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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0014]' for entry matching: ACOC_RAT World-2DPAGE Repository (0014):  ACOC_RAT ACOC_RAT General information about the entry View entry in simple text format Entry name ACOC_RAT Primary accession number Q63270 integrated into World-2DPAGE Repository (0014) on  October 13, 2008 (release 1) 2D Annotations were last modified on June 1, 2011 (version 3) General Annotations were last modified on  November 25, 2011 (version 2) Name and origin of the protein Description RecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1;. Gene name Name=Aco1 Synonyms=Ireb1, Irebp Annotated species Rattus norvegicus (Rat) [TaxID: 10116] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1002/pmic.200900680; Maurya D.K., Sundaram C.S., Bhargava P. ''Proteome profile of whole cerebellum of the mature rat'' Proteomics 10(23):4311-4319 (2010) 2D PAGE maps for identified proteins How to interpret a protein RAT_CEREBELLUM_21D {Proteome of 21 days old rat cerebellum} Rattus norvegicus (Rat) Tissue: Cerebellum   map experimental info   RAT_CEREBELLUM_21D MAP LOCATIONS: SPOT 2706: pI=7.73; Mw=76000   [identification data] IDENTIFICATION: SPOT 2706: SeqCov=26%. MascotPMF=112 [1]. MAPPING (identification): SPOT 2706: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India Cross-references PRIDE 10017. UniProtKB/Swiss-Prot Q63270; ACOC_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_11 Entry name ACOC_RAT Primary accession number Q63270 Sequence was last modified on  November 1, 1996 (version 1) Annotations were last modified on  November 16, 2011 (version 97) Name and origin of the protein Description RecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1; Gene name Name=Aco1 Synonyms=Ireb1, Irebp Encoded on Name=Aco1; Synonyms=Ireb1, Irebp Keywords 4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Reference proteome; RNA-binding; Tricarboxylic acid cycle. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L23874; AAA41449.1; -; mRNA IPI IPI00207003; -; . PIR A44154; A44154; . RefSeq NP_059017.1; NM_017321.1; . UniGene Rn.35934; -; . ProteinModelPortal Q63270; -; . SMR Q63270; 3-889; . STRING Q63270; -; . PhosphoSite Q63270; -; . PRIDE Q63270; -; . GeneID 50655; -; . KEGG rno:50655; -; . UCSC NM_017321; rat; . CTD 48; -; . RGD 2019; Aco1; . eggNOG roNOG06028; -; . GeneTree ENSGT00530000063060; -; . HOVERGEN HBG052147; -; . OrthoDB EOG4C2H8W; -; . PhylomeDB Q63270; -; . NextBio 610466; -; . ArrayExpress Q63270; -; . Genevestigator Q63270; -; . GermOnline ENSRNOG00000005849; Rattus norvegicus; . GO GO:0005829; C:cytosol; IDA:RGD; . GO GO:0005783; C:endoplasmic reticulum; IDA:RGD; . GO GO:0005794; C:Golgi apparatus; IDA:MGI; . GO GO:0005792; C:microsome; IDA:RGD; . GO GO:0005625; C:soluble fraction; IDA:RGD; . GO GO:0051539; F:4 iron; 4 sulfur cluster binding; ISS:UniProtKB GO GO:0003994; F:aconitate hydratase activity; ISS:UniProtKB; . GO GO:0052632; F:citrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC; . GO GO:0030350; F:iron-responsive element binding; ISS:UniProtKB; . GO GO:0052633; F:isocitrate hydro-lyase (cis-aconitate-forming) activity; IEA:EC; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0048027; F:mRNA 5'-UTR binding; IDA:RGD; . GO GO:0006879; P:cellular iron ion homeostasis; IDA:RGD; . GO GO:0006101; P:citrate metabolic process; ISS:UniProtKB; . GO GO:0006417; P:regulation of translation; TAS:RGD; . GO GO:0010040; P:response to iron(II) ion; ISS:UniProtKB; . GO GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW; . InterPro IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3; . InterPro IPR015937; Acoase/IPM_deHydtase; . InterPro IPR001030; Acoase/IPM_deHydtase_lsu_aba; . InterPro IPR015928; Aconitase/3IPM_dehydase_swvl; . InterPro IPR006249; Aconitase/Fe_reg_prot_2; . InterPro IPR015934; Aconitase/Fe_reg_prot_2/AcnD; . InterPro IPR015932; Aconitase/IPMdHydase_lsu_aba_2; . InterPro IPR018136; Aconitase_4Fe-4S_BS; . InterPro IPR000573; AconitaseA/IPMdHydase_ssu_swvl; . Gene3D G3DSA:3.30.499.10; Acnase/IPM_dHydase_lsu_aba_1/3; 3; . Gene3D G3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl; 1; . Gene3D G3DSA:3.40.1060.10; Aconitase/IPMdHydase_lsu_aba_2; 1; . KO K01681; -; . PANTHER PTHR11670; Aconitase-like_core; 1; . PANTHER PTHR11670:SF1; Aconitase/Fe_reg_prot_2/AcnD; 1; . Pfam PF00330; Aconitase; 1; . Pfam PF00694; Aconitase_C; 1; . PRINTS PR00415; ACONITASE; . SUPFAM SSF52016; Aconitase/3IPM_dehydase_swvl; 1; . SUPFAM SSF53732; Aconitase_N; 1; . TIGRFAMs TIGR01341; Aconitase_1; 1; . PROSITE PS00450; ACONITASE_1; 1; . PROSITE PS01244; ACONITASE_2; 1; . World-2DPAGE Repository (search AC)