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Sample Preparation and Post-separation Analysis



Searching in 'SWISS-2DPAGE' for entry matching: P09871




SWISS-2DPAGE:  P09871


P09871


General information about the entry
View entry in simple text format
Entry nameC1S_HUMAN
Primary accession numberP09871
integrated into SWISS-2DPAGE on August 1, 1993 (release 0)
2D Annotations were last modified onDecember 30, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 11)
Name and origin of the protein
DescriptionRecName: Full=Complement C1s subcomponent; EC=3.4.21.42; AltName: Full=C1 esterase; AltName: Full=Complement component 1 subcomponent s; Contains: RecName: Full=Complement C1s subcomponent heavy chain; Contains: RecName: Full=Complement C1s subcomponent light chain; Flags: Precursor;.
Gene nameName=C1S
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   MAPPING ON GEL
MEDLINE=82184798; PubMed=7074867; [NCBI, ExPASy, EBI, Israel, Japan]
Anderson N.G., Anderson N.L.
''''''The Human Protein Index'';'';''
Clin. Chem. 28(1):739-748(1982)
[2]   MAPPING ON GEL
MEDLINE=96007934; PubMed=7498157; [NCBI, ExPASy, EBI, Israel, Japan]
Sanchez J.-C., Appel R.D., Golaz O.G., Pasquali C., Ravier F., Bairoch A., Hochstrasser D.F.
''''''Inside SWISS-2DPAGE database'';'';''
Electrophoresis 16(1):1131-1151(1995)
Comments
  • SUBUNIT: SINGLE CHAIN
2D PAGE maps for identified proteins
How to interpret a protein

CSF_HUMAN {Cerebrospinal Fluid}
Homo sapiens (Human)
Tissue: Cerebrospinal fluid
CSF_HUMAN
  map experimental info
  protein estimated location
 
CSF_HUMAN

MAP LOCATIONS:
pI=4.67; Mw=100412
pI=4.73; Mw=97982
pI=4.77; Mw=96552
pI=4.82; Mw=95142

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



HEPG2SP_HUMAN {HepG2 Secreted Proteins}
Homo sapiens (Human)
Tissue: Hepatoblastoma
HEPG2SP_HUMAN
  map experimental info
  protein estimated location
 
HEPG2SP_HUMAN

MAP LOCATIONS:
pI=4.70; Mw=100565

MAPPING (identification):
MATCHING WITH THE PLASMA MASTER GEL [2].



PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma
PLASMA_HUMAN
  map experimental info
  protein estimated location
 
PLASMA_HUMAN

MAP LOCATIONS:
pI=4.79; Mw=89871
pI=4.81; Mw=88849
pI=4.83; Mw=88173
pI=4.84; Mw=87503

NORMAL LEVEL:
50 MG/L.

PATHOLOGICAL LEVEL:
DECREASED DURING LUPUS ERYTHEMATOSUS.

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright
This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://world-2dpage.expasy.org/swiss-2dpage/docs/license.html or send email from license@isb-sib.ch).
Cross-references
Siena-2DPAGEP09871; C1S_HUMAN.
UniProtKB/Swiss-ProtP09871; C1S_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameC1S_HUMAN
Primary accession numberP09871
Secondary accession number(s) D3DUT4 Q9UCU7 Q9UCU8 Q9UCU9 Q9UCV0 Q9UCV1 Q9UCV2 Q9UCV3 Q9UCV4 Q9UCV5 Q9UM14
Sequence was last modified on July 1, 1989 (version 1)
Annotations were last modified on October 19, 2011 (version 157)
Name and origin of the protein
DescriptionRecName: Full=Complement C1s subcomponent; EC=3.4.21.42; AltName: Full=C1 esterase; AltName: Full=Complement component 1 subcomponent s; Contains: RecName: Full=Complement C1s subcomponent heavy chain; Contains: RecName: Full=Complement C1s subcomponent light chain; Flags: Precursor;
Gene nameName=C1S
Encoded onName=C1S
Keywords3D-structure; Calcium; Complement pathway; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Glycoprotein; Hydrolase; Hydroxylation; Immunity; Innate immunity; Metal-binding; Polymorphism; Protease; Reference proteome; Repeat; Serine protease; Signal; Sushi.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX06596; CAA29817.1; -; mRNA
EMBLM18767; AAA51853.1; -; mRNA
EMBLJ04080; AAA51852.1; -; mRNA
EMBLCH471116; EAW88689.1; -; Genomic_DNA
EMBLCH471116; EAW88690.1; -; Genomic_DNA
EMBLBC056903; AAH56903.1; -; mRNA
EMBLAB009076; BAA86864.1; -; Genomic_DNA
IPIIPI00017696; -; .
PIRA40496; C1HUS; .
RefSeqNP_001725.1; NM_001734.3; .
RefSeqNP_958850.1; NM_201442.2; .
UniGeneHs.458355; -; .
PDB1ELV; X-ray; 1.70 A; A=358-688
PDB1NZI; X-ray; 1.50 A; A/B=16-174
PDBsum1ELV; -; .
PDBsum1NZI; -; .
ProteinModelPortalP09871; -; .
SMRP09871; 18-683; .
IntActP09871; 6; .
STRINGP09871; -; .
MEROPSS01.193; -; .
PhosphoSiteP09871; -; .
SWISS-2DPAGEP09871; -; .
PeptideAtlasP09871; -; .
PRIDEP09871; -; .
EnsemblENST00000328916; ENSP00000328173; ENSG00000182326; .
EnsemblENST00000360817; ENSP00000354057; ENSG00000182326; .
EnsemblENST00000406697; ENSP00000385035; ENSG00000182326; .
GeneID716; -; .
KEGGhsa:716; -; .
UCSCuc001qsj.1; human; .
CTD716; -; .
GeneCardsGC12P007028; -; .
H-InvDBHIX0019128; -; .
HGNCHGNC:1247; C1S; .
HPACAB016722; -; .
HPAHPA018852; -; .
MIM120580; gene; .
MIM613783; phenotype; .
neXtProtNX_P09871; -; .
Orphanet169147; Immunodeficiency due to an early component of complement deficiency; .
PharmGKBPA25636; -; .
eggNOGprNOG11309; -; .
GeneTreeENSGT00560000076882; -; .
HOVERGENHBG000559; -; .
InParanoidP09871; -; .
OMANGSWVNE; -; .
OrthoDBEOG4H19VC; -; .
PhylomeDBP09871; -; .
ReactomeREACT_6900; Immune System; .
DrugBankDB00054; Abciximab; .
DrugBankDB00051; Adalimumab; .
DrugBankDB00074; Basiliximab; .
DrugBankDB00002; Cetuximab; .
DrugBankDB00005; Etanercept; .
DrugBankDB00056; Gemtuzumab ozogamicin; .
DrugBankDB00078; Ibritumomab; .
DrugBankDB00028; Immune globulin; .
DrugBankDB00075; Muromonab; .
DrugBankDB00073; Rituximab; .
DrugBankDB00072; Trastuzumab; .
NextBio2912; -; .
PMAP-CutDBP09871; -; .
ArrayExpressP09871; -; .
BgeeP09871; -; .
GenevestigatorP09871; -; .
GermOnlineENSG00000182326; Homo sapiens; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005509; F:calcium ion binding; IEA:InterPro; .
GOGO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB; .
GOGO:0006958; P:complement activation; classical pathway; TAS:Reactome
GOGO:0045087; P:innate immune response; TAS:Reactome; .
GOGO:0006508; P:proteolysis; IEA:InterPro; .
InterProIPR016060; Complement_control_module; .
InterProIPR000859; CUB; .
InterProIPR001881; EGF-like_Ca-bd; .
InterProIPR000152; EGF-type_Asp/Asn_hydroxyl_site; .
InterProIPR018097; EGF_Ca-bd_CS; .
InterProIPR009003; Pept_cys/ser_Trypsin-like; .
InterProIPR024175; Pept_S1A_C1r/C1S/mannan-bd; .
InterProIPR018114; Peptidase_S1/S6_AS; .
InterProIPR001254; Peptidase_S1_S6; .
InterProIPR001314; Peptidase_S1A; .
InterProIPR000436; Sushi_SCR_CCP; .
Gene3DG3DSA:2.10.70.10; Complement_control_module; 2; .
Gene3DG3DSA:2.60.120.290; CUB; 2; .
PfamPF00431; CUB; 2; .
PfamPF07645; EGF_CA; 1; .
PfamPF00084; Sushi; 2; .
PfamPF00089; Trypsin; 1; .
PIRSFPIRSF001155; C1r_C1s_MASP; 1; .
PRINTSPR00722; CHYMOTRYPSIN; .
SMARTSM00032; CCP; 2; .
SMARTSM00042; CUB; 2; .
SMARTSM00179; EGF_CA; 1; .
SMARTSM00020; Tryp_SPc; 1; .
SUPFAMSSF57535; Complement_control_module; 2; .
SUPFAMSSF49854; CUB; 2; .
SUPFAMSSF50494; Pept_Ser_Cys; 1; .
PROSITEPS00010; ASX_HYDROXYL; 1; .
PROSITEPS01180; CUB; 2; .
PROSITEPS00022; EGF_1; FALSE_NEG; .
PROSITEPS01186; EGF_2; FALSE_NEG; .
PROSITEPS50026; EGF_3; FALSE_NEG; .
PROSITEPS01187; EGF_CA; 1; .
PROSITEPS50923; SUSHI; 2; .
PROSITEPS50240; TRYPSIN_DOM; 1; .
PROSITEPS00134; TRYPSIN_HIS; FALSE_NEG; .
PROSITEPS00135; TRYPSIN_SER; 1; .



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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server