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Searching in 'World-2DPAGE Repository [0022]' for entry matching: EZRI_RAT

World-2DPAGE Repository (0022):  EZRI_RAT


General information about the entry
View entry in simple text format
Entry nameEZRI_RAT
Primary accession numberP31977
integrated into World-2DPAGE Repository (0022) on May 7, 2010 (release 1)
2D Annotations were last modified onJune 22, 2011 (version 2)
General Annotations were last modified on November 24, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81;.
Gene nameName=Ezr
Annotated speciesRattus [TaxID: 10114]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae.
Burniston J.G., Kenyani J., Wastling J.M., Burant C.F., Qi N.R., Koch L.G., Britton S.L.
''Proteomic analysis reveals perturbed energy metabolism and elevated oxidative stress in hearts of rats with inborn low aerobic capacity''
Proteomics 11(16):3369-3379 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

Tissue: Heart
  map experimental info

pI=5.83; Mw=69462  [identification data]

IDENTIFICATION: SPOT 416: SeqCov=17.6%. Peptides MS=12/20. Mascot PMF Score=62 [1].
PEPTIDE EVIDENCE: SPOT 416: 238-IGFPWSEIR-246 (62) / 172-IQVWHAEHR-180 (17) / 264-APDFVFYAPR-273 (50) [1].
MAPPING (identification):
SPOT 416: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Jatin Burniston, Liverpool John Moores University, UK
UniProtKB/Swiss-ProtP31977; EZRI_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameEZRI_RAT
Primary accession numberP31977
Secondary accession number(s) Q5WQV4 Q66H97 Q8VHK3
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on November 16, 2011 (version 99)
Name and origin of the protein
DescriptionRecName: Full=Ezrin; AltName: Full=Cytovillin; AltName: Full=Villin-2; AltName: Full=p81;
Gene nameName=Ezr
Encoded onName=Ezr; Synonyms=Vil2
KeywordsAcetylation; Cell membrane; Cell projection; Cell shape; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLAY428869; AAR91694.1; -; mRNA
EMBLBC081958; AAH81958.1; -; mRNA
EMBLAF450298; AAL47844.1; -; mRNA
EMBLX67788; CAA48004.1; -; mRNA
IPIIPI00470254; -; .
PIRS58759; S58759; .
RefSeqNP_062230.1; NM_019357.1; .
UniGeneRn.773; -; .
ProteinModelPortalP31977; -; .
SMRP31977; 1-385; 500-586; .
IntActP31977; 1; .
STRINGP31977; -; .
PhosphoSiteP31977; -; .
World-2DPAGE0004:P31977; -; .
PRIDEP31977; -; .
EnsemblENSRNOT00000046746; ENSRNOP00000046593; ENSRNOG00000018524; .
GeneID54319; -; .
KEGGrno:54319; -; .
UCSCAY428869; rat; .
CTD7430; -; .
RGD621161; Ezr; .
eggNOGroNOG13879; -; .
GeneTreeENSGT00600000084066; -; .
HOVERGENHBG002185; -; .
InParanoidP31977; -; .
OrthoDBEOG4C5CJJ; -; .
ReactomeREACT_112697; Developmental Biology; .
NextBio611002; -; .
ArrayExpressP31977; -; .
GenevestigatorP31977; -; .
GermOnlineENSRNOG00000018524; Rattus norvegicus; .
GOGO:0005884; C:actin filament; ISS:UniProtKB; .
GOGO:0016324; C:apical plasma membrane; IDA:UniProtKB; .
GOGO:0005938; C:cell cortex; IEA:UniProtKB-SubCell; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0019898; C:extrinsic to membrane; ISS:UniProtKB; .
GOGO:0031528; C:microvillus membrane; IDA:UniProtKB; .
GOGO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell; .
GOGO:0051015; F:actin filament binding; ISS:UniProtKB; .
GOGO:0050839; F:cell adhesion molecule binding; ISS:BHF-UCL; .
GOGO:0005198; F:structural molecule activity; TAS:RGD; .
GOGO:0051017; P:actin filament bundle assembly; ISS:UniProtKB; .
GOGO:0030855; P:epithelial cell differentiation; IEP:RGD; .
GOGO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW; .
InterProIPR019749; Band_41_domain; .
InterProIPR019750; Band_41_fam; .
InterProIPR011174; ERM; .
InterProIPR011259; ERM_C; .
InterProIPR000798; Ez/rad/moesin; .
InterProIPR014352; FERM/acyl-CoA-bd_prot_3-hlx; .
InterProIPR019748; FERM_central; .
InterProIPR019747; FERM_CS; .
InterProIPR000299; FERM_domain; .
InterProIPR018979; FERM_N; .
InterProIPR018980; FERM_PH-like_C; .
InterProIPR008954; Moesin; .
InterProIPR011993; PH_type; .
Gene3DG3DSA:; ACBP; 1; .
Gene3DG3DSA:; PH_type; 1; .
KOK08007; -; .
PfamPF00769; ERM; 1; .
PfamPF09380; FERM_C; 1; .
PfamPF00373; FERM_M; 1; .
PfamPF09379; FERM_N; 1; .
PIRSFPIRSF002305; ERM; 1; .
PRINTSPR00935; BAND41; .
SMARTSM00295; B41; 1; .
SUPFAMSSF47031; FERM_3-hlx; 1; .
SUPFAMSSF48678; Moesin; 1; .
PROSITEPS00660; FERM_1; 1; .
PROSITEPS00661; FERM_2; 1; .
PROSITEPS50057; FERM_3; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server