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Searching in 'World-2DPAGE Repository [0027]' for entry matching: MFGM_MOUSE

World-2DPAGE Repository (0027):  MFGM_MOUSE


General information about the entry
View entry in simple text format
Entry nameMFGM_MOUSE
Primary accession numberP21956
integrated into World-2DPAGE Repository (0027) on September 30, 2010 (release 1)
2D Annotations were last modified onJune 21, 2011 (version 2)
General Annotations were last modified on November 23, 2011 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Lactadherin; AltName: Full=MFGM; AltName: Full=Milk fat globule-EGF factor 8; Short=MFG-E8; AltName: Full=SED1; AltName: Full=Sperm surface protein SP47; Short=MP47; Flags: Precursor;.
Gene nameName=Mfge8
Annotated speciesMus musculus (Mouse) [TaxID: 10090]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus.
Blutke A., Block C., Berendt F., Herbach N., Kemter E., Amann K., Frolich T., Arnold G.J., Wanke R.
''Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria''
Proteomics - Clinical Applications 5(6):375-381 (2011)
2D PAGE maps for identified proteins
How to interpret a protein

GIPRDN_4-7 {glomerular protein lysates of a GIPRdn-tg animal}
Mus musculus (Mouse)
  map experimental info

pI=5.92; Mw=56000  [identification data]

SPOT 9: Avg ratio GIPRdn-tg vs. control=1.61 (p-value=0.0031) [1].

IDENTIFICATION: SPOT 9: SeqCov=15%. Mascot protein score=71 [1].
MAPPING (identification):
SPOT 9: Peptide mass fingerprinting [1].

Data from Dr. Andreas Blutke, Institute of Veterinary Pathology, University Munich, Germany
UniProtKB/Swiss-ProtP21956; MFGM_MOUSE.
World-2DPAGE RepositoryP21956; MFGM_MOUSE.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_11
Entry nameMFGM_MOUSE
Primary accession numberP21956
Secondary accession number(s) P97800 Q3TBN5 Q3U8S9 Q9R1X9 Q9WTS3
Sequence was last modified on July 27, 2011 (version 3)
Annotations were last modified on November 16, 2011 (version 96)
Name and origin of the protein
DescriptionRecName: Full=Lactadherin; AltName: Full=MFGM; AltName: Full=Milk fat globule-EGF factor 8; Short=MFG-E8; AltName: Full=SED1; AltName: Full=Sperm surface protein SP47; Short=MP47; Flags: Precursor;
Gene nameName=Mfge8
Encoded onName=Mfge8
KeywordsAlternative splicing; Angiogenesis; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Fertilization; Glycoprotein; Membrane; Reference proteome; Repeat; Secreted; Signal.
Copyrighted by the UniProt Consortium, see Distributed under the Creative Commons Attribution-NoDerivs License
EMBLM38337; AAA39534.1; -; mRNA
EMBLY11684; CAA72380.2; -; mRNA
EMBLAB021130; BAA35180.1; -; mRNA
EMBLAB025280; BAA76386.1; -; mRNA
EMBLAK089211; BAC40794.1; -; mRNA
EMBLAK152088; BAE30938.1; -; mRNA
EMBLAK171143; BAE42274.1; -; mRNA
EMBLBC003892; AAH03892.1; -; mRNA
EMBLBC003904; AAH03904.1; -; mRNA
IPIIPI00322712; -; .
IPIIPI00411071; -; .
PIRA36479; A36479; .
RefSeqNP_032620.2; NM_008594.2; .
UniGeneMm.1451; -; .
ProteinModelPortalP21956; -; .
SMRP21956; 10-463; .
PhosphoSiteP21956; -; .
PRIDEP21956; -; .
EnsemblENSMUST00000032825; ENSMUSP00000032825; ENSMUSG00000030605; .
EnsemblENSMUST00000107409; ENSMUSP00000103032; ENSMUSG00000030605; .
GeneID17304; -; .
KEGGmmu:17304; -; .
NMPDRfig|10090.3.peg.16740; -; .
MGIMGI:102768; Mfge8; .
eggNOGroNOG12830; -; .
HOGENOMHBG714573; -; .
HOVERGENHBG002385; -; .
InParanoidP21956; -; .
OrthoDBEOG47D9G6; -; .
ArrayExpressP21956; -; .
BgeeP21956; -; .
CleanExMM_MFGE8; -; .
GenevestigatorP21956; -; .
GermOnlineENSMUSG00000030605; Mus musculus; .
GOGO:0009897; C:external side of plasma membrane; IDA:MGI; .
GOGO:0005615; C:extracellular space; IDA:MGI; .
GOGO:0019897; C:extrinsic to plasma membrane; IDA:MGI; .
GOGO:0005178; F:integrin binding; IDA:BHF-UCL; .
GOGO:0008429; F:phosphatidylethanolamine binding; IDA:MGI; .
GOGO:0001786; F:phosphatidylserine binding; IDA:MGI; .
GOGO:0001525; P:angiogenesis; IEA:UniProtKB-KW; .
GOGO:0007155; P:cell adhesion; IEA:UniProtKB-KW; .
GOGO:0006911; P:phagocytosis; engulfment; IDA:MGI
GOGO:0006910; P:phagocytosis; recognition; IDA:MGI
GOGO:2000427; P:positive regulation of apoptotic cell clearance; IDA:BHF-UCL; .
GOGO:0007338; P:single fertilization; IEA:UniProtKB-KW; .
InterProIPR000421; Coagulation_fac_5/8-C_type_dom; .
InterProIPR006209; EGF; .
InterProIPR006210; EGF-like; .
InterProIPR013032; EGF-like_reg_CS; .
InterProIPR000742; EGF_3; .
InterProIPR008979; Galactose-bd-like; .
PfamPF00008; EGF; 1; .
PfamPF00754; F5_F8_type_C; 2; .
SMARTSM00181; EGF; 2; .
SMARTSM00231; FA58C; 2; .
SUPFAMSSF49785; Gal_bind_like; 2; .
PROSITEPS00022; EGF_1; 2; .
PROSITEPS01186; EGF_2; 2; .
PROSITEPS50026; EGF_3; 2; .
PROSITEPS01285; FA58C_1; 2; .
PROSITEPS01286; FA58C_2; 2; .
PROSITEPS50022; FA58C_3; 2; .

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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the Expasy web server