World-2DPAGE Repository
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World-2DPAGE Repository
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Select Remote Interfaces
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SWISS-2DPAGE
World-2DPAGE Portal
Exclude local DBs
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Searching in 'World-2DPAGE Repository [0014]' for entry
matching:
ACOC_RAT
World-2DPAGE Repository
(0014):
ACOC_RAT
ACOC_RAT
General information about the entry
View entry in simple text format
Entry name
ACOC_RAT
Primary accession number
Q63270
integrated into World-2DPAGE Repository (0014) on
October 13, 2008 (release 1)
2D Annotations were last modified on
June 1, 2011 (version 3)
General Annotations were last modified on
November 25, 2011 (version 2)
Name and origin of the protein
Description
RecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1;.
Gene name
Name=Aco1
Synonyms=Ireb1, Irebp
Annotated species
Rattus norvegicus (Rat) [TaxID:
10116
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]
2D-PAGE GEL CHARACTERIZATION
DOI=
10.1002/pmic.200900680
;
Maurya D.K., Sundaram C.S., Bhargava P.
''Proteome profile of whole cerebellum of the mature rat''
Proteomics 10(23):4311-4319 (2010)
2D PAGE maps for identified proteins
How to interpret a protein
RAT_CEREBELLUM_21D
{Proteome of 21 days old rat cerebellum}
Rattus norvegicus (Rat)
Tissue: Cerebellum
map experimental info
RAT_CEREBELLUM_21D
MAP LOCATIONS:
SPOT 2706
:
pI=7.73; Mw=76000
[identification data]
IDENTIFICATION:
SPOT 2706: SeqCov=26%. MascotPMF=112 [
1
].
MAPPING (identification):
SPOT
2706
:
Peptide mass fingerprinting
[
1
];
Tandem mass spectrometry
[
1
].
Copyright
Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India
Cross-references
PRIDE
10017.
UniProtKB/Swiss-Prot
Q63270; ACOC_RAT.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
2011_11
Entry name
ACOC_RAT
Primary accession number
Q63270
Sequence was last modified on
November 1, 1996 (version 1)
Annotations were last modified on
November 16, 2011 (version 97)
Name and origin of the protein
Description
RecName: Full=Cytoplasmic aconitate hydratase; Short=Aconitase; EC=4.2.1.3; AltName: Full=Citrate hydro-lyase; AltName: Full=Iron regulatory protein 1; Short=IRP1; AltName: Full=Iron-responsive element-binding protein 1; Short=IRE-BP 1;
Gene name
Name=Aco1
Synonyms=Ireb1, Irebp
Encoded on
Name=Aco1; Synonyms=Ireb1, Irebp
Keywords
4Fe-4S
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Iron
;
Iron-sulfur
;
Lyase
;
Metal-binding
;
Reference proteome
;
RNA-binding
;
Tricarboxylic acid cycle
.
Copyright
Copyrighted by the UniProt Consortium, see
https://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
L23874; AAA41449.1
; -; mRNA
IPI
IPI00207003; -
; .
PIR
A44154; A44154
; .
RefSeq
NP_059017.1; NM_017321.1
; .
UniGene
Rn.35934; -
; .
ProteinModelPortal
Q63270; -
; .
SMR
Q63270; 3-889
; .
STRING
Q63270; -
; .
PhosphoSite
Q63270; -
; .
PRIDE
Q63270; -
; .
GeneID
50655; -
; .
KEGG
rno:50655; -
; .
UCSC
NM_017321; rat
; .
CTD
48; -
; .
RGD
2019; Aco1
; .
eggNOG
roNOG06028; -
; .
GeneTree
ENSGT00530000063060; -
; .
HOVERGEN
HBG052147; -
; .
OrthoDB
EOG4C2H8W; -
; .
PhylomeDB
Q63270; -
; .
NextBio
610466; -
; .
ArrayExpress
Q63270; -
; .
Genevestigator
Q63270; -
; .
GermOnline
ENSRNOG00000005849; Rattus norvegicus
; .
GO
GO:0005829; C:cytosol
; IDA:RGD; .
GO
GO:0005783; C:endoplasmic reticulum
; IDA:RGD; .
GO
GO:0005794; C:Golgi apparatus
; IDA:MGI; .
GO
GO:0005792; C:microsome
; IDA:RGD; .
GO
GO:0005625; C:soluble fraction
; IDA:RGD; .
GO
GO:0051539; F:4 iron
; 4 sulfur cluster binding; ISS:UniProtKB
GO
GO:0003994; F:aconitate hydratase activity
; ISS:UniProtKB; .
GO
GO:0052632; F:citrate hydro-lyase (cis-aconitate-forming) activity
; IEA:EC; .
GO
GO:0030350; F:iron-responsive element binding
; ISS:UniProtKB; .
GO
GO:0052633; F:isocitrate hydro-lyase (cis-aconitate-forming) activity
; IEA:EC; .
GO
GO:0046872; F:metal ion binding
; IEA:UniProtKB-KW; .
GO
GO:0048027; F:mRNA 5'-UTR binding
; IDA:RGD; .
GO
GO:0006879; P:cellular iron ion homeostasis
; IDA:RGD; .
GO
GO:0006101; P:citrate metabolic process
; ISS:UniProtKB; .
GO
GO:0006417; P:regulation of translation
; TAS:RGD; .
GO
GO:0010040; P:response to iron(II) ion
; ISS:UniProtKB; .
GO
GO:0006099; P:tricarboxylic acid cycle
; IEA:UniProtKB-KW; .
InterPro
IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3
; .
InterPro
IPR015937; Acoase/IPM_deHydtase
; .
InterPro
IPR001030; Acoase/IPM_deHydtase_lsu_aba
; .
InterPro
IPR015928; Aconitase/3IPM_dehydase_swvl
; .
InterPro
IPR006249; Aconitase/Fe_reg_prot_2
; .
InterPro
IPR015934; Aconitase/Fe_reg_prot_2/AcnD
; .
InterPro
IPR015932; Aconitase/IPMdHydase_lsu_aba_2
; .
InterPro
IPR018136; Aconitase_4Fe-4S_BS
; .
InterPro
IPR000573; AconitaseA/IPMdHydase_ssu_swvl
; .
Gene3D
G3DSA:3.30.499.10; Acnase/IPM_dHydase_lsu_aba_1/3
; 3; .
Gene3D
G3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl
; 1; .
Gene3D
G3DSA:3.40.1060.10; Aconitase/IPMdHydase_lsu_aba_2
; 1; .
KO
K01681; -
; .
PANTHER
PTHR11670; Aconitase-like_core
; 1; .
PANTHER
PTHR11670:SF1; Aconitase/Fe_reg_prot_2/AcnD
; 1; .
Pfam
PF00330; Aconitase
; 1; .
Pfam
PF00694; Aconitase_C
; 1; .
PRINTS
PR00415; ACONITASE
; .
SUPFAM
SSF52016; Aconitase/3IPM_dehydase_swvl
; 1; .
SUPFAM
SSF53732; Aconitase_N
; 1; .
TIGRFAMs
TIGR01341; Aconitase_1
; 1; .
PROSITE
PS00450; ACONITASE_1
; 1; .
PROSITE
PS01244; ACONITASE_2
; 1; .
World-2DPAGE Repository (search AC)
Database constructed and maintained by
SIB
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server