGKBPA36692; -; .
eggNOGprNOG10062; -; .
HOGENOMHBG505632; -; .
HOVERGENHBG107404; -; .
InParanoidP06753; -; .
OMASKQHEDE; -; .
ReactomeREACT_17044; Muscle contraction; .
NextBio28092; -; .
ArrayExpressP06753; -; .
BgeeP06753; -; .
CleanExHS_TPM3; -; .
GenevestigatorP06753; -; .
GermOnlineENSG00000143549; Homo sapiens; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005862; C:muscle thin filament tropomyosin; TAS:UniProtKB; .
GOGO:0001725; C:stress fiber; IDA:MGI; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0030049; P:muscle filament sliding; TAS:Reactome; .
GOGO:0006937; P:regulation of muscle contraction; NAS:UniProtKB; .
InterProIPR000533; Tropomyosin; .
PfamPF00261; Tropomyosin; 1; .
PRINTSPR00194; TROPOMYOSIN; .
PROSITEPS00326; TROPOMYOSIN; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server