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Searching in 'World-2DPAGE Repository [0014]' for entry matching: HMCS1_RAT

World-2DPAGE Repository (0014):  HMCS1_RAT


General information about the entry
View entry in simple text format
Entry nameHMCS1_RAT
Primary accession numberP17425
integrated into World-2DPAGE Repository (0014) on October 13, 2008 (release 1)
2D Annotations were last modified onJune 1, 2011 (version 3)
General Annotations were last modified on November 25, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Hydroxymethylglutaryl-CoA synthase, cytoplasmic; Short=HMG-CoA synthase; EC=; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase;.
Gene nameName=Hmgcs1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Maurya D.K., Sundaram C.S., Bhargava P.
''Proteome profile of whole cerebellum of the mature rat''
Proteomics 10(23):4311-4319 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

RAT_CEREBELLUM_21D {Proteome of 21 days old rat cerebellum}
Rattus norvegicus (Rat)
Tissue: Cerebellum
  map experimental info

pI=5.85; Mw=57000  [identification data]

IDENTIFICATION: SPOT 2850: SeqCov=28%. MascotPMF=71 [1].
MAPPING (identification):
SPOT 2850: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Data from Dr. Purnima Bhargava, Centre for Cellular and Molecular Biology, India
UniProtKB/Swiss-ProtP17425; HMCS1_RAT.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameHMCS1_RAT
Primary accession numberP17425
Sequence was last modified on August 1, 1990 (version 1)
Annotations were last modified on November 16, 2011 (version 104)
Name and origin of the protein
DescriptionRecName: Full=Hydroxymethylglutaryl-CoA synthase, cytoplasmic; Short=HMG-CoA synthase; EC=; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase;
Gene nameName=Hmgcs1
Encoded onName=Hmgcs1; Synonyms=Hmgcs
KeywordsAcetylation; Cholesterol biosynthesis; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid synthesis; Phosphoprotein; Reference proteome; Steroid biosynthesis; Sterol biosynthesis; Transferase.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLX52625; CAA36852.1; -; mRNA
IPIIPI00188158; -; .
PIRS12736; S12736; .
RefSeqNP_058964.1; NM_017268.1; .
UniGeneRn.5106; -; .
ProteinModelPortalP17425; -; .
SMRP17425; 16-470; .
STRINGP17425; -; .
PhosphoSiteP17425; -; .
PRIDEP17425; -; .
EnsemblENSRNOT00000023554; ENSRNOP00000023554; ENSRNOG00000016552; .
GeneID29637; -; .
KEGGrno:29637; -; .
NMPDRfig|10116.3.peg.15558; -; .
UCSCNM_017268; rat; .
CTD3157; -; .
RGD70970; Hmgcs1; .
eggNOGroNOG08859; -; .
GeneTreeENSGT00390000006096; -; .
HOVERGENHBG051912; -; .
InParanoidP17425; -; .
OrthoDBEOG4F1X30; -; .
PhylomeDBP17425; -; .
BRENDA2.3.3.10; 5301; .
NextBio609884; -; .
ArrayExpressP17425; -; .
GenevestigatorP17425; -; .
GermOnlineENSRNOG00000016552; Rattus norvegicus; .
GOGO:0005829; C:cytosol; IDA:RGD; .
GOGO:0008144; F:drug binding; IDA:RGD; .
GOGO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD; .
GOGO:0016853; F:isomerase activity; IDA:RGD; .
GOGO:0043177; F:organic acid binding; IDA:RGD; .
GOGO:0042803; F:protein homodimerization activity; IDA:RGD; .
GOGO:0007420; P:brain development; IEP:RGD; .
GOGO:0071397; P:cellular response to cholesterol; IEP:RGD; .
GOGO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD; .
GOGO:0071407; P:cellular response to organic cyclic compound; IEP:RGD; .
GOGO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW; .
GOGO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro; .
GOGO:0001889; P:liver development; IEP:RGD; .
GOGO:0008584; P:male gonad development; IEP:RGD; .
GOGO:0001101; P:response to acid; IEP:RGD; .
GOGO:0042493; P:response to drug; IEP:RGD; .
GOGO:0055094; P:response to lipoprotein stimulus; IEP:RGD; .
GOGO:0009645; P:response to low light intensity stimulus; IEP:RGD; .
GOGO:0010243; P:response to organic nitrogen; IDA:RGD; .
GOGO:0014074; P:response to purine-containing compound; IEP:RGD; .
GOGO:0046690; P:response to tellurium ion; IEP:RGD; .
GOGO:0033197; P:response to vitamin E; IEP:RGD; .
InterProIPR000590; HMG_CoA_synt_AS; .
InterProIPR013746; HMG_CoA_synt_C; .
InterProIPR013528; HMG_CoA_synth_N; .
InterProIPR010122; HMG_CoA_synthase_euk; .
InterProIPR016039; Thiolase-like; .
InterProIPR016038; Thiolase-like_subgr; .
Gene3DG3DSA:; Thiolase-like_subgr; 1; .
KOK01641; -; .
PfamPF08540; HMG_CoA_synt_C; 1; .
PfamPF01154; HMG_CoA_synt_N; 1; .
SUPFAMSSF53901; Thiolase-like; 2; .
TIGRFAMsTIGR01833; HMG-CoA-S_euk; 1; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server