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World-2DPAGE Repository  Search by  [accession number]  [description, ID or gene]  [author names]  [spot ID / serial number]  [identification methods]  [pI / Mw range]  [combined fields]  Maps  [experimental info]  [protein list]  [graphical interface]      Databases 0001 0002 0003 0004 0005 0006 0007 0008 0009 0010 0011 0012 0014 0017 0018 0019 0020 0021 0022 0023 0024 0026 0027 0029 0030 0031 0032 0034 0035 0036 0037 0038 0039 0040 0042 0043 0044 0046 0047 0050 0051 0053 0054 0056 0059 0061 0062 0063 0066 0068 0069 0076 0077 0080 0084 0085 0088 use 'Ctrl' to select several databases Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal Exclude local DBs has only effect if a remote interface is selected

Searching in 'World-2DPAGE Repository [0027]' for entry matching: FLNA_MOUSE World-2DPAGE Repository (0027):  FLNA_MOUSE FLNA_MOUSE General information about the entry View entry in simple text format Entry name FLNA_MOUSE Primary accession number Q8BTM8 integrated into World-2DPAGE Repository (0027) on  September 30, 2010 (release 1) 2D Annotations were last modified on June 21, 2011 (version 2) General Annotations were last modified on  November 23, 2011 (version 2) Name and origin of the protein Description RecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin;. Gene name Name=Flna Synonyms=Fln, Fln1 Annotated species Mus musculus (Mouse) [TaxID: 10090] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus. References [1]   2D-PAGE GEL CHARACTERIZATION DOI=10.1002/prca.201000103; Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R. ''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria'' Proteomics - Clinical Applications 5(6):375-381 (2011) 2D PAGE maps for identified proteins How to interpret a protein GH_4-7 {glomerular protein lysates of a GH-tg animal} Mus musculus (Mouse)   map experimental info   GH_4-7 MAP LOCATIONS: SPOT 2: pI=6.30; Mw=99000   [identification data] EXPRESSION: SPOT 2: Avg ratio GH-tg vs. control=1.52 (p-value=0.0054) [1]. IDENTIFICATION: SPOT 2: SeqCov=17%. Mascot protein score=305 [1]. MAPPING (identification): SPOT 2: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1]. Copyright Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany Cross-references UniProtKB/Swiss-Prot Q8BTM8; FLNA_MOUSE. World-2DPAGE Repository Q8BTM8; FLNA_MOUSE. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 2011_11 Entry name FLNA_MOUSE Primary accession number Q8BTM8 Secondary accession number(s) B7FAV0 O54934 Q7TQI1 Q8BLK1 Q8BTN7 Q8VHX5 Q8VHX8 Q99KQ2 Sequence was last modified on  July 27, 2011 (version 5) Annotations were last modified on  November 16, 2011 (version 100) Name and origin of the protein Description RecName: Full=Filamin-A; Short=FLN-A; AltName: Full=Actin-binding protein 280; Short=ABP-280; AltName: Full=Alpha-filamin; AltName: Full=Endothelial actin-binding protein; AltName: Full=Filamin-1; AltName: Full=Non-muscle filamin; Gene name Name=Flna Synonyms=Fln, Fln1 Encoded on Name=Flna; Synonyms=Fln, Fln1 Keywords Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat. Copyright Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AK044856; BAC32121.1; -; mRNA EMBL AK089195; BAC40787.1; ALT_INIT; mRNA EMBL AK089311; BAC40837.2; ALT_INIT; mRNA EMBL AL807376; CAT00728.1; -; Genomic_DNA EMBL BC004061; AAH04061.1; -; mRNA EMBL BC038478; -; NOT_ANNOTATED_CDS; mRNA EMBL BC054432; AAH54432.1; -; mRNA EMBL AF034129; AAC02062.1; -; mRNA EMBL AF353668; AAL68444.1; -; mRNA EMBL AF353671; AAL68447.1; -; mRNA IPI IPI00131138; -; . IPI IPI00387373; -; . RefSeq NP_034357.2; NM_010227.2; . UniGene Mm.295533; -; . ProteinModelPortal Q8BTM8; -; . SMR Q8BTM8; 39-269; 1044-1643; 1773-2329 2331-2522 2559-2647; . IntAct Q8BTM8; 2; . MINT MINT-1867095; -; . STRING Q8BTM8; -; . PhosphoSite Q8BTM8; -; . PRIDE Q8BTM8; -; . Ensembl ENSMUST00000033699; ENSMUSP00000033699; ENSMUSG00000031328; . GeneID 192176; -; . KEGG mmu:192176; -; . CTD 2316; -; . MGI MGI:95556; Flna; . eggNOG roNOG14400; -; . HOVERGEN HBG004163; -; . InParanoid Q8BTM8; -; . NextBio 371188; -; . ArrayExpress Q8BTM8; -; . Bgee Q8BTM8; -; . CleanEx MM_FLNA; -; . Genevestigator Q8BTM8; -; . GermOnline ENSMUSG00000031328; Mus musculus; . GO GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell; . GO GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell; . GO GO:0005634; C:nucleus; ISS:UniProtKB; . GO GO:0005886; C:plasma membrane; ISS:UniProtKB; . GO GO:0005802; C:trans-Golgi network; IDA:MGI; . GO GO:0051015; F:actin filament binding; ISS:UniProtKB; . GO GO:0034988; F:Fc-gamma receptor I complex binding; ISS:UniProtKB; . GO GO:0001948; F:glycoprotein binding; ISS:UniProtKB; . GO GO:0005080; F:protein kinase C binding; IDA:MGI; . GO GO:0048365; F:Rac GTPase binding; ISS:UniProtKB; . GO GO:0004871; F:signal transducer activity; ISS:UniProtKB; . GO GO:0008134; F:transcription factor binding; ISS:UniProtKB; . GO GO:0051764; P:actin crosslink formation; ISS:UniProtKB; . GO GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB; . GO GO:0051220; P:cytoplasmic sequestering of protein; ISS:UniProtKB; . GO GO:0045022; P:early endosome to late endosome transport; IDA:MGI; . GO GO:0045184; P:establishment of protein localization; ISS:UniProtKB; . GO GO:0007195; P:inhibition of adenylate cyclase activity by dopamine receptor signaling pathway; ISS:UniProtKB; . GO GO:0042177; P:negative regulation of protein catabolic process; ISS:UniProtKB; . GO GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB; . GO GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB; . GO GO:0042993; P:positive regulation of transcription factor import into nucleus; ISS:UniProtKB; . GO GO:0034394; P:protein localization at cell surface; ISS:UniProtKB; . GO GO:0050821; P:protein stabilization; ISS:UniProtKB; . GO GO:0043113; P:receptor clustering; ISS:UniProtKB; . InterPro IPR001589; Actinin_actin-bd_CS; . InterPro IPR001715; CH-domain; . InterPro IPR001298; Filamin; . InterPro IPR017868; Filamin/ABP280_repeat-like; . InterPro IPR013783; Ig-like_fold; . InterPro IPR014756; Ig_E-set; . Gene3D G3DSA:1.10.418.10; Calponin-homology; 2; . Gene3D G3DSA:2.60.40.10; Ig-like_fold; 24; . KO K04437; -; . Pfam PF00307; CH; 2; . Pfam PF00630; Filamin; 23; . SMART SM00033; CH; 2; . SMART SM00557; IG_FLMN; 24; . SUPFAM SSF47576; Calponin-homology; 1; . SUPFAM SSF81296; Ig_E-set; 24; . PROSITE PS00019; ACTININ_1; 1; . PROSITE PS00020; ACTININ_2; 1; . PROSITE PS50021; CH; 2; . PROSITE PS50194; FILAMIN_REPEAT; 24; . World-2DPAGE Repository (search AC)