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Sample Preparation and Post-separation Analysis

Searching in 'SWISS-2DPAGE' for entry matching: P18206



General information about the entry
View entry in simple text format
Entry nameVINC_HUMAN
Primary accession numberP18206
integrated into SWISS-2DPAGE on January 15, 1999 (release 9)
2D Annotations were last modified onMarch 31, 2004 (version 1)
General Annotations were last modified on May 19, 2011 (version 9)
Name and origin of the protein
DescriptionRecName: Full=Vinculin; AltName: Full=Metavinculin;.
Gene nameName=VCL
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Demalte-Annessi I., Sanchez J.-C., Hoogland C., Rouge V., Binz P.-A., Appel R.D., Hochstrasser D.F.
Submitted (JAN-1999) to SWISS-2DPAGE
2D PAGE maps for identified proteins
How to interpret a protein

DLD1_HUMAN {Colorectal adenocarcinoma cell line (DL-1)}
Homo sapiens (Human)
Tissue: Colon adenocarcinoma
  map experimental info
  protein estimated location

pI=5.89; Mw=129569  [identification data]

MAPPING (identification):
Peptide mass fingerprinting [1].

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See or send email from
DOSAC-COBS 2D-PAGEP18206; P18206.
UniProtKB/Swiss-ProtP18206; VINC_HUMAN.
2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_10
Entry nameVINC_HUMAN
Primary accession numberP18206
Secondary accession number(s) Q16450 Q5SWX2 Q7Z3B8 Q8IXU7
Sequence was last modified on January 23, 2007 (version 4)
Annotations were last modified on October 19, 2011 (version 138)
Name and origin of the protein
DescriptionRecName: Full=Vinculin; AltName: Full=Metavinculin;
Gene nameName=VCL
Encoded onName=VCL
Keywords3D-structure; Acetylation; Actin-binding; Alternative splicing; Cardiomyopathy; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Lipoprotein; Membrane; Myristate; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM33308; AAA61283.1; -; mRNA
EMBLBX537994; CAD97952.1; -; mRNA
EMBLAL596247; CAI13972.1; -; Genomic_DNA
EMBLAL731576; CAI13972.1; JOINED; Genomic_DNA
EMBLAL731576; CAI39673.1; -; Genomic_DNA
EMBLAL596247; CAI39673.1; JOINED; Genomic_DNA
EMBLBC039174; AAH39174.1; -; mRNA
EMBLL04933; AAA61271.1; -; Genomic_DNA
EMBLS87180; AAB21656.1; -; Genomic_DNA
EMBLS87175; AAB21656.1; JOINED; Genomic_DNA
EMBLS87178; AAB21656.1; JOINED; Genomic_DNA
EMBLS87223; AAB21657.1; -; Genomic_DNA
EMBLS87218; AAB21657.1; JOINED; Genomic_DNA
IPIIPI00291175; -; .
IPIIPI00307162; -; .
IPIIPI00384973; -; .
PIRA35955; A35955; .
RefSeqNP_003364.1; NM_003373.3; .
RefSeqNP_054706.1; NM_014000.2; .
UniGeneHs.643896; -; .
PDB1RKC; X-ray; 2.70 A; A=1-258
PDB1RKE; X-ray; 2.35 A; A=1-258
B=882-1134PDB; 1SYQ; X-ray; 2.42 A
A=1-258PDB; 1TR2; X-ray; 2.90 A
A/B=1-1134PDB; 1YDI; X-ray; 1.80 A
A=1-258PDB; 2GWW; X-ray; 2.72 A
A=1-257PDB; 2HSQ; X-ray; 3.97 A
A=2-257PDB; 2IBF; X-ray; 3.20 A
A=1-258PDB; 3H2U; X-ray; 2.75 A
A/C=879-1134PDB; 3H2V; X-ray; 2.90 A
A/B/C/D=879-1134PDB; 3MYI; X-ray; 2.20 A
A=959-1130PDB; 3RF3; X-ray; 1.61 A
A/B=1-258PDB; 3S90; X-ray; 1.97 A
A/B=1-252PDBsum; 1RKC; -; .
PDBsum1RKE; -; .
PDBsum1SYQ; -; .
PDBsum1TR2; -; .
PDBsum1YDI; -; .
PDBsum2GWW; -; .
PDBsum2HSQ; -; .
PDBsum2IBF; -; .
PDBsum3H2U; -; .
PDBsum3H2V; -; .
PDBsum3MYI; -; .
PDBsum3RF3; -; .
PDBsum3S90; -; .
ProteinModelPortalP18206; -; .
SMRP18206; 1-258; 961-1129; .
DIPDIP-35570N; -; .
IntActP18206; 7; .
MINTMINT-92846; -; .
STRINGP18206; -; .
PhosphoSiteP18206; -; .
SWISS-2DPAGEP18206; -; .
Aarhus/Ghent-2DPAGE3708; IEF; .
OGPP18206; -; .
UCD-2DPAGEP18206; -; .
PRIDEP18206; -; .
EnsemblENST00000211998; ENSP00000211998; ENSG00000035403; .
GeneID7414; -; .
KEGGhsa:7414; -; .
UCSCuc001jwd.1; human; .
UCSCuc001jwe.1; human; .
CTD7414; -; .
GeneCardsGC10P069753; -; .
HGNCHGNC:12665; VCL; .
HPACAB002453; -; .
HPAHPA002131; -; .
MIM193065; gene; .
MIM611407; phenotype; .
MIM613255; phenotype; .
neXtProtNX_P18206; -; .
Orphanet154; Familial isolated dilated cardiomyopathy; .
Orphanet155; Familial isolated hypertrophic cardiomyopathy; .
eggNOGprNOG17973; -; .
HOGENOMHBG358349; -; .
HOVERGENHBG079758; -; .
InParanoidP18206; -; .
OrthoDBEOG4P5K8C; -; .
PhylomeDBP18206; -; .
Pathway_Interaction_DBavb3_integrin_pathway; Integrins in angiogenesis; .
Pathway_Interaction_DBvegfr1_2_pathway; Signaling events mediated by VEGFR1 and VEGFR2; .
ReactomeREACT_17044; Muscle contraction; .
ReactomeREACT_604; Hemostasis; .
NextBio29028; -; .
ArrayExpressP18206; -; .
BgeeP18206; -; .
CleanExHS_VCL; -; .
GenevestigatorP18206; -; .
GermOnlineENSG00000035403; Homo sapiens; .
GOGO:0043034; C:costamere; ISS:UniProtKB; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0005576; C:extracellular region; TAS:Reactome; .
GOGO:0005925; C:focal adhesion; ISS:UniProtKB; .
GOGO:0003779; F:actin binding; IEA:UniProtKB-KW; .
GOGO:0045294; F:alpha-catenin binding; IPI:UniProtKB; .
GOGO:0008013; F:beta-catenin binding; ISS:BHF-UCL; .
GOGO:0002166; F:beta-dystroglycan binding; IPI:UniProtKB; .
GOGO:0045296; F:cadherin binding; ISS:BHF-UCL; .
GOGO:0005198; F:structural molecule activity; IEA:InterPro; .
GOGO:0034333; P:adherens junction assembly; IMP:BHF-UCL; .
GOGO:0043297; P:apical junction assembly; IMP:UniProtKB; .
GOGO:0007160; P:cell-matrix adhesion; TAS:BHF-UCL; .
GOGO:0006928; P:cellular component movement; TAS:UniProtKB; .
GOGO:0090136; P:epithelial cell-cell adhesion; IMP:BHF-UCL; .
GOGO:0030032; P:lamellipodium assembly; ISS:UniProtKB; .
GOGO:0002009; P:morphogenesis of an epithelium; IMP:BHF-UCL; .
GOGO:0006936; P:muscle contraction; TAS:Reactome; .
GOGO:0030336; P:negative regulation of cell migration; TAS:UniProtKB; .
GOGO:0030168; P:platelet activation; TAS:Reactome; .
GOGO:0002576; P:platelet degranulation; TAS:Reactome; .
GOGO:0034394; P:protein localization at cell surface; IMP:BHF-UCL; .
InterProIPR017997; Vinculin; .
InterProIPR006077; Vinculin/catenin; .
InterProIPR000633; Vinculin_CS; .
PfamPF01044; Vinculin; 3; .
SUPFAMSSF47220; Vinculin/catenin; 8; .


SWISS-2DPAGE (search AC)

Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server