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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0022]' for entry matching: DLDH_RAT World-2DPAGE Repository (0022):  DLDH_RAT DLDH_RAT General information about the entry View entry in simple text format Entry name DLDH_RAT Primary accession number Q6P6R2 integrated into World-2DPAGE Repository (0022) on  May 7, 2010 (release 1) 2D Annotations were last modified on June 22, 2011 (version 2) General Annotations were last modified on  November 24, 2011 (version 2) Name and origin of the protein Description RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial; EC=1.8.1.4; AltName: Full=Dihydrolipoamide dehydrogenase; Flags: Precursor;. Gene name Name=Dld Annotated species Rattus [TaxID: 10114] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1002/pmic.201000593; Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L. ''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity'' Proteomics 11(16):3369-3379 (2011) 2D PAGE maps for identified proteins How to interpret a protein HCR_LCR_HEART {HCR LCR Cardiac Map} Rattus Tissue: Heart   map experimental info   HCR_LCR_HEART MAP LOCATIONS: SPOT 870: pI=7.96; Mw=54574   [identification data] IDENTIFICATION: SPOT 870: SeqCov=32.8%. Peptides MS=13/20. Mascot PMF Score=118 [1]. PEPTIDE EVIDENCE: SPOT 870: 483-VCHAHPTLSEAFR-495 (79) / 301-AEVITCDVLLVCIGR-315 (80) / 316-RPFTQNLGLEELGIELDPK-334 (99) [1]. MAPPING (identification): SPOT 870: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Jatin Burniston, Liverpool John Moores University, UK Cross-references UniProtKB/Swiss-Prot Q6P6R2; DLDH_RAT. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_11 Entry name DLDH_RAT Primary accession number Q6P6R2 Sequence was last modified on  July 5, 2004 (version 1) Annotations were last modified on  November 16, 2011 (version 70) Name and origin of the protein Description RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial; EC=1.8.1.4; AltName: Full=Dihydrolipoamide dehydrogenase; Flags: Precursor; Gene name Name=Dld Encoded on Name=Dld Keywords Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Redox-active center; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL BC062069; AAH62069.1; -; mRNA IPI IPI00365545; -; . RefSeq NP_955417.1; NM_199385.1; . UniGene Rn.86962; -; . HSSP P09622; 2F5Z; . ProteinModelPortal Q6P6R2; -; . SMR Q6P6R2; 37-509; . IntAct Q6P6R2; 1; . MINT MINT-1775384; -; . STRING Q6P6R2; -; . PhosphoSite Q6P6R2; -; . PRIDE Q6P6R2; -; . Ensembl ENSRNOT00000008980; ENSRNOP00000008980; ENSRNOG00000006364; . GeneID 298942; -; . KEGG rno:298942; -; . NMPDR fig|10116.3.peg.24978; -; . UCSC NM_199385; rat; . CTD 1738; -; . RGD 735073; Dld; . eggNOG roNOG12361; -; . GeneTree ENSGT00550000074844; -; . HOVERGEN HBG002290; -; . OrthoDB EOG46Q6SC; -; . PhylomeDB Q6P6R2; -; . NextBio 644542; -; . ArrayExpress Q6P6R2; -; . Genevestigator Q6P6R2; -; . GermOnline ENSRNOG00000006364; Rattus norvegicus; . GO GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell; . GO GO:0045252; C:oxoglutarate dehydrogenase complex; IDA:RGD; . GO GO:0045254; C:pyruvate dehydrogenase complex; IDA:RGD; . GO GO:0004148; F:dihydrolipoyl dehydrogenase activity; IDA:RGD; . GO GO:0050660; F:flavin adenine dinucleotide binding; IDA:RGD; . GO GO:0043544; F:lipoamide binding; IDA:RGD; . GO GO:0051287; F:NAD binding; IDA:RGD; . GO GO:0006103; P:2-oxoglutarate metabolic process; IDA:RGD; . GO GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:RGD; . GO GO:0007568; P:aging; IEP:RGD; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0051068; P:dihydrolipoamide metabolic process; IDA:RGD; . GO GO:0009106; P:lipoate metabolic process; IDA:RGD; . InterPro IPR016156; FAD/NAD-linked_Rdtase_dimer; . InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase; . InterPro IPR006258; Lipoamide_DH; . InterPro IPR004099; Pyr_nucl-diS_OxRdtase_dimer; . InterPro IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD; . InterPro IPR012999; Pyr_OxRdtase_I_AS; . InterPro IPR001327; Pyr_OxRdtase_NAD-bd_dom; . Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1; . KO K00382; -; . PANTHER PTHR22912:SF20; Lipoamide_DH; 1; . Pfam PF00070; Pyr_redox; 1; . Pfam PF07992; Pyr_redox_2; 1; . Pfam PF02852; Pyr_redox_dim; 1; . PRINTS PR00368; FADPNR; . SUPFAM SSF55424; FAD/NAD-linked_reductase_dimer; 1; . TIGRFAMs TIGR01350; Lipoamide_DH; 1; . PROSITE PS00076; PYRIDINE_REDOX_1; 1; . World-2DPAGE Repository (search AC)