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Searching in 'World-2DPAGE Repository [0019]' for entry matching: MK01_MOUSE




World-2DPAGE Repository (0019):  MK01_MOUSE

MK01_MOUSE


General information about the entry
View entry in simple text format
Entry nameMK01_MOUSE
Primary accession numberP63085
integrated into World-2DPAGE Repository (0019) on December 9, 2009 (release 1)
2D Annotations were last modified onMay 30, 2011 (version 2)
General Annotations were last modified on January 13, 2012 (version 2)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;.
Gene nameName=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Annotated speciesRattus norvegicus (Rat) [TaxID: 10116]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
References
[1]   2D-PAGE GEL CHARACTERIZATION
DOI=10.1111/j.1471-4159.2010.06719.x;
VanGuilder H.D., Yan H., Farley J.A., Sonntag W.E., Freeman W.M.
''Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome''
J of Neurochemistry 113(6):1577-1588 (2010)
2D PAGE maps for identified proteins
How to interpret a protein

HIPP_SYNAP {Rat hippocampal synaptoproteome}
Rattus norvegicus (Rat)
Tissue: Hippocampus
HIPP_SYNAP
  map experimental info 		 
HIPP_SYNAP

MAP LOCATIONS:
pI=6.50; Mw=41648  [identification data]

IDENTIFICATION: SPOT 1183: Peptides number=7. SeqCov=22.1%. MOWSE score=1.05E+7 [1].
MAPPING (identification):
SPOT 1183: Peptide mass fingerprinting [1]; Tandem mass spectrometry [1].

Copyright
Data from Dr. Willard Freeman, Penn State College of Medicine, USA
Cross-references
UniProtKB/Swiss-ProtP63085; MK01_MOUSE.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 2011_12
Entry nameMK01_MOUSE
Primary accession numberP63085
Secondary accession number(s) P27703 Q3V1U6
Sequence was last modified on January 23, 2007 (version 3)
Annotations were last modified on December 14, 2011 (version 98)
Name and origin of the protein
DescriptionRecName: Full=Mitogen-activated protein kinase 1; Short=MAP kinase 1; Short=MAPK 1; EC=2.7.11.24; AltName: Full=ERT1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=MAP kinase isoform p42; Short=p42-MAPK; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2;
Gene nameName=Mapk1
Synonyms=Erk2, Mapk, Prkm1
Encoded onName=Mapk1; Synonyms=Erk2, Mapk, Prkm1
KeywordsAcetylation; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Copyright
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX58712; CAA41548.1; -; mRNA
EMBLAK035386; BAC29053.1; -; mRNA
EMBLAK048127; BAC33251.1; -; mRNA
EMBLAK087925; BAC40044.1; -; mRNA
EMBLAK132241; BAE21053.1; -; mRNA
EMBLBC058258; AAH58258.1; -; mRNA
EMBLD10939; BAA01733.1; -; mRNA
IPIIPI00119663; -; .
PIRS16444; S16444; .
RefSeqNP_001033752.1; NM_001038663.1; .
RefSeqNP_036079.1; NM_011949.3; .
UniGeneMm.196581; -; .
ProteinModelPortalP63085; -; .
SMRP63085; 6-355; .
DIPDIP-661N; -; .
IntActP63085; 16; .
MINTMINT-125264; -; .
STRINGP63085; -; .
PhosphoSiteP63085; -; .
PRIDEP63085; -; .
EnsemblENSMUST00000023462; ENSMUSP00000023462; ENSMUSG00000063358; .
EnsemblENSMUST00000069107; ENSMUSP00000065983; ENSMUSG00000063358; .
EnsemblENSMUST00000115731; ENSMUSP00000111396; ENSMUSG00000063358; .
GeneID26413; -; .
KEGGmmu:26413; -; .
NMPDRfig|10090.3.peg.30922; -; .
UCSCuc009jsn.1; mouse; .
CTD5594; -; .
MGIMGI:1346858; Mapk1; .
HOGENOMHBG755340; -; .
HOVERGENHBG014652; -; .
InParanoidP63085; -; .
OMARCKVPWN; -; .
OrthoDBEOG45HRXM; -; .
PhylomeDBP63085; -; .
ReactomeREACT_115202; Signal Transduction; .
ReactomeREACT_98458; Immune System; .
NextBio304409; -; .
ArrayExpressP63085; -; .
BgeeP63085; -; .
CleanExMM_MAPK1; -; .
GenevestigatorP63085; -; .
GermOnlineENSMUSG00000063358; Mus musculus; .
GOGO:0005829; C:cytosol; IDA:BHF-UCL; .
GOGO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell; .
GOGO:0005739; C:mitochondrion; IDA:MGI; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0031143; C:pseudopodium; IDA:UniProtKB; .
GOGO:0005524; F:ATP binding; IEA:UniProtKB-KW; .
GOGO:0004707; F:MAP kinase activity; IDA:MGI; .
GOGO:0001784; F:phosphotyrosine binding; IMP:MGI; .
GOGO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IDA:UniProtKB; .
GOGO:0050853; P:B cell receptor signaling pathway; IDA:MGI; .
GOGO:0007049; P:cell cycle; IEA:UniProtKB-KW; .
GOGO:0019858; P:cytosine metabolic process; IDA:MGI; .
GOGO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI; .
GOGO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:MGI; .
GOGO:0033598; P:mammary gland epithelial cell proliferation; IDA:MGI; .
GOGO:0045596; P:negative regulation of cell differentiation; IGI:MGI; .
GOGO:0009887; P:organ morphogenesis; IDA:MGI; .
GOGO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; NAS:UniProtKB; .
GOGO:0006974; P:response to DNA damage stimulus; IDA:MGI; .
GOGO:0043330; P:response to exogenous dsRNA; IDA:MGI; .
GOGO:0050852; P:T cell receptor signaling pathway; IDA:MGI; .
GOGO:0006351; P:transcription; DNA-dependent; NAS:UniProtKB
InterProIPR008349; Erk_1_2_MAPK; .
InterProIPR011009; Kinase-like_dom; .
InterProIPR003527; MAP_kinase_CS; .
InterProIPR000719; Prot_kinase_cat_dom; .
InterProIPR017441; Protein_kinase_ATP_BS; .
InterProIPR017442; Se/Thr_kinase-like_dom; .
InterProIPR008271; Ser/Thr_kinase_AS; .
InterProIPR002290; Ser/Thr_kinase_dom; .
KOK04371; -; .
PfamPF00069; Pkinase; 1; .
PRINTSPR01770; ERK1ERK2MAPK; .
SMARTSM00220; S_TKc; 1; .
SUPFAMSSF56112; Kinase_like; 1; .
PROSITEPS01351; MAPK; 1; .
PROSITEPS00107; PROTEIN_KINASE_ATP; 1; .
PROSITEPS50011; PROTEIN_KINASE_DOM; 1; .
PROSITEPS00108; PROTEIN_KINASE_ST; 1; .


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Database constructed and maintained by SIB, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server